Cadherins in development: cell adhesion, sorting, and tissue morphogenesis.


:Tissue morphogenesis during development is dependent on activities of the cadherin family of cell-cell adhesion proteins that includes classical cadherins, protocadherins, and atypical cadherins (Fat, Dachsous, and Flamingo). The extracellular domain of cadherins contains characteristic repeats that regulate homophilic and heterophilic interactions during adhesion and cell sorting. Although cadherins may have originated to facilitate mechanical cell-cell adhesion, they have evolved to function in many other aspects of morphogenesis. These additional roles rely on cadherin interactions with a wide range of binding partners that modify their expression and adhesion activity by local regulation of the actin cytoskeleton and diverse signaling pathways. Here we examine how different members of the cadherin family act in different developmental contexts, and discuss the mechanisms involved.


Genes Dev


Genes & development


Halbleib JM,Nelson WJ




Has Abstract


2006-12-01 00:00:00














  • The embryonic lethality of homozygous lethal yellow mice (Ay/Ay) is associated with the disruption of a novel RNA-binding protein.

    abstract::Lethal yellow (Ay) is a mutation at the mouse agouti (a) locus that is associated with an all-yellow coat color, obesity, diabetes, tumors in heterozygotes, and preimplantation embryonic lethality in homozygotes. Previously, we cloned and characterized the wild-type agouti gene and demonstrated that it expresses a 0.8...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Michaud EJ,Bultman SJ,Stubbs LJ,Woychik RP

    更新日期:1993-07-01 00:00:00

  • The loss of circadian PAR bZip transcription factors results in epilepsy.

    abstract::DBP (albumin D-site-binding protein), HLF (hepatic leukemia factor), and TEF (thyrotroph embryonic factor) are the three members of the PAR bZip (proline and acidic amino acid-rich basic leucine zipper) transcription factor family. All three of these transcriptional regulatory proteins accumulate with robust circadian...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Gachon F,Fonjallaz P,Damiola F,Gos P,Kodama T,Zakany J,Duboule D,Petit B,Tafti M,Schibler U

    更新日期:2004-06-15 00:00:00

  • Activation of a yeast replication origin near a double-stranded DNA break.

    abstract::Irradiation in the G1 phase of the cell cycle delays the onset of DNA synthesis and transiently inhibits the activation of replication origins in mammalian cells. It has been suggested that this inhibition is the result of the loss of torsional tension in the DNA after it has been damaged. Because irradiation causes D...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Raghuraman MK,Brewer BJ,Fangman WL

    更新日期:1994-03-01 00:00:00

  • Genome-wide identification of microRNA targets in human ES cells reveals a role for miR-302 in modulating BMP response.

    abstract::MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due t...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Lipchina I,Elkabetz Y,Hafner M,Sheridan R,Mihailovic A,Tuschl T,Sander C,Studer L,Betel D

    更新日期:2011-10-15 00:00:00

  • Cytosolic signaling protein Ecsit also localizes to mitochondria where it interacts with chaperone NDUFAF1 and functions in complex I assembly.

    abstract::Ecsit is a cytosolic adaptor protein essential for inflammatory response and embryonic development via the Toll-like and BMP (bone morphogenetic protein) signal transduction pathways, respectively. Here, we demonstrate a mitochondrial function for Ecsit (an evolutionary conserved signaling intermediate in Toll pathway...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Vogel RO,Janssen RJ,van den Brand MA,Dieteren CE,Verkaart S,Koopman WJ,Willems PH,Pluk W,van den Heuvel LP,Smeitink JA,Nijtmans LG

    更新日期:2007-03-01 00:00:00

  • Skewing X chromosome choice by modulating sense transcription across the Xist locus.

    abstract::The X-inactive-specific transcript (Xist) locus is a cis-acting switch that regulates X chromosome inactivation in mammals. Over recent years an important goal has been to understand how Xist is regulated at the initiation of X inactivation. Here we report the analysis of a series of targeted mutations at the 5' end o...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Nesterova TB,Johnston CM,Appanah R,Newall AE,Godwin J,Alexiou M,Brockdorff N

