Drosophila Brain Tumor is a translational repressor.

abstract：:The mammalian ATF/CREB family of transcription factors comprises a large group of basic-region leucine zipper (bZIP) proteins whose members mediate diverse transcriptional regulatory functions. Here we report that expression of a specific mouse ATF gene, ATFx, is down-regulated in a variety of cells undergoing apoptos...

journal_title：Genes & development

authors： Persengiev SP,Devireddy LR,Green MR

更新日期：2002-07-15 00:00:00

abstract：:Expression of the Arabidopsis CGS1 gene that codes for cystathionine gamma-synthase is feedback regulated at the step of mRNA stability in response to S-adenosyl-L-methionine (AdoMet). A short stretch of amino acid sequence, called the MTO1 region, encoded by the first exon of CGS1 itself is involved in this regulatio...

journal_title：Genes & development

authors： Onouchi H,Nagami Y,Haraguchi Y,Nakamoto M,Nishimura Y,Sakurai R,Nagao N,Kawasaki D,Kadokura Y,Naito S

更新日期：2005-08-01 00:00:00

abstract：:Cell differentiation is essential for the development of multicellular organisms. In flowering plants, the haploid male gametophytes (pollen grains) are generated in the anther from reproductive cells called microsporocytes. Several types of somatic cells ensure successful pollen development, and thus reproduction. Ho...

journal_title：Genes & development

authors： Zhao DZ,Wang GF,Speal B,Ma H

更新日期：2002-08-01 00:00:00

abstract：:The generation of neurons by progenitor cells involves the tight coordination of multiple cellular activities, including cell cycle exit, initiation of neuronal differentiation, and cell migration. The mechanisms that integrate these different events into a coherent developmental program are not well understood. Here ...

journal_title：Genes & development

authors： Nguyen L,Besson A,Heng JI,Schuurmans C,Teboul L,Parras C,Philpott A,Roberts JM,Guillemot F

更新日期：2006-06-01 00:00:00

abstract：:Cell growth and differentiation are usually antagonistic. Proteins of the basic helix-loop-helix (bHLH) family bind DNA and play important roles in the differentiation of specific cell types. Id proteins heterodimerize with bHLH transcription factors, blocking their activation of lineage-specific gene expression and t...

journal_title：Genes & development

authors： Iavarone A,Garg P,Lasorella A,Hsu J,Israel MA

更新日期：1994-06-01 00:00:00

abstract：:Nonhomologous end joining (NHEJ) and homologous recombination (HR) represent the two major pathways of DNA double-strand break (DSB) repair in eukaryotic cells. NHEJ repairs DSBs by ligation of cognate broken ends irrespective of homologous flanking sequences, whereas HR repairs DSBs using an undamaged homologous temp...

journal_title：Genes & development

authors： Mills KD,Ferguson DO,Essers J,Eckersdorff M,Kanaar R,Alt FW

更新日期：2004-06-01 00:00:00

abstract：:The human Y-family DNA polymerases, Poliota, Poleta, and Polkappa, function in promoting replication through DNA lesions. However, because of their low fidelity, any involvement of these polymerases in DNA synthesis during base excision repair (BER) would be highly mutagenic. Mechanisms, therefore, must exist to exclu...

journal_title：Genes & development

authors： Haracska L,Prakash L,Prakash S

更新日期：2003-11-15 00:00:00

abstract：:Myocardial infarction and ischemic heart disease are the leading cause of death in the industrial world. Therapies employed for treating these diseases are aimed at promoting increased blood flow to cardiac tissue. Pharmacological induction of new coronary growth has recently been explored, however, clinical trials wi...

journal_title：Genes & development

authors： Lavine KJ,White AC,Park C,Smith CS,Choi K,Long F,Hui CC,Ornitz DM

更新日期：2006-06-15 00:00:00

abstract：:Medulloblastoma (MB) is the most common pediatric CNS malignancy. We identify EAG2 as an overexpressed potassium channel in MBs across different molecular and histological subgroups. EAG2 knockdown not only impairs MB cell growth in vitro, but also reduces tumor burden in vivo and enhances survival in xenograft studie...

journal_title：Genes & development

authors： Huang X,Dubuc AM,Hashizume R,Berg J,He Y,Wang J,Chiang C,Cooper MK,Northcott PA,Taylor MD,Barnes MJ,Tihan T,Chen J,Hackett CS,Weiss WA,James CD,Rowitch DH,Shuman MA,Jan YN,Jan LY

更新日期：2012-08-15 00:00:00

abstract：:Cohesin is a chromosome-associated multisubunit protein complex that is highly conserved in eukaryotes and has close homologs in bacteria. Cohesin mediates cohesion between replicated sister chromatids and is therefore essential for chromosome segregation in dividing cells. Cohesin is also required for efficient repai...

