当前位置： SCI文献检索 > GENES & DEVELOPMENT期刊下所有文献 > Loss of function of def selectively up-regulates Delta113p53 expression to arrest expansion growth of digestive organs in zebrafish.

Loss of function of def selectively up-regulates Delta113p53 expression to arrest expansion growth of digestive organs in zebrafish.

Abstract：

:Transcription factor p53 forms a network with associated factors to regulate the cell cycle and apoptosis in response to environmental stresses. However, there is currently no direct genetic evidence to show if or how the p53 pathway functions during organogenesis. Here we present evidence to show that the zebrafish def (digestive-organ expansion factor) gene encodes a novel pan-endoderm-specific factor. A loss-of-function mutation in def confers hypoplastic digestive organs and selectively up-regulates the expression of Delta113p53, counterpart to a newly identified isoform of p53 produced by an alternative internal promoter in intron 4 of the p53 gene in human. The increased Delta113p53 expression is limited to within the mutant digestive organs, and this increase selectively induces the expression of p53-responsive genes to trigger the arrest of the cell cycle but not apoptosis, resulting in compromised organ growth in the mutant. Our data demonstrate that, while induction of expression of p53 and/or its isoforms is crucial to suppress abnormal cell growth, Delta113p53 is tightly regulated by an organ/tissue-specific factor Def, especially during organogenesis, to prevent adverse inhibition of organ/tissue growth.

journal_name

Genes Dev

journal_title

Genes & development

authors

Chen J,Ruan H,Ng SM,Gao C,Soo HM,Wu W,Zhang Z,Wen Z,Lane DP,Peng J

doi

10.1101/gad.1366405

subject

Has Abstract

pub_date

2005-12-01 00:00:00

pages

2900-11

issue

23

eissn

0890-9369

issn

1549-5477

pii

19/23/2900

journal_volume

19

pub_type

杂志文章

相关文献

GENES & DEVELOPMENT文献大全
  • Transcription factor Ebf1 regulates differentiation stage-specific signaling, proliferation, and survival of B cells.

    abstract：:The transcription factor Ebf1 is an important determinant of early B lymphopoiesis. To gain insight into the functions of Ebf1 at distinct stages of differentiation, we conditionally inactivated Ebf1. We found that Ebf1 is required for the proliferation, survival, and signaling of pro-B cells and peripheral B-cell sub...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.187328.112

    authors： Györy I,Boller S,Nechanitzky R,Mandel E,Pott S,Liu E,Grosschedl R

    更新日期：2012-04-01 00:00:00

  • Activities of Ligatin and MCT-1/DENR in eukaryotic translation initiation and ribosomal recycling.

    abstract：:Eukaryotic translation initiation begins with ribosomal recruitment of aminoacylated initiator tRNA (Met-tRNA(Met)(i)) by eukaryotic initiation factor eIF2. In cooperation with eIF3, eIF1, and eIF1A, Met-tRNA(Met)(i)/eIF2/GTP binds to 40S subunits yielding 43S preinitiation complexes that attach to the 5'-terminal reg...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.1957510

    authors： Skabkin MA,Skabkina OV,Dhote V,Komar AA,Hellen CU,Pestova TV

    更新日期：2010-08-15 00:00:00

  • cAMP stimulates the C/EBP-related transcription factor rNFIL-6 to trans-locate to the nucleus and induce c-fos transcription.

    abstract：:The c-fos serum response element (SRE) is a multifunctional regulatory region of the c-fos promoter that responds to a variety of inducers. Recently, we have demonstrated that the SRE binds the C/EBP-related transcription factor rat NFIL-6 (rNFIL-6). In this study we show that rNFIL-6 is regulated by the cAMP second m...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.5.10.1754

    authors： Metz R,Ziff E

    更新日期：1991-10-01 00:00:00

  • Loss of Topoisomerase I leads to R-loop-mediated transcriptional blocks during ribosomal RNA synthesis.

