Abstract:
:Restricted expression of a mouse Vasa homolog gene (Mvh) expression is first detected in primordial germ cells (PGCs) after colonization of the genital ridges. Subsequently, Mvh is maintained until postmeiotic germ cells are formed. Here, we demonstrate that male mice homozygous for a targeted mutation of Mvh exhibit a reproductive deficiency. Male homozygotes produce no sperm in the testes, where premeiotic germ cells cease differentiation by the zygotene stage and undergo apoptotic death. In addition, the proliferation of PGCs that colonize homozygous male gonads is significantly hampered, and OCT-3/4 expression appears to be reduced. These results indicate that the loss of Mvh function causes a deficiency in the proliferation and differentiation of mouse male germ cells.
journal_name
Genes Devjournal_title
Genes & developmentauthors
Tanaka SS,Toyooka Y,Akasu R,Katoh-Fukui Y,Nakahara Y,Suzuki R,Yokoyama M,Noce Tsubject
Has Abstractpub_date
2000-04-01 00:00:00pages
841-53issue
7eissn
0890-9369issn
1549-5477journal_volume
14pub_type
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