当前位置： SCI文献检索 > GENES & DEVELOPMENT期刊下所有文献 > miRNAs cooperate in apoptosis regulation during C. elegans development.

miRNAs cooperate in apoptosis regulation during C. elegans development.

Abstract：

:Programmed cell death occurs in a highly reproducible manner during Caenorhabditis elegans development. We demonstrate that, during embryogenesis, miR-35 and miR-58 bantam family microRNAs (miRNAs) cooperate to prevent the precocious death of mothers of cells programmed to die by repressing the gene egl-1, which encodes a proapoptotic BH3-only protein. In addition, we present evidence that repression of egl-1 is dependent on binding sites for miR-35 and miR-58 family miRNAs within the egl-1 3' untranslated region (UTR), which affect both mRNA copy number and translation. Furthermore, using single-molecule RNA fluorescent in situ hybridization (smRNA FISH), we show that egl-1 is transcribed in the mother of a cell programmed to die and that miR-35 and miR-58 family miRNAs prevent this mother from dying by keeping the copy number of egl-1 mRNA below a critical threshold. Finally, miR-35 and miR-58 family miRNAs can also dampen the transcriptional boost of egl-1 that occurs specifically in a daughter cell that is programmed to die. We propose that miRNAs compensate for lineage-specific differences in egl-1 transcriptional activation, thus ensuring that EGL-1 activity reaches the threshold necessary to trigger death only in daughter cells that are programmed to die.

journal_name

Genes Dev

journal_title

Genes & development

authors

Sherrard R,Luehr S,Holzkamp H,McJunkin K,Memar N,Conradt B

doi

10.1101/gad.288555.116

subject

Has Abstract

pub_date

2017-01-15 00:00:00

pages

209-222

issue

2

eissn

0890-9369

issn

1549-5477

pii

gad.288555.116

journal_volume

31

pub_type

杂志文章

相关文献

GENES & DEVELOPMENT文献大全
  • Activator-mediated disruption of sequence-specific DNA contacts by the general transcription factor TFIIB.

    abstract：:The transcription factor TFIIB plays a central role in preinitiation complex assembly, providing a bridge between promoter-bound TFIID and RNA Polymerase II. TFIIB possesses sequence-specific DNA-binding ability and interacts with the TFIIB-recognition element (BRE), present in many promoters. Here we show that the BR...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.206901

    authors： Evans R,Fairley JA,Roberts SG

    更新日期：2001-11-15 00:00:00

  • Gene encoding a morphogenic protein required in the assembly of the outer coat of the Bacillus subtilis endospore.

    abstract：:Endospores of Bacillus subtilis are encased in a two-layer protein shell known as the coat, which consists of a lammellar-like inner layer and an electron-dense outer layer. We report the cloning of the structural gene (designated cotE) for an alkali-soluble coat protein of 24 kD and show that the cotE gene product is...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.2.8.1047

    authors： Zheng LB,Donovan WP,Fitz-James PC,Losick R

    更新日期：1988-08-01 00:00:00

  • Human nonsense-mediated RNA decay initiates widely by endonucleolysis and targets snoRNA host genes.

    abstract：:Eukaryotic RNAs with premature termination codons (PTCs) are eliminated by nonsense-mediated decay (NMD). While human nonsense RNA degradation can be initiated either by an endonucleolytic cleavage event near the PTC or through decapping, the individual contribution of these activities on endogenous substrates has rem...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.246538.114

    authors： Lykke-Andersen S,Chen Y,Ardal BR,Lilje B,Waage J,Sandelin A,Jensen TH

    更新日期：2014-11-15 00:00:00

  • SCH9, a gene of Saccharomyces cerevisiae that encodes a protein distinct from, but functionally and structurally related to, cAMP-dependent protein kinase catalytic subunits.

    abstract：:A new gene, SCH9, was isolated from Saccharomyces cerevisiae by its ability to complement a cdc25ts mutation. Sequence analysis indicates that it encodes a 90,000-dalton protein with a carboxy-terminal domain homologous to yeast and mammalian cAMP-dependent protein kinase catalytic subunits. In addition to suppressing...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.2.5.517

    authors： Toda T,Cameron S,Sass P,Wigler M

    更新日期：1988-05-01 00:00:00

  • Structure and mechanism of the RNA polymerase II transcription machinery.

    abstract：:RNA polymerase II (Pol II) transcribes all protein-coding genes and many noncoding RNAs in eukaryotic genomes. Although Pol II is a complex, 12-subunit enzyme, it lacks the ability to initiate transcription and cannot consistently transcribe through long DNA sequences. To execute these essential functions, an array of...

    journal_title：Genes & development

    pub_type： 杂志文章,评审

    doi：10.1101/gad.335679.119

    authors： Schier AC,Taatjes DJ

    更新日期：2020-04-01 00:00:00

  • Identification of the sigma E subunit of Escherichia coli RNA polymerase: a second alternate sigma factor involved in high-temperature gene expression.