    abstract：:Pre-rRNA transcription by RNA Polymerase I (Pol I) is very robust on active rDNA repeats. Loss of yeast Topoisomerase I (Top1) generated truncated pre-rRNA fragments, which were stabilized in strains lacking TRAMP (Trf4/Trf5-Air1/Air2-Mtr4 polyadenylation complexes) or exosome degradation activities. Loss of both Top1...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.573310

    authors： El Hage A,French SL,Beyer AL,Tollervey D

    更新日期：2010-07-15 00:00:00

  • Raf-induced MMP9 disrupts tissue architecture of human breast cells in three-dimensional culture and is necessary for tumor growth in vivo.

    abstract：:Organization into polarized three-dimensional structures defines whether epithelial cells are normal or malignant. In a model of morphogenesis, we show that inhibiting key signaling pathways in human breast cancer cells leads to "phenotypic reversion" of the malignant cells. Using architecture as an endpoint, we repor...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.1990410

    authors： Beliveau A,Mott JD,Lo A,Chen EI,Koller AA,Yaswen P,Muschler J,Bissell MJ

    更新日期：2010-12-15 00:00:00

  • The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment.

    abstract：:Post-translational modifications of conserved N-terminal tail residues in histones regulate many aspects of chromosome activity. Thr 3 of histone H3 is highly conserved, but the significance of its phosphorylation is unclear, and the identity of the corresponding kinase unknown. Immunostaining with phospho-specific an...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.1267105

    authors： Dai J,Sultan S,Taylor SS,Higgins JM

    更新日期：2005-02-15 00:00:00

  • VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases.

    abstract：:The ECS (Elongin B/C-Cul2/Cul5-SOCS-box protein) complex is a member of a family of ubiquitin ligases that share a Cullin-Rbx module. SOCS-box proteins recruit substrates to the ECS complex and are linked to Cullin-Rbx via Elongin B/C. VHL has been implicated as a SOCS-box protein, but lacks a C-terminal sequence (dow...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.1252404

    authors： Kamura T,Maenaka K,Kotoshiba S,Matsumoto M,Kohda D,Conaway RC,Conaway JW,Nakayama KI

    更新日期：2004-12-15 00:00:00

  • Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans.

    abstract：:The superoxide radical (O(2)(-)) has long been considered a major cause of aging. O(2)(-) in cytosolic, extracellular, and mitochondrial pools is detoxified by dedicated superoxide dismutase (SOD) isoforms. We tested the impact of each SOD isoform in Caenorhabditis elegans by manipulating its five sod genes and saw no...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.504808

    authors： Doonan R,McElwee JJ,Matthijssens F,Walker GA,Houthoofd K,Back P,Matscheski A,Vanfleteren JR,Gems D

    更新日期：2008-12-01 00:00:00

  • Identification of in vivo mRNA targets of GLD-1, a maxi-KH motif containing protein required for C. elegans germ cell development.

    abstract：:Caenorhabditis elegans GLD-1, a KH motif containing RNA-binding protein of the GSG/STAR subfamily, controls diverse aspects of germ line development, suggesting that it may have multiple mRNA targets. We used an immunoprecipitation/subtractive hybridization/cloning strategy to identify 15 mRNAs that are putative targe...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.915901

    authors： Lee MH,Schedl T

    更新日期：2001-09-15 00:00:00

  • How do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells?

    abstract：:Chromosome replication occurs precisely once during the cell cycle of almost all eukaryotic cells, and is a highly complex process that is still understood relatively poorly. Two conserved kinases called Cdc7 (cell division cycle 7) and cyclin-dependent kinase (CDK) are required to establish replication forks during t...

    journal_title：Genes & development

    pub_type： 杂志文章,评审

    doi：10.1101/gad.1933010

    authors： Labib K

    更新日期：2010-06-15 00:00:00

  • Tissue-specific expression of the gene encoding hepatocyte nuclear factor 1 may involve hepatocyte nuclear factor 4.

