EGF domain swap converts a drosophila EGF receptor activator into an inhibitor.

abstract：:The transformer-2 (tra-2) gene of Drosophila melanogaster plays essential roles in both sexual differentiation in the female soma and spermatogenesis in the male germ line. In the female soma, tra-2 is known to act with other genes in the sex determination regulatory cascade to control the sex-specific alternative spl...

journal_title：Genes & development

authors： Mattox W,Palmer MJ,Baker BS

更新日期：1990-05-01 00:00:00

abstract：:During vascular development, endothelial platelet-derived growth factor B (PDGF-B) is critical for pericyte recruitment. Deletion of the conserved C-terminal heparin-binding motif impairs PDGF-BB retention and pericyte recruitment in vivo, suggesting a potential role for heparan sulfate (HS) in PDGF-BB function during...

journal_title：Genes & development

authors： Abramsson A,Kurup S,Busse M,Yamada S,Lindblom P,Schallmeiner E,Stenzel D,Sauvaget D,Ledin J,Ringvall M,Landegren U,Kjellén L,Bondjers G,Li JP,Lindahl U,Spillmann D,Betsholtz C,Gerhardt H

更新日期：2007-02-01 00:00:00

abstract：:To identify regions of the largest subunit of RNA polymerase that are potentially involved in transcript elongation and termination, we have characterized amino acid substitutions in the beta' subunit of Escherichia coli RNA polymerase that alter expression of reporter genes preceded by terminators in vivo. Terminatio...

journal_title：Genes & development

authors： Weilbaecher R,Hebron C,Feng G,Landick R

更新日期：1994-12-01 00:00:00

abstract：:The nucleosome remodeling factor (NURF) is one of several ISWI-containing protein complexes that catalyze ATP-dependent nucleosome sliding and facilitate transcription of chromatin in vitro. To establish the physiological requirements of NURF, and to distinguish NURF genetically from other ISWI-containing complexes, w...

journal_title：Genes & development

authors： Badenhorst P,Voas M,Rebay I,Wu C

更新日期：2002-12-15 00:00:00

abstract：:Telomere proteins protect the chromosomal terminus from nucleolytic degradation and end-to-end fusion, and they may contribute to telomere length control and the regulation of telomerase. The current studies investigate the effect of Oxytricha single-stranded telomere DNA-binding protein subunits alpha and beta on tel...

journal_title：Genes & development

authors： Froelich-Ammon SJ,Dickinson BA,Bevilacqua JM,Schultz SC,Cech TR

更新日期：1998-05-15 00:00:00

abstract：:RNase MRP is a ribonucleoprotein endoribonuclease that has been shown to cleave mitochondrial primer RNA sequences from a variety of sources. Most of the RNase MRP activity is found in the nucleus where it plays a role in the processing of 5.8S rRNA. A temperature-conditional point mutation in the yeast RNA component ...

journal_title：Genes & development

authors： Schmitt ME,Clayton DA

更新日期：1994-11-01 00:00:00

abstract：:Pcf11 is one of numerous proteins involved in pre-mRNA 3'-end processing and transcription termination. Using elongation complexes (ECs) formed from purified yeast RNA polymerase II (Pol II), we show that a 140-amino acid polypeptide from yeast Pcf11 is capable of dismantling the EC in vitro. This action depends on th...

journal_title：Genes & development

authors： Zhang Z,Fu J,Gilmour DS

更新日期：2005-07-01 00:00:00

abstract：:The hair follicle undergoes a lifelong developmental cycle that depends on the integration between activating and inhibitory signals acting to regulate and guide the proliferation and differentiation of pluripotent epithelial stem cells. The effectors and mechanisms responsible for re-entry of quiescent telogen hair f...

journal_title：Genes & development

authors： Coulombe PA,Caterina MJ

更新日期：2013-06-15 00:00:00

abstract：:The myc family of cellular oncogenes encodes three highly related nuclear phosphoproteins (c-Myc, N-Myc, and L-Myc) that are believed to function as sequence-specific transcription factors capable of regulating genes important in cellular growth and differentiation. Current evidence indicates that Myc family proteins ...

journal_title：Genes & development

authors： Mukherjee B,Morgenbesser SD,DePinho RA

更新日期：1992-08-01 00:00:00

abstract：:Faithful duplication of the genome relies on the ability to cope with an imperfect template. We investigated replication of UV-damaged DNA in Escherichia coli and found that ongoing replication stops for at least 15-20 min before resuming. Undamaged origins of replication (oriC) continue to fire at the normal rate and...

