Abstract:
:The ascidian tadpole represents the most simplified chordate body plan. It contains a notochord composed of just 40 cells, but as in vertebrates Brachyury is essential for notochord differentiation. Here, we show that the misexpression of the Brachyury gene (Ci-Bra) of Ciona intestinalis is sufficient to transform endoderm into notochord. Subtractive hybridization screens were conducted to identify potential Brachyury target genes that are induced upon Ci-Bra misexpression. Of 501 independent cDNA clones that were surveyed, 38 were specifically expressed in notochord cells. These potential Ci-Bra downstream genes appear to encode a broad spectrum of divergent proteins associated with notochord formation.
journal_name
Genes Devjournal_title
Genes & developmentauthors
Takahashi H,Hotta K,Erives A,Di Gregorio A,Zeller RW,Levine M,Satoh Ndoi
10.1101/gad.13.12.1519subject
Has Abstractpub_date
1999-06-15 00:00:00pages
1519-23issue
12eissn
0890-9369issn
1549-5477journal_volume
13pub_type
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journal_title:Genes & development
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journal_title:Genes & development
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journal_title:Genes & development
pub_type: 杂志文章
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journal_title:Genes & development
pub_type: 杂志文章
doi:10.1101/gad.12.21.3331
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journal_title:Genes & development
pub_type: 杂志文章
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更新日期:2004-04-01 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1101/gad.895601
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pub_type: 杂志文章
doi:10.1101/gad.270421.115
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doi:10.1101/gad.4.8.1288
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journal_title:Genes & development
pub_type: 杂志文章
doi:10.1101/gad.6.4.557
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journal_title:Genes & development
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journal_title:Genes & development
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journal_title:Genes & development
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