The large N-terminal region of the Brr2 RNA helicase guides productive spliceosome activation.

abstract：:Mammalian cells exhibit a complex response to DNA damage. The tumor suppressor BRCA1 and associated protein BARD1 are thought to play an important role in this response, and our previous work demonstrated that this includes transient inhibition of the pre-mRNA 3' processing machinery. Here we provide evidence that thi...

journal_title：Genes & development

authors： Kleiman FE,Wu-Baer F,Fonseca D,Kaneko S,Baer R,Manley JL

更新日期：2005-05-15 00:00:00

abstract：:Transabdominal (Tab), a dominant mutation in the Bithorax Complex (BX-C) of Drosophila, creates a sexually dimorphic pattern of segmental transformation that has complete penetrance and expressivity. Specific regions within the notum of the second thoracic segment (T2) are transformed into abdominal-like cuticle; thus...

journal_title：Genes & development

authors： Celniker SE,Lewis EB

更新日期：1987-04-01 00:00:00

abstract：:The p53 tumor suppressor is often disrupted in human cancers by the acquisition of missense mutations. We generated mice with a missense mutation at codon 172 that mimics the p53R175H hot spot mutation in human cancer. p53 homozygous mutant mice have unstable mutant p53 in normal cells and stabilize mutant p53 in some...

journal_title：Genes & development

authors： Terzian T,Suh YA,Iwakuma T,Post SM,Neumann M,Lang GA,Van Pelt CS,Lozano G

更新日期：2008-05-15 00:00:00

abstract：:Establishment of the steroid-producing Leydig cell lineage is an event downstream of Sry that is critical for masculinization of mammalian embryos. Neither the origin of fetal Leydig cell precursors nor the signaling pathway that specifies the Leydig cell lineage is known. Based on the sex-specific expression patterns...

journal_title：Genes & development

authors： Yao HH,Whoriskey W,Capel B

更新日期：2002-06-01 00:00:00

abstract：:The dihydrofolate reductase (DHFR) and 2BE2121 genes in the Chinese hamster are convergently transcribed in late G1 and ea ly S phase, and bracket an early-firing origin of replication that consists of a 55-kb zone of potential initiation sites. To test whether transcription through the DHFR gene is required to activa...

journal_title：Genes & development

authors： Saha S,Shan Y,Mesner LD,Hamlin JL

更新日期：2004-02-15 00:00:00

abstract：:The NF-kappa B transcription factor complex is comprised of two subunits, p50 and p65, that share significant homology to the rel oncogene. We have isolated a cDNA encoding a novel 66-kD rel-related protein, designated I-Rel. Unlike other rel-related proteins, I-Rel does not interact with DNA. I-Rel forms heterodimers...

journal_title：Genes & development

authors： Ruben SM,Klement JF,Coleman TA,Maher M,Chen CH,Rosen CA

更新日期：1992-05-01 00:00:00

abstract：:The Hedgehog (Hh) family of secreted proteins controls many aspects of animal development. In Drosophila, Hh transduces its signal via Cubitus interruptus (Ci), a transcription factor present in two forms: a full-length activator and a carboxy-terminally truncated repressor that is derived from the full-length form by...

journal_title：Genes & development

authors： Wang G,Wang B,Jiang J

更新日期：1999-11-01 00:00:00

abstract：:Genetic and cytologic data from Saccharomyces cerevisiae and mammals implicate the Mre11 complex, consisting of Mre11, Rad50, and Nbs1, as a sensor of DNA damage, and indicate that the complex influences the activity of ataxia-telangiectasia mutated (ATM) in the DNA damage response. Rad50(S/S) mice exhibit precipitous...

journal_title：Genes & development

authors： Morales M,Theunissen JW,Kim CF,Kitagawa R,Kastan MB,Petrini JH

更新日期：2005-12-15 00:00:00

abstract：:A transgenic mouse model for retinoblastoma was produced previously by directing SV40 T antigen expression to retinal photoreceptor cells using the promoter of the interstitial retinol-binding protein (IRBP) gene. This gene becomes active prior to the terminal differentiation of photoreceptors. Because T antigen-trans...

journal_title：Genes & development

authors： Howes KA,Ransom N,Papermaster DS,Lasudry JG,Albert DM,Windle JJ

更新日期：1994-06-01 00:00:00

abstract：:Stem cells have been identified as a source of virtually all highly differentiated cells that are replenished during the lifetime of an animal. The critical balance between stem and differentiated cell populations is crucial for the long-term maintenance of functional tissue types. Stem cells maintain this balance by ...

