Abstract：
:By studying neuroectoderm formation in the absence of mesoderm and mesectoderm in mutants of the zygotic genes snail and twist, we have found that the number of neuroblasts is not reduced in these mutants, suggesting that mesoderm and mesectoderm are not essential for the initiation of neural development. The position of the neuroectoderm, however, is ventrally shifted: Neuroectoderm takes over the presumptive peripheral mesoderm domain in single mutants, whereas the entire presumptive mesoderm domain in double mutants takes on the neuroectodermal fate. The shifted neuroectoderm still requires the proneural genes and the neurogenic genes. This shift is unlikely to be due to any shift in the nuclear localization gradient of the maternally supplied dorsal protein. A model for cell fate determination of the neuroectoderm, mesectoderm, and mesoderm will be discussed.
journal_name
Genes Devjournal_title
Genes & developmentauthors
Rao Y,Vaessin H,Jan LY,Jan YNdoi
10.1101/gad.5.9.1577subject
Has Abstractpub_date
1991-09-01 00:00:00pages
1577-88issue
9eissn
0890-9369issn
1549-5477journal_volume
5pub_type
杂志文章abstract：:Using an in vitro system in which a 5' splice site (5'SS) RNA oligo (AAG decreases GUAAGUAdT) is capable of inducing formation of U2/U4/U5/U6 snRNP complex we show that this oligo specifically binds to U4/U5/U6 snRNP and cross-links to U6 snRNA in the absence of U2 snRNP. Moreover, 5'SS RNA oligo bound to U4/U5/U6 snR...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.8.16.1962
更新日期：1994-08-15 00:00:00
abstract：:Cellular senescence is a potent tumor suppressor mechanism but also contributes to aging and aging-related diseases. Senescence is characterized by a stable cell cycle arrest and a complex proinflammatory secretome, termed the senescence-associated secretory phenotype (SASP). We recently discovered that cytoplasmic ch...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.331272.119
更新日期：2020-03-01 00:00:00
abstract：:Multiple congenital disorders often present complex phenotypes, but how the mutation of individual genetic factors can lead to multiple defects remains poorly understood. In the present study, we used human neuroepithelial (NE) cells and CHARGE patient-derived cells as an in vitro model system to identify the function...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.301887.117
更新日期：2018-01-15 00:00:00
abstract：:Chromosome replication occurs precisely once during the cell cycle of almost all eukaryotic cells, and is a highly complex process that is still understood relatively poorly. Two conserved kinases called Cdc7 (cell division cycle 7) and cyclin-dependent kinase (CDK) are required to establish replication forks during t...
journal_title：Genes & development
pub_type： 杂志文章,评审
doi：10.1101/gad.1933010
更新日期：2010-06-15 00:00:00
abstract：:The serine/threonine kinase Akt/PKB is a major downstream effector of growth factor-mediated cell survival. Activated Akt, like Bcl-2 and Bcl-xL, prevents closure of a PT pore component, the voltage-dependent anion channel (VDAC); intracellular acidification; mitochondrial hyperpolarization; and the decline in oxidati...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.889901
更新日期：2001-06-01 00:00:00
abstract：:The ultraviolet (UV)-induced (6-4) pyrimidine-pyrimidone photoproduct [(6-4) PP] confers a large structural distortion in DNA. Here we examine in human cells the roles of translesion synthesis (TLS) DNA polymerases (Pols) in promoting replication through a (6-4) TT photoproduct carried on a duplex plasmid where bidire...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1872810
更新日期：2010-01-15 00:00:00
abstract：:Identifying modifiers of dosage-sensitive genes involved in neurodegenerative disorders is imperative to discover novel genetic risk factors and potential therapeutic entry points. In this study, we focus on Ataxin-1 (ATXN1), a dosage-sensitive gene involved in the neurodegenerative disease spinocerebellar ataxia type...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.339317.120
更新日期：2020-09-01 00:00:00
abstract：:The RNA polymerase II (RNAPII) C-terminal domain kinase, CDK12, regulates genome stability, expression of DNA repair genes, and cancer cell resistance to chemotherapy and immunotherapy. In addition to its role in mRNA biosynthesis of DNA repair genes, we show here that CDK12 phosphorylates the mRNA 5' cap-binding repr...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.322339.118
更新日期：2019-04-01 00:00:00
