Genome-wide RNAi analysis of JAK/STAT signaling components in Drosophila.

abstract：:The Wnt signaling cascade is a central regulator of cell fate determination during embryonic development, whose deregulation contributes to oncogenesis. Naked cuticle is the first Wnt-induced antagonist found in this pathway, establishing a negative-feedback loop that limits the Wnt signal required for early segmentat...

journal_title：Genes & development

authors： Creyghton MP,Roël G,Eichhorn PJ,Hijmans EM,Maurer I,Destrée O,Bernards R

更新日期：2005-02-01 00:00:00

abstract：:The orphan nuclear receptor TLX regulates neural stem cell self-renewal in the adult brain and functions primarily as a transcription repressor through recruitment of Atrophin corepressors, which bind to TLX via a conserved peptide motif termed the Atro box. Here we report crystal structures of the human and insect TL...

journal_title：Genes & development

authors： Zhi X,Zhou XE,He Y,Searose-Xu K,Zhang CL,Tsai CC,Melcher K,Xu HE

更新日期：2015-02-15 00:00:00

abstract：:In recent years several new mouse models for lung cancer have been described. These include models for both non-small-cell lung cancer (NSCLC) and small-cell lung cancer (SCLC). Tumorigenesis in these conditional mouse tumor models can be initiated in adult mice through Cre-recombinase-induced activation of oncogenic ...

journal_title：Genes & development

authors： Meuwissen R,Berns A

更新日期：2005-03-15 00:00:00

abstract：:The myc family of cellular oncogenes encodes three highly related nuclear phosphoproteins (c-Myc, N-Myc, and L-Myc) that are believed to function as sequence-specific transcription factors capable of regulating genes important in cellular growth and differentiation. Current evidence indicates that Myc family proteins ...

journal_title：Genes & development

authors： Mukherjee B,Morgenbesser SD,DePinho RA

更新日期：1992-08-01 00:00:00

abstract：:In Drosophila the function of the epidermal growth factor (EGF) receptor is modulated zygotically by three EGF-like proteins: Spitz (Spi), which is a potent activator; Vein (Vn), which is a moderate activator; and Argos (Aos), which is an inhibitor. Chimeric molecules were constructed in which the EGF domain of Vn was...

journal_title：Genes & development

authors： Schnepp B,Donaldson T,Grumbling G,Ostrowski S,Schweitzer R,Shilo BZ,Simcox A

更新日期：1998-04-01 00:00:00

abstract：:In Drosophila germ cells, PIWI-interacting RNAs (piRNAs) are amplified through a PIWI slicer-dependent feed-forward loop termed the ping-pong cycle, yielding secondary piRNAs. However, the detailed mechanism remains poorly understood, largely because an ex vivo model system amenable to biochemical analyses has not bee...

journal_title：Genes & development

authors： Sumiyoshi T,Sato K,Yamamoto H,Iwasaki YW,Siomi H,Siomi MC

更新日期：2016-07-15 00:00:00

abstract：:Oxidative tissues such as heart undergo a dramatic perinatal mitochondrial biogenesis to meet the high-energy demands after birth. PPARgamma coactivator-1 (PGC-1) alpha and beta have been implicated in the transcriptional control of cellular energy metabolism. Mice with combined deficiency of PGC-1alpha and PGC-1beta ...

journal_title：Genes & development

authors： Lai L,Leone TC,Zechner C,Schaeffer PJ,Kelly SM,Flanagan DP,Medeiros DM,Kovacs A,Kelly DP

更新日期：2008-07-15 00:00:00

abstract：:Direct reprogramming of fibroblasts to cardiomyocytes represents a potential means of restoring cardiac function following myocardial injury. AKT1 in the presence of four cardiogenic transcription factors, GATA4, HAND2, MEF2C, and TBX5 (AGHMT), efficiently induces the cardiac gene program in mouse embryonic fibroblast...

journal_title：Genes & development

authors： Zhou H,Morales MG,Hashimoto H,Dickson ME,Song K,Ye W,Kim MS,Niederstrasser H,Wang Z,Chen B,Posner BA,Bassel-Duby R,Olson EN

更新日期：2017-09-01 00:00:00

abstract：:The genes pannier (pnr) and u-shaped (ush) are required for the regulation of achaete-scute during establishment of the bristle pattern in Drosophila. pnr encodes a protein belonging to the GATA family of transcription factors, whereas ush encodes a novel zinc finger protein. Genetic interactions between dominant pnr ...

journal_title：Genes & development

authors： Haenlin M,Cubadda Y,Blondeau F,Heitzler P,Lutz Y,Simpson P,Ramain P

更新日期：1997-11-15 00:00:00

abstract：:Hepatitis B virus (HBV) infects humans and causes a wide range of clinical manifestations, from acute hepatitis to hepatocellular carcinoma (HCC). The HBV genome contains multiple promoters with gene expression regulated predominantly by the cellular transcription initiation machinery. Accordingly, the HBV-encoded pX,...

