Abstract：
:Plant water homeostasis is maintained by the phytohormone abscisic acid (ABA), which triggers stomatal pore closure in response to drought stress. We identified the Arabidopsis small guanosine triphosphatase (GTPase) protein AtRac1 as a central component in the ABA-mediated stomatal closure process. ABA treatment induced inactivation of AtRac GTPases and disruption of the guard cell actin cytoskeleton. In contrast, in the ABA-insensitive mutant abi1-1, which is impaired in stomatal closure, neither AtRac inactivation nor actin cytoskeleton disruption was observed on ABA treatment. These observations indicate that AtRac1 inactivation is a limiting step in the ABA-signaling cascade leading to stomatal closure. Consistent with these findings, expression of a dominant-positive mutant of AtRac1 blocked the ABA-mediated effects on actin cytoskeleton and stomatal closure in wild-type plants, whereas expression of a dominant-negative AtRac1 mutant recapitulated the ABA effects in the absence of the hormone. Moreover, the dominant-negative form of AtRac1 could also restore stomatal closure in abi1-1. These results define AtRac1 as a central element for plant adaptation to drought.
journal_name
Genes Devjournal_title
Genes & developmentauthors
Lemichez E,Wu Y,Sanchez JP,Mettouchi A,Mathur J,Chua NHdoi
10.1101/gad.900401subject
Has Abstractpub_date
2001-07-15 00:00:00pages
1808-16issue
14eissn
0890-9369issn
1549-5477journal_volume
15pub_type
杂志文章abstract：:The yeast SAS (Something About Silencing) complex and the histone variant H2A.Z have both previously been linked to an antisilencing function at the subtelomeric regions. SAS is an H4 Lys 16-specific histone acetyltransferase complex. Here we demonstrate that the H4 Lys 16 acetylation by SAS is required for efficient ...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1439206
更新日期：2006-09-15 00:00:00
abstract：:Staurosporine, a potent inhibitor of protein kinase C, arrests fission yeast cell elongation specifically at a stage immediately after cell division. We isolated two genes, which, when carried on multicopy plasmids, confer drug resistance in fission yeast. One, spk1+, encodes a protein kinase highly similar (54% ident...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.5.1.60
更新日期：1991-01-01 00:00:00
abstract：:The efficiency of RNA 3'-end formation of spleen necrosis virus (SNV) is determined by the distance between the cap site and the poly(A) site. When the distance between the cap site and the poly(A) site was shorter than 500 bases, only 3-9% of the RNA was polyadenylated at the SNV poly(A) site. However, when the dista...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.4.12b.2299
更新日期：1990-12-01 00:00:00
abstract：:The transcription cofactor MAL is regulated by free actin levels and thus by actin dynamics. MAL, together with its DNA-binding partner, SRF, is required for invasive cell migration and in experimental metastasis. Although MAL/SRF has many targets, we provide genetic evidence in both Drosophila and human cellular mode...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.237743.114
更新日期：2014-05-15 00:00:00
abstract：:Gut homeostasis is controlled by both immune and developmental mechanisms, and its disruption can lead to inflammatory disorders or cancerous lesions of the intestine. While the impact of bacteria on the mucosal immune system is beginning to be precisely understood, little is known about the effects of bacteria on gut...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1827009
更新日期：2009-10-01 00:00:00
abstract：:Cosuppression is a silencing phenomenon triggered by the introduction of homologous DNA sequences into the genomes of organisms as diverse as plants, fungi, flies, and nematodes. Here we report sex-induced silencing (SIS), which is triggered by tandem integration of a transgene array in the human fungal pathogen Crypt...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1970910
更新日期：2010-11-15 00:00:00
abstract：:Pax3 is a key transcription factor implicated in development and human disease. To dissect the role of Pax3 in myogenesis and establish whether it is a repressor or activator, we generated loss- and gain-of-function alleles by targeting an nLacZ reporter and a sequence encoding the oncogenic fusion protein PAX3-FKHR i...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.281203
更新日期：2003-12-01 00:00:00
abstract：:Many bacterial small regulatory RNAs (sRNAs) pair with mRNA targets, stimulating or inhibiting mRNA stability and/or translation. Regulation of these sRNAs is usually due to tight transcriptional regulation of synthesis.In this issue of Genes & Development and a related paper in Molecular Microbiology, Figueroa-Bossi ...
