Regulating the regulator: an RNA decoy acts as an OFF switch for the regulation of an sRNA.

Abstract:

:Many bacterial small regulatory RNAs (sRNAs) pair with mRNA targets, stimulating or inhibiting mRNA stability and/or translation. Regulation of these sRNAs is usually due to tight transcriptional regulation of synthesis.In this issue of Genes & Development and a related paper in Molecular Microbiology, Figueroa-Bossi and colleagues (pp. 2004-2015) and Overgaard and colleagues report a novel regulatory mechanism in which induction of a competing mRNA acts to titrate away the sRNA, allowing expression of an otherwise strongly inhibited target gene.

journal_name

Genes Dev

journal_title

Genes & development

authors

Mandin P,Gottesman S

doi

10.1101/gad.1846609

subject

Has Abstract

pub_date

2009-09-01 00:00:00

pages

1981-5

issue

17

eissn

0890-9369

issn

1549-5477

pii

23/17/1981

journal_volume

23

pub_type

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