Abstract：
:Tissue morphogenesis during development is dependent on activities of the cadherin family of cell-cell adhesion proteins that includes classical cadherins, protocadherins, and atypical cadherins (Fat, Dachsous, and Flamingo). The extracellular domain of cadherins contains characteristic repeats that regulate homophilic and heterophilic interactions during adhesion and cell sorting. Although cadherins may have originated to facilitate mechanical cell-cell adhesion, they have evolved to function in many other aspects of morphogenesis. These additional roles rely on cadherin interactions with a wide range of binding partners that modify their expression and adhesion activity by local regulation of the actin cytoskeleton and diverse signaling pathways. Here we examine how different members of the cadherin family act in different developmental contexts, and discuss the mechanisms involved.
journal_name
Genes Devjournal_title
Genes & developmentauthors
Halbleib JM,Nelson WJdoi
10.1101/gad.1486806subject
Has Abstractpub_date
2006-12-01 00:00:00pages
3199-214issue
23eissn
0890-9369issn
1549-5477pii
20/23/3199journal_volume
20pub_type
杂志文章,评审abstract：:The Caenorhabditis elegans caudal homolog, pal-1, is required for neurogenesis in the male tail. We show that expression of pal-1 in the postembryonic neuroblast cell V6 can be initiated by two alternate pathways. One pathway, acting in wild type, requires a regulatory element in the fifth pal-1 intron. The other path...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.814700
更新日期：2000-09-01 00:00:00
abstract：:Alternative splicing factor/splicing factor 2 (ASF/SF2) is the prototype of a family of nuclear proteins highly conserved throughout metazoa, the SR (serine/arginine) proteins. Based largely on in vitro studies, SR proteins have been suggested to play important roles in constitutive and alternative splicing of pre-mRN...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.10.20.2588
更新日期：1996-10-15 00:00:00
abstract：:A novel system to study early hematopoietic development is described. This report documents the in vitro capacity of murine embryonic stem (ES) cells to differentiate into hematopoietic precursors of most, if not all, of the colony-forming cells found in normal bone marrow. This system is used to correlate the genetic...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.5.5.728
更新日期：1991-05-01 00:00:00
abstract：:The mammalian Daxx gene has been identified in a diverse set of yeast interaction trap experiments. Although a facilitating role for Daxx in Fas-induced apoptosis has been suggested, Daxx's physiologic function remains unknown. To elucidate the in vivo role of Daxx, we have generated Daxx-deficient mice. Surprisingly,...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.13.15.1918
更新日期：1999-08-01 00:00:00
abstract：:Spindle checkpoint silencing is a critical step during mitosis that initiates chromosome segregation, yet surprisingly little is known about its mechanism. Protein phosphatase I (PP1) was shown recently to be a key player in this process, and in this issue of Genes & Deverlopment, Akiyoshi and colleagues (pp. 2887-289...
journal_title：Genes & development
pub_type： 评论,杂志文章,评审
doi：10.1101/gad.1882109
更新日期：2009-12-15 00:00:00
abstract：:To determine whether 9-cis retinoic acid receptors (RXRs) regulate the biological activity of all-trans retinoic acid (tRA) and its receptors (RARs) in skin, we have targeted a dominant-negative RXR alpha (dnRXR alpha) lacking transactivation function AF-2 to differentiated suprabasal keratinocytes in the epidermis of...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.11.1.59
更新日期：1997-01-01 00:00:00
abstract：:Bardet-Biedl syndrome (BBS) is a genetically heterogeneous developmental disorder whose molecular basis is largely unknown. Here, we show that mutations in the Caenorhabditis elegans bbs-7 and bbs-8 genes cause structural and functional defects in cilia. C. elegans BBS proteins localize predominantly at the base of ci...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1194004
更新日期：2004-07-01 00:00:00
abstract：:Sex determination is regulated by diverse pathways. Although upstream signals vary, a cysteine-rich DNA-binding domain (the DM motif) is conserved within downstream transcription factors of Drosophila melanogaster (Doublesex) and Caenorhabditis elegans (MAB-3). Vertebrate DM genes have likewise been identified and, re...