    abstract：:Hepatocyte nuclear factor 1 (HNF-1) is a transcriptional regulatory protein possibly involved in the activation of many liver-specifically expressed genes. HNF-1 mRNA is restricted to a small number of tissues, suggesting that the HNF-1 gene itself is regulated at the transcriptional level. We have isolated and charac...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.5.12a.2225

    authors： Tian JM,Schibler U

    更新日期：1991-12-01 00:00:00

  • A novel, activin-inducible, blastopore lip-specific gene of Xenopus laevis contains a fork head DNA-binding domain.

    abstract：:The organizer region, or dorsal blastopore lip, plays a central role in the initiation of gastrulation and the formation of the body axis during Xenopus development. A similar process can also be induced in ectodermal explants by activin or by injection of activin mRNA into embryos. We have searched early embryo-speci...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.6.4.599

    authors： Dirksen ML,Jamrich M

    更新日期：1992-04-01 00:00:00

  • SAM68 is required for regulation of Pumilio by the NORAD long noncoding RNA.

    abstract：:The number of known long noncoding RNA (lncRNA) functions is rapidly growing, but how those functions are encoded in their sequence and structure remains poorly understood. NORAD (noncoding RNA activated by DNA damage) is a recently characterized, abundant, and highly conserved lncRNA that is required for proper mitot...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.309138.117

    authors： Tichon A,Perry RB,Stojic L,Ulitsky I

    更新日期：2018-01-01 00:00:00

  • A monocarboxylate transporter required for hepatocyte secretion of ketone bodies during fasting.

    abstract：:To find new genes that influence liver lipid mass, we performed a genetic screen for zebrafish mutants with hepatic steatosis, a pathological accumulation of fat. The red moon (rmn) mutant develops hepatic steatosis as maternally deposited yolk is depleted. Conversely, hepatic steatosis is suppressed in rmn mutants by...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.180968.111

    authors： Hugo SE,Cruz-Garcia L,Karanth S,Anderson RM,Stainier DY,Schlegel A

    更新日期：2012-02-01 00:00:00

  • MEK-2, a Caenorhabditis elegans MAP kinase kinase, functions in Ras-mediated vulval induction and other developmental events.

    abstract：:Activated Ras initiates a cascade of sequential phosphorylation events, including the protein kinases Raf, MEK, and MAP kinase. The Let-60 Ras-mediated signal transduction pathway controls vulval induction in Caenorhabditis elegans. Both Lin-45 Raf and Sur-1 MAP kinase have been determined to be essential factors duri...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.9.6.742

    authors： Wu Y,Han M,Guan KL

    更新日期：1995-03-15 00:00:00

  • Cell fusion induced by ERVWE1 or measles virus causes cellular senescence.

    abstract：:Cellular senescence limits proliferation of potentially detrimental cells, preventing tumorigenesis and restricting tissue damage. However, the function of senescence in nonpathological conditions is unknown. We found that the human placental syncytiotrophoblast exhibited the phenotype and expressed molecular markers ...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.227512.113

    authors： Chuprin A,Gal H,Biron-Shental T,Biran A,Amiel A,Rozenblatt S,Krizhanovsky V

    更新日期：2013-11-01 00:00:00

  • Rev-erbα and Rev-erbβ coordinately protect the circadian clock and normal metabolic function.

    abstract：:The nuclear receptor Rev-erbα regulates circadian rhythm and metabolism, but its effects are modest and it has been considered to be a secondary regulator of the cell-autonomous clock. Here we report that depletion of Rev-erbα together with closely related Rev-erbβ has dramatic effects on the cell-autonomous clock as ...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.186858.112

    authors： Bugge A,Feng D,Everett LJ,Briggs ER,Mullican SE,Wang F,Jager J,Lazar MA

    更新日期：2012-04-01 00:00:00

  • Genetics and biology of pancreatic ductal adenocarcinoma.

