A histone chaperone, DEK, transcriptionally coactivates a nuclear receptor.

abstract：:The ETS transcription factors perform distinct biological functions despite conserving a highly similar DNA-binding domain. One distinguishing property of a subset of ETS proteins is a conserved region of 80 amino acids termed the Pointed (PNT) domain. Using enzyme kinetics we determined that the Ets-1 PNT domain cont...

journal_title：Genes & development

authors： Seidel JJ,Graves BJ

更新日期：2002-01-01 00:00:00

abstract：:A new gene, SCH9, was isolated from Saccharomyces cerevisiae by its ability to complement a cdc25ts mutation. Sequence analysis indicates that it encodes a 90,000-dalton protein with a carboxy-terminal domain homologous to yeast and mammalian cAMP-dependent protein kinase catalytic subunits. In addition to suppressing...

journal_title：Genes & development

authors： Toda T,Cameron S,Sass P,Wigler M

更新日期：1988-05-01 00:00:00

abstract：:Structural cell-surface and extracellular-matrix proteins modulate intercellular signaling events during development, but how this is achieved remains largely unknown. Here we identify a novel family of Drosophila proteins, Nasrat and Polehole, that coat the oocyte surface and play two roles: They mediate assembly of ...

journal_title：Genes & development

authors： Jiménez G,González-Reyes A,Casanova J

更新日期：2002-04-15 00:00:00

abstract：:In this issue of Genes & Development, Abruzzi et al. (pp. 2374-2386) use chromatin immunoprecipitation (ChIP) tiling array assays (ChIP-chip) to show that physical interactions between circadian (≅24-h) clock machineries and genomes are more widespread than previously thought and provide novel insights into how clocks...

journal_title：Genes & development

authors： Edery I

更新日期：2011-11-15 00:00:00

abstract：:Members of the metazoan nuclear receptor superfamily regulate gene expression programs in response to binding of cognate lipophilic ligands. Evolutionary studies using bioinformatics tools have concluded that lower eukaryotes, such as fungi, lack nuclear receptor homologs. Here we review recent discoveries suggesting ...

journal_title：Genes & development

authors： Näär AM,Thakur JK

更新日期：2009-02-15 00:00:00

abstract：:Many tumors continuously depend on the initiating oncogenes, but whether this extends to their downstream targets is unclear. In this issue of Genes & Development, Sodir and colleagues (pp. 907-916) demonstrate an essential role for endogenous Myc proteins in maintaining the tumor microenvironment, providing an unexpe...

journal_title：Genes & development

authors： von Eyss B,Eilers M

更新日期：2011-05-01 00:00:00

abstract：:We have used the 100-kD HeLa cell octamer-binding protein OBP100 as a model to study flexible DNA sequence recognition by promoter-binding proteins. OBP100 binds to the conserved octamer motif ATGCAAAT found in numerous promoters and additionally to two degenerate octamer motifs (sites I and II) within the SV40 enhanc...

journal_title：Genes & development

authors： Baumruker T,Sturm R,Herr W

更新日期：1988-11-01 00:00:00

abstract：:Medulloblastomas are among the most common malignancies in childhood, and they are associated with substantial mortality and morbidity. The molecular pathogenesis as well as the ontogeny of these neoplasms is still poorly understood. We have generated a mouse model for medulloblastoma by Cre-LoxP-mediated inactivation...

journal_title：Genes & development

authors： Marino S,Vooijs M,van Der Gulden H,Jonkers J,Berns A

更新日期：2000-04-15 00:00:00

abstract：:Direct reprogramming of fibroblasts to cardiomyocytes represents a potential means of restoring cardiac function following myocardial injury. AKT1 in the presence of four cardiogenic transcription factors, GATA4, HAND2, MEF2C, and TBX5 (AGHMT), efficiently induces the cardiac gene program in mouse embryonic fibroblast...

journal_title：Genes & development

authors： Zhou H,Morales MG,Hashimoto H,Dickson ME,Song K,Ye W,Kim MS,Niederstrasser H,Wang Z,Chen B,Posner BA,Bassel-Duby R,Olson EN

更新日期：2017-09-01 00:00:00

abstract：:The neurogenic loci of Drosophila are required for proper partitioning of ectodermal cells into epidermal versus neural lineages. The loci appear to encode components of a developmental pathway involving cellular communication. In an effort to understand the role of the neurogenic locus mastermind in these processes, ...

journal_title：Genes & development

authors： Smoller D,Friedel C,Schmid A,Bettler D,Lam L,Yedvobnick B

更新日期：1990-10-01 00:00:00

abstract：:Oxidative tissues such as heart undergo a dramatic perinatal mitochondrial biogenesis to meet the high-energy demands after birth. PPARgamma coactivator-1 (PGC-1) alpha and beta have been implicated in the transcriptional control of cellular energy metabolism. Mice with combined deficiency of PGC-1alpha and PGC-1beta ...

