How do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells?

abstract：:C-factor, the product of the csgA gene, is a cell-surface associated short-range intercellular signaling protein in Myxococcus xanthus. C-factor is required for at least four responses during starvation-induced fruiting body morphogenesis: rippling, aggregation, sporulation, and full expression of the csgA gene, all o...

journal_title：Genes & development

authors： Søgaard-Andersen L,Slack FJ,Kimsey H,Kaiser D

更新日期：1996-03-15 00:00:00

abstract：:The fission yeast telomerase RNA (TER1) precursor harbors an intron immediately downstream from its mature 3' end. Unlike most introns, which are removed from precursor RNAs by the spliceosome in two sequential but tightly coupled transesterification reactions, TER1 only undergoes the first cleavage reaction during te...

journal_title：Genes & development

authors： Kannan R,Hartnett S,Voelker RB,Berglund JA,Staley JP,Baumann P

更新日期：2013-03-15 00:00:00

abstract：:The alternatively spliced exon EIIIB is regulated in a cell type-specific manner in the rat fibronectin gene. Splicing of EIIIB into fibronectin mRNA is dependent on sequences in the intron immediately downstream of EIIIB. We show that a short, highly repeated TGCATG motif in this intron is important for cell type-spe...

journal_title：Genes & development

authors： Huh GS,Hynes RO

更新日期：1994-07-01 00:00:00

abstract：:A euchromatic gene placed in the vicinity of heterochromatin by a chromosomal rearrangement generally exhibits position effect variegation (PEV), a clonally inherited pattern showing gene expression in some somatic cells but not in others. The mechanism responsible for this loss of gene expression is investigated here...

journal_title：Genes & development

authors： Wallrath LL,Elgin SC

更新日期：1995-05-15 00:00:00

abstract：:The progressive bone marrow failure syndrome dyskeratosis congenita (DC) is often caused by mutations in telomerase or the factors involved in telomerase biogenesis and trafficking. However, a subset of DC patients is heterozygous for mutations in the shelterin component TIN2. To determine how the TIN2-DC mutations af...

journal_title：Genes & development

authors： Frescas D,de Lange T

更新日期：2014-01-15 00:00:00

abstract：:The canoemisty1 (cnomis1) mutation was isolated by virtue of its severe rough eye phenotype from approximately 500 fly lines, each harboring a single autosomal insertion of a P element (Bm delta w). Excision of the P element generated a lethal, null allele, cnomis10, together with many revertants with normal eye morph...

journal_title：Genes & development

authors： Miyamoto H,Nihonmatsu I,Kondo S,Ueda R,Togashi S,Hirata K,Ikegami Y,Yamamoto D

更新日期：1995-03-01 00:00:00

abstract：:Deregulated expression of the c-myc proto-oncogene can lead to apoptosis under certain physiological conditions. By introducing a conditionally active Myc allele into primary embryo fibroblasts null for p53, and into fibroblasts without endogenous p53 expression but ectopically expressing a temperature-sensitive p53 a...

journal_title：Genes & development

authors： Wagner AJ,Kokontis JM,Hay N

更新日期：1994-12-01 00:00:00

abstract：:Unusually for a eukaryote, genes transcribed by RNA polymerase II (pol II) in Trypanosoma brucei are arranged in polycistronic transcription units. With one exception, no pol II promoter motifs have been identified, and how transcription is initiated remains an enigma. T. brucei has four histone variants: H2AZ, H2BV, ...

journal_title：Genes & development

authors： Siegel TN,Hekstra DR,Kemp LE,Figueiredo LM,Lowell JE,Fenyo D,Wang X,Dewell S,Cross GA

更新日期：2009-05-01 00:00:00

abstract：:Chromosomal translocations are a hallmark of hematopoietic malignancies. The initial molecular events or pathways that lead to translocations in hematopoietic cells are largely unknown, particularly in the stem cell-enriched population postulated to be the initial target for these events. We used in vitro differentiat...

journal_title：Genes & development

authors： Francis R,Richardson C

更新日期：2007-05-01 00:00:00

abstract：:In murine plasmacytoma and human Burkitt's lymphoma cells, one allele of c-myc is translocated into one of the immunoglobulin loci, resulting in a characteristic pattern of deregulated c-myc transcription. Translocation events between c-myc and the IgH locus segregate c-myc and the IgH intron enhancer to different rec...

journal_title：Genes & development

authors： Madisen L,Groudine M

更新日期：1994-09-15 00:00:00

abstract：:The activity of the polyoma virus (PyV) origin of DNA replication was used as a sensitive assay for enhancer function in one- and two-cell mouse embryos by injecting embryos with plasmid DNA containing different PyV ori configurations, allowing them to continue development in vitro, and then measuring plasmid DNA repl...

