Zeppo1 is a novel metastasis promoter that represses E-cadherin expression and regulates p120-catenin isoform expression and localization.


:Amplification of 8p11-12 in human breast cancers is associated with increased proliferation and tumor grade and reduced metastasis-free patient survival. We identified Zeppo1 (zinc finger elbow-related proline domain protein 1) (FLJ14299/ZNF703) within this amplicon as a regulator of cell adhesion, migration, and proliferation in mammary epithelial cells. Overexpression of Zeppo1 reduces cell-cell adhesion and stimulates migration and proliferation. Knockdown of Zeppo1 induces adhesion and lumen formation. Zeppo1 regulates transcription, complexing with Groucho and repressing E-cadherin expression and Wnt and TGFβ reporter expression. Zeppo1 promotes expression of metastasis-associated p120-catenin isoform 1 and alters p120-catenin localization upon cell contact with the extracellular matrix. Significantly, Zeppo1 overexpression in a mouse breast cancer model increases lung metastases, while reducing Zeppo1 expression reduces both tumor size and the number of lung metastases. These results indicate that Zeppo1 is a key regulator of breast cancer progression.


Genes Dev


Genes & development


Slorach EM,Chou J,Werb Z




Has Abstract


2011-03-01 00:00:00














  • Translational inactivation of ribosomal protein mRNAs during Xenopus oocyte maturation.

    abstract::Ribosomal protein synthesis ceases upon maturation of Xenopus oocytes. We find that this cessation results from the dissociation of ribosomal protein mRNAs from polysomes and is accompanied by the deadenylation of these transcripts. A synthetic mRNA encoding ribosomal protein L1, microinjected into stage VI oocytes, i...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Hyman LE,Wormington WM

    更新日期:1988-05-01 00:00:00

  • Tandem AP-1-binding sites within the human beta-globin dominant control region function as an inducible enhancer in erythroid cells.

    abstract::A powerful enhancer has been mapped to an 18-bp DNA segment located 11 kb 5' to the human epsilon-globin gene within the dominant control or locus-activating region. This enhancer is inducible in K562 human erythroleukemia cells, increasing linked gamma-globin promoter/luciferase gene expression to 170-fold over an en...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Ney PA,Sorrentino BP,McDonagh KT,Nienhuis AW

    更新日期:1990-06-01 00:00:00

  • In vivo analysis of the helix-turn-helix motif of the fushi tarazu homeo domain of Drosophila melanogaster.

    abstract::We report a systematic mutational analysis of the helix-turn-helix motif (HTH) of the fushi tarazu (ftz) homeo domain (HD) of Drosophila. We started out by testing the function of chimeric ftz proteins containing either a part of the Sex combs reduced (Scr) or the muscle segment homeobox (msh) HDs. By complementation ...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Furukubo-Tokunaga K,Müller M,Affolter M,Pick L,Kloter U,Gehring WJ

    更新日期:1992-06-01 00:00:00

  • A mechanism for the exclusion of low-fidelity human Y-family DNA polymerases from base excision repair.

    abstract::The human Y-family DNA polymerases, Poliota, Poleta, and Polkappa, function in promoting replication through DNA lesions. However, because of their low fidelity, any involvement of these polymerases in DNA synthesis during base excision repair (BER) would be highly mutagenic. Mechanisms, therefore, must exist to exclu...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Haracska L,Prakash L,Prakash S

    更新日期:2003-11-15 00:00:00

  • The cloned RNA polymerase II transcription factor IID selects RNA polymerase III to transcribe the human U6 gene in vitro.

    abstract::Although the human U2 and U6 snRNA genes are transcribed by different RNA polymerases (i.e., RNA polymerases II and III, respectively), their promoters are very similar in structure. Both contain a proximal sequence element (PSE) and an octamer motif-containing enhancer, and these elements are interchangeable between ...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Lobo SM,Lister J,Sullivan ML,Hernandez N

    更新日期:1991-08-01 00:00:00

  • Smad3-dependent nuclear translocation of beta-catenin is required for TGF-beta1-induced proliferation of bone marrow-derived adult human mesenchymal stem cells.

    abstract::Adult mesenchymal stem cells (MSCs) derived from bone marrow contribute to the regeneration of multiple types of mesenchymal tissues. Here we describe the functional role of a novel form of cross-talk between the transforming growth factor beta1 (TGF-beta1) and Wnt signaling pathways in regulating the activities of hu...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Jian H,Shen X,Liu I,Semenov M,He X,Wang XF

