Abstract:
:Sequence analysis of an embryonic transcript of Drosophila predicts a tyrosine protein kinase-related gene. The prediction is based on several protein domains that are homologous to the functional domains of kinase-related oncogenes and several serine, threonine, and tyrosine protein kinases. For this reason, we named this gene Drosophila tyrosine kinase related (dTKR). dTKR maps into chromosome band 2R 60F1. It is initially expressed at blastoderm stage, showing transient transcript accumulations at dorso-lateral positions of the embryo and differences along its longitudinal axis. At later stages of embryogenesis, dTKR transcripts are found exclusively in neural anlagen. Both the region-specific pattern of expression and the putative kinase function are consistent with the suggestion of a regulatory role for this gene during development, which remains to be elucidated.
journal_name
Genes Devjournal_title
Genes & developmentauthors
Haller J,Côté S,Brönner G,Jäckle Hdoi
10.1101/gad.1.8.862subject
Has Abstractpub_date
1987-10-01 00:00:00pages
862-7issue
8eissn
0890-9369issn
1549-5477journal_volume
1pub_type
杂志文章abstract::U6 small nuclear RNA is one of the spliceosomal RNAs involved in pre-mRNA splicing. In the fission yeast Schizosaccharomyces pombe, the U6 RNA gene was found to have an intron similar to a nuclear pre-mRNA intron, and it was proposed that the U6 intron might be inserted erroneously during pre-mRNA splicing. Using the ...
journal_title:Genes & development
pub_type: 杂志文章
doi:10.1101/gad.5.6.1022
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abstract::The C-terminal domain of the Escherichia coli RNA polymerase (RNAP) alpha subunit (alphaCTD) stimulates transcription initiation by interacting with upstream (UP) element DNA and a variety of transcription activators. Here we identify specific substitutions in region 4.2 of sigma 70 (sigma(70)) and in alphaCTD that de...
journal_title:Genes & development
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journal_title:Genes & development
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journal_title:Genes & development
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pub_type: 杂志文章
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journal_title:Genes & development
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journal_title:Genes & development
pub_type: 杂志文章
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journal_title:Genes & development
pub_type: 杂志文章
doi:10.1101/gad.5.8.1477
更新日期:1991-08-01 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
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journal_title:Genes & development
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journal_title:Genes & development
pub_type: 杂志文章
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更新日期:1990-06-01 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
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更新日期:2009-05-01 00:00:00
abstract::Epigenetic modifications of chromatin play an important role in the regulation of gene expression. KMT4/Dot1 is a conserved histone methyltransferase capable of methylating chromatin on Lys79 of histone H3 (H3K79). Here we report the identification of a multisubunit Dot1 complex (DotCom), which includes several of the...
journal_title:Genes & development
pub_type: 杂志文章
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更新日期:2010-03-15 00:00:00
abstract::Class switch recombination (CSR) diversifies antibodies for productive immune responses while maintaining stability of the B-cell genome. Transcription at the immunoglobulin heavy chain (Igh) locus targets CSR-associated DNA damage and is promoted by the BRCT domain-containing PTIP (Pax transactivation domain-interact...
journal_title:Genes & development
pub_type: 杂志文章
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abstract::The yeast Ste20 protein kinase is involved in pheromone response. Mammalian homologs of Ste20 exist, but their function remains unknown. We identified a novel yeast STE20 homolog, CLA4, in a screen for mutations lethal in the absence of the G1 cyclins Cln1 and Cln2. Cla4 is involved in budding and cytokinesis and inte...
journal_title:Genes & development
pub_type: 杂志文章
doi:10.1101/gad.9.15.1817
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journal_title:Genes & development
pub_type: 更正并重新发布的文章,杂志文章
doi:10.1101/gad.11.21.2926
更新日期:1997-11-01 00:00:00
abstract::The stage-specific embryonic antigen SSEA-1 is a cell-surface oligosaccharide molecule expressed with temporal precision during the murine preimplantation period and implicated in adhesive events involving the process of compaction. We used a mammalian transient expression system to isolate a cloned human cDNA that de...
journal_title:Genes & development
pub_type: 杂志文章
doi:10.1101/gad.4.8.1288
更新日期:1990-08-01 00:00:00
abstract::The subdivision of the Drosophila body into distinct terminal and central domains depends on the torso (tor) protein, a putative receptor tyrosine kinase that is active at both ends of the early embryo. We show that the tor protein is uniformly expressed along the surface membrane of early embryos despite its localize...
journal_title:Genes & development
pub_type: 杂志文章
doi:10.1101/gad.3.12b.2025
更新日期:1989-12-01 00:00:00
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journal_title:Genes & development
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journal_title:Genes & development
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journal_title:Genes & development
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journal_title:Genes & development
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更新日期:2018-07-01 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
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更新日期:2008-04-01 00:00:00
abstract::Cells have evolved checkpoint responses to arrest or delay the cell cycle, activate DNA repair networks, or induce apoptosis after genomic perturbation. Cells have also evolved the translesion synthesis processes to tolerate genomic lesions by either error-free or error-prone repair. Here, we show that after a replica...
journal_title:Genes & development
pub_type: 杂志文章
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更新日期:2003-01-01 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
doi:10.1101/gad.10.16.2079
更新日期:1996-08-15 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
doi:10.1101/gad.1783809
更新日期:2009-06-01 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
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更新日期:2017-06-15 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
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更新日期:2009-04-15 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
doi:10.1101/gad.12.10.1504
更新日期:1998-05-15 00:00:00
abstract::We have identified protein kinase C-zeta (PKC-zeta) as a novel suppressor of neoplastic transformation caused by the v-raf oncogene. PKC-zeta overexpression drastically retards proliferation, abolishes anchorage-independent growth, and reverts the morphological transformation of v-raf-transformed NIH-3T3 cells. The mo...
journal_title:Genes & development
pub_type: 杂志文章
doi:10.1101/gad.10.12.1455
更新日期:1996-06-15 00:00:00