The Nf2 tumor suppressor gene product is essential for extraembryonic development immediately prior to gastrulation.

abstract：:Drosophila melanogaster neural-specific protein, ELAV, has been shown to regulate the neural-specific splicing of three genes: neuroglian (nrg), erect wing, and armadillo. Alternative splicing of the nrg transcript involves alternative inclusion of a 3'-terminal exon. Here, using a minigene reporter, we show that the ...

journal_title：Genes & development

authors： Lisbin MJ,Qiu J,White K

更新日期：2001-10-01 00:00:00

abstract：:Mammalian development requires effective mechanisms to repress genes whose expression would generate inappropriately specified cells. The Polycomb-repressive complex 1 (PRC1) family complexes are central to maintaining this repression. These include a set of canonical PRC1 complexes, each of which contains four core p...

journal_title：Genes & development

authors： Plys AJ,Davis CP,Kim J,Rizki G,Keenen MM,Marr SK,Kingston RE

更新日期：2019-07-01 00:00:00

abstract：:The essential splicing factor human UAP56 (hUAP56) is a DExD/H-box protein known to promote prespliceosome assembly. Here, using a series of hUAP56 mutants that are defective for ATP-binding, ATP hydrolysis, or dsRNA unwindase/helicase activity, we assess the relative contributions of these biochemical functions to pr...

journal_title：Genes & development

authors： Shen H,Zheng X,Shen J,Zhang L,Zhao R,Green MR

更新日期：2008-07-01 00:00:00

abstract：:The recombination-activating gene 1 (RAG1) and RAG2 proteins initiate V(D)J recombination, the process that assembles the B- and T-lymphocyte antigen receptor genes of jawed vertebrates. RAG1 and RAG2 are thought to have arisen from a transposable element, but the origins of this element are not understood. We show th...

journal_title：Genes & development

authors： Carmona LM,Fugmann SD,Schatz DG

更新日期：2016-04-15 00:00:00

abstract：:Transcription factor IIA has been shown to interact with the TATA-binding protein and to act early during preinitiation complex formation. The human factor is composed of three subunits (alpha, beta, gamma). A human cDNA clone encoding the largest subunit of TFIIA (alpha) was isolated. The recombinant alpha polypeptid...

journal_title：Genes & development

authors： Ma D,Watanabe H,Mermelstein F,Admon A,Oguri K,Sun X,Wada T,Imai T,Shiroya T,Reinberg D

更新日期：1993-11-01 00:00:00

abstract：:Calcineurin, a Ca2+/calmodulin dependent protein phosphatase, regulates Ca2+-dependent processes in a wide variety of cells. In the yeast, Saccharomyces cerevisiae, calcineurin effects Ca2+-dependent changes in gene expression through regulation of the Crz1p transcription factor. We show here that calcineurin dephosph...

journal_title：Genes & development

authors： Stathopoulos-Gerontides A,Guo JJ,Cyert MS

更新日期：1999-04-01 00:00:00

abstract：:The evolutionarily conserved checkpoint protein kinase, TOR (target of rapamycin), has emerged as a major effector of cell growth and proliferation via the regulation of protein synthesis. Work in the last decade clearly demonstrates that TOR controls protein synthesis through a stunning number of downstream targets. ...

journal_title：Genes & development

authors： Hay N,Sonenberg N

更新日期：2004-08-15 00:00:00

abstract：:Alternative polyadenylation (APA) is widespread in neuronal development and activity-mediated neural plasticity. However, the underlying molecular mechanisms are largely unknown. We used systematic genetic studies and genome-wide surveys of the transcriptional landscape to identify a context-dependent regulatory pathw...

journal_title：Genes & development

authors： Chen F,Zhou Y,Qi YB,Khivansara V,Li H,Chun SY,Kim JK,Fu XD,Jin Y

更新日期：2015-11-15 00:00:00

abstract：:How RNA-binding proteins recognize specific sets of target mRNAs remains poorly understood because current approaches depend primarily on sequence information. In this study, we demonstrate that specific recognition of messenger RNAs (mRNAs) by RNA-binding proteins requires the correct spatial positioning of these seq...

journal_title：Genes & development

authors： Patel VL,Mitra S,Harris R,Buxbaum AR,Lionnet T,Brenowitz M,Girvin M,Levy M,Almo SC,Singer RH,Chao JA

更新日期：2012-01-01 00:00:00

abstract：:eIF2B is a heteropentameric guanine-nucleotide exchange factor essential for protein synthesis initiation in eukaryotes. Its activity is inhibited in response to starvation or stress by phosphorylation of the alpha subunit of its substrate, translation initiation factor eIF2, resulting in reduced rates of translation ...

