Abstract：
:The visual system is a powerful model for probing the development, connectivity, and function of neural circuits. Two genetically tractable species, mice and flies, are together providing a great deal of understanding of these processes. Current efforts focus on integrating knowledge gained from three cross-fostering fields of research: (1) understanding how the fates of different cell types are specified during development, (2) revealing the synaptic connections between identified cell types ("connectomics") by high-resolution three-dimensional circuit anatomy, and (3) causal testing of how identified circuit elements contribute to visual perception and behavior. Here we discuss representative examples from fly and mouse models to illustrate the ongoing success of this tripartite strategy, focusing on the ways it is enhancing our understanding of visual processing and other sensory systems.
journal_name
Genes Devjournal_title
Genes & developmentauthors
Wernet MF,Huberman AD,Desplan Cdoi
10.1101/gad.248245.114subject
Has Abstractpub_date
2014-12-01 00:00:00pages
2565-84issue
23eissn
0890-9369issn
1549-5477pii
28/23/2565journal_volume
28pub_type
杂志文章,评审abstract：:In Xenopus embryos, a dorsal-ventral patterning gradient is generated by diffusing Chordin/bone morphogenetic protein (BMP) complexes cleaved by BMP1/Tolloid metalloproteinases in the ventral side. We developed a new BMP1/Tolloid assay using a fluorogenic Chordin peptide substrate and identified an unexpected negative...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1839309
更新日期：2009-11-01 00:00:00
abstract：:The balance between proliferation and differentiation of muscle stem cells is tightly controlled, ensuring the maintenance of a cellular pool needed for muscle growth and repair. We demonstrate here that the transcriptional regulator Hes1 controls the balance between proliferation and differentiation of activated musc...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.322818.118
更新日期：2019-05-01 00:00:00
abstract：:A novel histone methyltransferase, termed Set9, was isolated from human cells. Set9 contains a SET domain, but lacks the pre- and post-SET domains. Set9 methylates specifically lysine 4 (K4) of histone H3 (H3-K4) and potentiates transcription activation. The histone H3 tail interacts specifically with the histone deac...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.967202
更新日期：2002-02-15 00:00:00
abstract：:A Drosophila FGF receptor homolog (DFGF-R2/DFRI) termed Heartless (Htl) is expressed in the embryonic mesoderm. The phenotypes of null mutant embryos demonstrated that Htl is a central player that is required for the development of several mesodermal lineages. No abnormalities in the primary specification of the mesod...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.10.23.2993
更新日期：1996-12-01 00:00:00
abstract：:The HOP2 and MND1 genes are indispensable for meiotic recombination. The products of these genes associate to form a stable heterodimeric complex that binds DNA and stimulates the recombinase activity of Rad51 and Dmc1. Here we conduct molecular studies to delineate the action mechanism of the Hop2-Mnd1 complex. We pr...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1563007
更新日期：2007-07-15 00:00:00
abstract：:Chromosomal translocations are a hallmark of hematopoietic malignancies. The initial molecular events or pathways that lead to translocations in hematopoietic cells are largely unknown, particularly in the stem cell-enriched population postulated to be the initial target for these events. We used in vitro differentiat...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1522807
更新日期：2007-05-01 00:00:00
abstract：:The Agrobacterium Ti plasmid (T-DNA) 6b proteins interact with many different host proteins implicated in plant cell proliferation. Here, we show that Arabidopsis plants overexpressing 6b display microRNA (miRNA) deficiency by directly targeting SERRATE and AGO1 via a specific loop fragment (residues 40-55). In additi...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1985511
更新日期：2011-01-01 00:00:00
abstract：:In mitosis, the spindle checkpoint protein Mad2 averts aneuploidy by delaying anaphase onset until chromosomes align. Here we show that depletion of Mad2 in meiosis I mouse oocytes induced an increased incidence of aneuploidy. Proteolysis of cyclin B and securin commenced earlier in Mad2-depleted oocytes, resulting in...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.328105
更新日期：2005-01-15 00:00:00
abstract：:Programmed cell death occurs in a highly reproducible manner during Caenorhabditis elegans development. We demonstrate that, during embryogenesis, miR-35 and miR-58 bantam family microRNAs (miRNAs) cooperate to prevent the precocious death of mothers of cells programmed to die by repressing the gene egl-1, which encod...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.288555.116
更新日期：2017-01-15 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.7.2.229
更新日期：1993-02-01 00:00:00
abstract：:Disruptions in the use of skeletal muscle lead to muscle atrophy. After short periods of disuse, muscle atrophy is reversible, and even after prolonged periods of inactivity, myofiber degeneration is uncommon. The pathways that regulate atrophy, initiated either by peripheral nerve damage, immobilization, aging, catab...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1318305
更新日期：2005-07-15 00:00:00
abstract：:We have developed a new technique, called 'toeprinting,' which has allowed a study of the tRNA-binding properties of Escherichia coli translation initiation complexes. In response to natural mRNAs, the initiator tRNA and a variety of elongator tRNAs bind to the same tRNA-binding site on the 30S ribosomal subunit as lo...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.3.12a.1899
更新日期：1989-12-01 00:00:00
abstract：:The human T cell-specific transcription factor TCF-1 alpha plays a key role in the tissue-specific activation of the T cell receptor (TCR) C alpha enhancer and binds to pyrimidine-rich elements (5'-PyCTTTG-3') present in a variety of other T cell-specific control regions. Using amino acid sequence information derived ...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.5.4.656
更新日期：1991-04-01 00:00:00
abstract：:Alternative pre-mRNA splicing determines many changes in gene expression during development. Two regulators known to control splicing patterns during neuron and muscle differentiation are the polypyrimidine tract-binding protein (PTB) and its neuronal homolog nPTB. These proteins repress certain exons in early myoblas...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1500707
更新日期：2007-01-01 00:00:00
abstract：:Many tumors continuously depend on the initiating oncogenes, but whether this extends to their downstream targets is unclear. In this issue of Genes & Development, Sodir and colleagues (pp. 907-916) demonstrate an essential role for endogenous Myc proteins in maintaining the tumor microenvironment, providing an unexpe...