    更新日期:2003-09-01 00:00:00

  • DNA damage activates p53 through a phosphorylation-acetylation cascade.

    abstract::Activation of p53-mediated transcription is a critical cellular response to DNA damage. p53 stability and site-specific DNA-binding activity and, therefore, transcriptional activity, are modulated by post-translational modifications including phosphorylation and acetylation. Here we show that p53 is acetylated in vitr...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Sakaguchi K,Herrera JE,Saito S,Miki T,Bustin M,Vassilev A,Anderson CW,Appella E

    更新日期:1998-09-15 00:00:00

  • The characterization of the TFIIIA synthesized in somatic cells of Xenopus laevis.

    abstract::In somatic cells of Xenopus, transcription of the TFIIIA gene initiates greater than 200 bp upstream from the start site used in oocytes. The resultant mRNA encodes a protein, S-TFIIIA, that is 22 amino acids longer at its amino terminus than the abundant form of TFIIIA in oocytes (O-TFIIIA). S-TFIIIA binds the 5S RNA...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Kim SH,Darby MK,Joho KE,Brown DD

    更新日期:1990-09-01 00:00:00

  • Regulation of splicing at an intermediate step in the formation of the spliceosome.

    abstract::In vivo experiments have demonstrated that the ribosomal protein L32 of Saccharomyces cerevisiae brings about the inhibition of splicing of the transcript of its own gene through an RNA structure comprised largely of the first exon. We now show that L32, itself, binds specifically to this RNA. Splicing of the RPL32 tr...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Vilardell J,Warner JR

    更新日期:1994-01-01 00:00:00

  • Extensive polymerase pausing during Drosophila axis patterning enables high-level and pliable transcription.

    abstract::Cascades of zygotic gene expression pattern the anterior-posterior (AP) and dorsal-ventral (DV) axes of the early Drosophila embryo. Here, we used the global run-on sequencing assay (GRO-seq) to map the genome-wide RNA polymerase distribution during early Drosophila embryogenesis, thus providing insights into how gene...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Saunders A,Core LJ,Sutcliffe C,Lis JT,Ashe HL

    更新日期:2013-05-15 00:00:00

  • Human nonsense-mediated RNA decay initiates widely by endonucleolysis and targets snoRNA host genes.

    abstract::Eukaryotic RNAs with premature termination codons (PTCs) are eliminated by nonsense-mediated decay (NMD). While human nonsense RNA degradation can be initiated either by an endonucleolytic cleavage event near the PTC or through decapping, the individual contribution of these activities on endogenous substrates has rem...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Lykke-Andersen S,Chen Y,Ardal BR,Lilje B,Waage J,Sandelin A,Jensen TH

    更新日期:2014-11-15 00:00:00

  • Addicted to Myc--but why?

    abstract::Many tumors continuously depend on the initiating oncogenes, but whether this extends to their downstream targets is unclear. In this issue of Genes & Development, Sodir and colleagues (pp. 907-916) demonstrate an essential role for endogenous Myc proteins in maintaining the tumor microenvironment, providing an unexpe...

    journal_title:Genes & development

    pub_type: 评论,杂志文章


    authors: von Eyss B,Eilers M

    更新日期:2011-05-01 00:00:00

  • Characterization of a unique protein component of yeast RNase MRP: an RNA-binding protein with a zinc-cluster domain.

    abstract::RNase MRP is a ribonucleoprotein endoribonuclease that has been shown to cleave mitochondrial primer RNA sequences from a variety of sources. Most of the RNase MRP activity is found in the nucleus where it plays a role in the processing of 5.8S rRNA. A temperature-conditional point mutation in the yeast RNA component ...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Schmitt ME,Clayton DA

    更新日期:1994-11-01 00:00:00

  • Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration.