journal_title：Genes & development

authors： Lai L,Leone TC,Zechner C,Schaeffer PJ,Kelly SM,Flanagan DP,Medeiros DM,Kovacs A,Kelly DP

更新日期：2008-07-15 00:00:00

abstract：:During vasculogenesis and angiogenesis, endothelial cell responses to growth factors are modulated by the compositional and mechanical properties of a surrounding three-dimensional (3D) extracellular matrix (ECM) that is dominated by either cross-linked fibrin or type I collagen. While 3D-embedded endothelial cells es...

journal_title：Genes & development

authors： Zhou X,Rowe RG,Hiraoka N,George JP,Wirtz D,Mosher DF,Virtanen I,Chernousov MA,Weiss SJ

更新日期：2008-05-01 00:00:00

abstract：:A Drosophila FGF receptor homolog (DFGF-R2/DFRI) termed Heartless (Htl) is expressed in the embryonic mesoderm. The phenotypes of null mutant embryos demonstrated that Htl is a central player that is required for the development of several mesodermal lineages. No abnormalities in the primary specification of the mesod...

journal_title：Genes & development

authors： Beiman M,Shilo BZ,Volk T

更新日期：1996-12-01 00:00:00

abstract：:The product of the nuclear MRS2 gene, Mrs2p, is the only candidate splicing factor essential for all group II introns in mitochondria of the yeast Saccharomyces cerevisiae. It has been shown to be an integral protein of the inner mitochondrial membrane, structurally and functionally related to the bacterial CorA Mg(2+...

journal_title：Genes & development

authors： Gregan J,Kolisek M,Schweyen RJ

更新日期：2001-09-01 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) can trigger repressive chromatin, but how they recruit silencing factors remains unclear. In Schizosaccharomyces pombe, heterochromatin assembly on transcribed noncoding pericentromeric repeats requires both RNAi and RNAi-independent mechanisms. In Saccharomyces cerevisiae, which lacks a ...

journal_title：Genes & development

authors： Marina DB,Shankar S,Natarajan P,Finn KJ,Madhani HD

更新日期：2013-09-01 00:00:00

abstract：:Telomeres protect the ends of linear chromosomes from degradation and abnormal recombination events, and in vertebrates may be important in cellular senescence and cancer. However, very little is known about the structure of human telomeres. In this report we purify telomeres and analyze their termini. We show that fo...

journal_title：Genes & development

authors： Wright WE,Tesmer VM,Huffman KE,Levene SD,Shay JW

更新日期：1997-11-01 00:00:00

abstract：:The canoemisty1 (cnomis1) mutation was isolated by virtue of its severe rough eye phenotype from approximately 500 fly lines, each harboring a single autosomal insertion of a P element (Bm delta w). Excision of the P element generated a lethal, null allele, cnomis10, together with many revertants with normal eye morph...

journal_title：Genes & development

authors： Miyamoto H,Nihonmatsu I,Kondo S,Ueda R,Togashi S,Hirata K,Ikegami Y,Yamamoto D

更新日期：1995-03-01 00:00:00

abstract：:Antigenic stimulation of the B-cell receptor (BCR) is a central event in the immune response. In contrast, antigen bound to IgG negatively regulates signals from the BCR by cross-linking it to the inhibitory receptor FcgammaRIIB. Here we show that upon cross-linking of BCR or BCR with FcgammaRIIB, the rasGAP-associate...

journal_title：Genes & development

authors： Yamanashi Y,Tamura T,Kanamori T,Yamane H,Nariuchi H,Yamamoto T,Baltimore D

更新日期：2000-01-01 00:00:00

abstract：:Children with trisomy 21/Down syndrome (DS) are at high risk to develop acute megakaryoblastic leukemia (DS-AMKL) and the related transient leukemia (DS-TL). The factors on human chromosome 21 (Hsa21) that confer this predisposing effect, especially in synergy with consistently mutated transcription factor GATA1 (GATA...

journal_title：Genes & development

authors： Klusmann JH,Li Z,Böhmer K,Maroz A,Koch ML,Emmrich S,Godinho FJ,Orkin SH,Reinhardt D

更新日期：2010-03-01 00:00:00

abstract：:Glucose and glutamine serve as the two primary carbon sources in proliferating cells, and uptake of both nutrients is directed by growth factor signaling. Although either glucose or glutamine can potentially support mitochondrial tricarboxylic acid (TCA) cycle integrity and ATP production, we found that glucose depriv...