journal_title：Genes & development
pub_type： 杂志文章
doi：
更新日期：2000-07-15 00:00:00
abstract：:In the metazoan germline, piwi proteins and associated piwi-interacting RNAs (piRNAs) provide a defense system against the expression of transposable elements. In the cytoplasm, piRNA sequences guide piwi complexes to destroy complementary transposon transcripts by endonucleolytic cleavage. However, some piwi family m...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.209841.112
更新日期：2013-02-15 00:00:00
abstract：:TGF-β receptors phosphorylate SMAD2 and SMAD3 transcription factors, which then form heterotrimeric complexes with SMAD4 and cooperate with context-specific transcription factors to activate target genes. Here we provide biochemical and structural evidence showing that binding of SMAD2 to DNA depends on the conformati...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.330837.119
更新日期：2019-11-01 00:00:00
abstract：:The timing of asexual fruiting body formation during Aspergillus nidulans colony development is precisely regulated so that conidiophores are typically produced 1-2 mm behind the growing edge of the colony. Mutations in any of four A. nidulans genes, flbB, flbC, flbD, or flbE, result in colonies that are delayed at le...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.9.4.491
更新日期：1995-02-15 00:00:00
abstract：:Cell differentiation is essential for the development of multicellular organisms. In flowering plants, the haploid male gametophytes (pollen grains) are generated in the anther from reproductive cells called microsporocytes. Several types of somatic cells ensure successful pollen development, and thus reproduction. Ho...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.997902
更新日期：2002-08-01 00:00:00
abstract：:Although progesterone has been recognized as essential for the establishment and maintenance of pregnancy, this steroid hormone has been recently implicated to have a functional role in a number of other reproductive events. The physiological effects of progesterone are mediated by the progesterone receptor (PR), a me...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.9.18.2266
更新日期：1995-09-15 00:00:00
abstract：:The widespread class of RNA viruses that utilize internal ribosome entry sites (IRESs) for translation include poliovirus and Hepatitis C virus. To identify host factors required for IRES-dependent translation and viral replication, we performed a genome-wide RNAi screen in Drosophila cells infected with Drosophila C ...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1267905
更新日期：2005-02-15 00:00:00
abstract：:In Drosophila, the development of the compound eye depends on the movement of a morphogenetic furrow (MF) from the posterior (P) to the anterior (A) of the eye imaginal disc. We define several subdomains along the A-P axis of the eye disc that express distinct combinations of transcription factors. One subdomain, ante...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1009002
更新日期：2002-09-15 00:00:00
abstract：:In response to DNA damage, cells activate a complex signal transduction network called the DNA damage response (DDR). To enhance our current understanding of the DDR network, we performed a genome-wide RNAi screen to identify genes required for resistance to ionizing radiation (IR). Along with a number of known DDR ge...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1934210
更新日期：2010-09-01 00:00:00
abstract：:The ability to maintain and expand the pool of adipocytes in adults is integral to the regulation of energy balance, tissue/stem cell homeostasis, and disease pathogenesis. For decades, our knowledge of adipocyte precursors has relied on cellular models. The identity of native adipocyte precursors has remained unclear...