journal_title：Genes & development

authors： Pavitt GD,Ramaiah KV,Kimball SR,Hinnebusch AG

更新日期：1998-02-15 00:00:00

abstract：:In eubacteria, the ClpS adaptor has been proposed to be essential for degradation of N-end rule substrates by the AAA(+) protease ClpAP. To test this model, we assayed degradation of substrates bearing N-end rule sequences isolated in a genetic screen for efficient degradation tags. ClpS was not vital for degradation ...

journal_title：Genes & development

authors： Wang KH,Sauer RT,Baker TA

更新日期：2007-02-15 00:00:00

abstract：:We demonstrate here that the previously described bacterial promoter upstream element (UP element) consists of two distinct subsites, each of which, by itself, can bind the RNA polymerase holoenzyme alpha subunit carboxy-terminal domain (RNAP alphaCTD) and stimulate transcription. Using binding-site-selection experime...

journal_title：Genes & development

authors： Estrem ST,Ross W,Gaal T,Chen ZW,Niu W,Ebright RH,Gourse RL

更新日期：1999-08-15 00:00:00

abstract：:NF-E1, a DNA-binding protein that recognizes the general consensus motif WGATAR, is the first tissue-specific factor to be identified in erythroid cells. Using a probe from the murine GF-1 (NF-E1) cDNA clone, we isolated three homologous chicken cDNAs: One of these corresponds to an mRNA (NF-E1a) that is abundantly an...

journal_title：Genes & development

authors： Yamamoto M,Ko LJ,Leonard MW,Beug H,Orkin SH,Engel JD

更新日期：1990-10-01 00:00:00

abstract：:Establishment of the steroid-producing Leydig cell lineage is an event downstream of Sry that is critical for masculinization of mammalian embryos. Neither the origin of fetal Leydig cell precursors nor the signaling pathway that specifies the Leydig cell lineage is known. Based on the sex-specific expression patterns...

journal_title：Genes & development

authors： Yao HH,Whoriskey W,Capel B

更新日期：2002-06-01 00:00:00

abstract：:Cyclin B3 has been conserved during higher eukaryote evolution as evidenced by its identification in chicken, nematodes, and insects. We demonstrate that Cyclin B3 is present in addition to Cyclins A and B in mitotically proliferating cells and not detectable in endoreduplicating tissues of Drosophila embryos. Cyclin ...

journal_title：Genes & development

authors： Jacobs HW,Knoblich JA,Lehner CF

更新日期：1998-12-01 00:00:00

abstract：:Several previously known transcription cofactors have been demonstrated in vitro recently to be histone acetyltransferases and deacetyltransferases, suggesting that remodeling of chromatin through histone acetylation plays a fundamental role in gene regulation. Clear evidence has not yet been obtained, however, to dem...

journal_title：Genes & development

authors： Wang L,Liu L,Berger SL

更新日期：1998-03-01 00:00:00

abstract：:Oxidative tissues such as heart undergo a dramatic perinatal mitochondrial biogenesis to meet the high-energy demands after birth. PPARgamma coactivator-1 (PGC-1) alpha and beta have been implicated in the transcriptional control of cellular energy metabolism. Mice with combined deficiency of PGC-1alpha and PGC-1beta ...

journal_title：Genes & development

authors： Lai L,Leone TC,Zechner C,Schaeffer PJ,Kelly SM,Flanagan DP,Medeiros DM,Kovacs A,Kelly DP

更新日期：2008-07-15 00:00:00

abstract：:The Snail zinc-finger transcription factors trigger epithelial-mesenchymal transitions (EMTs), endowing epithelial cells with migratory and invasive properties during both embryonic development and tumor progression. During EMT, Snail provokes the loss of epithelial markers, as well as changes in cell shape and the ex...

journal_title：Genes & development

authors： Vega S,Morales AV,Ocaña OH,Valdés F,Fabregat I,Nieto MA

更新日期：2004-05-15 00:00:00

abstract：:Mutations in the CSA or CSB complementation genes cause the Cockayne syndrome, a severe genetic disorder that results in patients' death in early adulthood. CSA and CSB act in a transcription-coupled repair (TCR) pathway, but their functional relationship is not understood. We have previously shown that CSA is a subun...

journal_title：Genes & development

authors： Groisman R,Kuraoka I,Chevallier O,Gaye N,Magnaldo T,Tanaka K,Kisselev AF,Harel-Bellan A,Nakatani Y

更新日期：2006-06-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDA) develops predominantly through pancreatic intraepithelial neoplasia (PanIN) and intraductal papillary mucinous neoplasm (IPMN) precursor lesions. Pancreatic acinar cells are reprogrammed to a "ductal-like" state during PanIN-PDA formation. Here, we demonstrate a parallel mechanis...

