Zeppo1 is a novel metastasis promoter that represses E-cadherin expression and regulates p120-catenin isoform expression and localization.

abstract：:The target gene(s) required for Myc-mediated tumorigenesis are still elusive. Here we show that while endogenous c-Myc is surprisingly dispensable for skin homeostasis and TPA-induced hyperplasia, c-Myc-deficient epidermis is resistant to Ras-mediated DMBA/TPAinduced tumorigenesis. This is mechanistically linked to p2...

journal_title：Genes & development

authors： Oskarsson T,Essers MA,Dubois N,Offner S,Dubey C,Roger C,Metzger D,Chambon P,Hummler E,Beard P,Trumpp A

更新日期：2006-08-01 00:00:00

abstract：:The chromo domain was identified as a homologous protein motif between Polycomb (Pc)--a member of the Pc-group genes encoding transcriptional repressors of the homeotic genes--and HP1--a heterochromatin-associated protein encoded by the suppressor of position effect variegation gene Su(var)205. Together with previous ...

journal_title：Genes & development

authors： Messmer S,Franke A,Paro R

更新日期：1992-07-01 00:00:00

abstract：:H4K20 methylation is a broad chromatin modification that has been linked with diverse epigenetic functions. Several enzymes target H4K20 methylation, consistent with distinct mono-, di-, and trimethylation states controlling different biological outputs. To analyze the roles of H4K20 methylation states, we generated c...

journal_title：Genes & development

authors： Schotta G,Sengupta R,Kubicek S,Malin S,Kauer M,Callén E,Celeste A,Pagani M,Opravil S,De La Rosa-Velazquez IA,Espejo A,Bedford MT,Nussenzweig A,Busslinger M,Jenuwein T

更新日期：2008-08-01 00:00:00

abstract：:Piwi-piRNA (Piwi-interacting RNA) ribonucleoproteins (piRNPs) enforce retrotransposon silencing, a function critical for preserving the genome integrity of germ cells. The molecular functions of most of the factors that have been genetically implicated in primary piRNA biogenesis are still elusive. Here we show that M...

journal_title：Genes & development

authors： Vourekas A,Zheng K,Fu Q,Maragkakis M,Alexiou P,Ma J,Pillai RS,Mourelatos Z,Wang PJ

更新日期：2015-03-15 00:00:00

abstract：:Chromosome replication occurs precisely once during the cell cycle of almost all eukaryotic cells, and is a highly complex process that is still understood relatively poorly. Two conserved kinases called Cdc7 (cell division cycle 7) and cyclin-dependent kinase (CDK) are required to establish replication forks during t...

journal_title：Genes & development

authors： Labib K

更新日期：2010-06-15 00:00:00

abstract：:Using an immunochemical approach, we have identified a unique antigen, PEP (protein on ecdysone puffs), which is associated in third-instar larvae with the active ecdysone-regulated loci on polytene chromosomes; PEP is not associated with most intermolt puffs and is found on some, but not all, heat shock-induced puffs...

journal_title：Genes & development

authors： Amero SA,Elgin SC,Beyer AL

更新日期：1991-02-01 00:00:00

abstract：:Transcriptional activation of the prolactin and growth hormone genes, occurring in a cell-specific fashion, requires short-range synergistic interactions between the pituitary-specific POU domain factor Pit-1 and other transcription factors, particularly nuclear receptors. Unexpectedly, we find that these events invol...

journal_title：Genes & development

authors： Holloway JM,Szeto DP,Scully KM,Glass CK,Rosenfeld MG

更新日期：1995-08-15 00:00:00

abstract：:Accurate completion of replication relies on the ability of cells to activate error-free recombination-mediated DNA damage bypass at sites of perturbed replication. However, as anti-recombinase activities are also recruited to replication forks, how recombination-mediated damage bypass is enabled at replication stress...

journal_title：Genes & development

authors： Urulangodi M,Sebesta M,Menolfi D,Szakal B,Sollier J,Sisakova A,Krejci L,Branzei D

更新日期：2015-10-01 00:00:00

abstract：:A transgenic mouse model for retinoblastoma was produced previously by directing SV40 T antigen expression to retinal photoreceptor cells using the promoter of the interstitial retinol-binding protein (IRBP) gene. This gene becomes active prior to the terminal differentiation of photoreceptors. Because T antigen-trans...

journal_title：Genes & development

authors： Howes KA,Ransom N,Papermaster DS,Lasudry JG,Albert DM,Windle JJ

更新日期：1994-06-01 00:00:00

abstract：:Ecsit is a cytosolic adaptor protein essential for inflammatory response and embryonic development via the Toll-like and BMP (bone morphogenetic protein) signal transduction pathways, respectively. Here, we demonstrate a mitochondrial function for Ecsit (an evolutionary conserved signaling intermediate in Toll pathway...