    abstract：:Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer death in the United States with a median survival of <6 mo and a dismal 5-yr survival rate of 3%-5%. The cancer's lethal nature stems from its propensity to rapidly disseminate to the lymphatic system and distant organs. This aggressive biol...

    journal_title：Genes & development

    pub_type： 杂志文章,评审

    doi：10.1101/gad.1415606

    authors： Hezel AF,Kimmelman AC,Stanger BZ,Bardeesy N,Depinho RA

    更新日期：2006-05-15 00:00:00

  • Suprabasal expression of a dominant-negative RXR alpha mutant in transgenic mouse epidermis impairs regulation of gene transcription and basal keratinocyte proliferation by RAR-selective retinoids.

    abstract：:To determine whether 9-cis retinoic acid receptors (RXRs) regulate the biological activity of all-trans retinoic acid (tRA) and its receptors (RARs) in skin, we have targeted a dominant-negative RXR alpha (dnRXR alpha) lacking transactivation function AF-2 to differentiated suprabasal keratinocytes in the epidermis of...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.11.1.59

    authors： Feng X,Peng ZH,Di W,Li XY,Rochette-Egly C,Chambon P,Voorhees JJ,Xiao JH

    更新日期：1997-01-01 00:00:00

  • Changes in histone gene dosage alter transcription in yeast.

    abstract：:Chromatin structure is believed to be important for a number of cellular processes, including transcription. However, the role of nucleosomes in transcription is not well understood. We have identified the yeast histone locus HTB1-HTB1, encoding histones H2A and H2B, as a suppressor of solo delta insertion mutations t...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.2.2.150

    authors： Clark-Adams CD,Norris D,Osley MA,Fassler JS,Winston F

    更新日期：1988-02-01 00:00:00

  • Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling.

    abstract：:Hypoxia induces rapid and dramatic changes in cellular metabolism, in part through inhibition of target of rapamycin (TOR) kinase complex 1 (TORC1) activity. Genetic studies have shown the tuberous sclerosis tumor suppressors TSC1/2 and the REDD1 protein to be essential for hypoxia regulation of TORC1 activity in Dros...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.1617608

    authors： DeYoung MP,Horak P,Sofer A,Sgroi D,Ellisen LW

    更新日期：2008-01-15 00:00:00

  • The PRC1 Polycomb group complex interacts with PLZF/RARA to mediate leukemic transformation.

    abstract：:Ectopic repression of retinoic acid (RA) receptor target genes by PML/RARA and PLZF/RARA fusion proteins through aberrant recruitment of nuclear corepressor complexes drives cellular transformation and acute promyelocytic leukemia (APL) development. In the case of PML/RARA, this repression can be reversed through trea...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.512009

    authors： Boukarabila H,Saurin AJ,Batsché E,Mossadegh N,van Lohuizen M,Otte AP,Pradel J,Muchardt C,Sieweke M,Duprez E

    更新日期：2009-05-15 00:00:00

  • Wnt signaling in Xenopus embryos inhibits bmp4 expression and activates neural development.

    abstract：:We report a new role for Wnt signaling in the vertebrate embryo: the induction of neural tissue from ectoderm. Early expression of mouse wnt8, Xwnt8, beta-catenin, or dominant-negative GSK3 induces the expression of neural-specific markers and inhibits the expression of Bmp4 in Xenopus ectoderm. We show that Wnt8, but...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.13.23.3149

    authors： Baker JC,Beddington RS,Harland RM

    更新日期：1999-12-01 00:00:00

  • The splicing regulator Rbfox2 is required for both cerebellar development and mature motor function.

    abstract：:The Rbfox proteins (Rbfox1, Rbfox2, and Rbfox3) regulate the alternative splicing of many important neuronal transcripts and have been implicated in a variety of neurological disorders. However, their roles in brain development and function are not well understood, in part due to redundancy in their activities. Here w...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.182477.111

    authors： Gehman LT,Meera P,Stoilov P,Shiue L,O'Brien JE,Meisler MH,Ares M Jr,Otis TS,Black DL