journal_title：Genes & development

authors： Haviv I,Matza Y,Shaul Y

更新日期：1998-04-15 00:00:00

abstract：:Genome integrity is constantly monitored by sophisticated cellular networks, collectively termed the DNA damage response (DDR). A common feature of DDR proteins is their mobilization in response to genotoxic stress. Here, we outline how the development of various complementary methodologies has provided valuable insig...

journal_title：Genes & development

authors： Polo SE,Jackson SP

更新日期：2011-03-01 00:00:00

abstract：:Treatment of early Xenopus embryos with retinoic acid (RA) produces a concentration-dependent series of defects in anterior axial structures that range from small deletions to embryos lacking heads. The graded series of axial defects obtained after RA administration to early embryos appears to result, in part, from ac...

journal_title：Genes & development

authors： Ruiz i Altaba A,Jessell T

更新日期：1991-02-01 00:00:00

abstract：:The Notch signaling pathway is essential for embryonic vascular development in vertebrates. Here we show that mouse embryos heterozygous for a targeted mutation in the gene encoding the DLL4 ligand exhibit haploinsufficient lethality because of defects in vascular remodeling. We also describe vascular defects in embry...

journal_title：Genes & development

authors： Krebs LT,Shutter JR,Tanigaki K,Honjo T,Stark KL,Gridley T

更新日期：2004-10-15 00:00:00

abstract：:The WD40 domain-containing protein WRAP53β (WD40 encoding RNA antisense to p53; also referred to as WDR79/TCAB1) controls trafficking of splicing factors and the telomerase enzyme to Cajal bodies, and its functional loss has been linked to carcinogenesis, premature aging, and neurodegeneration. Here, we identify WRAP5...

journal_title：Genes & development

authors： Henriksson S,Rassoolzadeh H,Hedström E,Coucoravas C,Julner A,Goldstein M,Imreh G,Zhivotovsky B,Kastan MB,Helleday T,Farnebo M

更新日期：2014-12-15 00:00:00

abstract：:We have developed a simple, effective genetic screen for mutant alleles of eukaryotic DNA topoisomerase I that manifest severely depressed or complete loss of enzymatic function. The screen is based on the extreme toxicity of vaccinia topoisomerase expression in the Escherichia coli lysogen strain BL21(DE3) and is not...

journal_title：Genes & development

authors： Morham SG,Shuman S

更新日期：1990-04-01 00:00:00

abstract：:Bardet-Biedl syndrome (BBS) is a genetically heterogeneous developmental disorder whose molecular basis is largely unknown. Here, we show that mutations in the Caenorhabditis elegans bbs-7 and bbs-8 genes cause structural and functional defects in cilia. C. elegans BBS proteins localize predominantly at the base of ci...

journal_title：Genes & development

authors： Blacque OE,Reardon MJ,Li C,McCarthy J,Mahjoub MR,Ansley SJ,Badano JL,Mah AK,Beales PL,Davidson WS,Johnsen RC,Audeh M,Plasterk RH,Baillie DL,Katsanis N,Quarmby LM,Wicks SR,Leroux MR

更新日期：2004-07-01 00:00:00

abstract：:Dosage compensation is a process required to balance the expression of X-linked genes between males and females. In Drosophila this is achieved by targeting the dosage compensation complex or the male-specific lethal (MSL) complex to the male X chromosome. In order to study the mechanism of targeting, we have studied ...

journal_title：Genes & development

authors： Kind J,Akhtar A

更新日期：2007-08-15 00:00:00

abstract：:Macrophage activation by the proinflammatory cytokine interferon-gamma (IFN-gamma) is a critical component of the host innate response to bacterial pathogenesis. However, the precise nature of the IFN-gamma-induced activation pathway is not known. Here we show using genome-wide expression and chromatin-binding profili...

journal_title：Genes & development

authors： Sonoda J,Laganière J,Mehl IR,Barish GD,Chong LW,Li X,Scheffler IE,Mock DC,Bataille AR,Robert F,Lee CH,Giguère V,Evans RM

更新日期：2007-08-01 00:00:00

abstract：:To find new genes that influence liver lipid mass, we performed a genetic screen for zebrafish mutants with hepatic steatosis, a pathological accumulation of fat. The red moon (rmn) mutant develops hepatic steatosis as maternally deposited yolk is depleted. Conversely, hepatic steatosis is suppressed in rmn mutants by...

journal_title：Genes & development

authors： Hugo SE,Cruz-Garcia L,Karanth S,Anderson RM,Stainier DY,Schlegel A

更新日期：2012-02-01 00:00:00

abstract：:Mismatch repair (MMR) has important roles in meiotic and mitotic recombination, DNA damage signaling, and various aspects of DNA metabolism including class-switch recombination, somatic hypermutation, and triplet-repeat expansion. Defects in MMR are responsible for human cancers characterized by microsatellite instabi...

