Abstract：
:The mottler of white (mw) locus has been determined to interact with alleles of the white (w) eye color locus which are a subset of the transposable element insertion mutants. The transposable elements belong to six different types, including copia, and are located at several sites within the w gene. Three X-ray-induced revertants of white-apricot (wa) no longer respond to mw, indicating that the transposable element must be present for mw to act. The mottling property of the original allele was analyzed by combining the mw mutant with extra copies of wa, either in a tandem duplication or in a transposable segment on chromosome two. Because neither duplication alters the mottling pattern, the event that results in the mottled pattern must occur at mw and not at w. The pattern of a deficiency for the locus heterozygous with the original allele differs from that of mw/mw females, confirming that this unique mottling property occurs at mw. A new allele of mw was induced in hybrid dysgenic crosses. It is not mottled, slightly enhances wa as a heterozygote, and further enhances as a homozygote or hemizygote. An analysis of RNA from wa with mw shows a reduction of the full-length normal RNA and a concomitant increase in certain RNAs that terminate within the copia element. These results suggest that several retrotransposon-induced alleles share an RNA processing function encoded by mw.
journal_name
Genes Devjournal_title
Genes & developmentauthors
Birchler JA,Hiebert JC,Rabinow Ldoi
10.1101/gad.3.1.73subject
Has Abstractpub_date
1989-01-01 00:00:00pages
73-84issue
1eissn
0890-9369issn
1549-5477journal_volume
3pub_type
杂志文章abstract：:Mutations that influence lin-12 activity in Caenorhabditis elegans may identify conserved factors that regulate the activity of lin-12/Notch proteins. We describe genetic evidence indicating that sel-10 is a negative regulator of lin-12/Notch-mediated signaling in C. elegans. Sequence analysis shows that SEL-10 is a m...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.11.23.3182
更新日期：1997-12-01 00:00:00
abstract：:Protection of the stalled replication fork is crucial for responding to replication stress and minimizing its impact on chromosome instability, thus preventing diseases, including cancer. We found a new component, Abro1, in the protection of stalled replication fork integrity. Abro1 deficiency results in increased chr...
journal_title：Genes & development
pub_type： 杂志文章
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更新日期：2017-07-15 00:00:00
abstract：:A relevant, yet little recognized feature of antisense regulation is the possibility of switching roles between regulatory and regulated RNAs. Here we show that induction of a Salmonella gene relies on the conversion of a small RNA from effector to regulatory target. The chiP gene (formerly ybfM), identified and chara...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.541609
更新日期：2009-09-01 00:00:00
abstract：:Macrophage activation by the proinflammatory cytokine interferon-gamma (IFN-gamma) is a critical component of the host innate response to bacterial pathogenesis. However, the precise nature of the IFN-gamma-induced activation pathway is not known. Here we show using genome-wide expression and chromatin-binding profili...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1553007
更新日期：2007-08-01 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
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更新日期：2008-06-15 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1025202
更新日期：2002-10-01 00:00:00
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journal_title：Genes & development
pub_type： 评论,杂志文章
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更新日期：2012-11-15 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.900401
更新日期：2001-07-15 00:00:00
abstract：:Gene inactivation can result when a delta element of the Ty1 transposon inserted into the yeast HIS4 promoter (his4-912delta) alters the transcription initiation site. Previous work has identified mutations that suppress this transcriptional defect by restoring the transcription start site to the native position, and ...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.10.5.604
更新日期：1996-03-01 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.9.18.2266
更新日期：1995-09-15 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.398207
更新日期：2007-02-01 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.243584.114
更新日期：2014-10-15 00:00:00
abstract：:The presence of Set2-mediated methylation of H3K36 (K36me) correlates with transcription frequency throughout the yeast genome. K36me targets the Rpd3S complex to deacetylate transcribed regions and suppress cryptic transcription initiation at certain genes. Here, using a genome-wide approach, we report that the Set2-...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1539307
更新日期：2007-06-01 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.8.20.2466
更新日期：1994-10-15 00:00:00
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journal_title：Genes & development
pub_type： 评论,杂志文章
doi：10.1101/gad.2080411
更新日期：2011-07-15 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.417707
更新日期：2007-05-01 00:00:00
abstract：:Pseudoplasmodia of developing Dictyostelium are organized with anteroposterior polarity. We have isolated CAR4, the gene for a new cell-surface, G protein-linked cAMP receptor. CAR4 mRNA is initially expressed during tip elongation and continues to accumulate into culmination. CAR4 is maximally expressed in pseudoplas...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.8.17.2086
更新日期：1994-09-01 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.6.12b.2569
更新日期：1992-12-01 00:00:00
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journal_title：Genes & development
pub_type： 评论,杂志文章,评审
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更新日期：2017-05-15 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
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更新日期：2004-09-01 00:00:00
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pub_type： 杂志文章
doi：10.1101/gad.11.21.2801
更新日期：1997-11-01 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.312355.118
更新日期：2018-08-01 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.917101
更新日期：2001-11-01 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
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更新日期：2013-01-01 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.13.14.1774
更新日期：1999-07-15 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.5.1.60
更新日期：1991-01-01 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1646208
更新日期：2008-04-01 00:00:00
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pub_type： 杂志文章
doi：10.1101/gad.5.5.751
更新日期：1991-05-01 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.7.8.1521
更新日期：1993-08-01 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.7.12b.2575
更新日期：1993-12-01 00:00:00