    abstract：:The rpoH gene of Escherichia coli encodes sigma 32, the 32-kD sigma-factor responsible for the heat-inducible transcription of the heat shock genes. rpoH is transcribed from at least three promoters. Two of these promoters are recognized by RNA polymerase containing sigma 70, the predominant sigma-factor. We purified ...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.3.9.1462

    authors： Erickson JW,Gross CA

    更新日期：1989-09-01 00:00:00

  • Zebrafish genetics gets the Scube on Hedgehog secretion.

    abstract：:Inspired by a zebrafish mutation, two recent studies by Creanga and colleagues (pp. 1312-1325) and Tukachinsky and colleagues have shed new light on the way in which lipidated Hedgehog proteins are secreted and released from expressing cells, suggesting a model for the sequential action of the Disp and Scube2 proteins...

    journal_title：Genes & development

    pub_type： 评论,杂志文章

    doi：10.1101/gad.207126.112

    authors： Ingham PW

    更新日期：2012-11-15 00:00:00

  • Phosphatidic acid mediates demyelination in Lpin1 mutant mice.

    abstract：:Lipids play crucial roles in many aspects of glial cell biology, affecting processes ranging from myelin membrane biosynthesis to axo-glial interactions. In order to study the role of lipid metabolism in myelinating glial cells, we specifically deleted in Schwann cells the Lpin1 gene, which encodes the Mg2+-dependent ...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.1638008

    authors： Nadra K,de Preux Charles AS,Médard JJ,Hendriks WT,Han GS,Grès S,Carman GM,Saulnier-Blache JS,Verheijen MH,Chrast R

    更新日期：2008-06-15 00:00:00

  • Molecular analysis of reverse mutations from nonagouti (a) to black-and-tan (a(t)) and white-bellied agouti (Aw) reveals alternative forms of agouti transcripts.

    abstract：:The agouti gene regulates the differential production of eumelanin (black or brown) and phaeomelanin (yellow) pigment granules by melanocytes in the hair follicles of mice. The original nonagouti (a) allele, which confers a predominantly black coat color, has been shown to revert to two other more dominant agouti alle...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.8.4.481

    authors： Bultman SJ,Klebig ML,Michaud EJ,Sweet HO,Davisson MT,Woychik RP

    更新日期：1994-02-15 00:00:00

  • Brg1 promotes both tumor-suppressive and oncogenic activities at distinct stages of pancreatic cancer formation.

    abstract：:Pancreatic ductal adenocarcinoma (PDA) develops predominantly through pancreatic intraepithelial neoplasia (PanIN) and intraductal papillary mucinous neoplasm (IPMN) precursor lesions. Pancreatic acinar cells are reprogrammed to a "ductal-like" state during PanIN-PDA formation. Here, we demonstrate a parallel mechanis...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.256628.114

    authors： Roy N,Malik S,Villanueva KE,Urano A,Lu X,Von Figura G,Seeley ES,Dawson DW,Collisson EA,Hebrok M

    更新日期：2015-03-15 00:00:00

  • Transcription factor Ebf1 regulates differentiation stage-specific signaling, proliferation, and survival of B cells.

    abstract：:The transcription factor Ebf1 is an important determinant of early B lymphopoiesis. To gain insight into the functions of Ebf1 at distinct stages of differentiation, we conditionally inactivated Ebf1. We found that Ebf1 is required for the proliferation, survival, and signaling of pro-B cells and peripheral B-cell sub...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.187328.112

    authors： Györy I,Boller S,Nechanitzky R,Mandel E,Pott S,Liu E,Grosschedl R

    更新日期：2012-04-01 00:00:00

  • TFIID can be rate limiting in vivo for TATA-containing, but not TATA-lacking, RNA polymerase II promoters.

    abstract：:We have studied the effect of exogenous expression of the basal transcription factor TFIID on the activities of several different TATA-containing and TATA-lacking promoters. Overexpression of TFIID from a transfected plasmid in Drosophila Schneider cells resulted in substantial concentration-dependent increases in exp...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.6.2.304

    authors： Colgan J,Manley JL

    更新日期：1992-02-01 00:00:00

  • Establishment of ventral cell fates in the Drosophila embryonic ectoderm requires DER, the EGF receptor homolog.

    abstract：:The embryonic ectoderm in Drosophila displays a highly organized arrangement of specific structures along the dorsal-ventral axis. To establish this characteristic design, cells must receive instructive cues regarding their position. We present evidence that during stages 8-9 of embryonic development, the Drosophila E...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.7.10.1937

    authors： Raz E,Shilo BZ

    更新日期：1993-10-01 00:00:00

  • Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration.

