H3.3 actively marks enhancers and primes gene transcription via opening higher-ordered chromatin.

abstract：:A powerful enhancer has been mapped to an 18-bp DNA segment located 11 kb 5' to the human epsilon-globin gene within the dominant control or locus-activating region. This enhancer is inducible in K562 human erythroleukemia cells, increasing linked gamma-globin promoter/luciferase gene expression to 170-fold over an en...

journal_title：Genes & development

authors： Ney PA,Sorrentino BP,McDonagh KT,Nienhuis AW

更新日期：1990-06-01 00:00:00

abstract：:Genomic imprinting is an epigenetic mechanism by which genes are expressed in a parental origin-dependent manner. We recently discovered that, like DNA methylation, oocyte-inherited H3K27me3 can also serve as an imprinting mark in mouse preimplantation embryos. In this study, we found H3K27me3 is strongly biased towar...

journal_title：Genes & development

authors： Zhang W,Chen Z,Yin Q,Zhang D,Racowsky C,Zhang Y

更新日期：2019-04-01 00:00:00

abstract：:Multiple congenital disorders often present complex phenotypes, but how the mutation of individual genetic factors can lead to multiple defects remains poorly understood. In the present study, we used human neuroepithelial (NE) cells and CHARGE patient-derived cells as an in vitro model system to identify the function...

journal_title：Genes & development

authors： Chai M,Sanosaka T,Okuno H,Zhou Z,Koya I,Banno S,Andoh-Noda T,Tabata Y,Shimamura R,Hayashi T,Ebisawa M,Sasagawa Y,Nikaido I,Okano H,Kohyama J

更新日期：2018-01-15 00:00:00

abstract：:It is postulated that the symmetric organization of plant lateral organs is based on two crossed axes, the abaxial-adaxial and the lateral axes. The PRESSED FLOWER (PRS) gene, the expression and function of which are dependent on the lateral axis, is reported in this study. In the prs mutant, growth of the lateral sep...

journal_title：Genes & development

authors： Matsumoto N,Okada K

更新日期：2001-12-15 00:00:00

abstract：:The acetylation state of histones plays a central role in determining gene expression in chromatin. The reestablishment of the acetylation state of nucleosomes after DNA replication and chromatin assembly requires both deacetylation and acetylation of specific lysine residues on newly incorporated histones. In this st...

journal_title：Genes & development

authors： Meijsing SH,Ehrenhofer-Murray AE

更新日期：2001-12-01 00:00:00

abstract：:Janus kinase 2 (JAK2) is a central kinase in hematopoietic stem/progenitor cells (HSPCs), and its uncontrolled activation is a prominent oncogenic driver of hematopoietic neoplasms. However, molecular mechanisms underlying the regulation of JAK2 have remained elusive. Here we report that the Casitas B-cell lymphoma (C...

journal_title：Genes & development

authors： Lv K,Jiang J,Donaghy R,Riling CR,Cheng Y,Chandra V,Rozenova K,An W,Mohapatra BC,Goetz BT,Pillai V,Han X,Todd EA,Jeschke GR,Langdon WY,Kumar S,Hexner EO,Band H,Tong W

更新日期：2017-05-15 00:00:00

abstract：:Gene silencing by double-stranded RNA is a widespread phenomenon called RNAi, involving homology-dependent degradation of mRNAs. Here we show that RNAi is established in the Drosophila female germ line. mRNA transcripts are translationally quiescent at the arrested oocyte stage and are insensitive to RNAi. Upon oocyte...

journal_title：Genes & development

authors： Kennerdell JR,Yamaguchi S,Carthew RW

更新日期：2002-08-01 00:00:00

abstract：:Tuberous sclerosis (TSC) is an autosomal dominant disease characterized by hamartoma formation in various organs and is caused by mutations targeting either the TSC1 or TSC2 genes. TSC1 and TSC2 proteins form a functionally interdependent dimeric complex. Phosphorylation of either TSC subunit by different kinases regu...

journal_title：Genes & development

authors： Hu J,Zacharek S,He YJ,Lee H,Shumway S,Duronio RJ,Xiong Y

更新日期：2008-04-01 00:00:00

abstract：:The subdivision of the lateral mesoderm into a visceral (splanchnic) and a somatic layer is a crucial event during early mesoderm development in both arthropod and vertebrate embryos. In Drosophila, this subdivision leads to the differential development of gut musculature versus body wall musculature. Here we report t...

journal_title：Genes & development

authors： Zaffran S,Küchler A,Lee HH,Frasch M

更新日期：2001-11-01 00:00:00

abstract：:In response to DNA damage, cells activate a complex signal transduction network called the DNA damage response (DDR). To enhance our current understanding of the DDR network, we performed a genome-wide RNAi screen to identify genes required for resistance to ionizing radiation (IR). Along with a number of known DDR ge...