journal_title：Genes & development
pub_type： 杂志文章,评审
doi：10.1101/gad.293704.116
更新日期：2017-01-15 00:00:00
abstract：:In Drosophila germ cells, PIWI-interacting RNAs (piRNAs) are amplified through a PIWI slicer-dependent feed-forward loop termed the ping-pong cycle, yielding secondary piRNAs. However, the detailed mechanism remains poorly understood, largely because an ex vivo model system amenable to biochemical analyses has not bee...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.283929.116
更新日期：2016-07-15 00:00:00
abstract：:During embryonic development, the two Caenorhabditis elegans HSN motor neurons migrate from their birthplace in the tail to positions near the middle of the embryo. Here, we demonstrate that of all cells that undergo long-range migrations, only the HSNs are affected in animals that lack function of the egl-43 gene. We...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.7.11.2097
更新日期：1993-11-01 00:00:00
abstract：:The choice of self-renewal versus differentiation is a fundamental issue in stem cell and cancer biology. Neural progenitors of the Drosophila post-embryonic brain, larval neuroblasts (NBs), divide asymmetrically in a stem cell-like fashion to generate a self-renewing NB and a Ganglion Mother Cell (GMC), which divides...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1487506
更新日期：2006-12-15 00:00:00
abstract：:Long noncoding RNAs (lncRNAs) can trigger repressive chromatin, but how they recruit silencing factors remains unclear. In Schizosaccharomyces pombe, heterochromatin assembly on transcribed noncoding pericentromeric repeats requires both RNAi and RNAi-independent mechanisms. In Saccharomyces cerevisiae, which lacks a ...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.226019.113
更新日期：2013-09-01 00:00:00
abstract：:Diverse developmental processes, such as neuronal growth cone migration and cell shape changes, are mediated by the interactions of cells with the extracellular matrix. We describe here a secreted molecule encoded by the Drosophila masquerade (mas) gene. Total loss of mas function causes defective muscle attachment. T...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.9.2.139
更新日期：1995-01-15 00:00:00
abstract：:The Tat protein of human immunodeficiency virus type 1 (HIV-1) activates transcription following binding to nascent trans-activation response (TAR) RNA downstream of the transcription start site. Because Tat functions when bound to RNA, and in a position-dependent manner, it has been proposed that Tat works by a novel...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.5.12b.2496
更新日期：1991-12-01 00:00:00
abstract：:The distal enhancer of the T-cell receptor (TCR) alpha chain gene has become a paradigm for studies of the assembly and activity of architectural enhancer complexes. Here we have reconstituted regulated TCR alpha enhancer activity in vitro on chromatin templates using purified T-cell transcription factors (LEF-1, AML1...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.11.7.887
更新日期：1997-04-01 00:00:00
abstract：:Kinetochores play an essential role in chromosome segregation by forming dynamic connections with spindle microtubules. Here, we identify a set of 10 copurifying kinetochore proteins from Caenorhabditis elegans, seven of which were previously uncharacterized. Using in vivo assays to monitor chromosome segregation, kin...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1234104
更新日期：2004-09-15 00:00:00
abstract：:The cooperation of oncogenes in the transformation of primary rat Schwann cells is a strikingly synergistic process. We have explored the molecular mechanisms involved. Activation of an inducible Raf kinase results in morphologically transformed cells that are arrested in G1 via the induction of p21(CiP1) and subseque...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.11.5.663
更新日期：1997-03-01 00:00:00
abstract：:Myocardial infarction and ischemic heart disease are the leading cause of death in the industrial world. Therapies employed for treating these diseases are aimed at promoting increased blood flow to cardiac tissue. Pharmacological induction of new coronary growth has recently been explored, however, clinical trials wi...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1411406
更新日期：2006-06-15 00:00:00
abstract：:PIWI clade Argonaute proteins silence transposon expression in animal gonads. Their target specificity is defined by bound ∼23- to 30-nucleotide (nt) PIWI-interacting RNAs (piRNAs) that are processed from single-stranded precursor transcripts via two distinct pathways. Primary piRNAs are defined by the endonuclease Zu...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.267252.115
更新日期：2015-08-15 00:00:00
abstract：:Mammalian cells exhibit a complex response to DNA damage. The tumor suppressor BRCA1 and associated protein BARD1 are thought to play an important role in this response, and our previous work demonstrated that this includes transient inhibition of the pre-mRNA 3' processing machinery. Here we provide evidence that thi...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1309505
更新日期：2005-05-15 00:00:00
abstract：:The efficiency of RNA 3'-end formation of spleen necrosis virus (SNV) is determined by the distance between the cap site and the poly(A) site. When the distance between the cap site and the poly(A) site was shorter than 500 bases, only 3-9% of the RNA was polyadenylated at the SNV poly(A) site. However, when the dista...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.4.12b.2299
更新日期：1990-12-01 00:00:00
