The efficiency of RNA 3'-end formation is determined by the distance between the cap site and the poly(A) site in spleen necrosis virus.

abstract：:The release of Agrin by motoneurons activates the muscle-specific receptor tyrosine kinase (MuSK) as the main organizer of subsynaptic specializations at the neuromuscular junction. MuSK downstream signaling is largely undefined. Here we show that protein kinase CK2 interacts and colocalizes with MuSK at post-synaptic...

journal_title：Genes & development

authors： Cheusova T,Khan MA,Schubert SW,Gavin AC,Buchou T,Jacob G,Sticht H,Allende J,Boldyreff B,Brenner HR,Hashemolhosseini S

更新日期：2006-07-01 00:00:00

abstract：:Signal transduction through the FGF receptor is essential for the specification of the vertebrate body plan. Blocking the FGF pathway in early Xenopus embryos inhibits mesoderm induction and results in truncation of the anterior-posterior axis. The Drosophila gene sprouty encodes an antagonist of FGF signaling, which ...

journal_title：Genes & development

authors： Nutt SL,Dingwell KS,Holt CE,Amaya E

更新日期：2001-05-01 00:00:00

abstract：:The Arabidopsis APETALA3 (AP3) and PISTILLATA (PI) proteins are thought to act as transcription factors and are required for specifying floral organ identities. To define the nuclear localization signals within these proteins, we generated translational fusions of the coding regions of AP3 and PI to the bacterial uidA...

journal_title：Genes & development

authors： McGonigle B,Bouhidel K,Irish VF

更新日期：1996-07-15 00:00:00

abstract：:Pcf11 is one of numerous proteins involved in pre-mRNA 3'-end processing and transcription termination. Using elongation complexes (ECs) formed from purified yeast RNA polymerase II (Pol II), we show that a 140-amino acid polypeptide from yeast Pcf11 is capable of dismantling the EC in vitro. This action depends on th...

journal_title：Genes & development

authors： Zhang Z,Fu J,Gilmour DS

更新日期：2005-07-01 00:00:00

abstract：:A transgenic mouse model for retinoblastoma was produced previously by directing SV40 T antigen expression to retinal photoreceptor cells using the promoter of the interstitial retinol-binding protein (IRBP) gene. This gene becomes active prior to the terminal differentiation of photoreceptors. Because T antigen-trans...

journal_title：Genes & development

authors： Howes KA,Ransom N,Papermaster DS,Lasudry JG,Albert DM,Windle JJ

更新日期：1994-06-01 00:00:00

abstract：:The Purkinje cell protein 2 (Pcp-2) is expressed in cerebellar Purkinje cells and retinal bipolar neurons. To illuminate how Pcp-2 expression is restricted to only two neuronal types and to derive tools to express heterologous genes in these neuronal subpopulations, genomic sequences of the mouse Pcp-2 gene have been ...

journal_title：Genes & development

authors： Vandaele S,Nordquist DT,Feddersen RM,Tretjakoff I,Peterson AC,Orr HT

更新日期：1991-07-01 00:00:00

abstract：:We have analyzed pre-mRNA splicing in yeast extracts immunodepleted of the PRP18 protein. We find that while the first step of splicing (cleavage at the 5' splice site, and generation of the exon 1 and lariat intermediates) is unaffected by the absence of PRP18, the second step of splicing (excision of the lariat intr...

journal_title：Genes & development

authors： Horowitz DS,Abelson J

更新日期：1993-02-01 00:00:00

abstract：:Two broad gene classes are distinguished within multicellular organisms: cell type-specific genes, which confer particular cellular properties, and ubiquitous genes that support general cellular functions. However, certain so-called ubiquitous genes show functionally relevant cell type-specific repression. How such re...

journal_title：Genes & development

authors： Drexel T,Mahofsky K,Latham R,Zimmer M,Cochella L

更新日期：2016-09-15 00:00:00

abstract：:Ribosomal protein synthesis ceases upon maturation of Xenopus oocytes. We find that this cessation results from the dissociation of ribosomal protein mRNAs from polysomes and is accompanied by the deadenylation of these transcripts. A synthetic mRNA encoding ribosomal protein L1, microinjected into stage VI oocytes, i...

journal_title：Genes & development

authors： Hyman LE,Wormington WM

更新日期：1988-05-01 00:00:00

abstract：:A novel cysteine-rich motif, named LIM, has been identified in the homeo box genes lin-11, Isl-1, and mec-3; the mec-3 and lin-11 genes determine cell lineages in Caenorhabditis elegans. We isolated LIM class homeo box genes from Xenopus laevis that are closely related to lin-11 and mec-3 in the LIM and homeo domains....

