当前位置： SCI文献检索 > GENES & DEVELOPMENT期刊下所有文献 > Activity and tissue-specific expression of the transcription factor NF-E1 multigene family.

Activity and tissue-specific expression of the transcription factor NF-E1 multigene family.

Abstract：

:NF-E1, a DNA-binding protein that recognizes the general consensus motif WGATAR, is the first tissue-specific factor to be identified in erythroid cells. Using a probe from the murine GF-1 (NF-E1) cDNA clone, we isolated three homologous chicken cDNAs: One of these corresponds to an mRNA (NF-E1a) that is abundantly and exclusively expressed in erythroid cells; a second mRNA (NF-E1b) is also expressed in all developmental stages of erythroid cells but is additionally found in a limited subset of other chicken tissues; mRNA representative of a third gene (NF-E1c) is expressed only in definitive (adult) erythrocytes within the red cell lineage but is also abundantly expressed in T lymphocytes and brain. All NF-E1 proteins are highly conserved within the DNA-binding domain and bind to the consensus motif with similar affinities in vitro; they are also all stimulatory trans-acting factors in vivo. The factors differ quantitatively in their ability to trans-activate reporter genes in which the number and position of cognate binding sites is varied relative to the transcriptional initiation site. These data suggest that the NF-E1 consensus motif directs a broader and more complicated array of developmental transcriptional regulatory processes than has been assumed and that NF-E1c may play a unique regulatory role in the developing chicken brain and in T lymphocytes.

journal_name

Genes Dev

journal_title

Genes & development

authors

Yamamoto M,Ko LJ,Leonard MW,Beug H,Orkin SH,Engel JD

doi

10.1101/gad.4.10.1650

subject

Has Abstract

pub_date

1990-10-01 00:00:00

pages

1650-62

issue

10

eissn

0890-9369

issn

1549-5477

journal_volume

4

pub_type

杂志文章

相关文献

GENES & DEVELOPMENT文献大全
  • Transabdominal, a dominant mutant of the Bithorax Complex, produces a sexually dimorphic segmental transformation in Drosophila.

    abstract：:Transabdominal (Tab), a dominant mutation in the Bithorax Complex (BX-C) of Drosophila, creates a sexually dimorphic pattern of segmental transformation that has complete penetrance and expressivity. Specific regions within the notum of the second thoracic segment (T2) are transformed into abdominal-like cuticle; thus...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.1.2.111

    authors： Celniker SE,Lewis EB

    更新日期：1987-04-01 00:00:00

  • TFIID can be rate limiting in vivo for TATA-containing, but not TATA-lacking, RNA polymerase II promoters.

    abstract：:We have studied the effect of exogenous expression of the basal transcription factor TFIID on the activities of several different TATA-containing and TATA-lacking promoters. Overexpression of TFIID from a transfected plasmid in Drosophila Schneider cells resulted in substantial concentration-dependent increases in exp...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.6.2.304

    authors： Colgan J,Manley JL

    更新日期：1992-02-01 00:00:00

  • The hematopoietic stem cell and its niche: a comparative view.

    abstract：:Stem cells have been identified as a source of virtually all highly differentiated cells that are replenished during the lifetime of an animal. The critical balance between stem and differentiated cell populations is crucial for the long-term maintenance of functional tissue types. Stem cells maintain this balance by ...

    journal_title：Genes & development

    pub_type： 杂志文章,评审

    doi：10.1101/gad.1602607

    authors： Martinez-Agosto JA,Mikkola HK,Hartenstein V,Banerjee U

    更新日期：2007-12-01 00:00:00

  • Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10.

    abstract：:Sox10 is a high-mobility-group transcriptional regulator in early neural crest. Without Sox10, no glia develop throughout the peripheral nervous system. Here we show that Sox10 is restricted in the central nervous system to myelin-forming oligodendroglia. In Sox10-deficient mice progenitors develop, but terminal diffe...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.215802

    authors： Stolt CC,Rehberg S,Ader M,Lommes P,Riethmacher D,Schachner M,Bartsch U,Wegner M

    更新日期：2002-01-15 00:00:00

  • The role of histone H2Av variant replacement and histone H4 acetylation in the establishment of Drosophila heterochromatin.

    abstract：:Activation and repression of transcription in eukaryotes involve changes in the chromatin fiber that can be accomplished by covalent modification of the histone tails or the replacement of the canonical histones with other variants. Here we show that the histone H2A variant of Drosophila melanogaster, H2Av, localizes ...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.1259105

    authors： Swaminathan J,Baxter EM,Corces VG

    更新日期：2005-01-01 00:00:00

  • Tissue-specific expression of the gene encoding hepatocyte nuclear factor 1 may involve hepatocyte nuclear factor 4.

