Xenopus Sprouty2 inhibits FGF-mediated gastrulation movements but does not affect mesoderm induction and patterning.

abstract：:Many bacterial small regulatory RNAs (sRNAs) pair with mRNA targets, stimulating or inhibiting mRNA stability and/or translation. Regulation of these sRNAs is usually due to tight transcriptional regulation of synthesis.In this issue of Genes & Development and a related paper in Molecular Microbiology, Figueroa-Bossi ...

journal_title：Genes & development

authors： Mandin P,Gottesman S

更新日期：2009-09-01 00:00:00

abstract：:The mottler of white (mw) locus has been determined to interact with alleles of the white (w) eye color locus which are a subset of the transposable element insertion mutants. The transposable elements belong to six different types, including copia, and are located at several sites within the w gene. Three X-ray-induc...

journal_title：Genes & development

authors： Birchler JA,Hiebert JC,Rabinow L

更新日期：1989-01-01 00:00:00

abstract：:Outward migration of epidermal progenitors occurs with induction of hundreds of differentiation genes, but the identities of all regulators required for this process are unknown. We used laser capture microdissection followed by RNA sequencing to identify calmodulin-like 5 (CALML5) as the most enriched gene in differe...

journal_title：Genes & development

authors： Sun BK,Boxer LD,Ransohoff JD,Siprashvili Z,Qu K,Lopez-Pajares V,Hollmig ST,Khavari PA

更新日期：2015-11-01 00:00:00

abstract：:The RAG-1 protein plays an essential role in V(D)j recombination, but its exact function has not yet been defined. Here we report that a particular mutation in RAG-1 affects recombination by altering the specificity of target sequence usage. Recombination mediated by wild-type RAG-1 is tolerant of a wide range of codi...

journal_title：Genes & development

authors： Sadofsky MJ,Hesse JE,van Gent DC,Gellert M

更新日期：1995-09-01 00:00:00

abstract：:Alu repetitive sequences are the most abundant short interspersed DNA elements in the human genome. Full-length Alu elements are composed of two tandem sequence monomers, the left and right Alu arms, both derived from the 7SL signal recognition particle RNA. Since Alu elements are common in protein-coding genes, they ...

journal_title：Genes & development

authors： Jády BE,Ketele A,Kiss T

更新日期：2012-09-01 00:00:00

abstract：:The orphan nuclear receptor TLX regulates neural stem cell self-renewal in the adult brain and functions primarily as a transcription repressor through recruitment of Atrophin corepressors, which bind to TLX via a conserved peptide motif termed the Atro box. Here we report crystal structures of the human and insect TL...

journal_title：Genes & development

authors： Zhi X,Zhou XE,He Y,Searose-Xu K,Zhang CL,Tsai CC,Melcher K,Xu HE

更新日期：2015-02-15 00:00:00

abstract：:To determine the prevalence of cotranscriptional splicing in Drosophila, we sequenced nascent RNA transcripts from Drosophila S2 cells as well as from Drosophila heads. Eighty-seven percent of the introns assayed manifest >50% cotranscriptional splicing. The remaining 13% are cotranscriptionally spliced poorly or slow...

journal_title：Genes & development

authors： Khodor YL,Rodriguez J,Abruzzi KC,Tang CH,Marr MT 2nd,Rosbash M

更新日期：2011-12-01 00:00:00

abstract：:Far1p is a bifunctional protein that is required to arrest the cell cycle and to establish cell polarity during yeast mating. Far1p is localized predominantly in the nucleus but accumulates in the cytoplasm in cells exposed to pheromones. Here we show that Far1p functions in both subcellular compartments: nuclear Far1...

journal_title：Genes & development

authors： Blondel M,Alepuz PM,Huang LS,Shaham S,Ammerer G,Peter M

更新日期：1999-09-01 00:00:00

abstract：:The p53 tumor suppressor activates either cell cycle arrest or apoptosis in response to cellular stress. Mouse embryo fibroblasts (MEFs) provide a powerful primary cell system to study both p53-dependent pathways. Specifically, in response to DNA damage, MEFs undergo p53-dependent G(1) arrest, whereas MEFs expressing ...

journal_title：Genes & development

authors： Attardi LD,Reczek EE,Cosmas C,Demicco EG,McCurrach ME,Lowe SW,Jacks T

更新日期：2000-03-15 00:00:00

abstract：:The Caenorhabditis elegans caudal homolog, pal-1, is required for neurogenesis in the male tail. We show that expression of pal-1 in the postembryonic neuroblast cell V6 can be initiated by two alternate pathways. One pathway, acting in wild type, requires a regulatory element in the fifth pal-1 intron. The other path...