journal_title：Genes & development

authors： Taira M,Jamrich M,Good PJ,Dawid IB

更新日期：1992-03-01 00:00:00

abstract：:The organizer region, or dorsal blastopore lip, plays a central role in the initiation of gastrulation and the formation of the body axis during Xenopus development. A similar process can also be induced in ectodermal explants by activin or by injection of activin mRNA into embryos. We have searched early embryo-speci...

journal_title：Genes & development

authors： Dirksen ML,Jamrich M

更新日期：1992-04-01 00:00:00

abstract：:DNA methylation is a key regulator of embryonic stem cell (ESC) biology, dynamically changing between naïve, primed, and differentiated states. The p53 tumor suppressor is a pivotal guardian of genomic stability, but its contributions to epigenetic regulation and stem cell biology are less explored. We report that, in...

journal_title：Genes & development

authors： Tovy A,Spiro A,McCarthy R,Shipony Z,Aylon Y,Allton K,Ainbinder E,Furth N,Tanay A,Barton M,Oren M

更新日期：2017-05-15 00:00:00

abstract：:The embryonic lethal abnormal visual system (ELAV) is a gene-specific regulator of alternative pre-mRNA processing in neurons of Drosophila. Here we define a functional in vivo binding site for ELAV in neurons through the development of a reporter gene system in transgenic animals in combination with in vitro binding ...

journal_title：Genes & development

authors： Soller M,White K

更新日期：2003-10-15 00:00:00

abstract：:One of the most common microsatellites in eukaryotes consists of tandem arrays of the dinucleotide GT. Although the study of the instability of such repetitive DNA has been extremely fruitful over the last decade, no biological function has been demonstrated for these sequences. We investigated the genetic behavior of...

journal_title：Genes & development

authors： Gendrel CG,Boulet A,Dutreix M

更新日期：2000-05-15 00:00:00

abstract：:Estrogen receptor α (ER) is the major driver of ∼75% of breast cancers, and multiple ER targeting drugs are routinely used clinically to treat patients with ER+ breast cancer. However, many patients relapse on these targeted therapies and ultimately develop metastatic and incurable disease, and understanding the mecha...

journal_title：Genes & development

authors： Siersbæk R,Kumar S,Carroll JS

更新日期：2018-09-01 00:00:00

abstract：:The ubiquitin-specific protease (USP) family is the largest group of cysteine proteases. Cancer genomic analysis identified frequent amplification of USP21 (22%) in human pancreatic ductal adenocarcinoma (PDAC). USP21 overexpression correlates with human PDAC progression, and enforced expression of USP21 accelerates m...

journal_title：Genes & development

authors： Hou P,Ma X,Zhang Q,Wu CJ,Liao W,Li J,Wang H,Zhao J,Zhou X,Guan C,Ackroyd J,Jiang S,Zhang J,Spring DJ,Wang YA,DePinho RA

更新日期：2019-10-01 00:00:00

abstract：:The yeast SAGA (Spt-Ada-Gcn5-acetyltransferase) coactivator complex exerts functions in gene expression, including activator interaction, histone acetylation, histone deubiquitination, mRNA export, chromatin recognition, and regulation of the basal transcription machinery. These diverse functions involve distinct modu...

journal_title：Genes & development

authors： Spedale G,Timmers HT,Pijnappel WW

更新日期：2012-03-15 00:00:00

abstract：:The subdivision of the lateral mesoderm into a visceral (splanchnic) and a somatic layer is a crucial event during early mesoderm development in both arthropod and vertebrate embryos. In Drosophila, this subdivision leads to the differential development of gut musculature versus body wall musculature. Here we report t...

journal_title：Genes & development

authors： Zaffran S,Küchler A,Lee HH,Frasch M

更新日期：2001-11-01 00:00:00

abstract：:Lineage commitment studies in mammary glands have focused on identifying cell populations that display stem or progenitor properties. However, the mechanisms that control cell fate have been incompletely explored. Herein we show that zinc finger protein 157 (Zfp157) is required to establish the balance between luminal...

journal_title：Genes & development

authors： Oliver CH,Khaled WT,Frend H,Nichols J,Watson CJ

更新日期：2012-05-15 00:00:00

abstract：:Checkpoint genes maintain genomic stability by arresting cells after DNA damage. Many of these genes also control cell cycle events in unperturbed cells. By conducting a screen for checkpoint genes in zebrafish, we found that dtl/cdt2 is an essential component of the early, radiation-induced G2/M checkpoint. We subseq...

journal_title：Genes & development

authors： Sansam CL,Shepard JL,Lai K,Ianari A,Danielian PS,Amsterdam A,Hopkins N,Lees JA

更新日期：2006-11-15 00:00:00

abstract：:Transcription is often stochastic. This is seemingly incompatible with the importance of gene expression during development. Here we show that during zebrafish embryogenesis, transcription activation is stochastic due to (1) genes acquiring transcriptional competence at different times in different cells, (2) differen...