journal_title：Genes & development

authors： Roy N,Malik S,Villanueva KE,Urano A,Lu X,Von Figura G,Seeley ES,Dawson DW,Collisson EA,Hebrok M

更新日期：2015-03-15 00:00:00

abstract：:All multisubunit DNA-dependent RNA polymerases (RNAP) are zinc metalloenzymes, and at least two zinc atoms are present per enzyme molecule. RNAP residues involved in zinc binding and the functional role of zinc ions in the transcription mechanism or RNAP structure are unknown. Here, we locate four cysteine residues in...

journal_title：Genes & development

authors： Markov D,Naryshkina T,Mustaev A,Severinov K

更新日期：1999-09-15 00:00:00

abstract：:RNA polymerase II nascent transcripts are capped during pausing before elongation. Here we report that hSPT5, the human homolog of yeast elongation factor SPT5, interacts directly with the capping enzyme. hSPT5 stimulated capping enzyme guanylylation and mRNA capping by severalfold. Although RNA 5'-triphosphatase acti...

journal_title：Genes & development

authors： Wen Y,Shatkin AJ

更新日期：1999-07-15 00:00:00

abstract：:Nonsense-mediated mRNA decay (NMD) is a quality control mechanism that detects and degrades mRNAs containing premature stop codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Degradation of PTC-containing mRNAs requires the endonucleolytic activity of SMG...

journal_title：Genes & development

authors： Kashima I,Jonas S,Jayachandran U,Buchwald G,Conti E,Lupas AN,Izaurralde E

更新日期：2010-11-01 00:00:00

abstract：:The structurally related POU homeo domain proteins Pit-1 and Oct-2 activate pituitary- and lymphoid-specific transcription, respectively, by binding to similar AT-rich motifs in their target genes. In this study we identify bases critical for recognition and activation by Pit-1 and examine how small differences in Pit...

journal_title：Genes & development

authors： Elsholtz HP,Albert VR,Treacy MN,Rosenfeld MG

更新日期：1990-01-01 00:00:00

abstract：:The superoxide radical (O(2)(-)) has long been considered a major cause of aging. O(2)(-) in cytosolic, extracellular, and mitochondrial pools is detoxified by dedicated superoxide dismutase (SOD) isoforms. We tested the impact of each SOD isoform in Caenorhabditis elegans by manipulating its five sod genes and saw no...

journal_title：Genes & development

authors： Doonan R,McElwee JJ,Matthijssens F,Walker GA,Houthoofd K,Back P,Matscheski A,Vanfleteren JR,Gems D

更新日期：2008-12-01 00:00:00

abstract：:The Rho family of small GTPases are critical elements involved in the regulation of signal transduction cascades from extracellular stimuli to the cell nucleus, including the JNK/SAPK signaling pathway, the c-fos serum response factor, and the p70 S6 kinase. Here we report a novel signaling pathway activated by the Rh...

journal_title：Genes & development

authors： Perona R,Montaner S,Saniger L,Sánchez-Pérez I,Bravo R,Lacal JC

更新日期：1997-02-15 00:00:00

abstract：:We have developed a new technique, called 'toeprinting,' which has allowed a study of the tRNA-binding properties of Escherichia coli translation initiation complexes. In response to natural mRNAs, the initiator tRNA and a variety of elongator tRNAs bind to the same tRNA-binding site on the 30S ribosomal subunit as lo...

journal_title：Genes & development

authors： Hartz D,McPheeters DS,Gold L

更新日期：1989-12-01 00:00:00

abstract：:Mutations that influence lin-12 activity in Caenorhabditis elegans may identify conserved factors that regulate the activity of lin-12/Notch proteins. We describe genetic evidence indicating that sel-10 is a negative regulator of lin-12/Notch-mediated signaling in C. elegans. Sequence analysis shows that SEL-10 is a m...

journal_title：Genes & development

authors： Hubbard EJ,Wu G,Kitajewski J,Greenwald I

更新日期：1997-12-01 00:00:00

abstract：:RBP is a cellular protein that functions as a transcriptional repressor in mammalian cells. RBP has elicited great interest lately because of its established roles in regulating gene expression, in Drosophila and mouse development, and as a component of the Notch signal transduction pathway. This report focuses on the...

journal_title：Genes & development

authors： Olave I,Reinberg D,Vales LD

更新日期：1998-06-01 00:00:00

abstract：:The spectrum of tumors associated with oncogenic Ras in humans often differs from those in mice either treated with carcinogens or engineered to sporadically express oncogenic Ras, suggesting that the mechanism of Ras transformation may be different in humans. Ras stimulates primarily three main classes of effector pr...

journal_title：Genes & development

authors： Hamad NM,Elconin JH,Karnoub AE,Bai W,Rich JN,Abraham RT,Der CJ,Counter CM

更新日期：2002-08-15 00:00:00