journal_title：Genes & development

authors： Zhang H,Emmons SW

更新日期：2000-09-01 00:00:00

abstract：:In meiosis I, homologous chromosomes pair and then attach to the spindle so that the homologs can be pulled apart at anaphase I. The segregation of homologs before pairing would be catastrophic. We describe two mechanisms that prevent this. First, in early meiosis, Ipl1, the budding yeast homolog of the mammalian Auro...

journal_title：Genes & development

authors： Kim S,Meyer R,Chuong H,Dawson DS

更新日期：2013-10-01 00:00:00

abstract：:The neurofibromatosis type II (NF2) tumor suppressor encodes a putative cytoskeletal associated protein, the loss of which leads to the development of Schwann cell tumors associated with NF2 in humans. The NF2 protein merlin belongs to the band 4.1 family of proteins that link membrane proteins to the cytoskeleton and...

journal_title：Genes & development

authors： McClatchey AI,Saotome I,Ramesh V,Gusella JF,Jacks T

更新日期：1997-05-15 00:00:00

abstract：:The essential splicing factor human UAP56 (hUAP56) is a DExD/H-box protein known to promote prespliceosome assembly. Here, using a series of hUAP56 mutants that are defective for ATP-binding, ATP hydrolysis, or dsRNA unwindase/helicase activity, we assess the relative contributions of these biochemical functions to pr...

journal_title：Genes & development

authors： Shen H,Zheng X,Shen J,Zhang L,Zhao R,Green MR

更新日期：2008-07-01 00:00:00

abstract：:In cytoplasm, the survival of motor neuron (SMN) complex delivers pre-small nuclear RNAs (pre-snRNAs) to the heptameric Sm ring for the assembly of the ring complex on pre-snRNAs at the conserved Sm site [A(U)4-6G]. Gemin5, a WD40 protein component of the SMN complex, is responsible for recognizing pre-snRNAs. In addi...

journal_title：Genes & development

authors： Xu C,Ishikawa H,Izumikawa K,Li L,He H,Nobe Y,Yamauchi Y,Shahjee HM,Wu XH,Yu YT,Isobe T,Takahashi N,Min J

更新日期：2016-11-01 00:00:00

abstract：:Sonic hedgehog (Shh) signaling plays a critical role during development and carcinogenesis. While Gli family members govern the transcriptional output of Shh signaling, little is known how Gli-mediated transcriptional activity is regulated. Here we identify the actin-binding protein Missing in Metastasis (MIM) as a ne...

journal_title：Genes & development

authors： Callahan CA,Ofstad T,Horng L,Wang JK,Zhen HH,Coulombe PA,Oro AE

更新日期：2004-11-15 00:00:00

abstract：:Pre-mRNA splicing is essential for generating mature mRNA and is also important for subsequent mRNA export and quality control. The splicing history is imprinted on spliced mRNA through the deposition of a splicing-dependent multiprotein complex, the exon junction complex (EJC), at approximately 20 nucleotides upstrea...

journal_title：Genes & development

authors： Shi H,Xu RM

更新日期：2003-04-15 00:00:00

abstract：:The progressive bone marrow failure syndrome dyskeratosis congenita (DC) is often caused by mutations in telomerase or the factors involved in telomerase biogenesis and trafficking. However, a subset of DC patients is heterozygous for mutations in the shelterin component TIN2. To determine how the TIN2-DC mutations af...

journal_title：Genes & development

authors： Frescas D,de Lange T

更新日期：2014-01-15 00:00:00

abstract：:In the Bar mutation of Drosophila, ommatidial differentiation is known to be suppressed in the anterior portion of the eye. Our structural analysis shows that the Bar region contains a pair of homeo box genes, BarH1 and BarH2. These genes encode polypeptides similar in size and sequence and share a common homeo domain...

journal_title：Genes & development

authors： Higashijima S,Kojima T,Michiue T,Ishimaru S,Emori Y,Saigo K

更新日期：1992-01-01 00:00:00

abstract：:Maternal imprinting at the Xist gene is essential to achieve paternal allele-specific imprinted X-chromosome inactivation (XCI) in female mammals. However, the mechanism underlying Xist imprinting is unclear. Here we show that the Xist locus is coated with a broad H3K27me3 domain that is established during oocyte grow...

journal_title：Genes & development

authors： Inoue A,Jiang L,Lu F,Zhang Y

更新日期：2017-10-01 00:00:00

abstract：:The recombinational enhancer of the Hin inversion system in Salmonella stimulates recombination in vitro 150-fold in the presence of the Escherichia coli host factor Fis. To gain an understanding of the roles of the enhancer and Fis in stimulating the Hin-mediated inversion reaction, we have used nuclease and chemical...

