Abstract:
:Maternal imprinting at the Xist gene is essential to achieve paternal allele-specific imprinted X-chromosome inactivation (XCI) in female mammals. However, the mechanism underlying Xist imprinting is unclear. Here we show that the Xist locus is coated with a broad H3K27me3 domain that is established during oocyte growth and persists through preimplantation development in mice. Loss of maternal H3K27me3 induces maternal Xist expression and maternal XCI in preimplantation embryos. Our study thus identifies maternal H3K27me3 as the imprinting mark of Xist.
journal_name
Genes Devjournal_title
Genes & developmentauthors
Inoue A,Jiang L,Lu F,Zhang Ydoi
10.1101/gad.304113.117subject
Has Abstractpub_date
2017-10-01 00:00:00pages
1927-1932issue
19eissn
0890-9369issn
1549-5477pii
31/19/1927journal_volume
31pub_type
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