Abstract：
:Although MAX is regarded as an obligate dimerization partner for MYC, its function in normal development and neoplasia is poorly defined. We show that B-cell-specific deletion of Max has a modest effect on B-cell development but completely abrogates Eµ-Myc-driven lymphomagenesis. While Max loss affects only a few hundred genes in normal B cells, it leads to the global down-regulation of Myc-activated genes in premalignant Eµ-Myc cells. We show that the balance between MYC-MAX and MNT-MAX interactions in B cells shifts in premalignant B cells toward a MYC-driven transcriptional program. Moreover, we found that MAX loss leads to a significant reduction in MYC protein levels and down-regulation of direct transcriptional targets, including regulators of MYC stability. This phenomenon is also observed in multiple cell lines treated with MYC-MAX dimerization inhibitors. Our work uncovers a layer of Myc autoregulation critical for lymphomagenesis yet partly dispensable for normal development.
journal_name
Genes Devjournal_title
Genes & developmentauthors
Mathsyaraja H,Freie B,Cheng PF,Babaeva E,Catchpole JT,Janssens D,Henikoff S,Eisenman RNdoi
10.1101/gad.325878.119subject
Has Abstractpub_date
2019-09-01 00:00:00pages
1252-1264issue
17-18eissn
0890-9369issn
1549-5477pii
gad.325878.119journal_volume
33pub_type
杂志文章abstract：:A novel cysteine-rich motif, named LIM, has been identified in the homeo box genes lin-11, Isl-1, and mec-3; the mec-3 and lin-11 genes determine cell lineages in Caenorhabditis elegans. We isolated LIM class homeo box genes from Xenopus laevis that are closely related to lin-11 and mec-3 in the LIM and homeo domains....
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.6.3.356
更新日期：1992-03-01 00:00:00
abstract：:The serine/threonine kinase Akt/PKB is a major downstream effector of growth factor-mediated cell survival. Activated Akt, like Bcl-2 and Bcl-xL, prevents closure of a PT pore component, the voltage-dependent anion channel (VDAC); intracellular acidification; mitochondrial hyperpolarization; and the decline in oxidati...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.889901
更新日期：2001-06-01 00:00:00
abstract：:The mechanisms that control energy homeostasis and tissue growth during development are closely linked through the insulin signal transduction pathway. Changes in the level of insulin and other hormones reflect the nutritional status of the animal to control circulating sugar levels and fat metabolism. Systemic defect...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.374406
更新日期：2006-02-15 00:00:00
abstract：:Disruption of the balanced modulation of reversible tyrosine phosphorylation has been implicated in the etiology of various human cancers, including breast cancer. Protein Tyrosine Phosphatase N23 (PTPN23) resides in chromosomal region 3p21.3, which is hemizygously or homozygously lost in some breast cancer patients. ...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.304261.117
更新日期：2017-10-01 00:00:00
abstract：:The LIM motif defines a double zinc finger structure found in proteins involved in cell fate determination and growth control. LIM proteins, which include LIM homeo domain, LIM kinase, focal adhesion, and LIM-only proteins, usually contain two or more LIM motifs clustered at their amino- or carboxy-terminal end. At pr...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.10.3.289
更新日期：1996-02-01 00:00:00
abstract：:The 134-bp enhancer region of the pancreatic elastase I gene is sufficient to direct pancreatic acinar cell-specific transcription in transgenic mice and in transfected cells in culture. Ten-base-pair scanner mutations in three separate enhancer domains that inactivate enhancer function in transfected pancreatic cells...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.3.5.687
更新日期：1989-05-01 00:00:00
abstract：:In Saccharomyces cerevisiae, the genes encoding the HO endonuclease, G1-specific cyclins CLN1 and CLN2, as well as most proteins involved in DNA synthesis, are periodically transcribed with maximal levels reached in late G1. For HO and the DNA replication genes, cell cycle stage-specific expression has been shown to b...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.6.4.557
更新日期：1992-04-01 00:00:00
abstract：:By studying neuroectoderm formation in the absence of mesoderm and mesectoderm in mutants of the zygotic genes snail and twist, we have found that the number of neuroblasts is not reduced in these mutants, suggesting that mesoderm and mesectoderm are not essential for the initiation of neural development. The position...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.5.9.1577
