Structural basis for distinct roles of SMAD2 and SMAD3 in FOXH1 pioneer-directed TGF-β signaling.

abstract：:The Rad51 and Lim15 proteins of lily, which are homologs of the bacterial RecA protein, were found on chromosomes in various stages of meiotic prophase 1. The presence of both Rad51 and Lim15 proteins as discrete foci on leptotene and zygotene chromosomes and their colocalization suggest that meiotic recombination beg...

journal_title：Genes & development

authors： Terasawa M,Shinohara A,Hotta Y,Ogawa H,Ogawa T

更新日期：1995-04-15 00:00:00

abstract：:Adult mesenchymal stem cells (MSCs) derived from bone marrow contribute to the regeneration of multiple types of mesenchymal tissues. Here we describe the functional role of a novel form of cross-talk between the transforming growth factor beta1 (TGF-beta1) and Wnt signaling pathways in regulating the activities of hu...

journal_title：Genes & development

authors： Jian H,Shen X,Liu I,Semenov M,He X,Wang XF

更新日期：2006-03-15 00:00:00

abstract：:Endospores of Bacillus subtilis are encased in a two-layer protein shell known as the coat, which consists of a lammellar-like inner layer and an electron-dense outer layer. We report the cloning of the structural gene (designated cotE) for an alkali-soluble coat protein of 24 kD and show that the cotE gene product is...

journal_title：Genes & development

authors： Zheng LB,Donovan WP,Fitz-James PC,Losick R

更新日期：1988-08-01 00:00:00

abstract：:Myocardial infarction and ischemic heart disease are the leading cause of death in the industrial world. Therapies employed for treating these diseases are aimed at promoting increased blood flow to cardiac tissue. Pharmacological induction of new coronary growth has recently been explored, however, clinical trials wi...

journal_title：Genes & development

authors： Lavine KJ,White AC,Park C,Smith CS,Choi K,Long F,Hui CC,Ornitz DM

更新日期：2006-06-15 00:00:00

abstract：:Codon usage bias is a universal feature of all genomes, but its in vivo biological functions in animal systems are not clear. To investigate the in vivo role of codon usage in animals, we took advantage of the sensitivity and robustness of the Drosophila circadian system. By codon-optimizing parts of Drosophila period...

journal_title：Genes & development

authors： Fu J,Murphy KA,Zhou M,Li YH,Lam VH,Tabuloc CA,Chiu JC,Liu Y

更新日期：2016-08-01 00:00:00

abstract：:Dorsal mesoderm induction in arthropods and ventral mesoderm induction in vertebrates are closely related processes that involve signals of the BMP family. In Drosophila, induction of visceral mesoderm, dorsal muscles, and the heart by Dpp is, at least in part, effected through the transcriptional activation and funct...

journal_title：Genes & development

authors： Xu X,Yin Z,Hudson JB,Ferguson EL,Frasch M

更新日期：1998-08-01 00:00:00

abstract：:To find new genes that influence liver lipid mass, we performed a genetic screen for zebrafish mutants with hepatic steatosis, a pathological accumulation of fat. The red moon (rmn) mutant develops hepatic steatosis as maternally deposited yolk is depleted. Conversely, hepatic steatosis is suppressed in rmn mutants by...

journal_title：Genes & development

authors： Hugo SE,Cruz-Garcia L,Karanth S,Anderson RM,Stainier DY,Schlegel A

更新日期：2012-02-01 00:00:00

abstract：:The RecQ protein family is a highly conserved group of DNA helicases that play roles in maintaining genomic stability. In this study, we present biochemical and genetic evidence that Escherichia coli RecQ processes stalled replication forks and participates in SOS signaling. Cells that carry dnaE486, a mutation in the...

journal_title：Genes & development

authors： Hishida T,Han YW,Shibata T,Kubota Y,Ishino Y,Iwasaki H,Shinagawa H

更新日期：2004-08-01 00:00:00

abstract：:The canoemisty1 (cnomis1) mutation was isolated by virtue of its severe rough eye phenotype from approximately 500 fly lines, each harboring a single autosomal insertion of a P element (Bm delta w). Excision of the P element generated a lethal, null allele, cnomis10, together with many revertants with normal eye morph...

journal_title：Genes & development

authors： Miyamoto H,Nihonmatsu I,Kondo S,Ueda R,Togashi S,Hirata K,Ikegami Y,Yamamoto D

更新日期：1995-03-01 00:00:00

abstract：:Piwi-piRNA (Piwi-interacting RNA) ribonucleoproteins (piRNPs) enforce retrotransposon silencing, a function critical for preserving the genome integrity of germ cells. The molecular functions of most of the factors that have been genetically implicated in primary piRNA biogenesis are still elusive. Here we show that M...

