TBP, Mot1, and NC2 establish a regulatory circuit that controls DPE-dependent versus TATA-dependent transcription.

Abstract:

:The RNA polymerase II core promoter is a structurally and functionally diverse transcriptional module. RNAi depletion and overexpression experiments revealed a genetic circuit that controls the balance of transcription from two core promoter motifs, the TATA box and the downstream core promoter element (DPE). In this circuit, TBP activates TATA-dependent transcription and represses DPE-dependent transcription, whereas Mot1 and NC2 block TBP function and thus repress TATA-dependent transcription and activate DPE-dependent transcription. This regulatory circuit is likely to be one means by which biological networks can transmit transcriptional signals, such as those from DPE-specific and TATA-specific enhancers, via distinct pathways.

journal_name

Genes Dev

journal_title

Genes & development

authors

Hsu JY,Juven-Gershon T,Marr MT 2nd,Wright KJ,Tjian R,Kadonaga JT

doi

10.1101/gad.1681808

subject

Has Abstract

pub_date

2008-09-01 00:00:00

pages

2353-8

issue

17

eissn

0890-9369

issn

1549-5477

pii

gad.1681808

journal_volume

22

pub_type

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