    abstract：:Hepatocyte nuclear factor 1 (HNF-1) is a transcriptional regulatory protein possibly involved in the activation of many liver-specifically expressed genes. HNF-1 mRNA is restricted to a small number of tissues, suggesting that the HNF-1 gene itself is regulated at the transcriptional level. We have isolated and charac...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.5.12a.2225

    authors： Tian JM,Schibler U

    更新日期：1991-12-01 00:00:00

  • DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly.

    abstract：:In the absence of growth signals, cells exit the cell cycle and enter into G0 or quiescence. Alternatively, cells enter senescence in response to inappropriate growth signals such as oncogene expression. The molecular mechanisms required for cell cycle exit into quiescence or senescence are poorly understood. The DREA...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.2034211

    authors： Litovchick L,Florens LA,Swanson SK,Washburn MP,DeCaprio JA

    更新日期：2011-04-15 00:00:00

  • Suprabasal expression of a dominant-negative RXR alpha mutant in transgenic mouse epidermis impairs regulation of gene transcription and basal keratinocyte proliferation by RAR-selective retinoids.

    abstract：:To determine whether 9-cis retinoic acid receptors (RXRs) regulate the biological activity of all-trans retinoic acid (tRA) and its receptors (RARs) in skin, we have targeted a dominant-negative RXR alpha (dnRXR alpha) lacking transactivation function AF-2 to differentiated suprabasal keratinocytes in the epidermis of...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.11.1.59

    authors： Feng X,Peng ZH,Di W,Li XY,Rochette-Egly C,Chambon P,Voorhees JJ,Xiao JH

    更新日期：1997-01-01 00:00:00

  • SR proteins are NXF1 adaptors that link alternative RNA processing to mRNA export.

    abstract：:Nuclear export factor 1 (NXF1) exports mRNA to the cytoplasm after recruitment to mRNA by specific adaptor proteins. How and why cells use numerous different export adaptors is poorly understood. Here we critically evaluate members of the SR protein family (SRSF1-7) for their potential to act as NXF1 adaptors that cou...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.276477.115

    authors： Müller-McNicoll M,Botti V,de Jesus Domingues AM,Brandl H,Schwich OD,Steiner MC,Curk T,Poser I,Zarnack K,Neugebauer KM

    更新日期：2016-03-01 00:00:00

  • TFIIIC determines RNA polymerase III specificity at the TATA-containing yeast U6 promoter.

    abstract：:The gene encoding yeast U6 snRNA that is transcribed by RNA polymerase III (Pol III) contains both a TATA box upstream of the transcription start site and a downstream binding site for the factor TFIIIC. This juxtaposition of elements typical of both Pol II- and Pol III-transcribed genes raises the question of how pol...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.9.7.832

    authors： Roberts S,Colbert T,Hahn S

    更新日期：1995-04-01 00:00:00

  • UPF1 helicase promotes TSN-mediated miRNA decay.

    abstract：:While microRNAs (miRNAs) regulate the vast majority of protein-encoding transcripts, little is known about how miRNAs themselves are degraded. We recently described Tudor-staphylococcal/micrococcal-like nuclease (TSN)-mediated miRNA decay (TumiD) as a cellular pathway in which the nuclease TSN promotes the decay of mi...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.303537.117

    authors： Elbarbary RA,Miyoshi K,Hedaya O,Myers JR,Maquat LE

    更新日期：2017-07-15 00:00:00

  • Novel role for a bacterial nucleoid protein in translation of mRNAs with suboptimal ribosome-binding sites.

    abstract：:In Escherichia coli, the major nucleoid protein H-NS limits transcription by acting as a repressor or transcriptional silencer, presumably by its ability to close the looped chromosome domains in the nucleoid through DNA-protein-DNA bridging. Here, we demonstrate the direct involvement of H-NS as a positive factor sti...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.576310

    authors： Park HS,Ostberg Y,Johansson J,Wagner EG,Uhlin BE

    更新日期：2010-07-01 00:00:00

  • Mesp2: a novel mouse gene expressed in the presegmented mesoderm and essential for segmentation initiation.

    abstract：:We isolated a novel bHLH protein gene Mesp2 (for mesoderm posterior 2) that cross-hybridizes with Mesp1 expressed in the early mouse mesoderm. Mesp2 is expressed in the rostral presomitic mesoderm, but down-regulated immediately after the formation of the segmented somites. To determine the function of MesP2 protein (...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.11.14.1827

    authors： Saga Y,Hata N,Koseki H,Taketo MM

    更新日期：1997-07-15 00:00:00

  • Identification of a localized nonsense-mediated decay pathway at the endoplasmic reticulum.

