miR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukemia.

abstract：:The association of transcription corepressors SMRT and N-CoR with retinoid and thyroid receptors results in suppression of basal transcriptional activity. A key event in nuclear receptor signaling is the hormone-dependent release of corepressor and the recruitment of coactivator. Biochemical and structural studies hav...

journal_title：Genes & development

authors： Nagy L,Kao HY,Love JD,Li C,Banayo E,Gooch JT,Krishna V,Chatterjee K,Evans RM,Schwabe JW

更新日期：1999-12-15 00:00:00

abstract：:AAUAAA is the most highly conserved motif in eukaryotic mRNA polyadenylation sites and, in mammals, is specifically recognized by the multisubunit CPSF (cleavage and polyadenylation specificity factor) complex. Despite its critical functions in mRNA 3' end formation, the molecular basis for CPSF-AAUAAA interaction rem...

journal_title：Genes & development

authors： Chan SL,Huppertz I,Yao C,Weng L,Moresco JJ,Yates JR 3rd,Ule J,Manley JL,Shi Y

更新日期：2014-11-01 00:00:00

abstract：:The repression of the maternally inherited Igf2 allele has been proposed to depend on a methylation-sensitive chromatin insulator organized by the 11 zinc finger protein CTCF at the H19 imprinting control region (ICR). Here we document that point mutations of the nucleotides in physical contact with CTCF within the en...

journal_title：Genes & development

authors： Pant V,Mariano P,Kanduri C,Mattsson A,Lobanenkov V,Heuchel R,Ohlsson R

更新日期：2003-03-01 00:00:00

abstract：:The P family of transposable elements in Drosophila transpose by a cut-and-paste mechanism involving double-strand gap repair. We report here that a Drosophila mutagen-sensitive mutant, mus3O9, contains a mutation in IRBP (inverted repeat binding protein), the Drosophila homolog of the mammalian Ku p70 gene. We show t...

journal_title：Genes & development

authors： Beall EL,Rio DC

更新日期：1996-04-15 00:00:00

abstract：:The Hedgehog (Hh) family of secreted proteins controls many aspects of animal development. In Drosophila, Hh transduces its signal via Cubitus interruptus (Ci), a transcription factor present in two forms: a full-length activator and a carboxy-terminally truncated repressor that is derived from the full-length form by...

journal_title：Genes & development

authors： Wang G,Wang B,Jiang J

更新日期：1999-11-01 00:00:00

abstract：:SpoIIIE is an FtsK-related protein that transports the forespore chromosome across the Bacillus subtilis sporulation septum. We use membrane photobleaching and protoplast assays to demonstrate that SpoIIIE is required for septal membrane fission in the presence of trapped DNA, and that DNA is transported across separa...

journal_title：Genes & development

authors： Fleming TC,Shin JY,Lee SH,Becker E,Huang KC,Bustamante C,Pogliano K

更新日期：2010-06-01 00:00:00

abstract：:The C-terminal domain of the Escherichia coli RNA polymerase (RNAP) alpha subunit (alphaCTD) stimulates transcription initiation by interacting with upstream (UP) element DNA and a variety of transcription activators. Here we identify specific substitutions in region 4.2 of sigma 70 (sigma(70)) and in alphaCTD that de...

journal_title：Genes & development

authors： Ross W,Schneider DA,Paul BJ,Mertens A,Gourse RL

更新日期：2003-05-15 00:00:00

abstract：:Outward migration of epidermal progenitors occurs with induction of hundreds of differentiation genes, but the identities of all regulators required for this process are unknown. We used laser capture microdissection followed by RNA sequencing to identify calmodulin-like 5 (CALML5) as the most enriched gene in differe...

journal_title：Genes & development

authors： Sun BK,Boxer LD,Ransohoff JD,Siprashvili Z,Qu K,Lopez-Pajares V,Hollmig ST,Khavari PA

更新日期：2015-11-01 00:00:00

abstract：:For all newborn mammals, mother's milk is the perfect nourishment, crucial for their postnatal development. Here we report that, unexpectedly, maternal western diet consumption in mice causes the production of toxic milk that contains excessive long chain and saturated fatty acids, which triggers ceramide accumulation...

journal_title：Genes & development

authors： Du Y,Yang M,Lee S,Behrendt CL,Hooper LV,Saghatelian A,Wan Y

更新日期：2012-06-15 00:00:00

abstract：:The product of the zygotically active decapentaplegic (dpp) gene appears to function as a morphogen that specifies positional information in the dorsal half of the Drosophila embryo. The dorsal-specific transcription of dpp is the key step in establishing a morphogen gradient. We demonstrate here that multiple regions...