    abstract：:Although Apc is well characterized as a tumor-suppressor gene in the intestine, the precise mechanism of this suppression remains to be defined. Using a novel inducible Ahcre transgenic line in conjunction with a loxP-flanked Apc allele we, show that loss of Apc acutely activates Wnt signaling through the nuclear accu...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.287404

    authors： Sansom OJ,Reed KR,Hayes AJ,Ireland H,Brinkmann H,Newton IP,Batlle E,Simon-Assmann P,Clevers H,Nathke IS,Clarke AR,Winton DJ

    更新日期：2004-06-15 00:00:00

  • A novel role for the 3' region of introns in pre-mRNA splicing of Saccharomyces cerevisiae.

    abstract：:To investigate the importance of sequences between the yeast (Saccharomyces cerevisiae) branch point (TACTAAC box) and 3' splice site (AG), we generated a series of pre-mRNA substrates that differed in the length of RNA retained on the 3' side of the TACTAAC box. These pre-mRNAs were compared as substrates for the fir...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.1.3.238

    authors： Rymond BC,Torrey DD,Rosbash M

    更新日期：1987-05-01 00:00:00

  • Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells.

    abstract：:Growth of numerous cancer types is believed to be driven by a subpopulation of poorly differentiated cells, often referred to as cancer stem cells (CSCs), that have the capacity for self-renewal, tumor initiation, and generation of nontumorigenic progeny. Despite their potentially key role in tumor establishment and m...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.188292.112

    authors： Janiszewska M,Suvà ML,Riggi N,Houtkooper RH,Auwerx J,Clément-Schatlo V,Radovanovic I,Rheinbay E,Provero P,Stamenkovic I

    更新日期：2012-09-01 00:00:00

  • RNAi in Xenopus: look before you leap.

    abstract：:RNAi has revolutionized reverse genetics; however, RNAi is not necessarily ubiquitous or constitutive. Lund and colleagues (pp. 1121-1131) show that microRNA (miRNA) effector Argonautes (Agos) are limiting and easily saturated during early Xenopus embryogenesis. Moreover, this stage is devoid of slicing capacity. Supp...

    journal_title：Genes & development

    pub_type： 评论,杂志文章

    doi：10.1101/gad.2062911

    authors： Flynt AS,Lai EC

    更新日期：2011-06-01 00:00:00

  • Novel pro- and anti-recombination activities of the Bloom's syndrome helicase.

    abstract：:Bloom's syndrome (BS) is an autosomal recessive disorder characterized by a strong cancer predisposition. The defining feature of BS is extreme genome instability. The gene mutated in Bloom's syndrome, BLM, encodes a DNA helicase (BLM) of the RecQ family. BLM plays a role in homologous recombination; however, its exac...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.1609007

    authors： Bugreev DV,Yu X,Egelman EH,Mazin AV

    更新日期：2007-12-01 00:00:00

  • Malignant melanoma: genetics and therapeutics in the genomic era.

    abstract：:Cell for cell, probably no human cancer is as aggressive as melanoma. It is among a handful of cancers whose dimensions are reported in millimeters. Tumor thickness approaching 4 mm presents a high risk of metastasis, and a diagnosis of metastatic melanoma carries with it an abysmal median survival of 6-9 mo. What fea...

    journal_title：Genes & development

    pub_type： 杂志文章,评审

    doi：10.1101/gad.1437206

    authors： Chin L,Garraway LA,Fisher DE

    更新日期：2006-08-15 00:00:00

  • Genome-wide RNAi analysis of JAK/STAT signaling components in Drosophila.

    abstract：:The cytokine-activated Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway plays an important role in the control of a wide variety of biological processes. When misregulated, JAK/STAT signaling is associated with various human diseases, such as immune disorders and tumorigenesis. To gai...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.1320705

    authors： Baeg GH,Zhou R,Perrimon N

    更新日期：2005-08-15 00:00:00

  • Antagonism between RSF1 and SR proteins for both splice-site recognition in vitro and Drosophila development.

    abstract：:Specific recognition of splice sites within metazoan mRNA precursors (pre-mRNAs) is a potential stage for gene regulation by alternative splicing. Splicing factors of the SR protein family play a major role in this regulation, as they are required for early recognition of splice sites during spliceosome assembly. Here...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.13.6.740

    authors： Labourier E,Bourbon HM,Gallouzi IE,Fostier M,Allemand E,Tazi J

    更新日期：1999-03-15 00:00:00

  • The stringent response in Myxococcus xanthus is regulated by SocE and the CsgA C-signaling protein.