journal_title：Genes & development

authors： Hurov KE,Cotta-Ramusino C,Elledge SJ

更新日期：2010-09-01 00:00:00

abstract：:Two broad gene classes are distinguished within multicellular organisms: cell type-specific genes, which confer particular cellular properties, and ubiquitous genes that support general cellular functions. However, certain so-called ubiquitous genes show functionally relevant cell type-specific repression. How such re...

journal_title：Genes & development

authors： Drexel T,Mahofsky K,Latham R,Zimmer M,Cochella L

更新日期：2016-09-15 00:00:00

abstract：:A major class of bacterial small RNAs (sRNAs), along with RNA-binding protein Hfq and endoribonuclease RNase E, acts on target mRNAs through base-pairing, leading to translational repression and rapid degradation of the mRNAs. In this issue of Genes & Development, Prévost and colleagues (pp. 385-396) demonstrate by us...

journal_title：Genes & development

authors： Morita T,Aiba H

更新日期：2011-02-15 00:00:00

abstract：:Motor axons make synaptic connections with specific muscles, and this specificity unfolds during development as motoneuron growth cones make specific pathway choices and ultimately recognize and synapse on their specific muscle targets. The Drosophila clueless mutation was identified previously in a genetic screen for...

journal_title：Genes & development

authors： Hu S,Fambrough D,Atashi JR,Goodman CS,Crews ST

更新日期：1995-12-01 00:00:00

abstract：:Cellular senescence limits proliferation of potentially detrimental cells, preventing tumorigenesis and restricting tissue damage. However, the function of senescence in nonpathological conditions is unknown. We found that the human placental syncytiotrophoblast exhibited the phenotype and expressed molecular markers ...

journal_title：Genes & development

authors： Chuprin A,Gal H,Biron-Shental T,Biran A,Amiel A,Rozenblatt S,Krizhanovsky V

更新日期：2013-11-01 00:00:00

abstract：:Genomic imprinting is an epigenetic process regulated by germline-derived DNA methylation, causing parental origin-specific monoallelic gene expression. Zinc finger protein 57 (ZFP57) is critical for maintenance of this epigenetic memory during post-fertilization reprogramming, yet incomplete penetrance of ZFP57 mutat...

journal_title：Genes & development

authors： Takahashi N,Coluccio A,Thorball CW,Planet E,Shi H,Offner S,Turelli P,Imbeault M,Ferguson-Smith AC,Trono D

更新日期：2019-01-01 00:00:00

abstract：:Two retrovirus promoter trap vectors (U3His and U3Neo) have been used to disrupt genes expressed in totipotent murine embryonal stem (ES) cells. Selection in L-histidinol or G418 produced clones in which the coding sequences for histidinol-dehydrogenase or neomycin-phosphotransferase were fused to sequences in or near...

journal_title：Genes & development

authors： von Melchner H,DeGregori JV,Rayburn H,Reddy S,Friedel C,Ruley HE

更新日期：1992-06-01 00:00:00

abstract：:Eph receptors and ephrin ligands are key players in many developmental processes including embryo patterning, angiogenesis, and axon guidance. Eph/ephrin interactions lead to the generation of a bidirectional signal, in which both the Eph receptors and the ephrins activate downstream signaling cascades simultaneously....

journal_title：Genes & development

authors： Davy A,Aubin J,Soriano P

更新日期：2004-03-01 00:00:00

abstract：:MCM1 is an essential yeast DNA-binding protein that affects both minichromosome maintenance, in a manner suggesting that it has DNA replication initiation function, and gene expression. It activates alpha-specific genes together with MAT alpha 1, and represses a-specific genes together with MAT alpha 2. Alone, MCM1 ca...

journal_title：Genes & development

authors： Christ C,Tye BK

更新日期：1991-05-01 00:00:00

abstract：:We characterized a gene, extradenticle, which seems to interact with a specific subset of Drosophila homeo domain proteins, possibly affecting their target specificity. This interpretation is based on an examination of the zygotic and maternal effect phenotypes of extradenticle mutations. In embryos with reduced level...

journal_title：Genes & development

authors： Peifer M,Wieschaus E

更新日期：1990-07-01 00:00:00

abstract：:U6 small nuclear RNA is one of the spliceosomal RNAs involved in pre-mRNA splicing. In the fission yeast Schizosaccharomyces pombe, the U6 RNA gene was found to have an intron similar to a nuclear pre-mRNA intron, and it was proposed that the U6 intron might be inserted erroneously during pre-mRNA splicing. Using the ...

journal_title：Genes & development

authors： Tani T,Ohshima Y

更新日期：1991-06-01 00:00:00

abstract：:A long-standing model postulates that X-chromosome dosage compensation in Drosophila occurs by twofold up-regulation of the single male X, but previous data cannot exclude an alternative model, in which male autosomes are down-regulated to balance gene expression. To distinguish between the two models, we used RNA int...