journal_title：Genes & development

authors： Rudolph CJ,Upton AL,Lloyd RG

更新日期：2007-03-15 00:00:00

abstract：:Reactive oxygen species (ROS) participate in numerous cell responses, including proliferation, DNA damage, and cell death. Based on these disparate activities, both promotion and inhibition of ROS have been proposed for cancer therapy. However, how the ROS response is determined is not clear. We examined the activitie...

journal_title：Genes & development

authors： Cheung EC,Lee P,Ceteci F,Nixon C,Blyth K,Sansom OJ,Vousden KH

更新日期：2016-01-01 00:00:00

abstract：:In budding yeast, a switch between the mutually exclusive pathways of cell cycle progression and conjugation is controlled at Start in late G1 phase. Mating pheromones promote conjugation by arresting cells in G1 phase before Start. Pheromone-induced cell cycle arrest requires a functional FAR1 gene. We have found tha...

journal_title：Genes & development

authors： McKinney JD,Chang F,Heintz N,Cross FR

更新日期：1993-05-01 00:00:00

abstract：:Alternative splicing factor/splicing factor 2 (ASF/SF2) is the prototype of a family of nuclear proteins highly conserved throughout metazoa, the SR (serine/arginine) proteins. Based largely on in vitro studies, SR proteins have been suggested to play important roles in constitutive and alternative splicing of pre-mRN...

journal_title：Genes & development

authors： Wang J,Takagaki Y,Manley JL

更新日期：1996-10-15 00:00:00

abstract：:Cellular signaling initiated by Hedgehog binding to Patched1 has profound importance in mammalian embryogenesis, genetic disease, and cancer. Hedgehog acts as a morphogen to specify distinctive cell fates using different concentration thresholds, but our knowledge of how the concentration gradient is interpreted into ...

journal_title：Genes & development

authors： Martinelli DC,Fan CM

更新日期：2007-05-15 00:00:00

abstract：:All multisubunit DNA-dependent RNA polymerases (RNAP) are zinc metalloenzymes, and at least two zinc atoms are present per enzyme molecule. RNAP residues involved in zinc binding and the functional role of zinc ions in the transcription mechanism or RNAP structure are unknown. Here, we locate four cysteine residues in...

journal_title：Genes & development

authors： Markov D,Naryshkina T,Mustaev A,Severinov K

更新日期：1999-09-15 00:00:00

abstract：:The integration of viral DNA into the host genome is an essential step in the retrovirus life cycle. To understand this process better, we have examined the native state of viral DNA in cells acutely infected by murine leukemia virus (MLV), using both a physical assay for viral DNA and a functional assay for integrati...

journal_title：Genes & development

authors： Bowerman B,Brown PO,Bishop JM,Varmus HE

更新日期：1989-04-01 00:00:00

abstract：:Transcription of frog rDNA by mouse cell factors is the only documented exception to the observed species selectivity of rRNA gene expression. This heterologous transcription is authentic in that it uses the normal frog upstream and core promoter domains, as well as the normal mouse polymerase I transcription factors,...

journal_title：Genes & development

authors： Pape LK,Windle JJ,Sollner-Webb B

更新日期：1990-01-01 00:00:00

abstract：:It is now well appreciated that the apoptosome, which governs caspase-dependent cell death, also drives nonapoptotic caspase activation to remodel cells. However, the determinants that specify whether the apoptosome acts to kill or remodel have yet to be identified. Here we report that Tango7 collaborates with the Dro...

journal_title：Genes & development

authors： D'Brot A,Chen P,Vaishnav M,Yuan S,Akey CW,Abrams JM

更新日期：2013-08-01 00:00:00

abstract：:Genomic imprinting, an inherently epigenetic phenomenon defined by parent of origin-dependent gene expression, is observed in mammals and flowering plants. Genome-scale surveys of imprinted expression and the underlying differential epigenetic marks have led to the discovery of hundreds of imprinted plant genes and co...

journal_title：Genes & development

authors： Rodrigues JA,Zilberman D

更新日期：2015-12-15 00:00:00

abstract：:The cJun N-terminal kinase 1 (JNK1) is implicated in diet-induced obesity. Indeed, germline ablation of the murine Jnk1 gene prevents diet-induced obesity. Here we demonstrate that selective deficiency of JNK1 in the murine nervous system is sufficient to suppress diet-induced obesity. The failure to increase body mas...

journal_title：Genes & development

authors： Sabio G,Cavanagh-Kyros J,Barrett T,Jung DY,Ko HJ,Ong H,Morel C,Mora A,Reilly J,Kim JK,Davis RJ

更新日期：2010-02-01 00:00:00

abstract：:To investigate functional differences between RNA polymerases IIA and IIO (Pol IIA and Pol IIO), with hypo- and hyperphosphorylated carboxy-terminal repeat domains (CTDs), respectively, we have visualized the in vivo distributions of the differentially phosphorylated forms of Pol II on Drosophila polytene chromosomes....

