Abstract:
:The empty spiracles (ems) homeo box gene is required for the development of the Drosophila larval filzkörper, which are structural specializations of the eighth abdominal segment. Filzkörper development is also dependent on the function of the homeotic selector gene Abdominal-B (Abd-B). Here, we show that ems is a downstream gene that is transcriptionally regulated by Abd-B proteins. This regulation is mediated by an Abd-B-dependent ems cis-regulatory element that in early- to mid-stage embryos is activated only in the eighth abdominal segment. Genetic epistasis tests suggest that both ems and Abd-B are required in combination for the specification of the filzkörper primordia. In a general sense, these results also provide evidence that the hierarchical level immediately downstream of the homeotic genes contains additional homeo domain transcription factors that define subsegmental domain identities.
journal_name
Genes Devjournal_title
Genes & developmentauthors
Jones B,McGinnis Wdoi
10.1101/gad.7.2.229subject
Has Abstractpub_date
1993-02-01 00:00:00pages
229-40issue
2eissn
0890-9369issn
1549-5477journal_volume
7pub_type
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journal_title:Genes & development
pub_type: 杂志文章
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journal_title:Genes & development
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journal_title:Genes & development
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journal_title:Genes & development
pub_type: 杂志文章
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journal_title:Genes & development
pub_type: 杂志文章
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journal_title:Genes & development
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journal_title:Genes & development
pub_type: 杂志文章
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journal_title:Genes & development
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journal_title:Genes & development
pub_type: 杂志文章
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journal_title:Genes & development
pub_type: 杂志文章
doi:10.1101/gad.188292.112
更新日期:2012-09-01 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
doi:10.1101/gad.13.6.740
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journal_title:Genes & development
pub_type: 评论,杂志文章
doi:10.1101/gad.200410.112
更新日期:2012-08-15 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
doi:10.1101/gad.11.4.463
更新日期:1997-02-15 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
doi:10.1101/gad.1171704
更新日期:2004-03-01 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
doi:10.1101/gad.12.11.1621
更新日期:1998-06-01 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章,评审
doi:10.1101/gad.324657.119
更新日期:2019-08-01 00:00:00
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journal_title:Genes & development
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journal_title:Genes & development
pub_type: 杂志文章
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journal_title:Genes & development
pub_type: 杂志文章
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journal_title:Genes & development
pub_type: 杂志文章
doi:10.1101/gad.1978310
更新日期:2010-12-01 00:00:00
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journal_title:Genes & development
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更新日期:1996-02-15 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
doi:10.1101/gad.287404
更新日期:2004-06-15 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
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journal_title:Genes & development
pub_type: 杂志文章
doi:10.1101/gad.7.10.1937
更新日期:1993-10-01 00:00:00
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journal_title:Genes & development
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journal_title:Genes & development
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pub_type: 杂志文章
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