journal_title：Genes & development

authors： Peters JM,Tedeschi A,Schmitz J

更新日期：2008-11-15 00:00:00

abstract：:The YAP transcription coactivator has been implicated as an oncogene and is amplified in human cancers. Recent studies have established that YAP is phosphorylated and inhibited by the Hippo tumor suppressor pathway. Here we demonstrate that the TEAD family transcription factors are essential in mediating YAP-dependent...

journal_title：Genes & development

authors： Zhao B,Ye X,Yu J,Li L,Li W,Li S,Yu J,Lin JD,Wang CY,Chinnaiyan AM,Lai ZC,Guan KL

更新日期：2008-07-15 00:00:00

abstract：:Small cell lung cancer (SCLC) is an aggressive neuroendocrine cancer characterized by initial chemosensitivity followed by emergence of chemoresistant disease. To study roles for MYCN amplification in SCLC progression and chemoresistance, we developed a genetically engineered mouse model of MYCN-overexpressing SCLC. I...

journal_title：Genes & development

authors： Grunblatt E,Wu N,Zhang H,Liu X,Norton JP,Ohol Y,Leger P,Hiatt JB,Eastwood EC,Thomas R,Ibrahim AH,Jia D,Basom R,Eaton KD,Martins R,Houghton AM,MacPherson D

更新日期：2020-09-01 00:00:00

abstract：:Transcriptional activation of the human U1 snRNA genes is dependent on a noncanonical octamer element contained within an upstream enhancer. The U1 octamer only weakly recruits the Oct-1 POU domain, although recruitment is stimulated by a peptide containing the Oct-1-binding domain of SNAP190. Structural analysis of t...

journal_title：Genes & development

authors： Hovde S,Hinkley CS,Strong K,Brooks A,Gu L,Henry RW,Geiger J

更新日期：2002-11-01 00:00:00

abstract：:We report a systematic mutational analysis of the helix-turn-helix motif (HTH) of the fushi tarazu (ftz) homeo domain (HD) of Drosophila. We started out by testing the function of chimeric ftz proteins containing either a part of the Sex combs reduced (Scr) or the muscle segment homeobox (msh) HDs. By complementation ...

journal_title：Genes & development

authors： Furukubo-Tokunaga K,Müller M,Affolter M,Pick L,Kloter U,Gehring WJ

更新日期：1992-06-01 00:00:00

abstract：:The alternatively spliced exon EIIIB is regulated in a cell type-specific manner in the rat fibronectin gene. Splicing of EIIIB into fibronectin mRNA is dependent on sequences in the intron immediately downstream of EIIIB. We show that a short, highly repeated TGCATG motif in this intron is important for cell type-spe...

journal_title：Genes & development

authors： Huh GS,Hynes RO

更新日期：1994-07-01 00:00:00

abstract：:Transcriptional profiling is a powerful approach for understanding development and disease. Current cell type-specific RNA purification methods have limitations, including cell dissociation trauma or inability to identify all RNA species. Here, we describe "mouse thiouracil (TU) tagging," a genetic and chemical inters...

journal_title：Genes & development

authors： Gay L,Miller MR,Ventura PB,Devasthali V,Vue Z,Thompson HL,Temple S,Zong H,Cleary MD,Stankunas K,Doe CQ

更新日期：2013-01-01 00:00:00

abstract：:MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due t...

journal_title：Genes & development

authors： Lipchina I,Elkabetz Y,Hafner M,Sheridan R,Mihailovic A,Tuschl T,Sander C,Studer L,Betel D

更新日期：2011-10-15 00:00:00

abstract：:Eukaryotic translation initiation begins with ribosomal recruitment of aminoacylated initiator tRNA (Met-tRNA(Met)(i)) by eukaryotic initiation factor eIF2. In cooperation with eIF3, eIF1, and eIF1A, Met-tRNA(Met)(i)/eIF2/GTP binds to 40S subunits yielding 43S preinitiation complexes that attach to the 5'-terminal reg...

journal_title：Genes & development

authors： Skabkin MA,Skabkina OV,Dhote V,Komar AA,Hellen CU,Pestova TV

更新日期：2010-08-15 00:00:00

abstract：:We report the discovery of mRNA 5'-leader trans-splicing (SL trans-splicing) in the chordates. In the ascidian protochordate Ciona intestinalis, the mRNAs of at least seven genes undergo trans-splicing of a 16-nucleotide 5'-leader apparently derived from a 46-nucleotide RNA that shares features with previously charact...

journal_title：Genes & development

authors： Vandenberghe AE,Meedel TH,Hastings KE

更新日期：2001-02-01 00:00:00

abstract：:We describe evidence that a regulatory B subunit of protein phosphatase 2A (PP2A) positively regulates an RTK-Ras-MAP kinase signaling cascade during Caenorhabditis elegans vulval induction. Although reduction of sur-6 PP2A-B function causes few vulval induction defects in an otherwise wild-type background, sur-6 PP2A...

