Abstract:
:The Snail zinc-finger transcription factors trigger epithelial-mesenchymal transitions (EMTs), endowing epithelial cells with migratory and invasive properties during both embryonic development and tumor progression. During EMT, Snail provokes the loss of epithelial markers, as well as changes in cell shape and the expression of mesenchymal markers. Here, we show that in addition to inducing dramatic phenotypic alterations, Snail attenuates the cell cycle and confers resistance to cell death induced by the withdrawal of survival factors and by pro-apoptotic signals. Hence, Snail favors changes in cell shape versus cell division, indicating that with respect to oncogenesis, although a deregulation/increase in proliferation is crucial for tumor formation and growth, this may not be so for tumor malignization. Finally, the resistance to cell death conferred by Snail provides a selective advantage to embryonic cells to migrate and colonize distant territories, and to malignant cells to separate from the primary tumor, invade, and form metastasis.
journal_name
Genes Devjournal_title
Genes & developmentauthors
Vega S,Morales AV,Ocaña OH,Valdés F,Fabregat I,Nieto MAdoi
10.1101/gad.294104subject
Has Abstractpub_date
2004-05-15 00:00:00pages
1131-43issue
10eissn
0890-9369issn
1549-5477pii
18/10/1131journal_volume
18pub_type
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