Abstract:
:The YAP transcription coactivator has been implicated as an oncogene and is amplified in human cancers. Recent studies have established that YAP is phosphorylated and inhibited by the Hippo tumor suppressor pathway. Here we demonstrate that the TEAD family transcription factors are essential in mediating YAP-dependent gene expression. TEAD is also required for YAP-induced cell growth, oncogenic transformation, and epithelial-mesenchymal transition. CTGF is identified as a direct YAP target gene important for cell growth. Moreover, the functional relationship between YAP and TEAD is conserved in Drosophila Yki (the YAP homolog) and Scalloped (the TEAD homolog). Our study reveals TEAD as a new component in the Hippo pathway playing essential roles in mediating biological functions of YAP.
journal_name
Genes Devjournal_title
Genes & developmentauthors
Zhao B,Ye X,Yu J,Li L,Li W,Li S,Yu J,Lin JD,Wang CY,Chinnaiyan AM,Lai ZC,Guan KLdoi
10.1101/gad.1664408subject
Has Abstractpub_date
2008-07-15 00:00:00pages
1962-71issue
14eissn
0890-9369issn
1549-5477pii
gad.1664408journal_volume
22pub_type
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