    abstract：:Nonsense-mediated decay (NMD) is a translation-dependent RNA quality control mechanism that occurs in the cytoplasm. However, it is unknown how NMD regulates the stability of RNAs translated at the endoplasmic reticulum (ER). Here, we identify a localized NMD pathway dedicated to ER-translated mRNAs. We previously ide...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.338061.120

    authors： Longman D,Jackson-Jones KA,Maslon MM,Murphy LC,Young RS,Stoddart JJ,Hug N,Taylor MS,Papadopoulos DK,Cáceres JF

    更新日期：2020-08-01 00:00:00

  • The role of a Williams-Beuren syndrome-associated helix-loop-helix domain-containing transcription factor in activin/nodal signaling.

    abstract：:We investigated the regulation of the activin/nodal-inducible distal element (DE) of the Xenopus goosecoid (gsc) promoter. On the basis of its interaction with the DE, we isolated a Xenopus homolog of the human Williams-Beuren syndrome critical region 11 (XWBSCR11), and further, show that it interacts with pathway-spe...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.963802

    authors： Ring C,Ogata S,Meek L,Song J,Ohta T,Miyazono K,Cho KW

    更新日期：2002-04-01 00:00:00

  • Intronic sequence elements impede exon ligation and trigger a discard pathway that yields functional telomerase RNA in fission yeast.

    abstract：:The fission yeast telomerase RNA (TER1) precursor harbors an intron immediately downstream from its mature 3' end. Unlike most introns, which are removed from precursor RNAs by the spliceosome in two sequential but tightly coupled transesterification reactions, TER1 only undergoes the first cleavage reaction during te...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.212738.112

    authors： Kannan R,Hartnett S,Voelker RB,Berglund JA,Staley JP,Baumann P

    更新日期：2013-03-15 00:00:00

  • Ste20-like protein kinases are required for normal localization of cell growth and for cytokinesis in budding yeast.

    abstract：:The yeast Ste20 protein kinase is involved in pheromone response. Mammalian homologs of Ste20 exist, but their function remains unknown. We identified a novel yeast STE20 homolog, CLA4, in a screen for mutations lethal in the absence of the G1 cyclins Cln1 and Cln2. Cla4 is involved in budding and cytokinesis and inte...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.9.15.1817

    authors： Cvrcková F,De Virgilio C,Manser E,Pringle JR,Nasmyth K

    更新日期：1995-08-01 00:00:00

  • Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells.

    abstract：:Growth of numerous cancer types is believed to be driven by a subpopulation of poorly differentiated cells, often referred to as cancer stem cells (CSCs), that have the capacity for self-renewal, tumor initiation, and generation of nontumorigenic progeny. Despite their potentially key role in tumor establishment and m...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.188292.112

    authors： Janiszewska M,Suvà ML,Riggi N,Houtkooper RH,Auwerx J,Clément-Schatlo V,Radovanovic I,Rheinbay E,Provero P,Stamenkovic I

    更新日期：2012-09-01 00:00:00

  • Direct regulation of nacre, a zebrafish MITF homolog required for pigment cell formation, by the Wnt pathway.

    abstract：:We have shown that Wnt signals are necessary and sufficient for neural crest cells to adopt pigment cell fates. nacre, a zebrafish homolog of MITF, is required for pigment cell differentiation. We isolated a promoter region of nacre that contains Tcf/Lef binding sites, which can mediate Wnt responsiveness. This promot...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：

    authors： Dorsky RI,Raible DW,Moon RT

    更新日期：2000-01-15 00:00:00

  • APC sets the Wnt tone necessary for cerebral cortical progenitor development.

    abstract：:Adenomatous polyposis coli (APC) regulates the activity of β-catenin, an integral component of Wnt signaling. However, the selective role of the APC-β-catenin pathway in cerebral cortical development is unknown. Here we genetically dissected the relative contributions of APC-regulated β-catenin signaling in cortical p...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.302679.117

    authors： Nakagawa N,Li J,Yabuno-Nakagawa K,Eom TY,Cowles M,Mapp T,Taylor R,Anton ES

    更新日期：2017-08-15 00:00:00

  • A variant limb deformity transcript expressed in the embryonic mouse limb defines a novel formin.

    abstract：:The formins constitute a set of protein isoforms encoded by the alternatively spliced transcripts arising from the limb deformity (ld) locus of the mouse. Mutations in this locus disrupt formation of the anteroposterior axis of the embryonic limb. Although ld transcripts are widely expressed during embryogenesis, we h...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.6.1.29

    authors： Jackson-Grusby L,Kuo A,Leder P

    更新日期：1992-01-01 00:00:00

  • TBP, Mot1, and NC2 establish a regulatory circuit that controls DPE-dependent versus TATA-dependent transcription.

