Dorsoventral patterning in the Drosophila central nervous system: the intermediate neuroblasts defective homeobox gene specifies intermediate column identity.

abstract：:The kinases ATM and ATR (Tel1 and Mec1 in the yeast Saccharomyces cerevisiae) control the response to DNA damage. We report that S. cerevisiae Tel2 acts at an early step of the TEL1/ATM pathway of DNA damage signaling. We show that Tel1 and Tel2 interact, and that even when Tel1 protein levels are high, this interacti...

journal_title：Genes & development

authors： Anderson CM,Korkin D,Smith DL,Makovets S,Seidel JJ,Sali A,Blackburn EH

更新日期：2008-04-01 00:00:00

abstract：:The mammalian ATF/CREB family of transcription factors comprises a large group of basic-region leucine zipper (bZIP) proteins whose members mediate diverse transcriptional regulatory functions. Here we report that expression of a specific mouse ATF gene, ATFx, is down-regulated in a variety of cells undergoing apoptos...

journal_title：Genes & development

authors： Persengiev SP,Devireddy LR,Green MR

更新日期：2002-07-15 00:00:00

abstract：:Sox10 is a high-mobility-group transcriptional regulator in early neural crest. Without Sox10, no glia develop throughout the peripheral nervous system. Here we show that Sox10 is restricted in the central nervous system to myelin-forming oligodendroglia. In Sox10-deficient mice progenitors develop, but terminal diffe...

journal_title：Genes & development

authors： Stolt CC,Rehberg S,Ader M,Lommes P,Riethmacher D,Schachner M,Bartsch U,Wegner M

更新日期：2002-01-15 00:00:00

abstract：:Nonsense-mediated decay (NMD) is a translation-dependent RNA quality control mechanism that occurs in the cytoplasm. However, it is unknown how NMD regulates the stability of RNAs translated at the endoplasmic reticulum (ER). Here, we identify a localized NMD pathway dedicated to ER-translated mRNAs. We previously ide...

journal_title：Genes & development

authors： Longman D,Jackson-Jones KA,Maslon MM,Murphy LC,Young RS,Stoddart JJ,Hug N,Taylor MS,Papadopoulos DK,Cáceres JF

更新日期：2020-08-01 00:00:00

abstract：:Chromatin reorganization is essential for transcriptional control by sequence-specific transcription factors. However, the molecular link between transcriptional control and chromatin reconfiguration remains unclear. By colocalization of the nuclear ecdysone receptor (EcR) on the ecdysone-induced puff in the salivary ...

journal_title：Genes & development

authors： Sawatsubashi S,Murata T,Lim J,Fujiki R,Ito S,Suzuki E,Tanabe M,Zhao Y,Kimura S,Fujiyama S,Ueda T,Umetsu D,Ito T,Takeyama K,Kato S

更新日期：2010-01-15 00:00:00

abstract：:Macrophages play critical roles in events ranging from host defense to obesity and cancer, where they infiltrate affected tissues and orchestrate immune responses in tandem with the remodeling of the extracellular matrix (ECM). Despite the dual roles played by macrophages in inflammation, the functions of macrophage-d...

journal_title：Genes & development

authors： Shimizu-Hirota R,Xiong W,Baxter BT,Kunkel SL,Maillard I,Chen XW,Sabeh F,Liu R,Li XY,Weiss SJ

更新日期：2012-02-15 00:00:00

abstract：:The mechanisms of RNA replication of plus-strand RNA viruses are still unclear. Here, we identified the first promoter element for RNA synthesis described in a flavivirus. Using dengue virus as a model, we found that the viral RdRp discriminates the viral RNA by specific recognition of a 5' element named SLA. We demon...

journal_title：Genes & development

authors： Filomatori CV,Lodeiro MF,Alvarez DE,Samsa MM,Pietrasanta L,Gamarnik AV

更新日期：2006-08-15 00:00:00

abstract：:Known prions (infectious proteins) are self-propagating amyloids or conformationally altered proteins, but in theory an enzyme necessary for its own activation could also be a prion (or a gene composed of protein). We show that yeast protease B is such a prion, called [beta].[beta] is infectious, reversibly curable, a...

journal_title：Genes & development

authors： Roberts BT,Wickner RB

更新日期：2003-09-01 00:00:00

abstract：:Structural cell-surface and extracellular-matrix proteins modulate intercellular signaling events during development, but how this is achieved remains largely unknown. Here we identify a novel family of Drosophila proteins, Nasrat and Polehole, that coat the oocyte surface and play two roles: They mediate assembly of ...

journal_title：Genes & development

authors： Jiménez G,González-Reyes A,Casanova J

更新日期：2002-04-15 00:00:00

abstract：:NF-E1, a DNA-binding protein that recognizes the general consensus motif WGATAR, is the first tissue-specific factor to be identified in erythroid cells. Using a probe from the murine GF-1 (NF-E1) cDNA clone, we isolated three homologous chicken cDNAs: One of these corresponds to an mRNA (NF-E1a) that is abundantly an...

