Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications.

Abstract:

:Genome integrity is constantly monitored by sophisticated cellular networks, collectively termed the DNA damage response (DDR). A common feature of DDR proteins is their mobilization in response to genotoxic stress. Here, we outline how the development of various complementary methodologies has provided valuable insights into the spatiotemporal dynamics of DDR protein assembly/disassembly at sites of DNA strand breaks in eukaryotic cells. Considerable advances have also been made in understanding the underlying molecular mechanisms for these events, with post-translational modifications of DDR factors being shown to play prominent roles in controlling the formation of foci in response to DNA-damaging agents. We review these regulatory mechanisms and discuss their biological significance to the DDR.

journal_name

Genes Dev

journal_title

Genes & development

authors

Polo SE,Jackson SP

doi

10.1101/gad.2021311

subject

Has Abstract

pub_date

2011-03-01 00:00:00

pages

409-33

issue

5

eissn

0890-9369

issn

1549-5477

pii

25/5/409

journal_volume

25

pub_type

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