Abstract:
:The alternatively spliced exon EIIIB is regulated in a cell type-specific manner in the rat fibronectin gene. Splicing of EIIIB into fibronectin mRNA is dependent on sequences in the intron immediately downstream of EIIIB. We show that a short, highly repeated TGCATG motif in this intron is important for cell type-specific recognition of EIIIB as an exon. This motif enhances usage of the EIIIB 5' splice site; furthermore, this repeated TGCATG sequence can activate an alternatively spliced exon in the unrelated rat preprotachykinin pre-mRNA. Interestingly, this sequence can also be found within cis-acting elements identified previously in other alternatively spliced genes. This short repeated TGCATG motif is therefore a cell type-specific element that, in addition to controlling fibronectin alternative splicing, may participate in the regulation of other alternative RNA processing events.
journal_name
Genes Devjournal_title
Genes & developmentauthors
Huh GS,Hynes ROdoi
10.1101/gad.8.13.1561subject
Has Abstractpub_date
1994-07-01 00:00:00pages
1561-74issue
13eissn
0890-9369issn
1549-5477journal_volume
8pub_type
杂志文章abstract::Disruption of the balanced modulation of reversible tyrosine phosphorylation has been implicated in the etiology of various human cancers, including breast cancer. Protein Tyrosine Phosphatase N23 (PTPN23) resides in chromosomal region 3p21.3, which is hemizygously or homozygously lost in some breast cancer patients. ...
journal_title:Genes & development
pub_type: 杂志文章
doi:10.1101/gad.304261.117
更新日期:2017-10-01 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
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journal_title:Genes & development
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journal_title:Genes & development
pub_type: 杂志文章
doi:10.1101/gad.17221311
更新日期:2011-10-15 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
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更新日期:2006-08-01 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
doi:10.1101/gad.11.5.663
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journal_title:Genes & development
pub_type: 杂志文章
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更新日期:2005-07-01 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
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journal_title:Genes & development
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journal_title:Genes & development
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更新日期:2005-11-01 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
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更新日期:2008-06-15 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
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更新日期:2010-03-01 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
doi:
更新日期:2000-04-15 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
doi:10.1101/gad.2.5.517
更新日期:1988-05-01 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
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更新日期:2010-07-01 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
doi:10.1101/gad.6.3.356
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journal_title:Genes & development
pub_type: 杂志文章
doi:10.1101/gad.3.2.224
更新日期:1989-02-01 00:00:00
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journal_title:Genes & development
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更新日期:2005-12-15 00:00:00
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journal_title:Genes & development
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更新日期:2013-01-15 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
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journal_title:Genes & development
pub_type: 杂志文章
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更新日期:2012-09-15 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
doi:
更新日期:2000-01-15 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
doi:10.1101/gad.3.9.1437
更新日期:1989-09-01 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
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更新日期:2015-04-01 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
doi:10.1101/gad.12.21.3331
更新日期:1998-11-01 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
doi:
更新日期:2000-05-15 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
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journal_title:Genes & development
pub_type: 杂志文章
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更新日期:2006-10-15 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
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更新日期:1990-05-01 00:00:00