journal_title：Genes & development

authors： Bruist MF,Glasgow AC,Johnson RC,Simon MI

更新日期：1987-10-01 00:00:00

abstract：:Genomic imprinting is an epigenetic phenomenon leading to parentally biased gene expression. Throughout the years, extensive efforts have been made to characterize the epigenetic marks underlying imprinting in animals and plants. As a result, DNA methylation asymmetries between parental genomes emerged as the primary ...

journal_title：Genes & development

authors： Batista RA,Köhler C

更新日期：2020-01-01 00:00:00

abstract：:DOCK180 is involved in integrin signaling through CrkII-p130(Cas) complexes. We have studied the involvement of DOCK180 in Rac1 signaling cascades. DOCK180 activated JNK in a manner dependent on Rac1, Cdc42Hs, and SEK, and overexpression of DOCK180 increased the amount of GTP-bound Rac1 in 293T cells. Coexpression of ...

journal_title：Genes & development

authors： Kiyokawa E,Hashimoto Y,Kobayashi S,Sugimura H,Kurata T,Matsuda M

更新日期：1998-11-01 00:00:00

abstract：:The efficiency of RNA 3'-end formation of spleen necrosis virus (SNV) is determined by the distance between the cap site and the poly(A) site. When the distance between the cap site and the poly(A) site was shorter than 500 bases, only 3-9% of the RNA was polyadenylated at the SNV poly(A) site. However, when the dista...

journal_title：Genes & development

authors： Iwasaki K,Temin HM

更新日期：1990-12-01 00:00:00

abstract：:The Saccharomyces cerevisiae protein kinase Rim15p was identified previously as a stimulator of meiotic gene expression. Here, we show that loss of Rim15p causes an additional pleiotropic phenotype in cells grown to stationary phase on rich medium; this phenotype includes defects in trehalose and glycogen accumulation...

journal_title：Genes & development

authors： Reinders A,Bürckert N,Boller T,Wiemken A,De Virgilio C

更新日期：1998-09-15 00:00:00

abstract：:Proximal-distal outgrowth of the vertebrate limb bud is regulated by the apical ectodermal ridge (AER), which forms at an invariant position along the dorsal-ventral (D/V) axis of the embryo. We have studied the genetic and cellular events that regulate AER formation in the mouse. In contrast to implications from prev...

journal_title：Genes & development

authors： Kimmel RA,Turnbull DH,Blanquet V,Wurst W,Loomis CA,Joyner AL

更新日期：2000-06-01 00:00:00

abstract：:IkappaB kinases (IKKs) IKK1 and IKK2 are two putative IkappaBalpha kinases involved in NF-kappaB activation. To examine the in vivo functions of IKK1, we generated IKK1-deficient mice. The mutant mice are perinatally lethal and exhibit a wide range of developmental defects. Newborn mutant mice have shiny, taut, and st...

journal_title：Genes & development

authors： Li Q,Lu Q,Hwang JY,Büscher D,Lee KF,Izpisua-Belmonte JC,Verma IM

更新日期：1999-05-15 00:00:00

abstract：:Our understanding of eukaryotic transcriptional activation mechanisms has been hampered by an inability to identify the direct in vivo targets of activator proteins, primarily because of lack of appropriate experimental methods. To circumvent this problem, we have developed a fluorescence resonance energy transfer (FR...

journal_title：Genes & development

authors： Bhaumik SR,Raha T,Aiello DP,Green MR

更新日期：2004-02-01 00:00:00

abstract：:The Komeda miniature rat Ishikawa (KMI) is a naturally occurring mutant caused by an autosomal recessive mutation mri, which exhibits longitudinal growth retardation. Here we identified the mri mutation as a deletion in the rat gene encoding cGMP-dependent protein kinase type II (cGKII). KMIs showed an expanded growth...

journal_title：Genes & development

authors： Chikuda H,Kugimiya F,Hoshi K,Ikeda T,Ogasawara T,Shimoaka T,Kawano H,Kamekura S,Tsuchida A,Yokoi N,Nakamura K,Komeda K,Chung UI,Kawaguchi H

更新日期：2004-10-01 00:00:00

abstract：:In this issue of Genes & Development, Dowen and colleagues (pp. 1515-1528) elegantly unify two previously unconnected aspects of physiology. The investigators provide significant genetic evidence to support a critical link between developmental timing decisions and the regulation of lipid mobilization at the transitio...

journal_title：Genes & development

authors： Weaver BP,Sewell AK,Han M

更新日期：2016-07-01 00:00:00

abstract：:As in many polarized cells, spindle alignment in yeast is essential and cell cycle regulated. A key step that governs spindle alignment is the selective binding of the Kar9 protein to only one of the two spindle pole bodies (SPBs). It has been suggested that cyclin-dependent kinase Cdc28, in complex with cyclin Clb4, ...

journal_title：Genes & development

authors： Maekawa H,Schiebel E

更新日期：2004-07-15 00:00:00