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Ste20-like protein kinases are required for normal localization of cell growth and for cytokinesis in budding yeast.

Abstract：

:The yeast Ste20 protein kinase is involved in pheromone response. Mammalian homologs of Ste20 exist, but their function remains unknown. We identified a novel yeast STE20 homolog, CLA4, in a screen for mutations lethal in the absence of the G1 cyclins Cln1 and Cln2. Cla4 is involved in budding and cytokinesis and interacts with Cdc42, a GTPase required for polarized cell growth. Despite a cytokinesis defect, cla4 mutants are viable. However, double cla4 ste20 mutants cannot maintain septin rings at the bud neck and cannot undergo cytokinesis. Mutations in CDC12, which encodes one of the septins, were found in the same screen. Cla4 and Ste20 kinases apparently share a function in localizing cell growth with respect to the septin ring.

journal_name

Genes Dev

journal_title

Genes & development

authors

Cvrcková F,De Virgilio C,Manser E,Pringle JR,Nasmyth K

doi

10.1101/gad.9.15.1817

subject

Has Abstract

pub_date

1995-08-01 00:00:00

pages

1817-30

issue

15

eissn

0890-9369

issn

1549-5477

journal_volume

9

pub_type

杂志文章

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