journal_title：Genes & development

authors： Vogel RO,Janssen RJ,van den Brand MA,Dieteren CE,Verkaart S,Koopman WJ,Willems PH,Pluk W,van den Heuvel LP,Smeitink JA,Nijtmans LG

更新日期：2007-03-01 00:00:00

abstract：:U4 and U6 small nuclear RNAs are associated by an extensive base-pairing interaction that must be disrupted and reformed with each round of splicing. U4 mutations within the U4/U6 interaction domain destabilize the complex in vitro and cause a cold-sensitive phenotype in vivo. Restabilization of the U4/U6 helix by dom...

journal_title：Genes & development

authors： Shannon KW,Guthrie C

更新日期：1991-05-01 00:00:00

abstract：:Bone morphogenic proteins 2 and 4 (BMP2 and BMP4) inhibit proliferation and induce differentiation of cerebellar granule neuron progenitors (GNPs) and primary GNP-like medulloblastoma (MB) cells. This occurs through rapid proteasome-mediated degradation of Math1 (Atoh1), a transcription factor expressed in proliferati...

journal_title：Genes & development

authors： Zhao H,Ayrault O,Zindy F,Kim JH,Roussel MF

更新日期：2008-03-15 00:00:00

abstract：:The subdivision of the lateral mesoderm into a visceral (splanchnic) and a somatic layer is a crucial event during early mesoderm development in both arthropod and vertebrate embryos. In Drosophila, this subdivision leads to the differential development of gut musculature versus body wall musculature. Here we report t...

journal_title：Genes & development

authors： Zaffran S,Küchler A,Lee HH,Frasch M

更新日期：2001-11-01 00:00:00

abstract：:Coliphage N4 is a double-stranded DNA virus that requires the sequential activity of three different RNA polymerases during infection. The N4 virion RNA polymerase, which is carried in the virion and is injected with the DNA at the start of infection, is responsible for the synthesis of N4 early RNAs. In vitro, the vi...

journal_title：Genes & development

authors： Markiewicz P,Malone C,Chase JW,Rothman-Denes LB

更新日期：1992-10-01 00:00:00

abstract：:Autophagy is crucial for cellular homeostasis and plays important roles in tumorigenesis. FIP200 (FAK family-interacting protein of 200 kDa) is an essential autophagy gene required for autophagy induction, functioning in the ULK1-ATG13-FIP200 complex. Our previous studies showed that conditional knockout of FIP200 sig...

journal_title：Genes & development

authors： Wei H,Wang C,Croce CM,Guan JL

更新日期：2014-06-01 00:00:00

abstract：:How muscle diversity is generated in the vertebrate body is poorly understood. In the limb, dorsal and ventral muscle masses constitute the first myogenic diversification, as each gives rise to distinct muscles. Myogenesis initiates after muscle precursor cells (MPCs) have migrated from the somites to the limb bud and...

journal_title：Genes & development

authors： Anderson C,Williams VC,Moyon B,Daubas P,Tajbakhsh S,Buckingham ME,Shiroishi T,Hughes SM,Borycki AG

更新日期：2012-09-15 00:00:00

abstract：:Repression of a-cell specific gene expression in yeast alpha cells requires MAT alpha 2 and MCM1, as well as two global repressors, SSN6 and TUP1. Previous studies demonstrated that nucleosomes positioned adjacent to the alpha 2/MCM1 operator in alpha cells directly contribute to repression. To investigate the possibi...

journal_title：Genes & development

authors： Cooper JP,Roth SY,Simpson RT

更新日期：1994-06-15 00:00:00

abstract：:Cells have evolved checkpoint responses to arrest or delay the cell cycle, activate DNA repair networks, or induce apoptosis after genomic perturbation. Cells have also evolved the translesion synthesis processes to tolerate genomic lesions by either error-free or error-prone repair. Here, we show that after a replica...

journal_title：Genes & development

authors： Kai M,Wang TS

更新日期：2003-01-01 00:00:00

abstract：:Estrogen receptor α (ER) is the major driver of ∼75% of breast cancers, and multiple ER targeting drugs are routinely used clinically to treat patients with ER+ breast cancer. However, many patients relapse on these targeted therapies and ultimately develop metastatic and incurable disease, and understanding the mecha...

journal_title：Genes & development

authors： Siersbæk R,Kumar S,Carroll JS

更新日期：2018-09-01 00:00:00

abstract：:We have developed a simple, effective genetic screen for mutant alleles of eukaryotic DNA topoisomerase I that manifest severely depressed or complete loss of enzymatic function. The screen is based on the extreme toxicity of vaccinia topoisomerase expression in the Escherichia coli lysogen strain BL21(DE3) and is not...

