Abstract:
:Genomic imprinting is an epigenetic process regulated by germline-derived DNA methylation, causing parental origin-specific monoallelic gene expression. Zinc finger protein 57 (ZFP57) is critical for maintenance of this epigenetic memory during post-fertilization reprogramming, yet incomplete penetrance of ZFP57 mutations in humans and mice suggests additional effectors. We reveal that ZNF445/ZFP445, which we trace to the origins of imprinting, binds imprinting control regions (ICRs) in mice and humans. In mice, ZFP445 and ZFP57 act together, maintaining all but one ICR in vivo, whereas earlier embryonic expression of ZNF445 and its intolerance to loss-of-function mutations indicate greater importance in the maintenance of human imprints.
journal_name
Genes Devjournal_title
Genes & developmentauthors
Takahashi N,Coluccio A,Thorball CW,Planet E,Shi H,Offner S,Turelli P,Imbeault M,Ferguson-Smith AC,Trono Ddoi
10.1101/gad.320069.118subject
Has Abstractpub_date
2019-01-01 00:00:00pages
49-54issue
1-2eissn
0890-9369issn
1549-5477pii
33/1-2/49journal_volume
33pub_type
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