Abstract:
:The RNA polymerase II core promoter is a structurally and functionally diverse transcriptional module. RNAi depletion and overexpression experiments revealed a genetic circuit that controls the balance of transcription from two core promoter motifs, the TATA box and the downstream core promoter element (DPE). In this circuit, TBP activates TATA-dependent transcription and represses DPE-dependent transcription, whereas Mot1 and NC2 block TBP function and thus repress TATA-dependent transcription and activate DPE-dependent transcription. This regulatory circuit is likely to be one means by which biological networks can transmit transcriptional signals, such as those from DPE-specific and TATA-specific enhancers, via distinct pathways.
journal_name
Genes Devjournal_title
Genes & developmentauthors
Hsu JY,Juven-Gershon T,Marr MT 2nd,Wright KJ,Tjian R,Kadonaga JTdoi
10.1101/gad.1681808subject
Has Abstractpub_date
2008-09-01 00:00:00pages
2353-8issue
17eissn
0890-9369issn
1549-5477pii
gad.1681808journal_volume
22pub_type
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journal_title:Genes & development
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journal_title:Genes & development
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journal_title:Genes & development
pub_type: 杂志文章
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更新日期:2005-08-15 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
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更新日期:2003-05-15 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
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更新日期:2007-04-01 00:00:00
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journal_title:Genes & development
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journal_title:Genes & development
pub_type: 杂志文章
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更新日期:2018-04-01 00:00:00
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journal_title:Genes & development
pub_type: 评论,杂志文章
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更新日期:1996-05-01 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
doi:10.1101/gad.304261.117
更新日期:2017-10-01 00:00:00
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journal_title:Genes & development
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journal_title:Genes & development
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journal_title:Genes & development
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journal_title:Genes & development
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