Changes in histone gene dosage alter transcription in yeast.

abstract：:Abcission, the natural shedding of leaves, flowers and fruits, is a fundamental component of plant development. Abscission is a highly regulated process that occurs at distinct zones of cells that undergo enlargement and subsequent separation. Although some components of abscission, including accumulation of the hormo...

journal_title：Genes & development

authors： Jinn TL,Stone JM,Walker JC

更新日期：2000-01-01 00:00:00

abstract：:Sequence analysis of an embryonic transcript of Drosophila predicts a tyrosine protein kinase-related gene. The prediction is based on several protein domains that are homologous to the functional domains of kinase-related oncogenes and several serine, threonine, and tyrosine protein kinases. For this reason, we named...

journal_title：Genes & development

authors： Haller J,Côté S,Brönner G,Jäckle H

更新日期：1987-10-01 00:00:00

abstract：:Innate immunity against pathogen infection is an evolutionarily conserved process among multicellular organisms. Arabidopsis SNC1 encodes a Resistance protein that combines attributes of multiple mammalian pattern recognition receptors. Utilizing snc1 as an autoimmune model, we identified a discrete protein complex co...

journal_title：Genes & development

authors： Palma K,Zhao Q,Cheng YT,Bi D,Monaghan J,Cheng W,Zhang Y,Li X

更新日期：2007-06-15 00:00:00

abstract：:Nuclear export factor 1 (NXF1) exports mRNA to the cytoplasm after recruitment to mRNA by specific adaptor proteins. How and why cells use numerous different export adaptors is poorly understood. Here we critically evaluate members of the SR protein family (SRSF1-7) for their potential to act as NXF1 adaptors that cou...

journal_title：Genes & development

authors： Müller-McNicoll M,Botti V,de Jesus Domingues AM,Brandl H,Schwich OD,Steiner MC,Curk T,Poser I,Zarnack K,Neugebauer KM

更新日期：2016-03-01 00:00:00

abstract：:Far1p is a bifunctional protein that is required to arrest the cell cycle and to establish cell polarity during yeast mating. Far1p is localized predominantly in the nucleus but accumulates in the cytoplasm in cells exposed to pheromones. Here we show that Far1p functions in both subcellular compartments: nuclear Far1...

journal_title：Genes & development

authors： Blondel M,Alepuz PM,Huang LS,Shaham S,Ammerer G,Peter M

更新日期：1999-09-01 00:00:00

abstract：:Activation and repression of transcription in eukaryotes involve changes in the chromatin fiber that can be accomplished by covalent modification of the histone tails or the replacement of the canonical histones with other variants. Here we show that the histone H2A variant of Drosophila melanogaster, H2Av, localizes ...

journal_title：Genes & development

authors： Swaminathan J,Baxter EM,Corces VG

更新日期：2005-01-01 00:00:00

abstract：:The chromo domain was identified as a homologous protein motif between Polycomb (Pc)--a member of the Pc-group genes encoding transcriptional repressors of the homeotic genes--and HP1--a heterochromatin-associated protein encoded by the suppressor of position effect variegation gene Su(var)205. Together with previous ...

journal_title：Genes & development

authors： Messmer S,Franke A,Paro R

更新日期：1992-07-01 00:00:00

abstract：:Alternative splicing factor/splicing factor 2 (ASF/SF2) is the prototype of a family of nuclear proteins highly conserved throughout metazoa, the SR (serine/arginine) proteins. Based largely on in vitro studies, SR proteins have been suggested to play important roles in constitutive and alternative splicing of pre-mRN...

journal_title：Genes & development

authors： Wang J,Takagaki Y,Manley JL

更新日期：1996-10-15 00:00:00

abstract：:NF-kappa B is an inducible transcription factor comprised of a 50-kD (p50) and a 65-kD (p65) subunit. Induction of NF-kappa B activity, which is a critical event in many signal transduction pathways, involves release from a cytoplasmic inhibitory protein, I kappa B, followed by translocation of the active transcriptio...

journal_title：Genes & development

authors： Beg AA,Ruben SM,Scheinman RI,Haskill S,Rosen CA,Baldwin AS Jr

更新日期：1992-10-01 00:00:00

abstract：:C-factor, the product of the csgA gene, is a cell-surface associated short-range intercellular signaling protein in Myxococcus xanthus. C-factor is required for at least four responses during starvation-induced fruiting body morphogenesis: rippling, aggregation, sporulation, and full expression of the csgA gene, all o...