journal_title：Genes & development

authors： Morham SG,Shuman S

更新日期：1990-04-01 00:00:00

abstract：:We report the discovery of mRNA 5'-leader trans-splicing (SL trans-splicing) in the chordates. In the ascidian protochordate Ciona intestinalis, the mRNAs of at least seven genes undergo trans-splicing of a 16-nucleotide 5'-leader apparently derived from a 46-nucleotide RNA that shares features with previously charact...

journal_title：Genes & development

authors： Vandenberghe AE,Meedel TH,Hastings KE

更新日期：2001-02-01 00:00:00

abstract：:Programmed cell death occurs in a highly reproducible manner during Caenorhabditis elegans development. We demonstrate that, during embryogenesis, miR-35 and miR-58 bantam family microRNAs (miRNAs) cooperate to prevent the precocious death of mothers of cells programmed to die by repressing the gene egl-1, which encod...

journal_title：Genes & development

authors： Sherrard R,Luehr S,Holzkamp H,McJunkin K,Memar N,Conradt B

更新日期：2017-01-15 00:00:00

abstract：:During gastrulation of Xenopus embryos the prospective mesoderm is induced initially with domains of dorsal and ventral fate, then further patterned to generate somitic mesoderm by signals from the gastrula organizer. Although Xwnt-8 is expressed in future ventrolateral mesoderm and induces prospective epidermis to di...

journal_title：Genes & development

authors： Hoppler S,Brown JD,Moon RT

更新日期：1996-11-01 00:00:00

abstract：:In Xenopus embryos, a dorsal-ventral patterning gradient is generated by diffusing Chordin/bone morphogenetic protein (BMP) complexes cleaved by BMP1/Tolloid metalloproteinases in the ventral side. We developed a new BMP1/Tolloid assay using a fluorogenic Chordin peptide substrate and identified an unexpected negative...

journal_title：Genes & development

authors： Lee HX,Mendes FA,Plouhinec JL,De Robertis EM

更新日期：2009-11-01 00:00:00

abstract：:The gene for an essential protein subunit of nuclear RNase P from Saccharomyces cerevisiae has been cloned. The gene for this protein, RPP1, was identified by virtue of its homology with a human scleroderma autoimmune antigen, Rpp30, which copurifies with human RNase P. Epitope-tagged Rpp1 can be found in association ...

journal_title：Genes & development

authors： Stolc V,Altman S

更新日期：1997-11-01 00:00:00

abstract：:Interactions required for inhibition of poly(A) polymerase (PAP) by the U1 snRNP-specific U1A protein, a reaction whose function is to autoregulate U1A protein production, are examined. PAP inhibition requires a substrate RNA to which at least two molecules of U1A protein can bind tightly, but we demonstrate that the ...

journal_title：Genes & development

authors： Gunderson SI,Vagner S,Polycarpou-Schwarz M,Mattaj IW

更新日期：1997-03-15 00:00:00

abstract：:Ssn6-Tup1 regulates multiple genes in yeast, providing a paradigm for corepressor functions. Tup1 interacts directly with histones H3 and H4, and mutation of these histones synergistically compromises Ssn6-Tup1-mediated repression. In vitro, Tup1 interacts preferentially with underacetylated isoforms of H3 and H4, sug...

journal_title：Genes & development

authors： Watson AD,Edmondson DG,Bone JR,Mukai Y,Yu Y,Du W,Stillman DJ,Roth SY

更新日期：2000-11-01 00:00:00

abstract：:We have shown that Wnt signals are necessary and sufficient for neural crest cells to adopt pigment cell fates. nacre, a zebrafish homolog of MITF, is required for pigment cell differentiation. We isolated a promoter region of nacre that contains Tcf/Lef binding sites, which can mediate Wnt responsiveness. This promot...

journal_title：Genes & development

authors： Dorsky RI,Raible DW,Moon RT

更新日期：2000-01-15 00:00:00

abstract：:We describe the developmental effects of the expression of a normal and mutated Drosophila ras gene ras2 in transgenic Drosophila. A Gly14----Val14 mutant (Gly14 in ras2 is equivalent to Gly12 in mammalian ras proteins) was constructed in ras2 by site-directed mutagenesis. Inducible constructs of ras2 and ras2Val14 we...

journal_title：Genes & development

authors： Bishop JG 3rd,Corces VG

更新日期：1988-05-01 00:00:00

abstract：:During embryonic development in vertebrates, the endoderm becomes patterned along the anteroposterior axis to produce distinct derivatives. How this regulation is controlled is not well understood. We report that the zebrafish hairy/enhancer of split [E(spl)]-related gene her5 plays a critical role in this process. At...

journal_title：Genes & development

authors： Bally-Cuif L,Goutel C,Wassef M,Wurst W,Rosa F

更新日期：2000-07-01 00:00:00