更新日期：1991-09-01 00:00:00
abstract：:RNA polymerase II nascent transcripts are capped during pausing before elongation. Here we report that hSPT5, the human homolog of yeast elongation factor SPT5, interacts directly with the capping enzyme. hSPT5 stimulated capping enzyme guanylylation and mRNA capping by severalfold. Although RNA 5'-triphosphatase acti...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.13.14.1774
更新日期：1999-07-15 00:00:00
abstract：:Eukaryotic translation initiation begins with ribosomal recruitment of aminoacylated initiator tRNA (Met-tRNA(Met)(i)) by eukaryotic initiation factor eIF2. In cooperation with eIF3, eIF1, and eIF1A, Met-tRNA(Met)(i)/eIF2/GTP binds to 40S subunits yielding 43S preinitiation complexes that attach to the 5'-terminal reg...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1957510
更新日期：2010-08-15 00:00:00
abstract：:Dynamic assembly and disassembly of actin filaments is a major driving force for cell movements. Border cells in the Drosophila ovary provide a simple and genetically tractable model to study the mechanisms regulating cell migration. To identify new genes that regulate cell movement in vivo, we screened lethal mutatio...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.2028611
更新日期：2011-04-01 00:00:00
abstract：:Subependymal nodules (SENs) and subependymal giant cell astrocytomas (SEGAs) are common brain lesions found in patients with tuberous sclerosis complex (TSC). These brain lesions present a mixed glioneuronal phenotype and have been hypothesized to originate from neural stem cells. However, this hypothesis has not been...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.16750211
更新日期：2011-08-01 00:00:00
abstract：:Hepatitis B virus (HBV) infects humans and causes a wide range of clinical manifestations, from acute hepatitis to hepatocellular carcinoma (HCC). The HBV genome contains multiple promoters with gene expression regulated predominantly by the cellular transcription initiation machinery. Accordingly, the HBV-encoded pX,...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.12.8.1217
更新日期：1998-04-15 00:00:00
abstract：:In many species, a dosage compensation complex (DCC) is targeted to X chromosomes of one sex to equalize levels of X-gene products between males (1X) and females (2X). Here we identify cis-acting regulatory elements that target the Caenorhabditis elegans X chromosome for repression by the DCC. The DCC binds to discret...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1751109
更新日期：2009-03-01 00:00:00
abstract：:The NF-kappa B transcription factor complex is comprised of two subunits, p50 and p65, that share significant homology to the rel oncogene. We have isolated a cDNA encoding a novel 66-kD rel-related protein, designated I-Rel. Unlike other rel-related proteins, I-Rel does not interact with DNA. I-Rel forms heterodimers...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.6.5.745
更新日期：1992-05-01 00:00:00
abstract：:The Drosophila external sensory organ forms in a lineage elaborating from a single precursor cell via a stereotypical series of asymmetric divisions. HAMLET transcription factor expression demarcates the lineage branch that generates two internal cell types, the external sensory neuron and thecogen. In HAMLET mutant o...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1170904
更新日期：2004-03-15 00:00:00
abstract：:Glucocorticoid (GC) receptor (GR) has been shown recently to bind a subset of mRNAs and elicit rapid mRNA degradation. However, the molecular details of GR-mediated mRNA decay (GMD) remain unclear. Here, we demonstrate that GMD triggers rapid degradation of target mRNAs in a translation-independent and exon junction c...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.286484.116
更新日期：2016-09-15 00:00:00
abstract：:We demonstrate here that the previously described bacterial promoter upstream element (UP element) consists of two distinct subsites, each of which, by itself, can bind the RNA polymerase holoenzyme alpha subunit carboxy-terminal domain (RNAP alphaCTD) and stimulate transcription. Using binding-site-selection experime...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.13.16.2134
更新日期：1999-08-15 00:00:00
abstract：:Transgenic mice expressing wild-type murine p53 under the control of the mouse mammary tumor virus long terminal repeat (MMTV LTR) undergo progressive renal failure due to abnormal kidney development. Similar phenotypes are observed in two transgenic lines that express wild-type p53 within the ureteric bud but not in ...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.10.7.836