journal_title：Genes & development

authors： Søgaard-Andersen L,Slack FJ,Kimsey H,Kaiser D

更新日期：1996-03-15 00:00:00

abstract：:Alternative polyadenylation (APA) is widespread in neuronal development and activity-mediated neural plasticity. However, the underlying molecular mechanisms are largely unknown. We used systematic genetic studies and genome-wide surveys of the transcriptional landscape to identify a context-dependent regulatory pathw...

journal_title：Genes & development

authors： Chen F,Zhou Y,Qi YB,Khivansara V,Li H,Chun SY,Kim JK,Fu XD,Jin Y

更新日期：2015-11-15 00:00:00

abstract：:The ATR (ATM and Rad3-related) kinase and its regulatory partner ATRIP (ATR-interacting protein) coordinate checkpoint responses to DNA damage and replication stress. TopBP1 functions as a general activator of ATR. However, the mechanism by which TopBP1 activates ATR is unknown. Here, we show that ATRIP contains a Top...

journal_title：Genes & development

authors： Mordes DA,Glick GG,Zhao R,Cortez D

更新日期：2008-06-01 00:00:00

abstract：:Disruption of the balanced modulation of reversible tyrosine phosphorylation has been implicated in the etiology of various human cancers, including breast cancer. Protein Tyrosine Phosphatase N23 (PTPN23) resides in chromosomal region 3p21.3, which is hemizygously or homozygously lost in some breast cancer patients. ...

journal_title：Genes & development

authors： Zhang S,Fan G,Hao Y,Hammell M,Wilkinson JE,Tonks NK

更新日期：2017-10-01 00:00:00

abstract：:Cdc42p, a Rho-related GTP-binding protein, regulates cytoskeletal polarization and rearrangements in eukaryotic cells, but the effectors mediating this control remain unknown. Through the use of the complete yeast genomic sequence, we have identified two novel Cdc42p targets, Gic1p and Gic2p, which contain consensus C...

journal_title：Genes & development

authors： Brown JL,Jaquenoud M,Gulli MP,Chant J,Peter M

更新日期：1997-11-15 00:00:00

abstract：:Transcriptional activation of the human U1 snRNA genes is dependent on a noncanonical octamer element contained within an upstream enhancer. The U1 octamer only weakly recruits the Oct-1 POU domain, although recruitment is stimulated by a peptide containing the Oct-1-binding domain of SNAP190. Structural analysis of t...

journal_title：Genes & development

authors： Hovde S,Hinkley CS,Strong K,Brooks A,Gu L,Henry RW,Geiger J

更新日期：2002-11-01 00:00:00

abstract：:Ste5, the prototypic mitogen-activated protein kinase (MAPK) scaffold protein, associates with plasma membrane-tethered Gbetagamma freed upon pheromone receptor occupancy, thereby initiating downstream signaling. We demonstrate that this interaction and membrane binding of an N-terminal amphipathic alpha-helix (PM mot...

journal_title：Genes & development

authors： Garrenton LS,Young SL,Thorner J

更新日期：2006-07-15 00:00:00

abstract：:In the absence of growth signals, cells exit the cell cycle and enter into G0 or quiescence. Alternatively, cells enter senescence in response to inappropriate growth signals such as oncogene expression. The molecular mechanisms required for cell cycle exit into quiescence or senescence are poorly understood. The DREA...

journal_title：Genes & development

authors： Litovchick L,Florens LA,Swanson SK,Washburn MP,DeCaprio JA

更新日期：2011-04-15 00:00:00

abstract：:Our understanding of eukaryotic transcriptional activation mechanisms has been hampered by an inability to identify the direct in vivo targets of activator proteins, primarily because of lack of appropriate experimental methods. To circumvent this problem, we have developed a fluorescence resonance energy transfer (FR...

journal_title：Genes & development

authors： Bhaumik SR,Raha T,Aiello DP,Green MR

更新日期：2004-02-01 00:00:00

abstract：:Sequence-specific DNA-binding activators, key regulators of gene expression, stimulate transcription in part by targeting the core promoter recognition TFIID complex and aiding in its recruitment to promoter DNA. Although it has been established that activators can interact with multiple components of TFIID, it is unk...

journal_title：Genes & development

authors： Liu WL,Coleman RA,Ma E,Grob P,Yang JL,Zhang Y,Dailey G,Nogales E,Tjian R

更新日期：2009-07-01 00:00:00

abstract：:The circadian rhythm of pineal melatonin requires the nocturnal increment of serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase [AANAT]) protein. To date, only limited information is available in the critical issue of how AANAT protein expression is up-regulated exclusively at night regardless of its sp...