journal_title：Genes & development

authors： Martínez-Salas E,Cupo DY,DePamphilis ML

更新日期：1988-09-01 00:00:00

abstract：:Animals alter their reproductive programs to accommodate changes in nutrient availability, yet the connections between known nutrient-sensing systems and reproductive programs are underexplored, and whether there is a mechanism that senses nucleotide levels to coordinate germline proliferation is unknown. We establish...

journal_title：Genes & development

authors： Chi C,Ronai D,Than MT,Walker CJ,Sewell AK,Han M

更新日期：2016-02-01 00:00:00

abstract：:SpoIIIE is an FtsK-related protein that transports the forespore chromosome across the Bacillus subtilis sporulation septum. We use membrane photobleaching and protoplast assays to demonstrate that SpoIIIE is required for septal membrane fission in the presence of trapped DNA, and that DNA is transported across separa...

journal_title：Genes & development

authors： Fleming TC,Shin JY,Lee SH,Becker E,Huang KC,Bustamante C,Pogliano K

更新日期：2010-06-01 00:00:00

abstract：:Human lymphoblastoid cells derived from different healthy individuals display considerable variation in their transcription profiles. Here we show that such variation in gene expression underlies interindividual susceptibility to DNA damaging agents. The results demonstrate the massive differences in sensitivity acros...

journal_title：Genes & development

authors： Fry RC,Svensson JP,Valiathan C,Wang E,Hogan BJ,Bhattacharya S,Bugni JM,Whittaker CA,Samson LD

更新日期：2008-10-01 00:00:00

abstract：:The agouti gene regulates the differential production of eumelanin (black or brown) and phaeomelanin (yellow) pigment granules by melanocytes in the hair follicles of mice. The original nonagouti (a) allele, which confers a predominantly black coat color, has been shown to revert to two other more dominant agouti alle...

journal_title：Genes & development

authors： Bultman SJ,Klebig ML,Michaud EJ,Sweet HO,Davisson MT,Woychik RP

更新日期：1994-02-15 00:00:00

abstract：:Overexpression of the type II transmembrane serine protease matriptase is a highly consistent feature of human epithelial tumors. Here we show that matriptase possesses a strong oncogenic potential when unopposed by its endogenous inhibitor, HAI-1. Modest orthotopic overexpression of matriptase in the skin of transgen...

journal_title：Genes & development

authors： List K,Szabo R,Molinolo A,Sriuranpong V,Redeye V,Murdock T,Burke B,Nielsen BS,Gutkind JS,Bugge TH

更新日期：2005-08-15 00:00:00

abstract：:The E2F transcription factor is required for S phase in Drosophila. While it also triggers expression of replication genes at the G1-S transition, the relevance of this transcription is not clear because many of the induced gene products are sufficiently stable that new expression is not required for S phase. However,...

journal_title：Genes & development

authors： Duronio RJ,O'Farrell PH

更新日期：1995-06-15 00:00:00

abstract：:U6 small nuclear RNA is one of the spliceosomal RNAs involved in pre-mRNA splicing. In the fission yeast Schizosaccharomyces pombe, the U6 RNA gene was found to have an intron similar to a nuclear pre-mRNA intron, and it was proposed that the U6 intron might be inserted erroneously during pre-mRNA splicing. Using the ...

journal_title：Genes & development

authors： Tani T,Ohshima Y

更新日期：1991-06-01 00:00:00

abstract：:We describe evidence that a regulatory B subunit of protein phosphatase 2A (PP2A) positively regulates an RTK-Ras-MAP kinase signaling cascade during Caenorhabditis elegans vulval induction. Although reduction of sur-6 PP2A-B function causes few vulval induction defects in an otherwise wild-type background, sur-6 PP2A...

journal_title：Genes & development

authors： Sieburth DS,Sundaram M,Howard RM,Han M

更新日期：1999-10-01 00:00:00

abstract：:Cyclin D1 is part of a cell cycle control node consistently deregulated in most human cancers. However, studies with cyclin D1-null mice indicate that it is dispensable for normal mouse development as well as cell growth in culture. Here, we provide evidence that ras-mediated tumorigenesis depends on signaling pathway...

journal_title：Genes & development

authors： Robles AI,Rodriguez-Puebla ML,Glick AB,Trempus C,Hansen L,Sicinski P,Tennant RW,Weinberg RA,Yuspa SH,Conti CJ