journal_title：Genes & development

authors： Stapel LC,Zechner C,Vastenhouw NL

更新日期：2017-08-15 00:00:00

abstract：:DNA methylation is tightly regulated throughout mammalian development, and altered DNA methylation patterns are a general hallmark of cancer. The methylcytosine dioxygenase TET2 is frequently mutated in hematological disorders, including acute myeloid leukemia (AML), and has been suggested to protect CG dinucleotide (...

journal_title：Genes & development

authors： Rasmussen KD,Jia G,Johansen JV,Pedersen MT,Rapin N,Bagger FO,Porse BT,Bernard OA,Christensen J,Helin K

更新日期：2015-05-01 00:00:00

abstract：:DOCK180 is involved in integrin signaling through CrkII-p130(Cas) complexes. We have studied the involvement of DOCK180 in Rac1 signaling cascades. DOCK180 activated JNK in a manner dependent on Rac1, Cdc42Hs, and SEK, and overexpression of DOCK180 increased the amount of GTP-bound Rac1 in 293T cells. Coexpression of ...

journal_title：Genes & development

authors： Kiyokawa E,Hashimoto Y,Kobayashi S,Sugimura H,Kurata T,Matsuda M

更新日期：1998-11-01 00:00:00

abstract：:In yeast, galactose triggers a rapid GAL4-dependent induction of galactose/melibiose regulon (GAL/MEL) gene transcription, and glucose represses this activation. We discovered that alterations in the physical state of the GAL4 protein correlate with activation and repression of the GAL/MEL genes. Using Western immunob...

journal_title：Genes & development

authors： Mylin LM,Bhat JP,Hopper JE

更新日期：1989-08-01 00:00:00

abstract：:Discrete sequence elements known as exonic splicing enhancers (ESEs) have been shown to influence both the efficiency of splicing and the profile of mature mRNAs in multicellular eukaryotes. While the existence of ESEs has not been demonstrated previously in unicellular eukaryotes, the factors known to recognize these...

journal_title：Genes & development

authors： Webb CJ,Romfo CM,van Heeckeren WJ,Wise JA

更新日期：2005-01-15 00:00:00

abstract：:How muscle diversity is generated in the vertebrate body is poorly understood. In the limb, dorsal and ventral muscle masses constitute the first myogenic diversification, as each gives rise to distinct muscles. Myogenesis initiates after muscle precursor cells (MPCs) have migrated from the somites to the limb bud and...

journal_title：Genes & development

authors： Anderson C,Williams VC,Moyon B,Daubas P,Tajbakhsh S,Buckingham ME,Shiroishi T,Hughes SM,Borycki AG

更新日期：2012-09-15 00:00:00

abstract：:Somitogenesis involves the segmentation of the paraxial mesoderm into units along the anteroposterior axis. Here we show a role for Eph and ephrin signaling in the patterning of presomitic mesoderm and formation of the somites. Ephrin-A-L1 and ephrin-B2 are expressed in an iterative manner in the developing somites an...

journal_title：Genes & development

authors： Durbin L,Brennan C,Shiomi K,Cooke J,Barrios A,Shanmugalingam S,Guthrie B,Lindberg R,Holder N

更新日期：1998-10-01 00:00:00

abstract：:During vasculogenesis and angiogenesis, endothelial cell responses to growth factors are modulated by the compositional and mechanical properties of a surrounding three-dimensional (3D) extracellular matrix (ECM) that is dominated by either cross-linked fibrin or type I collagen. While 3D-embedded endothelial cells es...

journal_title：Genes & development

authors： Zhou X,Rowe RG,Hiraoka N,George JP,Wirtz D,Mosher DF,Virtanen I,Chernousov MA,Weiss SJ

更新日期：2008-05-01 00:00:00

abstract：:Multidimensional cancer genome analysis and validation has defined Quaking (QKI), a member of the signal transduction and activation of RNA (STAR) family of RNA-binding proteins, as a novel glioblastoma multiforme (GBM) tumor suppressor. Here, we establish that p53 directly regulates QKI gene expression, and QKI prote...

journal_title：Genes & development

authors： Chen AJ,Paik JH,Zhang H,Shukla SA,Mortensen R,Hu J,Ying H,Hu B,Hurt J,Farny N,Dong C,Xiao Y,Wang YA,Silver PA,Chin L,Vasudevan S,Depinho RA

更新日期：2012-07-01 00:00:00

abstract：:Tissue morphogenesis during development is dependent on activities of the cadherin family of cell-cell adhesion proteins that includes classical cadherins, protocadherins, and atypical cadherins (Fat, Dachsous, and Flamingo). The extracellular domain of cadherins contains characteristic repeats that regulate homophili...

journal_title：Genes & development

authors： Halbleib JM,Nelson WJ

更新日期：2006-12-01 00:00:00