    更新日期:2006-03-15 00:00:00

  • The an11 locus controlling flower pigmentation in petunia encodes a novel WD-repeat protein conserved in yeast, plants, and animals.

    abstract::In petunia flowers, the loci an1, an2, and an11 control the pigmentation of the flower by stimulating the transcription of anthocyanin biosynthetic genes. The an1 and an2 locus were recently cloned and encode a basic helix-loop-helix (bHLH) and MYB-domain transcriptional activator, respectively. Here, we report the is...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: de Vetten N,Quattrocchio F,Mol J,Koes R

    更新日期:1997-06-01 00:00:00

  • Exon coconversion biases accompanying intron homing: battle of the nucleases.

    abstract::Intron homing in phage T4 occurs in the context of recombination-dependent replication, by virtue of intron-encoded endonucleolytic activity. After the td intron endonuclease I-TevI cleaves the intronless recipient 23 and 25 nucleotides upstream of the intron insertion site, exonucleolytic degradation is required for ...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Mueller JE,Smith D,Belfort M

    更新日期:1996-09-01 00:00:00

  • APC sets the Wnt tone necessary for cerebral cortical progenitor development.

    abstract::Adenomatous polyposis coli (APC) regulates the activity of β-catenin, an integral component of Wnt signaling. However, the selective role of the APC-β-catenin pathway in cerebral cortical development is unknown. Here we genetically dissected the relative contributions of APC-regulated β-catenin signaling in cortical p...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Nakagawa N,Li J,Yabuno-Nakagawa K,Eom TY,Cowles M,Mapp T,Taylor R,Anton ES

    更新日期:2017-08-15 00:00:00

  • Activator-mediated disruption of sequence-specific DNA contacts by the general transcription factor TFIIB.

    abstract::The transcription factor TFIIB plays a central role in preinitiation complex assembly, providing a bridge between promoter-bound TFIID and RNA Polymerase II. TFIIB possesses sequence-specific DNA-binding ability and interacts with the TFIIB-recognition element (BRE), present in many promoters. Here we show that the BR...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Evans R,Fairley JA,Roberts SG

    更新日期:2001-11-15 00:00:00

  • Bacterial promoter architecture: subsite structure of UP elements and interactions with the carboxy-terminal domain of the RNA polymerase alpha subunit.

    abstract::We demonstrate here that the previously described bacterial promoter upstream element (UP element) consists of two distinct subsites, each of which, by itself, can bind the RNA polymerase holoenzyme alpha subunit carboxy-terminal domain (RNAP alphaCTD) and stimulate transcription. Using binding-site-selection experime...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Estrem ST,Ross W,Gaal T,Chen ZW,Niu W,Ebright RH,Gourse RL

    更新日期:1999-08-15 00:00:00

  • Seven-up, the Drosophila homolog of the COUP-TF orphan receptors, controls cell proliferation in the insect kidney.

    abstract::Morphogenesis of the insect kidney, the Malpighian tubules, is controlled in Drosophila by a single large cell, the tip cell. It has been postulated that this cell sends out a mitogenic signal that induces the division of neighboring cells. The signal and the molecules that receive it have remained elusive. We show th...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Kerber B,Fellert S,Hoch M

    更新日期:1998-06-15 00:00:00

  • A model for the abrogation of the SOS response by an SOS protein: a negatively charged helix in DinI mimics DNA in its interaction with RecA.

    abstract::DinI is a recently described negative regulator of the SOS response in Escherichia coli. Here we show that it physically interacts with RecA and prevents the binding of single-stranded DNA to RecA, which is required for the activation of the latter. DinI also displaces ssDNA from a stable RecA-DNA cofilament, thus eli...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Voloshin ON,Ramirez BE,Bax A,Camerini-Otero RD

    更新日期:2001-02-15 00:00:00

  • Pcf11 orchestrates transcription termination pathways in yeast.

    abstract::In Saccharomyces cerevisiae, short noncoding RNA (ncRNA) generated by RNA polymerase II (Pol II) are terminated by the NRD complex consisting of Nrd1, Nab3, and Sen1. We now show that Pcf11, a component of the cleavage and polyadenylation complex (CPAC), is also generally required for NRD-dependent transcription termi...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Grzechnik P,Gdula MR,Proudfoot NJ