journal_title：Genes & development

authors： Wellen KE,Lu C,Mancuso A,Lemons JM,Ryczko M,Dennis JW,Rabinowitz JD,Coller HA,Thompson CB

更新日期：2010-12-15 00:00:00

abstract：:A recent study has shown that the dimeric form of the 50-kD DNA-binding subunit of the NF-kappa B transcription factor is commonly associated with two molecules of a 65-kD protein (p65) and that p65 appears to be required for inactivation of the p50 dimer by the inhibitory subunit I kappa B. Here, we provide evidence ...

journal_title：Genes & development

authors： Urban MB,Baeuerle PA

更新日期：1990-11-01 00:00:00

abstract：:Restricted expression of a mouse Vasa homolog gene (Mvh) expression is first detected in primordial germ cells (PGCs) after colonization of the genital ridges. Subsequently, Mvh is maintained until postmeiotic germ cells are formed. Here, we demonstrate that male mice homozygous for a targeted mutation of Mvh exhibit ...

journal_title：Genes & development

authors： Tanaka SS,Toyooka Y,Akasu R,Katoh-Fukui Y,Nakahara Y,Suzuki R,Yokoyama M,Noce T

更新日期：2000-04-01 00:00:00

abstract：:Although the transporter-like protein Patched (Ptc) is genetically implicated in reception of the extracellular Hedgehog (Hh) protein signal, a clear definition of the Hh receptor is complicated by the existence of additional Hh-binding proteins and, in Drosophila, by the lack of physical evidence for direct binding o...

journal_title：Genes & development

authors： Zheng X,Mann RK,Sever N,Beachy PA

更新日期：2010-01-01 00:00:00

abstract：:A novel cysteine-rich motif, named LIM, has been identified in the homeo box genes lin-11, Isl-1, and mec-3; the mec-3 and lin-11 genes determine cell lineages in Caenorhabditis elegans. We isolated LIM class homeo box genes from Xenopus laevis that are closely related to lin-11 and mec-3 in the LIM and homeo domains....

journal_title：Genes & development

authors： Taira M,Jamrich M,Good PJ,Dawid IB

更新日期：1992-03-01 00:00:00

abstract：:Eukaryotic RNAs with premature termination codons (PTCs) are eliminated by nonsense-mediated decay (NMD). While human nonsense RNA degradation can be initiated either by an endonucleolytic cleavage event near the PTC or through decapping, the individual contribution of these activities on endogenous substrates has rem...

journal_title：Genes & development

authors： Lykke-Andersen S,Chen Y,Ardal BR,Lilje B,Waage J,Sandelin A,Jensen TH

更新日期：2014-11-15 00:00:00

abstract：:Morphogenesis of the insect kidney, the Malpighian tubules, is controlled in Drosophila by a single large cell, the tip cell. It has been postulated that this cell sends out a mitogenic signal that induces the division of neighboring cells. The signal and the molecules that receive it have remained elusive. We show th...

journal_title：Genes & development

authors： Kerber B,Fellert S,Hoch M

更新日期：1998-06-15 00:00:00

abstract：:The subdivision of the Drosophila body into distinct terminal and central domains depends on the torso (tor) protein, a putative receptor tyrosine kinase that is active at both ends of the early embryo. We show that the tor protein is uniformly expressed along the surface membrane of early embryos despite its localize...

journal_title：Genes & development

authors： Casanova J,Struhl G

更新日期：1989-12-01 00:00:00

abstract：:The alternatively spliced exon EIIIB is regulated in a cell type-specific manner in the rat fibronectin gene. Splicing of EIIIB into fibronectin mRNA is dependent on sequences in the intron immediately downstream of EIIIB. We show that a short, highly repeated TGCATG motif in this intron is important for cell type-spe...

journal_title：Genes & development

authors： Huh GS,Hynes RO

更新日期：1994-07-01 00:00:00

abstract：:We have cloned four cyclin-B homologs from Saccharomyces cerevisiae, CLB1-CLB4, using the polymerase chain reaction and low stringency hybridization approaches. These genes form two classes based on sequence relatedness: CLB1 and CLB2 show highest homology to the Schizosaccharomyces pombe cyclin-B homolog cdc13 involv...

journal_title：Genes & development

authors： Richardson H,Lew DJ,Henze M,Sugimoto K,Reed SI

更新日期：1992-11-01 00:00:00

abstract：:The distal enhancer of the T-cell receptor (TCR) alpha chain gene has become a paradigm for studies of the assembly and activity of architectural enhancer complexes. Here we have reconstituted regulated TCR alpha enhancer activity in vitro on chromatin templates using purified T-cell transcription factors (LEF-1, AML1...

journal_title：Genes & development

authors： Mayall TP,Sheridan PL,Montminy MR,Jones KA

更新日期：1997-04-01 00:00:00