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Migrations of the Caenorhabditis elegans HSNs are regulated by egl-43, a gene encoding two zinc finger proteins.

Abstract：

:During embryonic development, the two Caenorhabditis elegans HSN motor neurons migrate from their birthplace in the tail to positions near the middle of the embryo. Here, we demonstrate that of all cells that undergo long-range migrations, only the HSNs are affected in animals that lack function of the egl-43 gene. We also show that egl-43 function is required for normal development of phasmid neurons, which are sensory neurons located in the tail. The egl-43 gene encodes two proteins containing zinc finger motifs that are similar to the zinc fingers of the murine Evi-1 proto-oncoprotein. Our genetic and molecular results suggest that egl-43 encodes two transcription factors and acts to control HSN migration and phasmid neuron development, presumably by regulating other genes that function directly in these processes.

journal_name

Genes Dev

journal_title

Genes & development

authors

Garriga G,Guenther C,Horvitz HR

doi

10.1101/gad.7.11.2097

subject

Has Abstract

pub_date

1993-11-01 00:00:00

pages

2097-109

issue

11

eissn

0890-9369

issn

1549-5477

journal_volume

7

pub_type

杂志文章

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