journal_title：Genes & development

authors： Weeks JR,Hardin SE,Shen J,Lee JM,Greenleaf AL

更新日期：1993-12-01 00:00:00

abstract：:Centromeres are maintained epigenetically by the presence of CENP-A, an evolutionarily conserved histone H3 variant, which directs kinetochore assembly and hence centromere function. To identify factors that promote assembly of CENP-A chromatin, we affinity-selected solubilized fission yeast CENP-ACnp1 chromatin. All ...

journal_title：Genes & development

authors： Singh PP,Shukla M,White SA,Lafos M,Tong P,Auchynnikava T,Spanos C,Rappsilber J,Pidoux AL,Allshire RC

更新日期：2020-02-01 00:00:00

abstract：:Animals alter their reproductive programs to accommodate changes in nutrient availability, yet the connections between known nutrient-sensing systems and reproductive programs are underexplored, and whether there is a mechanism that senses nucleotide levels to coordinate germline proliferation is unknown. We establish...

journal_title：Genes & development

authors： Chi C,Ronai D,Than MT,Walker CJ,Sewell AK,Han M

更新日期：2016-02-01 00:00:00

abstract：:The target gene(s) required for Myc-mediated tumorigenesis are still elusive. Here we show that while endogenous c-Myc is surprisingly dispensable for skin homeostasis and TPA-induced hyperplasia, c-Myc-deficient epidermis is resistant to Ras-mediated DMBA/TPAinduced tumorigenesis. This is mechanistically linked to p2...

journal_title：Genes & development

authors： Oskarsson T,Essers MA,Dubois N,Offner S,Dubey C,Roger C,Metzger D,Chambon P,Hummler E,Beard P,Trumpp A

更新日期：2006-08-01 00:00:00

abstract：:In the absence of growth signals, cells exit the cell cycle and enter into G0 or quiescence. Alternatively, cells enter senescence in response to inappropriate growth signals such as oncogene expression. The molecular mechanisms required for cell cycle exit into quiescence or senescence are poorly understood. The DREA...

journal_title：Genes & development

authors： Litovchick L,Florens LA,Swanson SK,Washburn MP,DeCaprio JA

更新日期：2011-04-15 00:00:00

abstract：:RNAi has revolutionized reverse genetics; however, RNAi is not necessarily ubiquitous or constitutive. Lund and colleagues (pp. 1121-1131) show that microRNA (miRNA) effector Argonautes (Agos) are limiting and easily saturated during early Xenopus embryogenesis. Moreover, this stage is devoid of slicing capacity. Supp...

journal_title：Genes & development

authors： Flynt AS,Lai EC

更新日期：2011-06-01 00:00:00

abstract：:Macrophage activation by the proinflammatory cytokine interferon-gamma (IFN-gamma) is a critical component of the host innate response to bacterial pathogenesis. However, the precise nature of the IFN-gamma-induced activation pathway is not known. Here we show using genome-wide expression and chromatin-binding profili...

journal_title：Genes & development

authors： Sonoda J,Laganière J,Mehl IR,Barish GD,Chong LW,Li X,Scheffler IE,Mock DC,Bataille AR,Robert F,Lee CH,Giguère V,Evans RM

更新日期：2007-08-01 00:00:00

abstract：:The transcription factor TFIIB plays a central role in preinitiation complex assembly, providing a bridge between promoter-bound TFIID and RNA Polymerase II. TFIIB possesses sequence-specific DNA-binding ability and interacts with the TFIIB-recognition element (BRE), present in many promoters. Here we show that the BR...

journal_title：Genes & development

authors： Evans R,Fairley JA,Roberts SG

更新日期：2001-11-15 00:00:00

abstract：:Treatment with retinoic acid (RA) is known to produce complex teratogenic effects in vertebrates, and its presence in the developing embryo as an endogenous substance has led to the suggestion that RA might be a natural morphogenetic agent. Although our understanding of the molecular mechanism of RA action has improve...

journal_title：Genes & development

authors： Rossant J,Zirngibl R,Cado D,Shago M,Giguère V

更新日期：1991-08-01 00:00:00

abstract：:Serotonin is a bioamine regulating bone mass accrual differently depending on its site of synthesis. It decreases accrual when synthesized in the gut, and increases it when synthesized in the brain. The signal transduction events elicited by gut-derived serotonin once it binds to the Htr1b receptor present on osteobla...

journal_title：Genes & development

authors： Oury F,Yadav VK,Wang Y,Zhou B,Liu XS,Guo XE,Tecott LH,Schutz G,Means AR,Karsenty G

更新日期：2010-10-15 00:00:00