Abro1 maintains genome stability and limits replication stress by protecting replication fork stability.

abstract：:Stem cells have been identified as a source of virtually all highly differentiated cells that are replenished during the lifetime of an animal. The critical balance between stem and differentiated cell populations is crucial for the long-term maintenance of functional tissue types. Stem cells maintain this balance by ...

journal_title：Genes & development

authors： Martinez-Agosto JA,Mikkola HK,Hartenstein V,Banerjee U

更新日期：2007-12-01 00:00:00

abstract：:Bone metastases are the most common skeletal complication of malignancy. Tumor cells disrupt normal bone remodeling to promote bone destruction and its associated morbidity. In the August 15, 2009, issue of Genes & Development, Lu and colleagues (pp. 1882-1894) propose a novel molecular mechanism by which tumor-produc...

journal_title：Genes & development

authors： Guise TA

更新日期：2009-09-15 00:00:00

abstract：:The organizer region, or dorsal blastopore lip, plays a central role in the initiation of gastrulation and the formation of the body axis during Xenopus development. A similar process can also be induced in ectodermal explants by activin or by injection of activin mRNA into embryos. We have searched early embryo-speci...

journal_title：Genes & development

authors： Dirksen ML,Jamrich M

更新日期：1992-04-01 00:00:00

abstract：:IkappaB kinases (IKKs) IKK1 and IKK2 are two putative IkappaBalpha kinases involved in NF-kappaB activation. To examine the in vivo functions of IKK1, we generated IKK1-deficient mice. The mutant mice are perinatally lethal and exhibit a wide range of developmental defects. Newborn mutant mice have shiny, taut, and st...

journal_title：Genes & development

authors： Li Q,Lu Q,Hwang JY,Büscher D,Lee KF,Izpisua-Belmonte JC,Verma IM

更新日期：1999-05-15 00:00:00

abstract：:The Tat protein of human immunodeficiency virus type 1 (HIV-1) activates transcription following binding to nascent trans-activation response (TAR) RNA downstream of the transcription start site. Because Tat functions when bound to RNA, and in a position-dependent manner, it has been proposed that Tat works by a novel...

journal_title：Genes & development

authors： Southgate CD,Green MR

更新日期：1991-12-01 00:00:00

abstract：:Mammalian cells exhibit a complex response to DNA damage. The tumor suppressor BRCA1 and associated protein BARD1 are thought to play an important role in this response, and our previous work demonstrated that this includes transient inhibition of the pre-mRNA 3' processing machinery. Here we provide evidence that thi...

journal_title：Genes & development

authors： Kleiman FE,Wu-Baer F,Fonseca D,Kaneko S,Baer R,Manley JL

更新日期：2005-05-15 00:00:00

abstract：:The mammary tumor-associated proto-oncogene Wnt-1/int-1 encodes a secreted protein implicated in the regulation of neural development in vertebrates and segmental pattern in Drosophila. Using a PCR-based strategy, we isolated cDNAs encoding six novel, related proteins that are expressed in fetal mice. Predicted protei...

journal_title：Genes & development

authors： Gavin BJ,McMahon JA,McMahon AP

更新日期：1990-12-01 00:00:00

abstract：:The allosteric and torpedo models have been used for 30 yr to explain how transcription terminates on protein-coding genes. The former invokes termination via conformational changes in the transcription complex and the latter proposes that degradation of the downstream product of poly(A) signal (PAS) processing is imp...

journal_title：Genes & development

authors： Eaton JD,Francis L,Davidson L,West S

更新日期：2020-01-01 00:00:00

abstract：:Ecsit is a cytosolic adaptor protein essential for inflammatory response and embryonic development via the Toll-like and BMP (bone morphogenetic protein) signal transduction pathways, respectively. Here, we demonstrate a mitochondrial function for Ecsit (an evolutionary conserved signaling intermediate in Toll pathway...

journal_title：Genes & development

authors： Vogel RO,Janssen RJ,van den Brand MA,Dieteren CE,Verkaart S,Koopman WJ,Willems PH,Pluk W,van den Heuvel LP,Smeitink JA,Nijtmans LG

更新日期：2007-03-01 00:00:00

abstract：:Abcission, the natural shedding of leaves, flowers and fruits, is a fundamental component of plant development. Abscission is a highly regulated process that occurs at distinct zones of cells that undergo enlargement and subsequent separation. Although some components of abscission, including accumulation of the hormo...