journal_title：Genes & development

authors： Vourekas A,Zheng K,Fu Q,Maragkakis M,Alexiou P,Ma J,Pillai RS,Mourelatos Z,Wang PJ

更新日期：2015-03-15 00:00:00

abstract：:A novel system to study early hematopoietic development is described. This report documents the in vitro capacity of murine embryonic stem (ES) cells to differentiate into hematopoietic precursors of most, if not all, of the colony-forming cells found in normal bone marrow. This system is used to correlate the genetic...

journal_title：Genes & development

authors： Schmitt RM,Bruyns E,Snodgrass HR

更新日期：1991-05-01 00:00:00

abstract：:Two independent two-dimensional (2D) gel methods were used to map an origin of replication that is developmentally regulated by the steroid hormone ecdysone, namely an origin for DNA puff amplification in the fungus fly Sciara coprophila. Initiation of replication was found to occur within a small region of no larger ...

journal_title：Genes & development

authors： Liang C,Spitzer JD,Smith HS,Gerbi SA

更新日期：1993-06-01 00:00:00

abstract：:Cancer stem cells (CSCs) are postulated to be a small subset of tumor cells with tumor-initiating ability that shares features with normal tissue-specific stem cells. The origin of CSCs and the mechanisms underlying their genesis are poorly understood, and it is uncertain whether it is possible to obliterate CSCs with...

journal_title：Genes & development

authors： Song Y,Lu B

更新日期：2011-12-15 00:00:00

abstract：:Intron homing in phage T4 occurs in the context of recombination-dependent replication, by virtue of intron-encoded endonucleolytic activity. After the td intron endonuclease I-TevI cleaves the intronless recipient 23 and 25 nucleotides upstream of the intron insertion site, exonucleolytic degradation is required for ...

journal_title：Genes & development

authors： Mueller JE,Smith D,Belfort M

更新日期：1996-09-01 00:00:00

abstract：:Histone post-translational modifications regulate chromatin structure and function largely through interactions with effector proteins that often contain multiple histone-binding domains. While significant progress has been made characterizing individual effector domains, the role of paired domains and how they functi...

journal_title：Genes & development

authors： Rothbart SB,Dickson BM,Ong MS,Krajewski K,Houliston S,Kireev DB,Arrowsmith CH,Strahl BD

更新日期：2013-06-01 00:00:00

abstract：:The number of known long noncoding RNA (lncRNA) functions is rapidly growing, but how those functions are encoded in their sequence and structure remains poorly understood. NORAD (noncoding RNA activated by DNA damage) is a recently characterized, abundant, and highly conserved lncRNA that is required for proper mitot...

journal_title：Genes & development

authors： Tichon A,Perry RB,Stojic L,Ulitsky I

更新日期：2018-01-01 00:00:00

abstract：:Neurofibromatosis type 1 (NF1) is a prevalent genetic disorder that affects growth properties of neural-crest-derived cell populations. In addition, approximately one-half of NF1 patients exhibit learning disabilities. To characterize NF1 function both in vitro and in vivo, we circumvent the embryonic lethality of NF1...

journal_title：Genes & development

authors： Zhu Y,Romero MI,Ghosh P,Ye Z,Charnay P,Rushing EJ,Marth JD,Parada LF

更新日期：2001-04-01 00:00:00

abstract：:The Drosophila scratch (scrt) gene is expressed in most or all neuronal precursor cells and encodes a predicted zinc finger transcription factor closely related to the product of the mesoderm determination gene snail (sna). Adult flies homozygous for scrt null alleles have a reduced number of photoreceptors in the eye...

journal_title：Genes & development

authors： Roark M,Sturtevant MA,Emery J,Vaessin H,Grell E,Bier E

更新日期：1995-10-01 00:00:00

abstract：:Interruption of translation in Escherichia coli can lead to the addition of an 11-residue carboxy-terminal peptide tail to the nascent chain. This modification is mediated by SsrA RNA (also called 10Sa RNA and tmRNA) and marks the tagged polypeptide for proteolysis. Degradation in vivo of lambda repressor amino-termin...

journal_title：Genes & development

authors： Gottesman S,Roche E,Zhou Y,Sauer RT

更新日期：1998-05-01 00:00:00

abstract：:The histone variants H3.3 and H2A.Z have recently emerged as two of the most important features in transcriptional regulation, the molecular mechanism of which still remains poorly understood. In this study, we investigated the regulation of H3.3 and H2A.Z on chromatin dynamics during transcriptional activation. Our i...

journal_title：Genes & development

authors： Chen P,Zhao J,Wang Y,Wang M,Long H,Liang D,Huang L,Wen Z,Li W,Li X,Feng H,Zhao H,Zhu P,Li M,Wang QF,Li G