abstract：:Symbiotic nitrogen fixation involves the development of specialized organs called nodules within which plant photosynthates are exchanged for combined nitrogen of bacterial origin. To determine the importance of bacterial nitrogen metabolism in symbiosis, we have characterized a key regulator of this metabolism in Rhi...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.11.9.1194
更新日期：1997-05-01 00:00:00
abstract：:The mottler of white (mw) locus has been determined to interact with alleles of the white (w) eye color locus which are a subset of the transposable element insertion mutants. The transposable elements belong to six different types, including copia, and are located at several sites within the w gene. Three X-ray-induc...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.3.1.73
更新日期：1989-01-01 00:00:00
abstract：:Bistability in developmental pathways refers to the generation of binary outputs from graded or noisy inputs. Signaling thresholds are critical for bistability. Specification of the left/right (LR) axis in vertebrate embryos involves bistable expression of transforming growth factor beta (TGFbeta) member NODAL in the ...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1682108
更新日期：2008-11-01 00:00:00
abstract：:The 134-bp enhancer region of the pancreatic elastase I gene is sufficient to direct pancreatic acinar cell-specific transcription in transgenic mice and in transfected cells in culture. Ten-base-pair scanner mutations in three separate enhancer domains that inactivate enhancer function in transfected pancreatic cells...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.3.5.687
更新日期：1989-05-01 00:00:00
abstract：:Nonhomologous end joining (NHEJ) and homologous recombination (HR) represent the two major pathways of DNA double-strand break (DSB) repair in eukaryotic cells. NHEJ repairs DSBs by ligation of cognate broken ends irrespective of homologous flanking sequences, whereas HR repairs DSBs using an undamaged homologous temp...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1204304
更新日期：2004-06-01 00:00:00
abstract：:The liver is a unique organ with a remarkably high potential to regenerate upon injuries. In severely damaged livers where hepatocyte proliferation is impaired, facultative liver progenitor cells (LPCs) proliferate and are assumed to contribute to regeneration. An expansion of LPCs is often observed in patients with v...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.204776.112
更新日期：2013-01-15 00:00:00
abstract：:Accurate and regulated transcription by RNA polymerase II requires the assembly of an initiation complex involving multiple protein-DNA and protein-protein interactions. A key event is binding of TFIID, a complex consisting of TBP and associated factors (TAFs) to the template DNA. The TAF subunits of TFIID carry out d...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.9.22.2747
更新日期：1995-11-15 00:00:00
abstract：:Transcription of erythroid-expressed genes and normal erythroid development in vivo are dependent on a regulatory protein (GATA-1) that recognizes a consensus GATA motif. GATA-1 expression is itself restricted to erythroid progenitors and to two related hematopoietic lineages, megakaryocytes and mast cells. During cel...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.5.6.919
更新日期：1991-06-01 00:00:00
abstract：:Glucose and glutamine serve as the two primary carbon sources in proliferating cells, and uptake of both nutrients is directed by growth factor signaling. Although either glucose or glutamine can potentially support mitochondrial tricarboxylic acid (TCA) cycle integrity and ATP production, we found that glucose depriv...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1985910
更新日期：2010-12-15 00:00:00
abstract：:We hypothesized that basic helix-loop-helix (bHLH) MIST1 (BHLHA15) is a "scaling factor" that universally establishes secretory morphology in cells that perform regulated secretion. Here, we show that targeted deletion of MIST1 caused dismantling of the secretory apparatus of diverse exocrine cells. Parietal cells (PC...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.285684.116
更新日期：2017-01-15 00:00:00
abstract：:Changes in the pattern of gene expression play an important role in allowing cancer cells to acquire their hallmark characteristics, while genomic instability enables cells to acquire genetic alterations that promote oncogenesis. Chromatin plays central roles in both transcriptional regulation and the maintenance of g...