journal_title：Genes & development

authors： Jinn TL,Stone JM,Walker JC

更新日期：2000-01-01 00:00:00

abstract：:In this issue of Genes & Development, Wierzbicki and colleagues (pp. 1825-1836) examine the current model of RNA-directed DNA methylation (RdDM) by determining genome-wide distributions of RNA polymerase V (Pol V) occupancy, siRNAs, and DNA methylation. Their data support the key role of base-pairing between Pol V tra...

journal_title：Genes & development

authors： Zhang H,Zhu JK

更新日期：2012-08-15 00:00:00

abstract：:Checkpoint genes maintain genomic stability by arresting cells after DNA damage. Many of these genes also control cell cycle events in unperturbed cells. By conducting a screen for checkpoint genes in zebrafish, we found that dtl/cdt2 is an essential component of the early, radiation-induced G2/M checkpoint. We subseq...

journal_title：Genes & development

authors： Sansam CL,Shepard JL,Lai K,Ianari A,Danielian PS,Amsterdam A,Hopkins N,Lees JA

更新日期：2006-11-15 00:00:00

abstract：:Two retrovirus promoter trap vectors (U3His and U3Neo) have been used to disrupt genes expressed in totipotent murine embryonal stem (ES) cells. Selection in L-histidinol or G418 produced clones in which the coding sequences for histidinol-dehydrogenase or neomycin-phosphotransferase were fused to sequences in or near...

journal_title：Genes & development

authors： von Melchner H,DeGregori JV,Rayburn H,Reddy S,Friedel C,Ruley HE

更新日期：1992-06-01 00:00:00

abstract：:In eubacteria, the ClpS adaptor has been proposed to be essential for degradation of N-end rule substrates by the AAA(+) protease ClpAP. To test this model, we assayed degradation of substrates bearing N-end rule sequences isolated in a genetic screen for efficient degradation tags. ClpS was not vital for degradation ...

journal_title：Genes & development

authors： Wang KH,Sauer RT,Baker TA

更新日期：2007-02-15 00:00:00

abstract：:Faithful duplication of the genome relies on the ability to cope with an imperfect template. We investigated replication of UV-damaged DNA in Escherichia coli and found that ongoing replication stops for at least 15-20 min before resuming. Undamaged origins of replication (oriC) continue to fire at the normal rate and...

journal_title：Genes & development

authors： Rudolph CJ,Upton AL,Lloyd RG

更新日期：2007-03-15 00:00:00

abstract：:Export to the cytoplasm of U3 RNA transcribed from a rat U3 gene injected into the nucleus of Xenopus oocytes indicates that the biogenesis of U3 RNA, like that of the previously studied Sm-precipitable nucleoplasmic snRNAs (U1, U2, U4, and U5), includes a cytoplasmic phase. The regulation of import of the U3 snRNA in...

journal_title：Genes & development

authors： Baserga SJ,Gilmore-Hebert M,Yang XW

更新日期：1992-06-01 00:00:00

abstract：:A novel histone methyltransferase, termed Set9, was isolated from human cells. Set9 contains a SET domain, but lacks the pre- and post-SET domains. Set9 methylates specifically lysine 4 (K4) of histone H3 (H3-K4) and potentiates transcription activation. The histone H3 tail interacts specifically with the histone deac...

journal_title：Genes & development

authors： Nishioka K,Chuikov S,Sarma K,Erdjument-Bromage H,Allis CD,Tempst P,Reinberg D

更新日期：2002-02-15 00:00:00

abstract：:The mammalian high mobility group proteins HMG1 and HMG2 are abundant, chromatin-associated proteins whose cellular function is not known. In this study we show that these proteins can substitute for the prokaryotic DNA-bending protein HU in promoting the assembly of the Hin invertasome, an intermediate structure in H...

journal_title：Genes & development

authors： Paull TT,Haykinson MJ,Johnson RC

更新日期：1993-08-01 00:00:00

abstract：:In vivo experiments have demonstrated that the ribosomal protein L32 of Saccharomyces cerevisiae brings about the inhibition of splicing of the transcript of its own gene through an RNA structure comprised largely of the first exon. We now show that L32, itself, binds specifically to this RNA. Splicing of the RPL32 tr...

journal_title：Genes & development

authors： Vilardell J,Warner JR

更新日期：1994-01-01 00:00:00

abstract：:The HAT4 gene from the plant Arabidopsis thaliana encodes a homeo domain protein that contains a leucine zipper motif. Homeo domain-leucine zipper (HD-Zip) proteins have not been found in animal systems, suggesting that HAT4 may define a new family of transcription factors that regulate higher plant development. To ex...