journal_title：Genes & development
pub_type： 评论,杂志文章
doi：10.1101/gad.2053311
更新日期：2011-05-01 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.374406
更新日期：2006-02-15 00:00:00
abstract：:Kinase suppressor of Ras (KSR) is a recently identified component of Ras-dependent signaling pathways. In this report, we show that murine KSR1 (mKSR1) cooperates with activated Ras to promote Xenopus oocyte maturation and cellular transformation and provide evidence that this cooperation occurs by accelerating mitoge...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.10.21.2684
更新日期：1996-11-01 00:00:00
abstract：:Exposure of hematopoietic progenitors to gamma-irradiation (IR) induces p53-dependent apoptosis and a p53-independent G2/M cell cycle arrest. These responses to DNA-damage can be inhibited by treatment with cytokine growth factors. Here we report that gamma-IR-induced apoptosis and cell cycle arrest are suppressed by ...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.12.8.1099
更新日期：1998-04-15 00:00:00
abstract：:The chromo domain was identified as a homologous protein motif between Polycomb (Pc)--a member of the Pc-group genes encoding transcriptional repressors of the homeotic genes--and HP1--a heterochromatin-associated protein encoded by the suppressor of position effect variegation gene Su(var)205. Together with previous ...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.6.7.1241
更新日期：1992-07-01 00:00:00
abstract：:In Saccharomyces cerevisiae, gene silencing at the HMR and HML loci is normally dependent on Sir2p, Sir3p, and Sir4p, which are structural components of silenced chromatin. Sir2p is a NAD+-dependent histone deacetylase required for silencing. Silencing can be restored in cells lacking Sir proteins by a dominant mutati...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.873601
更新日期：2001-04-15 00:00:00
abstract：:Far1p is a bifunctional protein that is required to arrest the cell cycle and to establish cell polarity during yeast mating. Far1p is localized predominantly in the nucleus but accumulates in the cytoplasm in cells exposed to pheromones. Here we show that Far1p functions in both subcellular compartments: nuclear Far1...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.13.17.2284
更新日期：1999-09-01 00:00:00
abstract：:The mammalian ATF/CREB family of transcription factors comprises a large group of basic-region leucine zipper (bZIP) proteins whose members mediate diverse transcriptional regulatory functions. Here we report that expression of a specific mouse ATF gene, ATFx, is down-regulated in a variety of cells undergoing apoptos...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.992202
更新日期：2002-07-15 00:00:00
abstract：:Transformation of primary rodent cells by the adenovirus E1A and E1B oncogenes is a two-step process, where E1A-dependent induction of proliferation is coupled to E1B-dependent suppression of programmed cell death (apoptosis). The E1B gene encodes two distinct transforming proteins, the 19K and 55K proteins, both of w...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.7.4.546
更新日期：1993-04-01 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.3.6.770
更新日期：1989-06-01 00:00:00
abstract：:Establishment of the steroid-producing Leydig cell lineage is an event downstream of Sry that is critical for masculinization of mammalian embryos. Neither the origin of fetal Leydig cell precursors nor the signaling pathway that specifies the Leydig cell lineage is known. Based on the sex-specific expression patterns...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.981202
更新日期：2002-06-01 00:00:00
abstract：:The identification of telomerase-negative HAATI (heterochromatin amplification-mediated and telomerase-independent) cells, in which telomeres are superseded by nontelomeric heterochromatin tracts, challenged the idea that canonical telomeres are essential for chromosome linearity and raised crucial questions as to how...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.311712.118
更新日期：2018-04-01 00:00:00
abstract：:The enzyme telomerase, which elongates chromosome termini, is a critical factor in determining long-term cellular proliferation and tissue renewal. Hence, even small differences in telomerase levels can have substantial consequences for human health. In budding yeast, telomerase consists of the catalytic Est2 protein ...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.246256.114
更新日期：2014-10-01 00:00:00
abstract：:Cohesin is a chromosome-associated multisubunit protein complex that is highly conserved in eukaryotes and has close homologs in bacteria. Cohesin mediates cohesion between replicated sister chromatids and is therefore essential for chromosome segregation in dividing cells. Cohesin is also required for efficient repai...
journal_title：Genes & development
pub_type： 杂志文章,评审
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更新日期：2008-11-15 00:00:00
abstract：:Previous work has shown that rRNA synthesis is strongly inhibited in yeast top1-top2 double mutants. Here, we show that inactivation of yeast topoisomerases can have paradoxical effects on transcription by RNA polymerase I. For example, transcription of ribosomal minigenes on extrachromosomal plasmids is greatly stimu...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.6.7.1332
更新日期：1992-07-01 00:00:00
abstract：:For a number of human genes that encode transcripts containing inverted repeat Alu elements (IRAlus) within their 3' untranslated region (UTR), product mRNA is efficiently exported to the cytoplasm when the IRAlus, which mediate nuclear retention, are removed by alternative polyadenylation. Here we report a new mechan...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.220962.113
更新日期：2013-07-01 00:00:00