journal_title：Genes & development

authors： Martinez-Agosto JA,Mikkola HK,Hartenstein V,Banerjee U

更新日期：2007-12-01 00:00:00

abstract：:U4 and U6 small nuclear RNAs are associated by an extensive base-pairing interaction that must be disrupted and reformed with each round of splicing. U4 mutations within the U4/U6 interaction domain destabilize the complex in vitro and cause a cold-sensitive phenotype in vivo. Restabilization of the U4/U6 helix by dom...

journal_title：Genes & development

authors： Shannon KW,Guthrie C

更新日期：1991-05-01 00:00:00

abstract：:We have developed a new technique, called 'toeprinting,' which has allowed a study of the tRNA-binding properties of Escherichia coli translation initiation complexes. In response to natural mRNAs, the initiator tRNA and a variety of elongator tRNAs bind to the same tRNA-binding site on the 30S ribosomal subunit as lo...

journal_title：Genes & development

authors： Hartz D,McPheeters DS,Gold L

更新日期：1989-12-01 00:00:00

abstract：:Accurate completion of replication relies on the ability of cells to activate error-free recombination-mediated DNA damage bypass at sites of perturbed replication. However, as anti-recombinase activities are also recruited to replication forks, how recombination-mediated damage bypass is enabled at replication stress...

journal_title：Genes & development

authors： Urulangodi M,Sebesta M,Menolfi D,Szakal B,Sollier J,Sisakova A,Krejci L,Branzei D

更新日期：2015-10-01 00:00:00

abstract：:Subependymal nodules (SENs) and subependymal giant cell astrocytomas (SEGAs) are common brain lesions found in patients with tuberous sclerosis complex (TSC). These brain lesions present a mixed glioneuronal phenotype and have been hypothesized to originate from neural stem cells. However, this hypothesis has not been...

journal_title：Genes & development

authors： Zhou J,Shrikhande G,Xu J,McKay RM,Burns DK,Johnson JE,Parada LF

更新日期：2011-08-01 00:00:00

abstract：:Infection of metazoan cells with some viruses alters the balance of cellular mRNA export to favor viral RNA export and to retain cellular transcripts in the nucleus. Here, evidence is presented to show that the herpes simplex virus 1 (HSV-1) essential regulatory protein ICP27, which inhibits host cell-splicing, result...

journal_title：Genes & development

authors： Sandri-Goldin RM

更新日期：1998-03-15 00:00:00

abstract：:The discovery of transcription factors (TFs) controlling pathways in health and disease is of paramount interest. We designed a widely applicable method, dubbed barcorded synthetic tandem repeat promoter screening (BC-STAR-PROM), to identify signal-activated TFs without any a priori knowledge about their properties. T...

journal_title：Genes & development

authors： Gosselin P,Rando G,Fleury-Olela F,Schibler U

更新日期：2016-08-15 00:00:00

abstract：:The crucifer Arabidopsis thaliana has been used widely as a model organism for the study of plant development. We describe here the development of an efficient insertional mutagenesis system in Arabidopsis that permits identification of genes by their patterns of expression during development. Transposable elements of...

journal_title：Genes & development

authors： Sundaresan V,Springer P,Volpe T,Haward S,Jones JD,Dean C,Ma H,Martienssen R

更新日期：1995-07-15 00:00:00

abstract：:Kinase suppressor of Ras (KSR) is a recently identified component of Ras-dependent signaling pathways. In this report, we show that murine KSR1 (mKSR1) cooperates with activated Ras to promote Xenopus oocyte maturation and cellular transformation and provide evidence that this cooperation occurs by accelerating mitoge...

journal_title：Genes & development

authors： Therrien M,Michaud NR,Rubin GM,Morrison DK

更新日期：1996-11-01 00:00:00

abstract：:Many short-lived mRNAs, including those encoding lymphokines, cytokines, and proto-oncogenes, contain an AU-rich sequence in their 3'-untranslated regions. These AU domains and, more specifically, AUUUA motifs within them, are widely thought to mediate the extreme instability of the corresponding mRNAs. This is most c...

journal_title：Genes & development

authors： Savant-Bhonsale S,Cleveland DW

更新日期：1992-10-01 00:00:00

abstract：:The presence of a single EGF receptor in Drosophila is contrasted by multiple ligands activating it. This work explores the role of two ligands, Spitz and Vein, in the embryonic ventral ectoderm. Spitz is a potent ligand, whereas Vein is an intrinsically weak activating ligand. We show that secreted Spitz emanating fr...

journal_title：Genes & development

authors： Golembo M,Yarnitzky T,Volk T,Shilo BZ

更新日期：1999-01-15 00:00:00

abstract：:The mechanisms that determine the relative positions of floral organs, and thereby their numbers, is a poorly understood aspect of flower development. We isolated a petunia mutant, floozy (fzy), in which the formation of floral organ primordia in the outermost three floral whorls and one of the two bracts at the base ...