journal_title：Genes & development

authors： Huang JD,Schwyter DH,Shirokawa JM,Courey AJ

更新日期：1993-04-01 00:00:00

abstract：:The gamma delta T-cell receptor (TCR) is the first TCR to be expressed in ontogeny in all vertebrates in which it has been examined thoroughly. Murine gamma delta cell-surface protein is detected by the fourteenth day of gestation. In this work, the activation of gamma delta RNA has been studied. Data indicate that th...

journal_title：Genes & development

authors： Carding SR,Kyes S,Jenkinson EJ,Kingston R,Bottomly K,Owen JJ,Hayday AC

更新日期：1990-08-01 00:00:00

abstract：:Long-range migrating progenitor cells generate hypaxial muscle, for instance the muscle of the limbs, hypoglossal cord, and diaphragm. We show here that migrating muscle progenitors express the chemokine receptor CXCR4. The corresponding ligand, SDF1, is expressed in limb and branchial arch mesenchyme; i.e., along the...

journal_title：Genes & development

authors： Vasyutina E,Stebler J,Brand-Saberi B,Schulz S,Raz E,Birchmeier C

更新日期：2005-09-15 00:00:00

abstract：:The homeless (hls) gene of Drosophila is required for anteroposterior and dorsoventral axis formation during oogenesis. At a low frequency, females homozygous for mutations in hls generate early egg chambers in which the oocyte is positioned incorrectly within the cyst. At a high frequency, late-stage egg chambers exh...

journal_title：Genes & development

authors： Gillespie DE,Berg CA

更新日期：1995-10-15 00:00:00

abstract：:During Drosophila embryogenesis, ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally. This process, dorsal closure, requires two signaling pathways: the Drosophila Jun-amino-terminal kinase (DJNK) pathway and the Dpp pathway. We...

journal_title：Genes & development

authors： Riesgo-Escovar JR,Hafen E

更新日期：1997-07-01 00:00:00

abstract：:RUNX1/AML1 is required for the development of definitive hematopoiesis, and its activity is altered by mutations, deletions, and chromosome translocations in human acute leukemia. RUNX1 function can be regulated by post-translational modifications and protein-protein interactions. We show that RUNX1 is arginine-methyl...

journal_title：Genes & development

authors： Zhao X,Jankovic V,Gural A,Huang G,Pardanani A,Menendez S,Zhang J,Dunne R,Xiao A,Erdjument-Bromage H,Allis CD,Tempst P,Nimer SD

更新日期：2008-03-01 00:00:00

abstract：:Rb mutants exhibit aneuploidy and aberrant chromosome structure during mitosis. In this issue of Genes & Development, a new paper from Longworth and colleagues (1011-1024) describes both physical and functional interactions between Drosophila Rbf1 and the dCAP-D3 subunit of condensin II. This work directly implicates ...

journal_title：Genes & development

authors： Lavoie BD

更新日期：2008-04-15 00:00:00

abstract：:The POU transcription factor Oct-4 is expressed specifically in the germ line, pluripotent cells of the pregastrulation embryo and stem cell lines derived from the early embryo. Osteopontin (OPN) is a protein secreted by cells of the preimplantation embryo and contains a GRGDS motif that can bind to specific integrin ...

journal_title：Genes & development

authors： Botquin V,Hess H,Fuhrmann G,Anastassiadis C,Gross MK,Vriend G,Schöler HR

更新日期：1998-07-01 00:00:00

abstract：:The assembly of a nervous system requires the extension of axons and dendrites to specific regions where they are matched with appropriate synaptic targets. Although the cues that guide long-range outgrowth have been characterized extensively, additional mechanisms are required to explain short-range guidance in neura...

journal_title：Genes & development

authors： Dow E,Siletti K,Hudspeth AJ

更新日期：2015-05-15 00:00:00

abstract：:Orexin A and Orexin B (also known as hypocretins) are neuropeptides that bind two related G-coupled protein receptors (OXR1 and OXR2) and thus induce wakefulness, food consumption, and locomotion. Conversely, deletion of the orexin gene in mice produces a condition similar to canine and human narcolepsy. Despite the c...

journal_title：Genes & development

authors： Sikder D,Kodadek T

更新日期：2007-11-15 00:00:00

abstract：:Diverse developmental processes, such as neuronal growth cone migration and cell shape changes, are mediated by the interactions of cells with the extracellular matrix. We describe here a secreted molecule encoded by the Drosophila masquerade (mas) gene. Total loss of mas function causes defective muscle attachment. T...