    abstract::Although Apc is well characterized as a tumor-suppressor gene in the intestine, the precise mechanism of this suppression remains to be defined. Using a novel inducible Ahcre transgenic line in conjunction with a loxP-flanked Apc allele we, show that loss of Apc acutely activates Wnt signaling through the nuclear accu...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Sansom OJ,Reed KR,Hayes AJ,Ireland H,Brinkmann H,Newton IP,Batlle E,Simon-Assmann P,Clevers H,Nathke IS,Clarke AR,Winton DJ

    更新日期:2004-06-15 00:00:00

  • Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila.

    abstract::Gut homeostasis is controlled by both immune and developmental mechanisms, and its disruption can lead to inflammatory disorders or cancerous lesions of the intestine. While the impact of bacteria on the mucosal immune system is beginning to be precisely understood, little is known about the effects of bacteria on gut...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Buchon N,Broderick NA,Chakrabarti S,Lemaitre B

    更新日期:2009-10-01 00:00:00

  • Most human introns are recognized via multiple and tissue-specific branchpoints.

    abstract::Although branchpoint recognition is an essential component of intron excision during the RNA splicing process, the branchpoint itself is frequently assumed to be a basal, rather than regulatory, sequence feature. However, this assumption has not been systematically tested due to the technical difficulty of identifying...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Pineda JMB,Bradley RK

    更新日期:2018-04-01 00:00:00

  • Eph signaling is required for segmentation and differentiation of the somites.

    abstract::Somitogenesis involves the segmentation of the paraxial mesoderm into units along the anteroposterior axis. Here we show a role for Eph and ephrin signaling in the patterning of presomitic mesoderm and formation of the somites. Ephrin-A-L1 and ephrin-B2 are expressed in an iterative manner in the developing somites an...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Durbin L,Brennan C,Shiomi K,Cooke J,Barrios A,Shanmugalingam S,Guthrie B,Lindberg R,Holder N

    更新日期:1998-10-01 00:00:00

  • Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint.

    abstract::We report on the function of the human ortholog of Saccharomyces cerevisiae Rif1 (Rap1-interacting factor 1). Yeast Rif1 associates with telomeres and regulates their length. In contrast, human Rif1 did not accumulate at functional telomeres, but localized to dysfunctional telomeres and to telomeric DNA clusters in AL...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Silverman J,Takai H,Buonomo SB,Eisenhaber F,de Lange T

    更新日期:2004-09-01 00:00:00

  • c-Jun is required for the specification of joint cell fates.

    abstract::Joints form within the developing skeleton through the segmentation and cavitation of initially continuous cartilage condensations. However, the molecular pathways controlling joint formation largely remain to be clarified. In particular, while several critical secreted signals have been identified, no transcription f...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Kan A,Tabin CJ

    更新日期:2013-03-01 00:00:00

  • Seeing the forest for the trees: a wide perspective on RNA-directed DNA methylation.

    abstract::In this issue of Genes & Development, Wierzbicki and colleagues (pp. 1825-1836) examine the current model of RNA-directed DNA methylation (RdDM) by determining genome-wide distributions of RNA polymerase V (Pol V) occupancy, siRNAs, and DNA methylation. Their data support the key role of base-pairing between Pol V tra...

    journal_title:Genes & development

    pub_type: 评论,杂志文章


    authors: Zhang H,Zhu JK

    更新日期:2012-08-15 00:00:00

  • Phosphatidic acid mediates demyelination in Lpin1 mutant mice.

    abstract::Lipids play crucial roles in many aspects of glial cell biology, affecting processes ranging from myelin membrane biosynthesis to axo-glial interactions. In order to study the role of lipid metabolism in myelinating glial cells, we specifically deleted in Schwann cells the Lpin1 gene, which encodes the Mg2+-dependent ...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Nadra K,de Preux Charles AS,Médard JJ,Hendriks WT,Han GS,Grès S,Carman GM,Saulnier-Blache JS,Verheijen MH,Chrast R

    更新日期:2008-06-15 00:00:00

  • 3D reconstruction of the Mu transposase and the Type 1 transpososome: a structural framework for Mu DNA transposition.