    abstract：:Myxococcus xanthus fruiting body development is induced by amino acid limitation. The decision to grow or develop is established by the RelA-dependent stringent response and A-signaling. We identified two new members of this regulatory hierarchy, socE and the C-signaling gene csgA. SocE depletion arrests growth and in...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：

    authors： Crawford EW Jr,Shimkets LJ

    更新日期：2000-02-15 00:00:00

  • Integrative genome analysis of somatic p53 mutant osteosarcomas identifies Ets2-dependent regulation of small nucleolar RNAs by mutant p53 protein.

    abstract：:TP53 is the most frequently mutated gene in human cancer. Many mutant p53 proteins exert oncogenic gain-of-function (GOF) properties that contribute to metastasis, but the mechanisms mediating these functions remain poorly defined in vivo. To elucidate how mutant p53 GOF drives metastasis, we developed a traceable som...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.304972.117

    authors： Pourebrahim R,Zhang Y,Liu B,Gao R,Xiong S,Lin PP,McArthur MJ,Ostrowski MC,Lozano G

    更新日期：2017-09-15 00:00:00

  • A specific protein substrate for a deubiquitinating enzyme: Liquid facets is the substrate of Fat facets.

    abstract：:Eukaryotic genomes encode large families of deubiquitinating enzymes (DUBs). Genetic data suggest that Fat facets (Faf), a Drosophila DUB essential for patterning the compound eye, might have a novel regulatory function; Faf might reverse the ubiquitination of a specific substrate, thereby preventing proteasomal degra...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.961502

    authors： Chen X,Zhang B,Fischer JA

    更新日期：2002-02-01 00:00:00

  • Eph signaling is required for segmentation and differentiation of the somites.

    abstract：:Somitogenesis involves the segmentation of the paraxial mesoderm into units along the anteroposterior axis. Here we show a role for Eph and ephrin signaling in the patterning of presomitic mesoderm and formation of the somites. Ephrin-A-L1 and ephrin-B2 are expressed in an iterative manner in the developing somites an...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.12.19.3096

    authors： Durbin L,Brennan C,Shiomi K,Cooke J,Barrios A,Shanmugalingam S,Guthrie B,Lindberg R,Holder N

    更新日期：1998-10-01 00:00:00

  • Calcineurin-dependent regulation of Crz1p nuclear export requires Msn5p and a conserved calcineurin docking site.

    abstract：:Calcineurin, a conserved Ca(2+)/calmodulin-regulated protein phosphatase, plays a crucial role in Ca(2+) signaling in a wide variety of cell types. In Saccharomyces cerevisiae, calcineurin positively regulates transcription in response to stress by dephosphorylating the transcription factor Crz1p/Tcn1p. Dephosphorylat...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.967602

    authors： Boustany LM,Cyert MS

    更新日期：2002-03-01 00:00:00

  • Stable nucleosome positioning and complete repression by the yeast alpha 2 repressor are disrupted by amino-terminal mutations in histone H4.

    abstract：:Nucleosomes are positioned in the presence of the yeast repressor alpha 2 in minichromosomes containing the alpha 2 operator and on the promoters of a-cell-specific genes regulated by alpha 2. To investigate the possibility that alpha 2 directs nucleosome position through an interaction with a component of the core pa...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.6.3.411

    authors： Roth SY,Shimizu M,Johnson L,Grunstein M,Simpson RT

    更新日期：1992-03-01 00:00:00

  • Circular forms of developmentally excised DNA in Euplotes crassus have a heteroduplex junction.

    abstract：:Extensive DNA elimination via a DNA breakage and rejoining process occurs during macronuclear development in the hypotrich ciliate Euplotes crassus. The excision process involves the removal of short, unique segments of DNA (internal eliminated sequences; IESs) and at least two highly repetitive families of transposon...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.7.1.84

    authors： Klobutcher LA,Turner LR,LaPlante J

    更新日期：1993-01-01 00:00:00

  • RecE/RecT and Redalpha/Redbeta initiate double-stranded break repair by specifically interacting with their respective partners.

    abstract：:The initial steps of double-stranded break (DSB) repair by homologous recombination mediated by the 5'-3' exonuclease/annealing protein pairs, RecE/RecT and Redalpha/Redbeta, were analyzed. Recombination was RecA-independent and required the expression of both components of an orthologous pair, even when the need for ...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：

    authors： Muyrers JP,Zhang Y,Buchholz F,Stewart AF

    更新日期：2000-08-01 00:00:00

  • CTD-dependent dismantling of the RNA polymerase II elongation complex by the pre-mRNA 3'-end processing factor, Pcf11.

    abstract：:Pcf11 is one of numerous proteins involved in pre-mRNA 3'-end processing and transcription termination. Using elongation complexes (ECs) formed from purified yeast RNA polymerase II (Pol II), we show that a 140-amino acid polypeptide from yeast Pcf11 is capable of dismantling the EC in vitro. This action depends on th...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.1296305

    authors： Zhang Z,Fu J,Gilmour DS

    更新日期：2005-07-01 00:00:00