journal_title：Genes & development

authors： Tobeña-Santamaria R,Bliek M,Ljung K,Sandberg G,Mol JN,Souer E,Koes R

更新日期：2002-03-15 00:00:00

abstract：:Dosage compensation is a process required to balance the expression of X-linked genes between males and females. In Drosophila this is achieved by targeting the dosage compensation complex or the male-specific lethal (MSL) complex to the male X chromosome. In order to study the mechanism of targeting, we have studied ...

journal_title：Genes & development

authors： Kind J,Akhtar A

更新日期：2007-08-15 00:00:00

abstract：:A recent study has shown that the dimeric form of the 50-kD DNA-binding subunit of the NF-kappa B transcription factor is commonly associated with two molecules of a 65-kD protein (p65) and that p65 appears to be required for inactivation of the p50 dimer by the inhibitory subunit I kappa B. Here, we provide evidence ...

journal_title：Genes & development

authors： Urban MB,Baeuerle PA

更新日期：1990-11-01 00:00:00

abstract：:Ribonucleotide reductase activity is essential for progression through the cell cycle, catalyzing the rate-limiting step for the production of deoxyribonucleotides needed for DNA synthesis. The enzymatic activity of the enzyme fluctuates in the cell cycle with an activity maximum in S phase. We have identified and cha...

journal_title：Genes & development

authors： Elledge SJ,Davis RW

更新日期：1990-05-01 00:00:00

abstract：:The target gene(s) required for Myc-mediated tumorigenesis are still elusive. Here we show that while endogenous c-Myc is surprisingly dispensable for skin homeostasis and TPA-induced hyperplasia, c-Myc-deficient epidermis is resistant to Ras-mediated DMBA/TPAinduced tumorigenesis. This is mechanistically linked to p2...

journal_title：Genes & development

authors： Oskarsson T,Essers MA,Dubois N,Offner S,Dubey C,Roger C,Metzger D,Chambon P,Hummler E,Beard P,Trumpp A

更新日期：2006-08-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDA) develops predominantly through pancreatic intraepithelial neoplasia (PanIN) and intraductal papillary mucinous neoplasm (IPMN) precursor lesions. Pancreatic acinar cells are reprogrammed to a "ductal-like" state during PanIN-PDA formation. Here, we demonstrate a parallel mechanis...

journal_title：Genes & development

authors： Roy N,Malik S,Villanueva KE,Urano A,Lu X,Von Figura G,Seeley ES,Dawson DW,Collisson EA,Hebrok M

更新日期：2015-03-15 00:00:00

abstract：:By studying neuroectoderm formation in the absence of mesoderm and mesectoderm in mutants of the zygotic genes snail and twist, we have found that the number of neuroblasts is not reduced in these mutants, suggesting that mesoderm and mesectoderm are not essential for the initiation of neural development. The position...

journal_title：Genes & development

authors： Rao Y,Vaessin H,Jan LY,Jan YN

更新日期：1991-09-01 00:00:00

abstract：:Dendrite arborization patterns are critical determinants of neuronal function. To explore the basis of transcriptional regulation in dendrite pattern formation, we used RNA interference (RNAi) to screen 730 transcriptional regulators and identified 78 genes involved in patterning the stereotyped dendritic arbors of cl...

journal_title：Genes & development

authors： Parrish JZ,Kim MD,Jan LY,Jan YN

更新日期：2006-04-01 00:00:00

abstract：:TGF-β receptors phosphorylate SMAD2 and SMAD3 transcription factors, which then form heterotrimeric complexes with SMAD4 and cooperate with context-specific transcription factors to activate target genes. Here we provide biochemical and structural evidence showing that binding of SMAD2 to DNA depends on the conformati...

journal_title：Genes & development

authors： Aragón E,Wang Q,Zou Y,Morgani SM,Ruiz L,Kaczmarska Z,Su J,Torner C,Tian L,Hu J,Shu W,Agrawal S,Gomes T,Márquez JA,Hadjantonakis AK,Macias MJ,Massagué J

更新日期：2019-11-01 00:00:00

abstract：:DBP (albumin D-site-binding protein), HLF (hepatic leukemia factor), and TEF (thyrotroph embryonic factor) are the three members of the PAR bZip (proline and acidic amino acid-rich basic leucine zipper) transcription factor family. All three of these transcriptional regulatory proteins accumulate with robust circadian...

journal_title：Genes & development

authors： Gachon F,Fonjallaz P,Damiola F,Gos P,Kodama T,Zakany J,Duboule D,Petit B,Tafti M,Schibler U

更新日期：2004-06-15 00:00:00