Double-bromo and extraterminal (BET) domain proteins regulate dendrite morphology and mechanosensory function.

Abstract:

:A complex array of genetic factors regulates neuronal dendrite morphology. Epigenetic regulation of gene expression represents a plausible mechanism to control pathways responsible for specific dendritic arbor shapes. By studying the Drosophila dendritic arborization (da) neurons, we discovered a role of the double-bromodomain and extraterminal (BET) family proteins in regulating dendrite arbor complexity. A loss-of-function mutation in the single Drosophila BET protein encoded by female sterile 1 homeotic [fs(1)h] causes loss of fine, terminal dendritic branches. Moreover, fs(1)h is necessary for the induction of branching caused by a previously identified transcription factor, Cut (Ct), which regulates subtype-specific dendrite morphology. Finally, disrupting fs(1)h function impairs the mechanosensory response of class III da sensory neurons without compromising the expression of the ion channel NompC, which mediates the mechanosensitive response. Thus, our results identify a novel role for BET family proteins in regulating dendrite morphology and a possible separation of developmental pathways specifying neural cell morphology and ion channel expression. Since the BET proteins are known to bind acetylated histone tails, these results also suggest a role of epigenetic histone modifications and the "histone code," in regulating dendrite morphology.

journal_name

Genes Dev

journal_title

Genes & development

authors

Bagley JA,Yan Z,Zhang W,Wildonger J,Jan LY,Jan YN

doi

10.1101/gad.239962.114

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

1940-56

issue

17

eissn

0890-9369

issn

1549-5477

pii

28/17/1940

journal_volume

28

pub_type

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