journal_title：Genes & development

authors： Schena M,Lloyd AM,Davis RW

更新日期：1993-03-01 00:00:00

abstract：:TFIID is a multisubunit protein containing the TATA box-binding polypeptide (TBP) and associated factors (TFIID-TAFs) required for activated transcription by RNA polymerase II. TBPs from different eukaryotes contain a highly conserved carboxy-terminal domain and very divergent amino-terminal domains. Earlier studies p...

journal_title：Genes & development

authors： Zhou Q,Boyer TG,Berk AJ

更新日期：1993-02-01 00:00:00

abstract：:RNA polymerase II nascent transcripts are capped during pausing before elongation. Here we report that hSPT5, the human homolog of yeast elongation factor SPT5, interacts directly with the capping enzyme. hSPT5 stimulated capping enzyme guanylylation and mRNA capping by severalfold. Although RNA 5'-triphosphatase acti...

journal_title：Genes & development

authors： Wen Y,Shatkin AJ

更新日期：1999-07-15 00:00:00

abstract：:In meiosis I, homologous chromosomes pair and then attach to the spindle so that the homologs can be pulled apart at anaphase I. The segregation of homologs before pairing would be catastrophic. We describe two mechanisms that prevent this. First, in early meiosis, Ipl1, the budding yeast homolog of the mammalian Auro...

journal_title：Genes & development

authors： Kim S,Meyer R,Chuong H,Dawson DS

更新日期：2013-10-01 00:00:00

abstract：:Staurosporine, a potent inhibitor of protein kinase C, arrests fission yeast cell elongation specifically at a stage immediately after cell division. We isolated two genes, which, when carried on multicopy plasmids, confer drug resistance in fission yeast. One, spk1+, encodes a protein kinase highly similar (54% ident...

journal_title：Genes & development

authors： Toda T,Shimanuki M,Yanagida M

更新日期：1991-01-01 00:00:00

abstract：:Developmental responses to the plant hormone auxin are thought to be mediated by interacting pairs from two protein families: short-lived inhibitory IAA proteins and ARF transcription factors binding to auxin-response elements. monopteros mutants lacking activating ARF5 and the auxin-insensitive mutant bodenlos fail t...

journal_title：Genes & development

authors： Hamann T,Benkova E,Bäurle I,Kientz M,Jürgens G

更新日期：2002-07-01 00:00:00

abstract：:The mammalian Daxx gene has been identified in a diverse set of yeast interaction trap experiments. Although a facilitating role for Daxx in Fas-induced apoptosis has been suggested, Daxx's physiologic function remains unknown. To elucidate the in vivo role of Daxx, we have generated Daxx-deficient mice. Surprisingly,...

journal_title：Genes & development

authors： Michaelson JS,Bader D,Kuo F,Kozak C,Leder P

更新日期：1999-08-01 00:00:00

abstract：:A prominent feature of cell differentiation is the initiation and maintenance of an irreversible cell cycle arrest with the complex involvement of the retinoblastoma (RB) family (RB, p130, p107). We have isolated the HBP1 transcriptional repressor as a potential target of the RB family in differentiated cells. By homo...

journal_title：Genes & development

authors： Tevosian SG,Shih HH,Mendelson KG,Sheppard KA,Paulson KE,Yee AS

更新日期：1997-02-01 00:00:00

abstract：:To define the functional pathways regulating epithelial cell migration, we performed a genome-wide RNAi screen using 55,000 pooled lentiviral shRNAs targeting ∼11,000 genes, selecting for transduced cells with increased motility. A stringent validation protocol generated a set of 31 genes representing diverse pathways...

journal_title：Genes & development

authors： Smolen GA,Zhang J,Zubrowski MJ,Edelman EJ,Luo B,Yu M,Ng LW,Scherber CM,Schott BJ,Ramaswamy S,Irimia D,Root DE,Haber DA

更新日期：2010-12-01 00:00:00

abstract：:Direct reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) provides a unique opportunity to derive patient-specific stem cells with potential applications in tissue replacement therapies and without the ethical concerns of human embryonic stem cells (hESCs). However, cellular senescence, which c...

journal_title：Genes & development

authors： Lapasset L,Milhavet O,Prieur A,Besnard E,Babled A,Aït-Hamou N,Leschik J,Pellestor F,Ramirez JM,De Vos J,Lehmann S,Lemaitre JM

更新日期：2011-11-01 00:00:00

abstract：:Male sexual development in the nematode Caenorhabditis elegans requires the genes fem-1, fem-2, and fem-3. The current model of sex determination portrays the FEM proteins as components of a novel signal transduction pathway, but the mechanisms involved in signaling through the pathway are not understood. We report th...

journal_title：Genes & development

authors： Chin-Sang ID,Spence AM

更新日期：1996-09-15 00:00:00