journal_title：Genes & development

authors： Yamamoto M,Ko LJ,Leonard MW,Beug H,Orkin SH,Engel JD

更新日期：1990-10-01 00:00:00

abstract：:We have developed a simple, effective genetic screen for mutant alleles of eukaryotic DNA topoisomerase I that manifest severely depressed or complete loss of enzymatic function. The screen is based on the extreme toxicity of vaccinia topoisomerase expression in the Escherichia coli lysogen strain BL21(DE3) and is not...

journal_title：Genes & development

authors： Morham SG,Shuman S

更新日期：1990-04-01 00:00:00

abstract：:Alternative polyadenylation (APA) is widespread in neuronal development and activity-mediated neural plasticity. However, the underlying molecular mechanisms are largely unknown. We used systematic genetic studies and genome-wide surveys of the transcriptional landscape to identify a context-dependent regulatory pathw...

journal_title：Genes & development

authors： Chen F,Zhou Y,Qi YB,Khivansara V,Li H,Chun SY,Kim JK,Fu XD,Jin Y

更新日期：2015-11-15 00:00:00

abstract：:Hypocretin (orexin; Hcrt)-containing neurons of the hypothalamus are essential for the normal regulation of sleep and wake behaviors and have been implicated in feeding, anxiety, depression, and reward. The absence of these neurons causes narcolepsy in humans and model organisms. However, little is known about the mol...

journal_title：Genes & development

authors： Dalal J,Roh JH,Maloney SE,Akuffo A,Shah S,Yuan H,Wamsley B,Jones WB,de Guzman Strong C,Gray PA,Holtzman DM,Heintz N,Dougherty JD

更新日期：2013-03-01 00:00:00

abstract：:Cells have evolved checkpoint responses to arrest or delay the cell cycle, activate DNA repair networks, or induce apoptosis after genomic perturbation. Cells have also evolved the translesion synthesis processes to tolerate genomic lesions by either error-free or error-prone repair. Here, we show that after a replica...

journal_title：Genes & development

authors： Kai M,Wang TS

更新日期：2003-01-01 00:00:00

abstract：:RNA polymerase II (Pol II) transcribes all protein-coding genes and many noncoding RNAs in eukaryotic genomes. Although Pol II is a complex, 12-subunit enzyme, it lacks the ability to initiate transcription and cannot consistently transcribe through long DNA sequences. To execute these essential functions, an array of...

journal_title：Genes & development

authors： Schier AC,Taatjes DJ

更新日期：2020-04-01 00:00:00

abstract：:Direct reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) provides a unique opportunity to derive patient-specific stem cells with potential applications in tissue replacement therapies and without the ethical concerns of human embryonic stem cells (hESCs). However, cellular senescence, which c...

journal_title：Genes & development

authors： Lapasset L,Milhavet O,Prieur A,Besnard E,Babled A,Aït-Hamou N,Leschik J,Pellestor F,Ramirez JM,De Vos J,Lehmann S,Lemaitre JM

更新日期：2011-11-01 00:00:00

abstract：:The nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ) is known to regulate lipid metabolism in many tissues, including macrophages. Here we report that peritoneal macrophage respiration is enhanced by rosiglitazone, an activating PPARγ ligand, in a PPARγ-dependent manner. Moreover, PPARγ is require...

journal_title：Genes & development

authors： Nelson VL,Nguyen HCB,Garcìa-Cañaveras JC,Briggs ER,Ho WY,DiSpirito JR,Marinis JM,Hill DA,Lazar MA

更新日期：2018-08-01 00:00:00

abstract：:The formins constitute a set of protein isoforms encoded by the alternatively spliced transcripts arising from the limb deformity (ld) locus of the mouse. Mutations in this locus disrupt formation of the anteroposterior axis of the embryonic limb. Although ld transcripts are widely expressed during embryogenesis, we h...

journal_title：Genes & development

authors： Jackson-Grusby L,Kuo A,Leder P

更新日期：1992-01-01 00:00:00

abstract：:The retinoblastoma tumor suppressor (pRb) protein associates with chromatin and regulates gene expression. Numerous studies have identified Rb-dependent RNA signatures, but the proteomic effects of Rb loss are largely unexplored. We acutely ablated Rb in adult mice and conducted a quantitative analysis of RNA and prot...

journal_title：Genes & development

authors： Nicolay BN,Danielian PS,Kottakis F,Lapek JD Jr,Sanidas I,Miles WO,Dehnad M,Tschöp K,Gierut JJ,Manning AL,Morris R,Haigis K,Bardeesy N,Lees JA,Haas W,Dyson NJ

更新日期：2015-09-01 00:00:00

abstract：:The neurofibromatosis type II (NF2) tumor suppressor encodes a putative cytoskeletal associated protein, the loss of which leads to the development of Schwann cell tumors associated with NF2 in humans. The NF2 protein merlin belongs to the band 4.1 family of proteins that link membrane proteins to the cytoskeleton and...