journal_title：Genes & development

authors： Hamada FN,Park PJ,Gordadze PR,Kuroda MI

更新日期：2005-10-01 00:00:00

abstract：:Members of the metazoan nuclear receptor superfamily regulate gene expression programs in response to binding of cognate lipophilic ligands. Evolutionary studies using bioinformatics tools have concluded that lower eukaryotes, such as fungi, lack nuclear receptor homologs. Here we review recent discoveries suggesting ...

journal_title：Genes & development

authors： Näär AM,Thakur JK

更新日期：2009-02-15 00:00:00

abstract：:Macrophage activation by the proinflammatory cytokine interferon-gamma (IFN-gamma) is a critical component of the host innate response to bacterial pathogenesis. However, the precise nature of the IFN-gamma-induced activation pathway is not known. Here we show using genome-wide expression and chromatin-binding profili...

journal_title：Genes & development

authors： Sonoda J,Laganière J,Mehl IR,Barish GD,Chong LW,Li X,Scheffler IE,Mock DC,Bataille AR,Robert F,Lee CH,Giguère V,Evans RM

更新日期：2007-08-01 00:00:00

abstract：:Long understood as a bona fide tumor suppressor that safeguards the integrity of the genome via regulating numerous cellular outcomes, p53 may also exert its decisive and versatile functions by controlling DNA methylation. In this issue of Genes & Development, Tovy and colleagues (pp. 959-972) report that, in naïve mo...

journal_title：Genes & development

authors： Laptenko O,Prives C

更新日期：2017-05-15 00:00:00

abstract：:Sox10 is a high-mobility-group transcriptional regulator in early neural crest. Without Sox10, no glia develop throughout the peripheral nervous system. Here we show that Sox10 is restricted in the central nervous system to myelin-forming oligodendroglia. In Sox10-deficient mice progenitors develop, but terminal diffe...

journal_title：Genes & development

authors： Stolt CC,Rehberg S,Ader M,Lommes P,Riethmacher D,Schachner M,Bartsch U,Wegner M

更新日期：2002-01-15 00:00:00

abstract：:Antigenic stimulation of the B-cell receptor (BCR) is a central event in the immune response. In contrast, antigen bound to IgG negatively regulates signals from the BCR by cross-linking it to the inhibitory receptor FcgammaRIIB. Here we show that upon cross-linking of BCR or BCR with FcgammaRIIB, the rasGAP-associate...

journal_title：Genes & development

authors： Yamanashi Y,Tamura T,Kanamori T,Yamane H,Nariuchi H,Yamamoto T,Baltimore D

更新日期：2000-01-01 00:00:00

abstract：:Somitogenesis involves the segmentation of the paraxial mesoderm into units along the anteroposterior axis. Here we show a role for Eph and ephrin signaling in the patterning of presomitic mesoderm and formation of the somites. Ephrin-A-L1 and ephrin-B2 are expressed in an iterative manner in the developing somites an...

journal_title：Genes & development

authors： Durbin L,Brennan C,Shiomi K,Cooke J,Barrios A,Shanmugalingam S,Guthrie B,Lindberg R,Holder N

更新日期：1998-10-01 00:00:00

abstract：:The liver X receptors (LXRs) are members of the nuclear hormone receptor superfamily that are bound and activated by oxysterols. These receptors serve as sterol sensors to regulate the transcription of gene products that control intracellular cholesterol homeostasis through catabolism and transport. In this report, we...

journal_title：Genes & development

authors： Repa JJ,Liang G,Ou J,Bashmakov Y,Lobaccaro JM,Shimomura I,Shan B,Brown MS,Goldstein JL,Mangelsdorf DJ

更新日期：2000-11-15 00:00:00

abstract：:Cohesin is a chromosome-associated multisubunit protein complex that is highly conserved in eukaryotes and has close homologs in bacteria. Cohesin mediates cohesion between replicated sister chromatids and is therefore essential for chromosome segregation in dividing cells. Cohesin is also required for efficient repai...

journal_title：Genes & development

authors： Peters JM,Tedeschi A,Schmitz J

更新日期：2008-11-15 00:00:00

abstract：:During vascular development, endothelial platelet-derived growth factor B (PDGF-B) is critical for pericyte recruitment. Deletion of the conserved C-terminal heparin-binding motif impairs PDGF-BB retention and pericyte recruitment in vivo, suggesting a potential role for heparan sulfate (HS) in PDGF-BB function during...

journal_title：Genes & development

authors： Abramsson A,Kurup S,Busse M,Yamada S,Lindblom P,Schallmeiner E,Stenzel D,Sauvaget D,Ledin J,Ringvall M,Landegren U,Kjellén L,Bondjers G,Li JP,Lindahl U,Spillmann D,Betsholtz C,Gerhardt H

更新日期：2007-02-01 00:00:00