journal_title：Genes & development

authors： Murugasu-Oei B,Rodrigues V,Yang X,Chia W

更新日期：1995-01-15 00:00:00

abstract：:P-element transformants of a single rRNA gene (rDNA) were used to investigate the relationship between the organization of the nucleolus organizer (NO) and rDNA function in Drosophila melanogaster. In situ hybridization to rRNA in polytene nuclei of salivary glands demonstrated that an rRNA gene can be transcribed at ...

journal_title：Genes & development

authors： Karpen GH,Schaefer JE,Laird CD

更新日期：1988-12-01 00:00:00

abstract：:Our understanding of eukaryotic transcriptional activation mechanisms has been hampered by an inability to identify the direct in vivo targets of activator proteins, primarily because of lack of appropriate experimental methods. To circumvent this problem, we have developed a fluorescence resonance energy transfer (FR...

journal_title：Genes & development

authors： Bhaumik SR,Raha T,Aiello DP,Green MR

更新日期：2004-02-01 00:00:00

abstract：:In the absence of growth signals, cells exit the cell cycle and enter into G0 or quiescence. Alternatively, cells enter senescence in response to inappropriate growth signals such as oncogene expression. The molecular mechanisms required for cell cycle exit into quiescence or senescence are poorly understood. The DREA...

journal_title：Genes & development

authors： Litovchick L,Florens LA,Swanson SK,Washburn MP,DeCaprio JA

更新日期：2011-04-15 00:00:00

abstract：:Lethal yellow (Ay) is a mutation at the mouse agouti (a) locus that is associated with an all-yellow coat color, obesity, diabetes, tumors in heterozygotes, and preimplantation embryonic lethality in homozygotes. Previously, we cloned and characterized the wild-type agouti gene and demonstrated that it expresses a 0.8...

journal_title：Genes & development

authors： Michaud EJ,Bultman SJ,Stubbs LJ,Woychik RP

更新日期：1993-07-01 00:00:00

abstract：:High-fidelity chromosome transmission is fundamental in controlling the quality of the cell division cycle. The spindle pole-to-pole distance remains constant from metaphase to anaphase A. We show that fission yeast sister centromere-connecting proteins, Mis6 and Mis12, are required for correct spindle morphogenesis, ...

journal_title：Genes & development

authors： Goshima G,Saitoh S,Yanagida M

更新日期：1999-07-01 00:00:00

abstract：:Nuclear export factor 1 (NXF1) exports mRNA to the cytoplasm after recruitment to mRNA by specific adaptor proteins. How and why cells use numerous different export adaptors is poorly understood. Here we critically evaluate members of the SR protein family (SRSF1-7) for their potential to act as NXF1 adaptors that cou...

journal_title：Genes & development

authors： Müller-McNicoll M,Botti V,de Jesus Domingues AM,Brandl H,Schwich OD,Steiner MC,Curk T,Poser I,Zarnack K,Neugebauer KM

更新日期：2016-03-01 00:00:00

abstract：:TP53 is the most frequently mutated gene in human cancer. Many mutant p53 proteins exert oncogenic gain-of-function (GOF) properties that contribute to metastasis, but the mechanisms mediating these functions remain poorly defined in vivo. To elucidate how mutant p53 GOF drives metastasis, we developed a traceable som...

journal_title：Genes & development

authors： Pourebrahim R,Zhang Y,Liu B,Gao R,Xiong S,Lin PP,McArthur MJ,Ostrowski MC,Lozano G

更新日期：2017-09-15 00:00:00

abstract：:An insulin receptor-like signaling pathway regulates Caenorhabditis elegans metabolism, development, and longevity. Inactivation of the insulin receptor homolog DAF-2, the AGE-1 PI3K, or the AKT-1 and AKT-2 kinases causes a developmental arrest at the dauer stage. A null mutation in the daf-16 Fork head transcription ...

journal_title：Genes & development

authors： Paradis S,Ailion M,Toker A,Thomas JH,Ruvkun G

更新日期：1999-06-01 00:00:00

abstract：:Chromatin structure is believed to be important for a number of cellular processes, including transcription. However, the role of nucleosomes in transcription is not well understood. We have identified the yeast histone locus HTB1-HTB1, encoding histones H2A and H2B, as a suppressor of solo delta insertion mutations t...

journal_title：Genes & development

authors： Clark-Adams CD,Norris D,Osley MA,Fassler JS,Winston F

更新日期：1988-02-01 00:00:00

abstract：:During embryonic development, the two Caenorhabditis elegans HSN motor neurons migrate from their birthplace in the tail to positions near the middle of the embryo. Here, we demonstrate that of all cells that undergo long-range migrations, only the HSNs are affected in animals that lack function of the egl-43 gene. We...

journal_title：Genes & development

authors： Garriga G,Guenther C,Horvitz HR

更新日期：1993-11-01 00:00:00