journal_title：Genes & development
pub_type： 杂志文章,评审
doi：10.1101/gad.255182.114
更新日期：2015-02-01 00:00:00
abstract：:Dosage compensation in Drosophila occurs by a twofold increase in transcription per copy of X-linked genes in males (XY) compared with females (XX). msl-1 is one of four genes that are essential for dosage compensation in males, and MSL-1 protein is associated specifically with the male X chromosome. To explore the ba...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.8.6.698
更新日期：1994-03-15 00:00:00
abstract：:The crucifer Arabidopsis thaliana has been used widely as a model organism for the study of plant development. We describe here the development of an efficient insertional mutagenesis system in Arabidopsis that permits identification of genes by their patterns of expression during development. Transposable elements of...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.9.14.1797
更新日期：1995-07-15 00:00:00
abstract：:Structural cell-surface and extracellular-matrix proteins modulate intercellular signaling events during development, but how this is achieved remains largely unknown. Here we identify a novel family of Drosophila proteins, Nasrat and Polehole, that coat the oocyte surface and play two roles: They mediate assembly of ...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.223902
更新日期：2002-04-15 00:00:00
abstract：:The mechanisms that control energy homeostasis and tissue growth during development are closely linked through the insulin signal transduction pathway. Changes in the level of insulin and other hormones reflect the nutritional status of the animal to control circulating sugar levels and fat metabolism. Systemic defect...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.374406
更新日期：2006-02-15 00:00:00
abstract：:In meiosis I, homologous chromosomes pair and then attach to the spindle so that the homologs can be pulled apart at anaphase I. The segregation of homologs before pairing would be catastrophic. We describe two mechanisms that prevent this. First, in early meiosis, Ipl1, the budding yeast homolog of the mammalian Auro...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.227454.113
更新日期：2013-10-01 00:00:00
abstract：:Multiple DNA repair pathways maintain genome stability and ensure that DNA remains essentially unchanged over the life of a cell. Various human diseases occur if DNA repair is compromised, and most of these impact the nervous system, in some cases exclusively. However, it is often unclear what specific endogenous dama...
journal_title：Genes & development
pub_type： 杂志文章,评审
doi：10.1101/gad.301325.117
更新日期：2017-06-15 00:00:00
abstract：:Checkpoint genes maintain genomic stability by arresting cells after DNA damage. Many of these genes also control cell cycle events in unperturbed cells. By conducting a screen for checkpoint genes in zebrafish, we found that dtl/cdt2 is an essential component of the early, radiation-induced G2/M checkpoint. We subseq...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1482106
更新日期：2006-11-15 00:00:00
abstract：:DNA methylation is tightly regulated throughout mammalian development, and altered DNA methylation patterns are a general hallmark of cancer. The methylcytosine dioxygenase TET2 is frequently mutated in hematological disorders, including acute myeloid leukemia (AML), and has been suggested to protect CG dinucleotide (...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.260174.115
更新日期：2015-05-01 00:00:00
abstract：:Dynamic assembly and disassembly of actin filaments is a major driving force for cell movements. Border cells in the Drosophila ovary provide a simple and genetically tractable model to study the mechanisms regulating cell migration. To identify new genes that regulate cell movement in vivo, we screened lethal mutatio...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.2028611
更新日期：2011-04-01 00:00:00
abstract：:Transabdominal (Tab), a dominant mutation in the Bithorax Complex (BX-C) of Drosophila, creates a sexually dimorphic pattern of segmental transformation that has complete penetrance and expressivity. Specific regions within the notum of the second thoracic segment (T2) are transformed into abdominal-like cuticle; thus...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1.2.111
更新日期：1987-04-01 00:00:00
abstract：:Mammalian development requires effective mechanisms to repress genes whose expression would generate inappropriately specified cells. The Polycomb-repressive complex 1 (PRC1) family complexes are central to maintaining this repression. These include a set of canonical PRC1 complexes, each of which contains four core p...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.326488.119
更新日期：2019-07-01 00:00:00