journal_title：Genes & development
pub_type： 评论,杂志文章
doi：10.1101/gad.1846609
更新日期：2009-09-01 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1.3.238
更新日期：1987-05-01 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
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更新日期：2009-03-01 00:00:00
abstract：:The current model for endocrine cell specification in the pancreas invokes high-level production of the transcription factor Neurogenin 3 (Neurog3) in Sox9(+) bipotent epithelial cells as the trigger for endocrine commitment, cell cycle exit, and rapid delamination toward proto-islet clusters. This model posits a tran...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.284729.116
更新日期：2016-08-15 00:00:00
abstract：:The YAP transcription coactivator has been implicated as an oncogene and is amplified in human cancers. Recent studies have established that YAP is phosphorylated and inhibited by the Hippo tumor suppressor pathway. Here we demonstrate that the TEAD family transcription factors are essential in mediating YAP-dependent...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1664408
更新日期：2008-07-15 00:00:00
abstract：:Direct reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) provides a unique opportunity to derive patient-specific stem cells with potential applications in tissue replacement therapies and without the ethical concerns of human embryonic stem cells (hESCs). However, cellular senescence, which c...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.173922.111
更新日期：2011-11-01 00:00:00
abstract：:Although MAX is regarded as an obligate dimerization partner for MYC, its function in normal development and neoplasia is poorly defined. We show that B-cell-specific deletion of Max has a modest effect on B-cell development but completely abrogates Eµ-Myc-driven lymphomagenesis. While Max loss affects only a few hund...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.325878.119
更新日期：2019-09-01 00:00:00
abstract：:The rpoH gene of Escherichia coli encodes sigma 32, the 32-kD sigma-factor responsible for the heat-inducible transcription of the heat shock genes. rpoH is transcribed from at least three promoters. Two of these promoters are recognized by RNA polymerase containing sigma 70, the predominant sigma-factor. We purified ...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.3.9.1462
更新日期：1989-09-01 00:00:00
abstract：:Integrin receptors for extracellular matrix are critical for cell motility, but the signals that determine when to stop are not known. Analysis of distal tip cell (DTC) migration during gonadogenesis in Caenorhabditis elegans has revealed the importance of transcription factor vab-3/Pax6 in regulating the alpha integr...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1534807
更新日期：2007-07-01 00:00:00
abstract：:The heterochromatin-like structure formed by the yeast silent information regulator complex (SIR) represses transcription at the silent mating type loci and telomeres. Here, we report that tight protein-DNA complexes induce ectopic recruitment of the SIR complex, promoting gene silencing and changes in subnuclear loca...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.611011
更新日期：2011-07-01 00:00:00
abstract：:Using an in vitro system in which a 5' splice site (5'SS) RNA oligo (AAG decreases GUAAGUAdT) is capable of inducing formation of U2/U4/U5/U6 snRNP complex we show that this oligo specifically binds to U4/U5/U6 snRNP and cross-links to U6 snRNA in the absence of U2 snRNP. Moreover, 5'SS RNA oligo bound to U4/U5/U6 snR...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.8.16.1962
更新日期：1994-08-15 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.870801
更新日期：2001-03-15 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.237628.114
更新日期：2014-05-01 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
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更新日期：2008-02-01 00:00:00
abstract：:During embryonic development in vertebrates, the endoderm becomes patterned along the anteroposterior axis to produce distinct derivatives. How this regulation is controlled is not well understood. We report that the zebrafish hairy/enhancer of split [E(spl)]-related gene her5 plays a critical role in this process. At...
journal_title：Genes & development
pub_type： 杂志文章
doi：
更新日期：2000-07-01 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.829100
更新日期：2000-11-01 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
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更新日期：2009-06-15 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章,评审
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更新日期：2008-11-15 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.8.22.2743
更新日期：1994-11-15 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
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更新日期：2010-03-15 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
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更新日期：2015-03-15 00:00:00
abstract：:How RNA-binding proteins recognize specific sets of target mRNAs remains poorly understood because current approaches depend primarily on sequence information. In this study, we demonstrate that specific recognition of messenger RNAs (mRNAs) by RNA-binding proteins requires the correct spatial positioning of these seq...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.177428.111
更新日期：2012-01-01 00:00:00
abstract：:The sigma(28) protein is a member of the bacterial sigma(70)-family of transcription factors that directs RNA polymerase to flagellar late (class 3) promoters. The sigma(28) protein is regulated in response to flagellar assembly by the anti-sigma(28) factor FlgM. FlgM inhibits sigma(28)-dependent transcription of gene...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.380406
更新日期：2006-08-15 00:00:00