更新日期：2013-10-01 00:00:00

abstract：:During development of the somatic macronucleus of Tetrahymena thermophila, the rDNA is excised from its germ-line chromosome, rearranged into a palindrome, and amplified to 10(4) copies. We have identified a cis-acting germ-line mutation, rmm11/6, that prevents amplification of the rDNA in all but approximately 1 in 1...

journal_title：Genes & development

authors： Kapler GM,Blackburn EH

更新日期：1994-01-01 00:00:00

abstract：:The transcription factor TFIIB plays a central role in preinitiation complex assembly, providing a bridge between promoter-bound TFIID and RNA Polymerase II. TFIIB possesses sequence-specific DNA-binding ability and interacts with the TFIIB-recognition element (BRE), present in many promoters. Here we show that the BR...

journal_title：Genes & development

authors： Evans R,Fairley JA,Roberts SG

更新日期：2001-11-15 00:00:00

abstract：:The Brr2 helicase provides the key remodeling activity for spliceosome catalytic activation, during which it disrupts the U4/U6 di-snRNP (small nuclear RNA protein), and its activity has to be tightly regulated. Brr2 exhibits an unusual architecture, including an ∼ 500-residue N-terminal region, whose functions and mo...

journal_title：Genes & development

authors： Absmeier E,Wollenhaupt J,Mozaffari-Jovin S,Becke C,Lee CT,Preussner M,Heyd F,Urlaub H,Lührmann R,Santos KF,Wahl MC

更新日期：2015-12-15 00:00:00

abstract：:We report the discovery of mRNA 5'-leader trans-splicing (SL trans-splicing) in the chordates. In the ascidian protochordate Ciona intestinalis, the mRNAs of at least seven genes undergo trans-splicing of a 16-nucleotide 5'-leader apparently derived from a 46-nucleotide RNA that shares features with previously charact...

journal_title：Genes & development

authors： Vandenberghe AE,Meedel TH,Hastings KE

更新日期：2001-02-01 00:00:00

abstract：:Multidimensional cancer genome analysis and validation has defined Quaking (QKI), a member of the signal transduction and activation of RNA (STAR) family of RNA-binding proteins, as a novel glioblastoma multiforme (GBM) tumor suppressor. Here, we establish that p53 directly regulates QKI gene expression, and QKI prote...

journal_title：Genes & development

authors： Chen AJ,Paik JH,Zhang H,Shukla SA,Mortensen R,Hu J,Ying H,Hu B,Hurt J,Farny N,Dong C,Xiao Y,Wang YA,Silver PA,Chin L,Vasudevan S,Depinho RA

更新日期：2012-07-01 00:00:00

abstract：:We have purified and cloned a new splicing factor, KSRP. KSRP is a component of a multiprotein complex that binds specifically to an intronic splicing enhancer element downstream of the neuron-specific c-src N1 exon. This 75-kD protein induces the assembly of five other proteins, including the heterogeneous nuclear ri...

journal_title：Genes & development

authors： Min H,Turck CW,Nikolic JM,Black DL

更新日期：1997-04-15 00:00:00

abstract：:Known prions (infectious proteins) are self-propagating amyloids or conformationally altered proteins, but in theory an enzyme necessary for its own activation could also be a prion (or a gene composed of protein). We show that yeast protease B is such a prion, called [beta].[beta] is infectious, reversibly curable, a...

journal_title：Genes & development

authors： Roberts BT,Wickner RB

更新日期：2003-09-01 00:00:00

abstract：:The visual system is a powerful model for probing the development, connectivity, and function of neural circuits. Two genetically tractable species, mice and flies, are together providing a great deal of understanding of these processes. Current efforts focus on integrating knowledge gained from three cross-fostering ...

journal_title：Genes & development

authors： Wernet MF,Huberman AD,Desplan C

更新日期：2014-12-01 00:00:00

abstract：:To investigate the relationship between splicing and polyadenylation during the production of vertebrate mRNAs, we examined the effect of mutation of a poly(A) site on splicing of upstream introns. Mutation of the AAUAAA polyadenylation consensus sequence inhibited in vitro splicing of an upstream intron. The magnitud...

journal_title：Genes & development

authors： Niwa M,Berget SM

更新日期：1991-11-01 00:00:00

abstract：:The cJun N-terminal kinase 1 (JNK1) is implicated in diet-induced obesity. Indeed, germline ablation of the murine Jnk1 gene prevents diet-induced obesity. Here we demonstrate that selective deficiency of JNK1 in the murine nervous system is sufficient to suppress diet-induced obesity. The failure to increase body mas...

journal_title：Genes & development

authors： Sabio G,Cavanagh-Kyros J,Barrett T,Jung DY,Ko HJ,Ong H,Morel C,Mora A,Reilly J,Kim JK,Davis RJ

更新日期：2010-02-01 00:00:00