journal_title：Genes & development

authors： Kim TD,Woo KC,Cho S,Ha DC,Jang SK,Kim KT

更新日期：2007-04-01 00:00:00

abstract：:Macrophages play critical roles in events ranging from host defense to obesity and cancer, where they infiltrate affected tissues and orchestrate immune responses in tandem with the remodeling of the extracellular matrix (ECM). Despite the dual roles played by macrophages in inflammation, the functions of macrophage-d...

journal_title：Genes & development

authors： Shimizu-Hirota R,Xiong W,Baxter BT,Kunkel SL,Maillard I,Chen XW,Sabeh F,Liu R,Li XY,Weiss SJ

更新日期：2012-02-15 00:00:00

abstract：:Placental development is profoundly influenced by oxygen (O(2)) tension. Human cytotrophoblasts proliferate in vitro under low O(2) conditions but differentiate at higher O(2) levels, mimicking the developmental transition they undergo as they invade the placental bed to establish the maternal-fetal circulation in viv...

journal_title：Genes & development

authors： Adelman DM,Gertsenstein M,Nagy A,Simon MC,Maltepe E

更新日期：2000-12-15 00:00:00

abstract：:Several previously known transcription cofactors have been demonstrated in vitro recently to be histone acetyltransferases and deacetyltransferases, suggesting that remodeling of chromatin through histone acetylation plays a fundamental role in gene regulation. Clear evidence has not yet been obtained, however, to dem...

journal_title：Genes & development

authors： Wang L,Liu L,Berger SL

更新日期：1998-03-01 00:00:00

abstract：:Genomic imprinting is an epigenetic phenomenon leading to parentally biased gene expression. Throughout the years, extensive efforts have been made to characterize the epigenetic marks underlying imprinting in animals and plants. As a result, DNA methylation asymmetries between parental genomes emerged as the primary ...

journal_title：Genes & development

authors： Batista RA,Köhler C

更新日期：2020-01-01 00:00:00

abstract：:Dynamic assembly and disassembly of actin filaments is a major driving force for cell movements. Border cells in the Drosophila ovary provide a simple and genetically tractable model to study the mechanisms regulating cell migration. To identify new genes that regulate cell movement in vivo, we screened lethal mutatio...

journal_title：Genes & development

authors： Kim JH,Cho A,Yin H,Schafer DA,Mouneimne G,Simpson KJ,Nguyen KV,Brugge JS,Montell DJ

更新日期：2011-04-01 00:00:00

abstract：:Mutations that influence lin-12 activity in Caenorhabditis elegans may identify conserved factors that regulate the activity of lin-12/Notch proteins. We describe genetic evidence indicating that sel-10 is a negative regulator of lin-12/Notch-mediated signaling in C. elegans. Sequence analysis shows that SEL-10 is a m...

journal_title：Genes & development

authors： Hubbard EJ,Wu G,Kitajewski J,Greenwald I

更新日期：1997-12-01 00:00:00

abstract：:Accurate and regulated transcription by RNA polymerase II requires the assembly of an initiation complex involving multiple protein-DNA and protein-protein interactions. A key event is binding of TFIID, a complex consisting of TBP and associated factors (TAFs) to the template DNA. The TAF subunits of TFIID carry out d...

journal_title：Genes & development

authors： Ruppert S,Tjian R

更新日期：1995-11-15 00:00:00

abstract：:The rpoH gene of Escherichia coli encodes sigma 32, the 32-kD sigma-factor responsible for the heat-inducible transcription of the heat shock genes. rpoH is transcribed from at least three promoters. Two of these promoters are recognized by RNA polymerase containing sigma 70, the predominant sigma-factor. We purified ...

journal_title：Genes & development

authors： Erickson JW,Gross CA

更新日期：1989-09-01 00:00:00

abstract：:In Escherichia coli, the major nucleoid protein H-NS limits transcription by acting as a repressor or transcriptional silencer, presumably by its ability to close the looped chromosome domains in the nucleoid through DNA-protein-DNA bridging. Here, we demonstrate the direct involvement of H-NS as a positive factor sti...

journal_title：Genes & development

authors： Park HS,Ostberg Y,Johansson J,Wagner EG,Uhlin BE

更新日期：2010-07-01 00:00:00

abstract：:Direct reprogramming of fibroblasts to cardiomyocytes represents a potential means of restoring cardiac function following myocardial injury. AKT1 in the presence of four cardiogenic transcription factors, GATA4, HAND2, MEF2C, and TBX5 (AGHMT), efficiently induces the cardiac gene program in mouse embryonic fibroblast...

journal_title：Genes & development

authors： Zhou H,Morales MG,Hashimoto H,Dickson ME,Song K,Ye W,Kim MS,Niederstrasser H,Wang Z,Chen B,Posner BA,Bassel-Duby R,Olson EN

更新日期：2017-09-01 00:00:00