更新日期：1996-04-01 00:00:00
abstract：:All multisubunit DNA-dependent RNA polymerases (RNAP) are zinc metalloenzymes, and at least two zinc atoms are present per enzyme molecule. RNAP residues involved in zinc binding and the functional role of zinc ions in the transcription mechanism or RNAP structure are unknown. Here, we locate four cysteine residues in...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.13.18.2439
更新日期：1999-09-15 00:00:00
abstract：:Studying the early stages of cancer can provide important insight into the molecular basis of the disease. We identified a preneoplastic stage in the patched (ptc) mutant mouse, a model for the brain tumor medulloblastoma. Preneoplastic cells (PNCs) are found in most ptc mutants during early adulthood, but only 15% of...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1759909
更新日期：2009-01-15 00:00:00
abstract：:C-factor, the product of the csgA gene, is a cell-surface associated short-range intercellular signaling protein in Myxococcus xanthus. C-factor is required for at least four responses during starvation-induced fruiting body morphogenesis: rippling, aggregation, sporulation, and full expression of the csgA gene, all o...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.10.6.740
更新日期：1996-03-15 00:00:00
abstract：:The c-fos serum response element (SRE) is a multifunctional regulatory region of the c-fos promoter that responds to a variety of inducers. Recently, we have demonstrated that the SRE binds the C/EBP-related transcription factor rat NFIL-6 (rNFIL-6). In this study we show that rNFIL-6 is regulated by the cAMP second m...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.5.10.1754
更新日期：1991-10-01 00:00:00
abstract：:The yeast SAS (Something About Silencing) complex and the histone variant H2A.Z have both previously been linked to an antisilencing function at the subtelomeric regions. SAS is an H4 Lys 16-specific histone acetyltransferase complex. Here we demonstrate that the H4 Lys 16 acetylation by SAS is required for efficient ...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1439206
更新日期：2006-09-15 00:00:00
abstract：:The current model for endocrine cell specification in the pancreas invokes high-level production of the transcription factor Neurogenin 3 (Neurog3) in Sox9(+) bipotent epithelial cells as the trigger for endocrine commitment, cell cycle exit, and rapid delamination toward proto-islet clusters. This model posits a tran...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.284729.116
更新日期：2016-08-15 00:00:00
abstract：:Previous genetic mosaic studies established that expression of the Drosophila bride of sevenless (boss) gene is required in photoreceptor neuron R8 for the development of photoreceptor neuron R7. This led to the proposal that boss encodes or regulates an R7-specific inductive cue. We have identified the boss gene base...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.4.11.1835
更新日期：1990-11-01 00:00:00
abstract：:It is postulated that the symmetric organization of plant lateral organs is based on two crossed axes, the abaxial-adaxial and the lateral axes. The PRESSED FLOWER (PRS) gene, the expression and function of which are dependent on the lateral axis, is reported in this study. In the prs mutant, growth of the lateral sep...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.931001
更新日期：2001-12-15 00:00:00
abstract：:Cap-dependent translation is mediated by eIF4F, a protein complex composed of three subunits as follows: eIF4E, which recognizes the mRNA 5' cap structure; eIF4A, an RNA-helicase; and eIF4G, a scaffolding protein that binds eIF4E, eIF4A, and the eIF4E-kinase Mnk1 simultaneously. eIF4E is hypophosphorylated and cap-dep...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.889201
更新日期：2001-08-15 00:00:00
abstract：:Telomeres are specialized nucleoprotein structures that protect chromosome ends from DNA damage response (DDR) and DNA rearrangements. The telomeric shelterin protein TRF2 suppresses the DDR, and this function has been attributed to its abilities to trigger t-loop formation or prevent massive decompaction and loss of ...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.294082.116
更新日期：2017-03-15 00:00:00
abstract：:Classical embryology has provided a clear view of the timing and hormonal cues that govern sexual differentiation. Molecular biology has added important details to this picture. The cloning of SRY, MIS, and INSL3 provide insight into the molecular signals that provide important cues at the cellular level. Continued un...
journal_title：Genes & development
pub_type： 杂志文章,评审
doi：10.1101/gad.843800
更新日期：2000-12-15 00:00:00