journal_title：Genes & development

authors： Sieburth DS,Sundaram M,Howard RM,Han M

更新日期：1999-10-01 00:00:00

abstract：:Dosage compensation in Drosophila occurs by a twofold increase in transcription per copy of X-linked genes in males (XY) compared with females (XX). msl-1 is one of four genes that are essential for dosage compensation in males, and MSL-1 protein is associated specifically with the male X chromosome. To explore the ba...

journal_title：Genes & development

authors： Palmer MJ,Richman R,Richter L,Kuroda MI

更新日期：1994-03-15 00:00:00

abstract：:Protection of the stalled replication fork is crucial for responding to replication stress and minimizing its impact on chromosome instability, thus preventing diseases, including cancer. We found a new component, Abro1, in the protection of stalled replication fork integrity. Abro1 deficiency results in increased chr...

journal_title：Genes & development

authors： Xu S,Wu X,Wu L,Castillo A,Liu J,Atkinson E,Paul A,Su D,Schlacher K,Komatsu Y,You MJ,Wang B

更新日期：2017-07-15 00:00:00

abstract：:Classical embryology has provided a clear view of the timing and hormonal cues that govern sexual differentiation. Molecular biology has added important details to this picture. The cloning of SRY, MIS, and INSL3 provide insight into the molecular signals that provide important cues at the cellular level. Continued un...

journal_title：Genes & development

authors： Nef S,Parada LF

更新日期：2000-12-15 00:00:00

abstract：:Mismatch repair (MMR) has important roles in meiotic and mitotic recombination, DNA damage signaling, and various aspects of DNA metabolism including class-switch recombination, somatic hypermutation, and triplet-repeat expansion. Defects in MMR are responsible for human cancers characterized by microsatellite instabi...

journal_title：Genes & development

authors： Siegl-Cachedenier I,Muñoz P,Flores JM,Klatt P,Blasco MA

更新日期：2007-09-01 00:00:00

abstract：:The mitotic kinase Aurora A (Aur-A) is required for formation of a bipolar mitotic spindle and accurate chromosome segregation. In somatic cells, Aur-A protein and kinase activity levels peak during mitosis, and Aur-A is degraded during mitotic exit. Here, we investigated how Aur-A protein and kinase activity levels a...

journal_title：Genes & development

authors： Littlepage LE,Ruderman JV

更新日期：2002-09-01 00:00:00

abstract：:Cap-dependent translation is mediated by eIF4F, a protein complex composed of three subunits as follows: eIF4E, which recognizes the mRNA 5' cap structure; eIF4A, an RNA-helicase; and eIF4G, a scaffolding protein that binds eIF4E, eIF4A, and the eIF4E-kinase Mnk1 simultaneously. eIF4E is hypophosphorylated and cap-dep...

journal_title：Genes & development

authors： Pyronnet S,Dostie J,Sonenberg N

更新日期：2001-08-15 00:00:00

abstract：:The p53 inhibitor murine double-minute gene 2 (Mdm2) is a target for potential cancer therapies, however increased p53 function can be lethal. To directly address whether reduced Mdm2 function can inhibit tumorigenesis without causing detrimental side effects, we exploited a hypomorphic murine allele of mdm2 to compar...

journal_title：Genes & development

authors： Mendrysa SM,O'Leary KA,McElwee MK,Michalowski J,Eisenman RN,Powell DA,Perry ME

更新日期：2006-01-01 00:00:00

abstract：:Members of the metazoan nuclear receptor superfamily regulate gene expression programs in response to binding of cognate lipophilic ligands. Evolutionary studies using bioinformatics tools have concluded that lower eukaryotes, such as fungi, lack nuclear receptor homologs. Here we review recent discoveries suggesting ...

journal_title：Genes & development

authors： Näär AM,Thakur JK

更新日期：2009-02-15 00:00:00

abstract：:The Hedgehog (Hh) family of secreted proteins controls many aspects of animal development. In Drosophila, Hh transduces its signal via Cubitus interruptus (Ci), a transcription factor present in two forms: a full-length activator and a carboxy-terminally truncated repressor that is derived from the full-length form by...

journal_title：Genes & development

authors： Wang G,Wang B,Jiang J

更新日期：1999-11-01 00:00:00

abstract：:MicroRNAs (miRNAs) and transcription factors (TFs) are primary metazoan gene regulators. Whereas much attention has focused on finding the targets of both miRNAs and TFs, the transcriptional networks that regulate miRNA expression remain largely unexplored. Here, we present the first genome-scale Caenorhabditis elegan...

journal_title：Genes & development

authors： Martinez NJ,Ow MC,Barrasa MI,Hammell M,Sequerra R,Doucette-Stamm L,Roth FP,Ambros VR,Walhout AJ

更新日期：2008-09-15 00:00:00