journal_title：Genes & development

authors： Siegl-Cachedenier I,Muñoz P,Flores JM,Klatt P,Blasco MA

更新日期：2007-09-01 00:00:00

abstract：:Two recent reports, including one by Reinders and colleagues (pp. 939-950) in the April 15, 2009, issue of Genes & Development, describe the construction of Arabidopsis recombinant inbred populations that maximize epigenetic rather than genetic variation. The distribution and behavior of phenotypic variation in these ...

journal_title：Genes & development

authors： Richards EJ

更新日期：2009-07-15 00:00:00

abstract：:DBP (albumin D-site-binding protein), HLF (hepatic leukemia factor), and TEF (thyrotroph embryonic factor) are the three members of the PAR bZip (proline and acidic amino acid-rich basic leucine zipper) transcription factor family. All three of these transcriptional regulatory proteins accumulate with robust circadian...

journal_title：Genes & development

authors： Gachon F,Fonjallaz P,Damiola F,Gos P,Kodama T,Zakany J,Duboule D,Petit B,Tafti M,Schibler U

更新日期：2004-06-15 00:00:00

abstract：:Transcriptionally silent genes must be activated throughout development. This requires nucleosomes be removed from promoters and enhancers to allow transcription factor (TF) binding and recruitment of coactivators and RNA polymerase II (Pol II). Specialized pioneer TFs bind nucleosome-wrapped DNA to perform this chrom...

journal_title：Genes & development

authors： Judd J,Duarte FM,Lis JT

更新日期：2021-01-01 00:00:00

abstract：:Intron homing in phage T4 occurs in the context of recombination-dependent replication, by virtue of intron-encoded endonucleolytic activity. After the td intron endonuclease I-TevI cleaves the intronless recipient 23 and 25 nucleotides upstream of the intron insertion site, exonucleolytic degradation is required for ...

journal_title：Genes & development

authors： Mueller JE,Smith D,Belfort M

更新日期：1996-09-01 00:00:00

abstract：:The reelin (reln) and disabled 1 (dab1) genes both ensure correct neuronal positioning during brain development. We have found that the intracellular Dab1 protein receives a tyrosine phosphorylation signal from extracellular Reln protein. Genetic analysis shows that reln function depends on dab1, and vice versa, as ex...

journal_title：Genes & development

authors： Howell BW,Herrick TM,Cooper JA

更新日期：1999-03-15 00:00:00

abstract：:To investigate the importance of sequences between the yeast (Saccharomyces cerevisiae) branch point (TACTAAC box) and 3' splice site (AG), we generated a series of pre-mRNA substrates that differed in the length of RNA retained on the 3' side of the TACTAAC box. These pre-mRNAs were compared as substrates for the fir...

journal_title：Genes & development

authors： Rymond BC,Torrey DD,Rosbash M

更新日期：1987-05-01 00:00:00

abstract：:The Drosophila somatic sex-determination regulatory pathway has been well studied, but little is known about the target genes that it ultimately controls. In a differential screen for sex-specific transcripts expressed in fly heads, we identified a highly male-enriched transcript encoding Takeout, a protein related to...

journal_title：Genes & development

authors： Dauwalder B,Tsujimoto S,Moss J,Mattox W

更新日期：2002-11-15 00:00:00

abstract：:Previous work has shown that rRNA synthesis is strongly inhibited in yeast top1-top2 double mutants. Here, we show that inactivation of yeast topoisomerases can have paradoxical effects on transcription by RNA polymerase I. For example, transcription of ribosomal minigenes on extrachromosomal plasmids is greatly stimu...

journal_title：Genes & development

authors： Schultz MC,Brill SJ,Ju Q,Sternglanz R,Reeder RH

更新日期：1992-07-01 00:00:00

abstract：:We report on the function of the human ortholog of Saccharomyces cerevisiae Rif1 (Rap1-interacting factor 1). Yeast Rif1 associates with telomeres and regulates their length. In contrast, human Rif1 did not accumulate at functional telomeres, but localized to dysfunctional telomeres and to telomeric DNA clusters in AL...

journal_title：Genes & development

authors： Silverman J,Takai H,Buonomo SB,Eisenhaber F,de Lange T

更新日期：2004-09-01 00:00:00

abstract：:Previous studies have shown that differentiation of 3T3-L1 preadipocytes leads to the transcriptional activation of a group of adipose-specific genes. As an approach to defining the mechanism responsible for activating the expression of these genes, we investigated the binding of nuclear factors to the promoters of tw...

journal_title：Genes & development

authors： Christy RJ,Yang VW,Ntambi JM,Geiman DE,Landschulz WH,Friedman AD,Nakabeppu Y,Kelly TJ,Lane MD

更新日期：1989-09-01 00:00:00