更新日期：1998-08-15 00:00:00

abstract：:In recent years several new mouse models for lung cancer have been described. These include models for both non-small-cell lung cancer (NSCLC) and small-cell lung cancer (SCLC). Tumorigenesis in these conditional mouse tumor models can be initiated in adult mice through Cre-recombinase-induced activation of oncogenic ...

journal_title：Genes & development

authors： Meuwissen R,Berns A

更新日期：2005-03-15 00:00:00

abstract：:During Drosophila embryogenesis, ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally. This process, dorsal closure, requires two signaling pathways: the Drosophila Jun-amino-terminal kinase (DJNK) pathway and the Dpp pathway. We...

journal_title：Genes & development

authors： Riesgo-Escovar JR,Hafen E

更新日期：1997-07-01 00:00:00

abstract：:The ultraviolet (UV)-induced (6-4) pyrimidine-pyrimidone photoproduct [(6-4) PP] confers a large structural distortion in DNA. Here we examine in human cells the roles of translesion synthesis (TLS) DNA polymerases (Pols) in promoting replication through a (6-4) TT photoproduct carried on a duplex plasmid where bidire...

journal_title：Genes & development

authors： Yoon JH,Prakash L,Prakash S

更新日期：2010-01-15 00:00:00

abstract：:Human ELAV proteins are implicated in cell growth and differentiation via regulation of mRNA expression in the cytoplasm. In human embryonic teratocarcinoma (hNT2) cells transfected with the human neuronal ELAV-like protein, Hel-N1, neurites formed, yet cells were not terminally differentiated. Cells in which neurite ...

journal_title：Genes & development

authors： Antic D,Lu N,Keene JD

更新日期：1999-02-15 00:00:00

abstract：:Small cell lung cancer (SCLC) is an aggressive neuroendocrine cancer characterized by initial chemosensitivity followed by emergence of chemoresistant disease. To study roles for MYCN amplification in SCLC progression and chemoresistance, we developed a genetically engineered mouse model of MYCN-overexpressing SCLC. I...

journal_title：Genes & development

authors： Grunblatt E,Wu N,Zhang H,Liu X,Norton JP,Ohol Y,Leger P,Hiatt JB,Eastwood EC,Thomas R,Ibrahim AH,Jia D,Basom R,Eaton KD,Martins R,Houghton AM,MacPherson D

更新日期：2020-09-01 00:00:00

abstract：:Infection of metazoan cells with some viruses alters the balance of cellular mRNA export to favor viral RNA export and to retain cellular transcripts in the nucleus. Here, evidence is presented to show that the herpes simplex virus 1 (HSV-1) essential regulatory protein ICP27, which inhibits host cell-splicing, result...

journal_title：Genes & development

authors： Sandri-Goldin RM

更新日期：1998-03-15 00:00:00

abstract：:Mu DNA transposition proceeds through a series of higher-order nucleoprotein complexes called transpososomes. The structural core of the transpososome is a tetramer of the transposase, Mu A, bound to the two transposon ends. High-resolution structural analysis of the intact transposase and the transpososome has not be...

journal_title：Genes & development

authors： Yuan JF,Beniac DR,Chaconas G,Ottensmeyer FP

更新日期：2005-04-01 00:00:00

abstract：:AMP-activated protein kinase (AMPK) is a sensor of energy status that maintains cellular energy homeostasis. It arose very early during eukaryotic evolution, and its ancestral role may have been in the response to starvation. Recent work shows that the kinase is activated by increases not only in AMP, but also in ADP....

journal_title：Genes & development

authors： Hardie DG

更新日期：2011-09-15 00:00:00

abstract：:Eukaryotic translation initiation begins with ribosomal recruitment of aminoacylated initiator tRNA (Met-tRNA(Met)(i)) by eukaryotic initiation factor eIF2. In cooperation with eIF3, eIF1, and eIF1A, Met-tRNA(Met)(i)/eIF2/GTP binds to 40S subunits yielding 43S preinitiation complexes that attach to the 5'-terminal reg...

journal_title：Genes & development

authors： Skabkin MA,Skabkina OV,Dhote V,Komar AA,Hellen CU,Pestova TV

更新日期：2010-08-15 00:00:00

abstract：:The gene encoding yeast U6 snRNA that is transcribed by RNA polymerase III (Pol III) contains both a TATA box upstream of the transcription start site and a downstream binding site for the factor TFIIIC. This juxtaposition of elements typical of both Pol II- and Pol III-transcribed genes raises the question of how pol...

journal_title：Genes & development

authors： Roberts S,Colbert T,Hahn S

更新日期：1995-04-01 00:00:00