Abstract:
:Two broad gene classes are distinguished within multicellular organisms: cell type-specific genes, which confer particular cellular properties, and ubiquitous genes that support general cellular functions. However, certain so-called ubiquitous genes show functionally relevant cell type-specific repression. How such repression is achieved is poorly understood. MicroRNAs (miRNAs) are repressors, many of which are expressed with high cell type specificity. Here we show that mir-791, expressed exclusively in the CO2-sensing neurons in Caenorhabditis elegans, represses two otherwise broadly expressed genes. This repression is necessary for normal neuronal function and behavior of the animals toward CO2 miRNA-mediated repression of broadly transcribed genes is a previously unappreciated strategy for cellular specialization.
journal_name
Genes Devjournal_title
Genes & developmentauthors
Drexel T,Mahofsky K,Latham R,Zimmer M,Cochella Ldoi
10.1101/gad.287904.116subject
Has Abstractpub_date
2016-09-15 00:00:00pages
2042-2047issue
18eissn
0890-9369issn
1549-5477pii
gad.287904.116journal_volume
30pub_type
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