Abstract:
:The nucleosome remodeling factor (NURF) is one of several ISWI-containing protein complexes that catalyze ATP-dependent nucleosome sliding and facilitate transcription of chromatin in vitro. To establish the physiological requirements of NURF, and to distinguish NURF genetically from other ISWI-containing complexes, we isolated mutations in the gene encoding the large NURF subunit, nurf301. We confirm that NURF is required for transcription activation in vivo. In animals lacking NURF301, heat-shock transcription factor binding to and transcription of the hsp70 and hsp26 genes are impaired. Additionally, we show that NURF is required for homeotic gene expression. Consistent with this, nurf301 mutants recapitulate the phenotypes of Enhancer of bithorax, a positive regulator of the Bithorax-Complex previously localized to the same genetic interval. Finally, mutants in NURF subunits exhibit neoplastic transformation of larval blood cells that causes melanotic tumors to form.
journal_name
Genes Devjournal_title
Genes & developmentauthors
Badenhorst P,Voas M,Rebay I,Wu Cdoi
10.1101/gad.1032202subject
Has Abstractpub_date
2002-12-15 00:00:00pages
3186-98issue
24eissn
0890-9369issn
1549-5477journal_volume
16pub_type
杂志文章abstract::The molecular mechanisms driving brain development at risk in autism spectrum disorders (ASDs) remain mostly unknown. Previous studies have implicated the transcription factor FOXP1 in both brain development and ASD pathophysiology. However, the specific molecular pathways both upstream of and downstream from FOXP1 ar...
journal_title:Genes & development
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更新日期:2017-10-15 00:00:00
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journal_title:Genes & development
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pub_type: 更正并重新发布的文章,杂志文章
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doi:10.1101/gad.4.6.1044
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journal_title:Genes & development
pub_type: 杂志文章
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更新日期:2007-08-15 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
doi:10.1101/gad.4.12b.2319
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journal_title:Genes & development
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更新日期:2001-04-15 00:00:00
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journal_title:Genes & development
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journal_title:Genes & development
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journal_title:Genes & development
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更新日期:2013-12-15 00:00:00
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