ZNF445 is a primary regulator of genomic imprinting.

Abstract:

:Genomic imprinting is an epigenetic process regulated by germline-derived DNA methylation, causing parental origin-specific monoallelic gene expression. Zinc finger protein 57 (ZFP57) is critical for maintenance of this epigenetic memory during post-fertilization reprogramming, yet incomplete penetrance of ZFP57 mutations in humans and mice suggests additional effectors. We reveal that ZNF445/ZFP445, which we trace to the origins of imprinting, binds imprinting control regions (ICRs) in mice and humans. In mice, ZFP445 and ZFP57 act together, maintaining all but one ICR in vivo, whereas earlier embryonic expression of ZNF445 and its intolerance to loss-of-function mutations indicate greater importance in the maintenance of human imprints.

journal_name

Genes Dev

journal_title

Genes & development

authors

Takahashi N,Coluccio A,Thorball CW,Planet E,Shi H,Offner S,Turelli P,Imbeault M,Ferguson-Smith AC,Trono D

doi

10.1101/gad.320069.118

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

49-54

issue

1-2

eissn

0890-9369

issn

1549-5477

pii

33/1-2/49

journal_volume

33

pub_type

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