    abstract：:The RNA polymerase II core promoter is a structurally and functionally diverse transcriptional module. RNAi depletion and overexpression experiments revealed a genetic circuit that controls the balance of transcription from two core promoter motifs, the TATA box and the downstream core promoter element (DPE). In this ...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.1681808

    authors： Hsu JY,Juven-Gershon T,Marr MT 2nd,Wright KJ,Tjian R,Kadonaga JT

    更新日期：2008-09-01 00:00:00

  • A subtilisin-like serine protease involved in the regulation of stomatal density and distribution in Arabidopsis thaliana.

    abstract：:Stomata are specialized cellular structures in the epidermis of aerial plant organs that control gas exchange (H(2)O release and CO(2) uptake) between leaves and the atmosphere by modulating the aperture of a pore flanked by two guard cells. Stomata are nonrandomly distributed, and their density is controlled by endog...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：

    authors： Berger D,Altmann T

    更新日期：2000-05-01 00:00:00

  • Tango7 directs cellular remodeling by the Drosophila apoptosome.

    abstract：:It is now well appreciated that the apoptosome, which governs caspase-dependent cell death, also drives nonapoptotic caspase activation to remodel cells. However, the determinants that specify whether the apoptosome acts to kill or remodel have yet to be identified. Here we report that Tango7 collaborates with the Dro...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.219287.113

    authors： D'Brot A,Chen P,Vaishnav M,Yuan S,Akey CW,Abrams JM

    更新日期：2013-08-01 00:00:00

  • Tel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break.

    abstract：:The kinases ATM and ATR (Tel1 and Mec1 in the yeast Saccharomyces cerevisiae) control the response to DNA damage. We report that S. cerevisiae Tel2 acts at an early step of the TEL1/ATM pathway of DNA damage signaling. We show that Tel1 and Tel2 interact, and that even when Tel1 protein levels are high, this interacti...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.1646208

    authors： Anderson CM,Korkin D,Smith DL,Makovets S,Seidel JJ,Sali A,Blackburn EH

    更新日期：2008-04-01 00:00:00

  • Integrative genome analysis of somatic p53 mutant osteosarcomas identifies Ets2-dependent regulation of small nucleolar RNAs by mutant p53 protein.

    abstract：:TP53 is the most frequently mutated gene in human cancer. Many mutant p53 proteins exert oncogenic gain-of-function (GOF) properties that contribute to metastasis, but the mechanisms mediating these functions remain poorly defined in vivo. To elucidate how mutant p53 GOF drives metastasis, we developed a traceable som...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.304972.117

    authors： Pourebrahim R,Zhang Y,Liu B,Gao R,Xiong S,Lin PP,McArthur MJ,Ostrowski MC,Lozano G

    更新日期：2017-09-15 00:00:00

  • A nucleolar mechanism controlling cell proliferation in stem cells and cancer cells.

    abstract：:The unique property of stem cells to self-renew suggests specific mechanisms that regulate their cell-cycle progression. In the present study, we identify a novel protein, nucleostemin, found in the nucleoli of CNS stem cells, embryonic stem cells, and several cancer cell lines and preferentially expressed by other st...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.55671

    authors： Tsai RY,McKay RD

    更新日期：2002-12-01 00:00:00

  • A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability.

    abstract：:In response to DNA damage, cells activate a complex signal transduction network called the DNA damage response (DDR). To enhance our current understanding of the DDR network, we performed a genome-wide RNAi screen to identify genes required for resistance to ionizing radiation (IR). Along with a number of known DDR ge...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.1934210

    authors： Hurov KE,Cotta-Ramusino C,Elledge SJ

    更新日期：2010-09-01 00:00:00

  • Inactivation of AtRac1 by abscisic acid is essential for stomatal closure.

    abstract：:Plant water homeostasis is maintained by the phytohormone abscisic acid (ABA), which triggers stomatal pore closure in response to drought stress. We identified the Arabidopsis small guanosine triphosphatase (GTPase) protein AtRac1 as a central component in the ABA-mediated stomatal closure process. ABA treatment indu...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.900401

    authors： Lemichez E,Wu Y,Sanchez JP,Mettouchi A,Mathur J,Chua NH

    更新日期：2001-07-15 00:00:00

  • sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins.

    abstract：:Mutations that influence lin-12 activity in Caenorhabditis elegans may identify conserved factors that regulate the activity of lin-12/Notch proteins. We describe genetic evidence indicating that sel-10 is a negative regulator of lin-12/Notch-mediated signaling in C. elegans. Sequence analysis shows that SEL-10 is a m...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.11.23.3182

    authors： Hubbard EJ,Wu G,Kitajewski J,Greenwald I

    更新日期：1997-12-01 00:00:00