    更新日期：2012-03-01 00:00:00

  • p53 domains: identification and characterization of two autonomous DNA-binding regions.

    abstract：:We have investigated the DNA-binding, oligomerization, and trans-activation functions of isolated segments of murine p53. We find that p53 has two autonomous DNA-binding regions. One domain, from amino acid 280 to 390, forms stable tetramers and binds DNA nonspecifically. The biological significance, if any, of this D...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.7.12b.2575

    authors： Wang Y,Reed M,Wang P,Stenger JE,Mayr G,Anderson ME,Schwedes JF,Tegtmeyer P

    更新日期：1993-12-01 00:00:00

  • The C. elegans microRNA let-7 binds to imperfect let-7 complementary sites from the lin-41 3'UTR.

    abstract：:Caenorhabditis elegans let-7, a founding member of the microRNA family, is predicted to bind to six sites in the 3'UTR of the mRNA of its target gene, lin-41, to down-regulate LIN-41. Here, we demonstrate that wild-type let-7 microRNA binds in vitro to RNA from the lin-41 3'UTR. This interaction is dependent on two co...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.1165404

    authors： Vella MC,Choi EY,Lin SY,Reinert K,Slack FJ

    更新日期：2004-01-15 00:00:00

  • Cdc34 and the F-box protein Met30 are required for degradation of the Cdk-inhibitory kinase Swe1.

    abstract：:Ubiquitin-mediated proteolysis controls the abundance of many cell cycle regulatory proteins. Recent work in Saccharomyces cerevisiae suggests that a complex consisting of Cdc53, Skp1, and a third component known as an F-box protein (termed SCF) in combination with Cdc34 specifically targets regulatory proteins for de...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.12.16.2587

    authors： Kaiser P,Sia RA,Bardes EG,Lew DJ,Reed SI

    更新日期：1998-08-15 00:00:00

  • Developmentally regulated fetal thymic and extrathymic T-cell receptor gamma delta gene expression.

    abstract：:The gamma delta T-cell receptor (TCR) is the first TCR to be expressed in ontogeny in all vertebrates in which it has been examined thoroughly. Murine gamma delta cell-surface protein is detected by the fourteenth day of gestation. In this work, the activation of gamma delta RNA has been studied. Data indicate that th...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.4.8.1304

    authors： Carding SR,Kyes S,Jenkinson EJ,Kingston R,Bottomly K,Owen JJ,Hayday AC

    更新日期：1990-08-01 00:00:00

  • An adenovirus early region 4 gene product is required for induction of the infection-specific form of cellular E2F activity.

    abstract：:E2F is a cellular, sequence-specific DNA-binding factor that binds to pairs of sites that occur upstream of the E1A and E2 early mRNA cap sites. During adenovirus infection, there is induction of a form of E2F that binds cooperatively to the pair of sites in the E2 control region. Production of the infection-specific ...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.3.7.1062

    authors： Hardy S,Engel DA,Shenk T

    更新日期：1989-07-01 00:00:00

  • Cytosolic signaling protein Ecsit also localizes to mitochondria where it interacts with chaperone NDUFAF1 and functions in complex I assembly.

    abstract：:Ecsit is a cytosolic adaptor protein essential for inflammatory response and embryonic development via the Toll-like and BMP (bone morphogenetic protein) signal transduction pathways, respectively. Here, we demonstrate a mitochondrial function for Ecsit (an evolutionary conserved signaling intermediate in Toll pathway...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.408407

    authors： Vogel RO,Janssen RJ,van den Brand MA,Dieteren CE,Verkaart S,Koopman WJ,Willems PH,Pluk W,van den Heuvel LP,Smeitink JA,Nijtmans LG

    更新日期：2007-03-01 00:00:00