    更新日期:2015-04-15 00:00:00

  • The incidental pore: CaV1.2 and stem cell activation in quiescent hair follicles.

    abstract::The hair follicle undergoes a lifelong developmental cycle that depends on the integration between activating and inhibitory signals acting to regulate and guide the proliferation and differentiation of pluripotent epithelial stem cells. The effectors and mechanisms responsible for re-entry of quiescent telogen hair f...

    journal_title:Genes & development

    pub_type: 评论,杂志文章


    authors: Coulombe PA,Caterina MJ

    更新日期:2013-06-15 00:00:00

  • A unique zinc finger protein is associated preferentially with active ecdysone-responsive loci in Drosophila.

    abstract::Using an immunochemical approach, we have identified a unique antigen, PEP (protein on ecdysone puffs), which is associated in third-instar larvae with the active ecdysone-regulated loci on polytene chromosomes; PEP is not associated with most intermolt puffs and is found on some, but not all, heat shock-induced puffs...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Amero SA,Elgin SC,Beyer AL

    更新日期:1991-02-01 00:00:00

  • Caught at its own game: regulatory small RNA inactivated by an inducible transcript mimicking its target.

    abstract::A relevant, yet little recognized feature of antisense regulation is the possibility of switching roles between regulatory and regulated RNAs. Here we show that induction of a Salmonella gene relies on the conversion of a small RNA from effector to regulatory target. The chiP gene (formerly ybfM), identified and chara...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Figueroa-Bossi N,Valentini M,Malleret L,Fiorini F,Bossi L

    更新日期:2009-09-01 00:00:00

  • The cAMP receptor CAR4 regulates axial patterning and cellular differentiation during late development of Dictyostelium.

    abstract::Pseudoplasmodia of developing Dictyostelium are organized with anteroposterior polarity. We have isolated CAR4, the gene for a new cell-surface, G protein-linked cAMP receptor. CAR4 mRNA is initially expressed during tip elongation and continues to accumulate into culmination. CAR4 is maximally expressed in pseudoplas...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Louis JM,Ginsburg GT,Kimmel AR

    更新日期:1994-09-01 00:00:00

  • The dishevelled protein is modified by wingless signaling in Drosophila.

    abstract::Wingless (Wg) is an important signaling molecule in the development of Drosophila, but little is known about its signal transduction pathway. Genetic evidence indicates that another segment polarity gene, dishevelled (dsh) is required for Wg signaling. We have recently developed a cell culture system for Wg protein ac...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Yanagawa S,van Leeuwen F,Wodarz A,Klingensmith J,Nusse R

    更新日期:1995-05-01 00:00:00

  • Oocyte and somatic tyrosine tRNA genes in Xenopus laevis.

    abstract::Over a period of many months, Xenopus oocytes stockpile large quantities of tRNA for use during the first few hours of embryogenesis. To test the idea that these tRNAs are transcribed from one set of genes and that another set is used by somatic cells, we used synthetic oligonucleotides to analyze the sequence and ste...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Stutz F,Gouilloud E,Clarkson SG

    更新日期:1989-08-01 00:00:00

  • Cytosolic signaling protein Ecsit also localizes to mitochondria where it interacts with chaperone NDUFAF1 and functions in complex I assembly.

    abstract::Ecsit is a cytosolic adaptor protein essential for inflammatory response and embryonic development via the Toll-like and BMP (bone morphogenetic protein) signal transduction pathways, respectively. Here, we demonstrate a mitochondrial function for Ecsit (an evolutionary conserved signaling intermediate in Toll pathway...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Vogel RO,Janssen RJ,van den Brand MA,Dieteren CE,Verkaart S,Koopman WJ,Willems PH,Pluk W,van den Heuvel LP,Smeitink JA,Nijtmans LG

    更新日期:2007-03-01 00:00:00

  • Unbiased identification of signal-activated transcription factors by barcoded synthetic tandem repeat promoter screening (BC-STAR-PROM).

    abstract::The discovery of transcription factors (TFs) controlling pathways in health and disease is of paramount interest. We designed a widely applicable method, dubbed barcorded synthetic tandem repeat promoter screening (BC-STAR-PROM), to identify signal-activated TFs without any a priori knowledge about their properties. T...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Gosselin P,Rando G,Fleury-Olela F,Schibler U