    abstract::Mu DNA transposition proceeds through a series of higher-order nucleoprotein complexes called transpososomes. The structural core of the transpososome is a tetramer of the transposase, Mu A, bound to the two transposon ends. High-resolution structural analysis of the intact transposase and the transpososome has not be...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Yuan JF,Beniac DR,Chaconas G,Ottensmeyer FP

    更新日期:2005-04-01 00:00:00

  • 3'-end formation of mouse pre-rRNA involves both transcription termination and a specific processing reaction.

    abstract::We have studied the sequence requirements for 3'-end formation of rDNA transcripts in a cell-free system and show that the generation of correct ends of mouse pre-rRNA is brought about by a two-step process that involves a bona fide termination reaction, followed by a specific trimming of the primary transcript by 10 ...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Kuhn A,Grummt I

    更新日期:1989-02-01 00:00:00

  • Epigenetic effects on yeast transcription caused by mutations in an actin-related protein present in the nucleus.

    abstract::Gene inactivation can result when a delta element of the Ty1 transposon inserted into the yeast HIS4 promoter (his4-912delta) alters the transcription initiation site. Previous work has identified mutations that suppress this transcriptional defect by restoring the transcription start site to the native position, and ...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Jiang YW,Stillman DJ

    更新日期:1996-03-01 00:00:00

  • Expression of a dominant-negative Wnt blocks induction of MyoD in Xenopus embryos.

    abstract::During gastrulation of Xenopus embryos the prospective mesoderm is induced initially with domains of dorsal and ventral fate, then further patterned to generate somitic mesoderm by signals from the gastrula organizer. Although Xwnt-8 is expressed in future ventrolateral mesoderm and induces prospective epidermis to di...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Hoppler S,Brown JD,Moon RT

    更新日期:1996-11-01 00:00:00

  • Functional analysis and in vivo footprinting implicate the erythroid transcription factor GATA-1 as a positive regulator of its own promoter.

    abstract::Transcription of erythroid-expressed genes and normal erythroid development in vivo are dependent on a regulatory protein (GATA-1) that recognizes a consensus GATA motif. GATA-1 expression is itself restricted to erythroid progenitors and to two related hematopoietic lineages, megakaryocytes and mast cells. During cel...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Tsai SF,Strauss E,Orkin SH

    更新日期:1991-06-01 00:00:00

  • The first 28 amino acids of mature LamB are required for rapid and efficient export from the cytoplasm.

    abstract::Our laboratory has been utilizing the Escherichia coli outer membrane protein LamB to study the mechanism of protein localization. Various lines of evidence suggest that, in addition to a signal sequence, regions within the mature protein are required for efficient localization. In particular, studies using LamB-LacZ ...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Rasmussen BA,Silhavy TJ

    更新日期:1987-04-01 00:00:00

  • On the role of homologous sequences in chromosomal rearrangements.

    abstract::Deletions and other chromosomal rearrangements can be generated by recombination between repeated sequences. It has been shown in a number of systems that the probability of exchange or gene conversion decreases with increasing distance between repeats. This paper examines the question of how repeats find each other, ...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Singer BS

    更新日期:1988-12-01 00:00:00

  • Dual mechanisms prevent premature chromosome segregation during meiosis.

    abstract::In meiosis I, homologous chromosomes pair and then attach to the spindle so that the homologs can be pulled apart at anaphase I. The segregation of homologs before pairing would be catastrophic. We describe two mechanisms that prevent this. First, in early meiosis, Ipl1, the budding yeast homolog of the mammalian Auro...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Kim S,Meyer R,Chuong H,Dawson DS

    更新日期:2013-10-01 00:00:00

  • Localized surface activity of torso, a receptor tyrosine kinase, specifies terminal body pattern in Drosophila.

    abstract::The subdivision of the Drosophila body into distinct terminal and central domains depends on the torso (tor) protein, a putative receptor tyrosine kinase that is active at both ends of the early embryo. We show that the tor protein is uniformly expressed along the surface membrane of early embryos despite its localize...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Casanova J,Struhl G

    更新日期:1989-12-01 00:00:00