journal_title：Genes & development

authors： McClatchey AI,Saotome I,Ramesh V,Gusella JF,Jacks T

更新日期：1997-05-15 00:00:00

abstract：:Here we show that the cell cycle defects of dE2F1-depleted cells depend on the cooperative effects of dE2F2 and DACAPO (DAP), an inhibitor of Cyclin E/cyclin-dependent kinase 2 (CycE/cdk2). The different properties of cells lacking dE2F1/dE2F2 and dE2F1/DAP lead to the surprising observation that dE2F2-mediated repres...

journal_title：Genes & development

authors： Frolov MV,Stevaux O,Moon NS,Dimova D,Kwon EJ,Morris EJ,Dyson NJ

更新日期：2003-03-15 00:00:00

abstract：:The histone variants H3.3 and H2A.Z have recently emerged as two of the most important features in transcriptional regulation, the molecular mechanism of which still remains poorly understood. In this study, we investigated the regulation of H3.3 and H2A.Z on chromatin dynamics during transcriptional activation. Our i...

journal_title：Genes & development

authors： Chen P,Zhao J,Wang Y,Wang M,Long H,Liang D,Huang L,Wen Z,Li W,Li X,Feng H,Zhao H,Zhu P,Li M,Wang QF,Li G

更新日期：2013-10-01 00:00:00

abstract：:Children with trisomy 21/Down syndrome (DS) are at high risk to develop acute megakaryoblastic leukemia (DS-AMKL) and the related transient leukemia (DS-TL). The factors on human chromosome 21 (Hsa21) that confer this predisposing effect, especially in synergy with consistently mutated transcription factor GATA1 (GATA...

journal_title：Genes & development

authors： Klusmann JH,Li Z,Böhmer K,Maroz A,Koch ML,Emmrich S,Godinho FJ,Orkin SH,Reinhardt D

更新日期：2010-03-01 00:00:00

abstract：:The Arabidopsis APETALA3 (AP3) and PISTILLATA (PI) proteins are thought to act as transcription factors and are required for specifying floral organ identities. To define the nuclear localization signals within these proteins, we generated translational fusions of the coding regions of AP3 and PI to the bacterial uidA...

journal_title：Genes & development

authors： McGonigle B,Bouhidel K,Irish VF

更新日期：1996-07-15 00:00:00

abstract：:Amplification of 8p11-12 in human breast cancers is associated with increased proliferation and tumor grade and reduced metastasis-free patient survival. We identified Zeppo1 (zinc finger elbow-related proline domain protein 1) (FLJ14299/ZNF703) within this amplicon as a regulator of cell adhesion, migration, and prol...

journal_title：Genes & development

authors： Slorach EM,Chou J,Werb Z

更新日期：2011-03-01 00:00:00

abstract：:Mice carrying a germ-line null mutation of the prolactin receptor gene have been produced by gene targeting in embryonic stem cells. Heterozygous females showed almost complete failure of lactation attributable to greatly reduced mammary gland development after their first, but not subsequent, pregnancies. Homozygous ...

journal_title：Genes & development

authors： Ormandy CJ,Camus A,Barra J,Damotte D,Lucas B,Buteau H,Edery M,Brousse N,Babinet C,Binart N,Kelly PA

更新日期：1997-01-15 00:00:00

abstract：:Human TFIIA activity is composed of three subunits (alpha, beta, gamma). Here we report the isolation of a human cDNA clone encoding the gamma-subunit and the reconstitution of TFIIA activity from recombinant polypeptides (holo-TFIIA). Protein-protein interaction analysis established that the beta and gamma subunits o...

journal_title：Genes & development

authors： Sun X,Ma D,Sheldon M,Yeung K,Reinberg D

更新日期：1994-10-01 00:00:00

abstract：:In meiosis I, homologous chromosomes pair and then attach to the spindle so that the homologs can be pulled apart at anaphase I. The segregation of homologs before pairing would be catastrophic. We describe two mechanisms that prevent this. First, in early meiosis, Ipl1, the budding yeast homolog of the mammalian Auro...

journal_title：Genes & development

authors： Kim S,Meyer R,Chuong H,Dawson DS

更新日期：2013-10-01 00:00:00

abstract：:The gene for an essential protein subunit of nuclear RNase P from Saccharomyces cerevisiae has been cloned. The gene for this protein, RPP1, was identified by virtue of its homology with a human scleroderma autoimmune antigen, Rpp30, which copurifies with human RNase P. Epitope-tagged Rpp1 can be found in association ...

journal_title：Genes & development

authors： Stolc V,Altman S

更新日期：1997-11-01 00:00:00

abstract：:One of the central requirements for eukaryotic chromosome stability is the maintenance of the simple sequence tracts at telomeres. In this study, we use genetic and physical assays to reveal the nature of a novel mechanism by which telomere length is controlled. This mechanism, telomeric rapid deletion (TRD), is capab...

journal_title：Genes & development

authors： Li B,Lustig AJ

更新日期：1996-06-01 00:00:00