    更新日期:2016-08-15 00:00:00

  • Cellular projections from sensory hair cells form polarity-specific scaffolds during synaptogenesis.

    abstract::The assembly of a nervous system requires the extension of axons and dendrites to specific regions where they are matched with appropriate synaptic targets. Although the cues that guide long-range outgrowth have been characterized extensively, additional mechanisms are required to explain short-range guidance in neura...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Dow E,Siletti K,Hudspeth AJ

    更新日期:2015-05-15 00:00:00

  • The Lats2 tumor suppressor augments p53-mediated apoptosis by promoting the nuclear proapoptotic function of ASPP1.

    abstract::Apoptosis is an important mechanism to eliminate potentially tumorigenic cells. The tumor suppressor p53 plays a pivotal role in this process. Many tumors harbor mutant p53, but others evade its tumor-suppressive effects by altering the expression of proteins that regulate the p53 pathway. ASPP1 (apoptosis-stimulating...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Aylon Y,Ofir-Rosenfeld Y,Yabuta N,Lapi E,Nojima H,Lu X,Oren M

    更新日期:2010-11-01 00:00:00

  • Fibroblast growth factor signals regulate a wave of Hedgehog activation that is essential for coronary vascular development.

    abstract::Myocardial infarction and ischemic heart disease are the leading cause of death in the industrial world. Therapies employed for treating these diseases are aimed at promoting increased blood flow to cardiac tissue. Pharmacological induction of new coronary growth has recently been explored, however, clinical trials wi...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Lavine KJ,White AC,Park C,Smith CS,Choi K,Long F,Hui CC,Ornitz DM

    更新日期:2006-06-15 00:00:00

  • Dynamic expression and essential functions of Hes7 in somite segmentation.

    abstract::The basic helix-loop-helix (bHLH) gene Hes7, a putative Notch effector, encodes a transcriptional repressor. Here, we found that Hes7 expression oscillates in 2-h cycles in the presomitic mesoderm (PSM). In Hes7-null mice, somites are not properly segmented and their anterior-posterior polarity is disrupted. As a resu...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Bessho Y,Sakata R,Komatsu S,Shiota K,Yamada S,Kageyama R

    更新日期:2001-10-15 00:00:00

  • RAG-1 mutations that affect the target specificity of V(D)j recombination: a possible direct role of RAG-1 in site recognition.

    abstract::The RAG-1 protein plays an essential role in V(D)j recombination, but its exact function has not yet been defined. Here we report that a particular mutation in RAG-1 affects recombination by altering the specificity of target sequence usage. Recombination mediated by wild-type RAG-1 is tolerant of a wide range of codi...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Sadofsky MJ,Hesse JE,van Gent DC,Gellert M

    更新日期:1995-09-01 00:00:00

  • A monocarboxylate transporter required for hepatocyte secretion of ketone bodies during fasting.

    abstract::To find new genes that influence liver lipid mass, we performed a genetic screen for zebrafish mutants with hepatic steatosis, a pathological accumulation of fat. The red moon (rmn) mutant develops hepatic steatosis as maternally deposited yolk is depleted. Conversely, hepatic steatosis is suppressed in rmn mutants by...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Hugo SE,Cruz-Garcia L,Karanth S,Anderson RM,Stainier DY,Schlegel A

    更新日期:2012-02-01 00:00:00

  • The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families.

    abstract::The Elongin BC complex was identified initially as a positive regulator of RNA polymerase II (Pol II) elongation factor Elongin A and subsequently as a component of the multiprotein von Hippel-Lindau (VHL) tumor suppressor complex, in which it participates in both tumor suppression and negative regulation of hypoxia-i...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Kamura T,Sato S,Haque D,Liu L,Kaelin WG Jr,Conaway RC,Conaway JW

    更新日期:1998-12-15 00:00:00

  • Neurofibromatosis-1 regulation of neural stem cell proliferation and multilineage differentiation operates through distinct RAS effector pathways.

    abstract::Neurofibromatosis type 1 (NF1) is a common neurodevelopmental disorder caused by impaired function of the neurofibromin RAS regulator. Using a combination of Nf1 genetically engineered mice and pharmacological/genetic inhibition approaches, we report that neurofibromin differentially controls neural stem cell (NSC) pr...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Chen YH,Gianino SM,Gutmann DH

    更新日期:2015-08-15 00:00:00