Abstract:
:The subdivision of the Drosophila body into distinct terminal and central domains depends on the torso (tor) protein, a putative receptor tyrosine kinase that is active at both ends of the early embryo. We show that the tor protein is uniformly expressed along the surface membrane of early embryos despite its localized activity at both poles. Further, we present evidence that polarized activity of this protein depends on other terminal gene functions, one of which may be a localized extracellular ligand generated during oogenesis. Finally, using the temperature-sensitive gain-of-function mutation torRL3, we show that different levels of active tor protein can specify distinct portions of the terminal pattern. Thus, we argue (1) that for functions as a ubiquitous surface receptor that is activated by a spatially restricted ligand, and (2) that localized activity of the tor kinase may generate one or more gradients of intracellular signals that control body pattern.
journal_name
Genes Devjournal_title
Genes & developmentauthors
Casanova J,Struhl Gdoi
10.1101/gad.3.12b.2025subject
Has Abstractpub_date
1989-12-01 00:00:00pages
2025-38issue
12Beissn
0890-9369issn
1549-5477journal_volume
3pub_type
杂志文章abstract::In Saccharomyces cerevisiae, short noncoding RNA (ncRNA) generated by RNA polymerase II (Pol II) are terminated by the NRD complex consisting of Nrd1, Nab3, and Sen1. We now show that Pcf11, a component of the cleavage and polyadenylation complex (CPAC), is also generally required for NRD-dependent transcription termi...
journal_title:Genes & development
pub_type: 杂志文章
doi:10.1101/gad.251470.114
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journal_title:Genes & development
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journal_title:Genes & development
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journal_title:Genes & development
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journal_title:Genes & development
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journal_title:Genes & development
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journal_title:Genes & development
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journal_title:Genes & development
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journal_title:Genes & development
pub_type: 杂志文章
doi:10.1101/gad.12.2.198
更新日期:1998-01-15 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
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journal_title:Genes & development
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journal_title:Genes & development
pub_type: 杂志文章
doi:10.1101/gad.455407
更新日期:2007-12-15 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
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journal_title:Genes & development
pub_type: 杂志文章
doi:10.1101/gad.179663.111
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更新日期:2010-12-01 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
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journal_title:Genes & development
pub_type: 杂志文章
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journal_title:Genes & development
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journal_title:Genes & development
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pub_type: 杂志文章
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