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Bipartite stimulatory action of the Hop2-Mnd1 complex on the Rad51 recombinase.

Abstract：

:The HOP2 and MND1 genes are indispensable for meiotic recombination. The products of these genes associate to form a stable heterodimeric complex that binds DNA and stimulates the recombinase activity of Rad51 and Dmc1. Here we conduct molecular studies to delineate the action mechanism of the Hop2-Mnd1 complex. We present evidence to implicate Hop2 as the major DNA-binding subunit and Mnd1 as the prominent Rad51 interaction entity. Hop2-Mnd1 stabilizes the Rad51-single-stranded DNA (ssDNA) nucleoprotein filament, the catalytic intermediate in recombination reactions. We also show that Hop2-Mnd1 enhances the ability of the Rad51-ssDNA nucleoprotein filament to capture duplex DNA, an obligatory step in the formation of the synaptic complex critical for DNA joint formation. Thus, our results unveil a bipartite mechanism of Hop2-Mnd1 in homologous DNA pairing: stabilization of the Rad51 presynaptic filament and duplex DNA capture to enhance synaptic complex formation.

journal_name

Genes Dev

journal_title

Genes & development

authors

Chi P,San Filippo J,Sehorn MG,Petukhova GV,Sung P

doi

10.1101/gad.1563007

subject

Has Abstract

pub_date

2007-07-15 00:00:00

pages

1747-57

issue

14

eissn

0890-9369

issn

1549-5477

pii

21/14/1747

journal_volume

21

pub_type

杂志文章

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