Retinoic acid modifies mesodermal patterning in early Xenopus embryos.


:Treatment of early Xenopus embryos with retinoic acid (RA) produces a concentration-dependent series of defects in anterior axial structures that range from small deletions to embryos lacking heads. The graded series of axial defects obtained after RA administration to early embryos appears to result, in part, from actions of RA on embryonic mesoderm. RA modifies the differentiation of anterior dorsal mesoderm from animal cap ectoderm induced by mesoderm-inducing peptide growth factors (PGFs). Concentrations of RA that suppress anterior dorsal mesoderm result in the differentiation of mesoderm of more posterior or ventral character. The suppression of anterior dorsal mesoderm may account for the absence of anterior neural ectoderm after RA treatment. Although RA changes the character of mesoderm, it does not seem to affect mesodermal induction by PGFs or the levels of Xhox3 mRNA induced in the mesoderm by PGFs. RA therefore appears to affect steps downstream from those involved in the initial induction of mesoderm. In experiments to examine the possible physiological role of RA in early Xenopus development, dorsal and ventral ectoderm were found to respond differently to identical concentrations of PGFs. One potential basis for this heterogeneity is the existence of a localized inhibitor, possibly RA, in the early Xenopus embryo. RA could therefore contribute to axial patterning by inhibiting the development of mesoderm of different character induced by PGFs.


Genes Dev


Genes & development


Ruiz i Altaba A,Jessell T




Has Abstract


1991-02-01 00:00:00












  • GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2.

    abstract::Mammalian cells possess two amino acid-sensing kinases: general control nonderepressible 2 (GCN2) and mechanistic target of rapamycin complex 1 (mTORC1). Their combined effects orchestrate cellular adaptation to amino acid levels, but how their activities are coordinated remains poorly understood. Here, we demonstrate...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Ye J,Palm W,Peng M,King B,Lindsten T,Li MO,Koumenis C,Thompson CB

    更新日期:2015-11-15 00:00:00

  • The stringent response in Myxococcus xanthus is regulated by SocE and the CsgA C-signaling protein.

    abstract::Myxococcus xanthus fruiting body development is induced by amino acid limitation. The decision to grow or develop is established by the RelA-dependent stringent response and A-signaling. We identified two new members of this regulatory hierarchy, socE and the C-signaling gene csgA. SocE depletion arrests growth and in...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Crawford EW Jr,Shimkets LJ

    更新日期:2000-02-15 00:00:00

  • Phenotypic selection and characterization of mutant alleles of a eukaryotic DNA topoisomerase I.

    abstract::We have developed a simple, effective genetic screen for mutant alleles of eukaryotic DNA topoisomerase I that manifest severely depressed or complete loss of enzymatic function. The screen is based on the extreme toxicity of vaccinia topoisomerase expression in the Escherichia coli lysogen strain BL21(DE3) and is not...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Morham SG,Shuman S

    更新日期:1990-04-01 00:00:00

  • Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity.

    abstract::RUNX1/AML1 is required for the development of definitive hematopoiesis, and its activity is altered by mutations, deletions, and chromosome translocations in human acute leukemia. RUNX1 function can be regulated by post-translational modifications and protein-protein interactions. We show that RUNX1 is arginine-methyl...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Zhao X,Jankovic V,Gural A,Huang G,Pardanani A,Menendez S,Zhang J,Dunne R,Xiao A,Erdjument-Bromage H,Allis CD,Tempst P,Nimer SD

    更新日期:2008-03-01 00:00:00

  • Chromatin remodeler CHD7 regulates the stem cell identity of human neural progenitors.

    abstract::Multiple congenital disorders often present complex phenotypes, but how the mutation of individual genetic factors can lead to multiple defects remains poorly understood. In the present study, we used human neuroepithelial (NE) cells and CHARGE patient-derived cells as an in vitro model system to identify the function...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Chai M,Sanosaka T,Okuno H,Zhou Z,Koya I,Banno S,Andoh-Noda T,Tabata Y,Shimamura R,Hayashi T,Ebisawa M,Sasagawa Y,Nikaido I,Okano H,Kohyama J

    更新日期:2018-01-15 00:00:00

  • Drosophila Brain Tumor is a translational repressor.

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    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Sonoda J,Wharton RP

    更新日期:2001-03-15 00:00:00

  • Molecular genetics of aristaless, a prd-type homeo box gene involved in the morphogenesis of proximal and distal pattern elements in a subset of appendages in Drosophila.

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    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Schneitz K,Spielmann P,Noll M

    更新日期:1993-01-01 00:00:00

  • Compound mutants for the paralogous hoxa-4, hoxb-4, and hoxd-4 genes show more complete homeotic transformations and a dose-dependent increase in the number of vertebrae transformed.

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    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Horan GS,Ramírez-Solis R,Featherstone MS,Wolgemuth DJ,Bradley A,Behringer RR

    更新日期:1995-07-01 00:00:00

  • Purkinje cell protein-2 regulatory regions and transgene expression in cerebellar compartments.

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    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Vandaele S,Nordquist DT,Feddersen RM,Tretjakoff I,Peterson AC,Orr HT

    更新日期:1991-07-01 00:00:00

  • Regulation of cell growth by Notch signaling and its differential requirement in normal vs. tumor-forming stem cells in Drosophila.

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    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Song Y,Lu B

    更新日期:2011-12-15 00:00:00

  • Analysis of the lethal interaction between the prune and Killer of prune mutations of Drosophila.

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    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Biggs J,Tripoulas N,Hersperger E,Dearolf C,Shearn A

    更新日期:1988-10-01 00:00:00

  • ZNF281 enhances cardiac reprogramming by modulating cardiac and inflammatory gene expression.

    abstract::Direct reprogramming of fibroblasts to cardiomyocytes represents a potential means of restoring cardiac function following myocardial injury. AKT1 in the presence of four cardiogenic transcription factors, GATA4, HAND2, MEF2C, and TBX5 (AGHMT), efficiently induces the cardiac gene program in mouse embryonic fibroblast...

    journal_title:Genes & development

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    authors: Zhou H,Morales MG,Hashimoto H,Dickson ME,Song K,Ye W,Kim MS,Niederstrasser H,Wang Z,Chen B,Posner BA,Bassel-Duby R,Olson EN

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  • STAU1 binding 3' UTR IRAlus complements nuclear retention to protect cells from PKR-mediated translational shutdown.

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    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Elbarbary RA,Li W,Tian B,Maquat LE

    更新日期:2013-07-01 00:00:00

  • Expression of two members of the Wnt family during mouse development--restricted temporal and spatial patterns in the developing neural tube.

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    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Roelink H,Nusse R

    更新日期:1991-03-01 00:00:00

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    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Schmitt ME,Clayton DA

    更新日期:1994-11-01 00:00:00

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    journal_title:Genes & development

    pub_type: 评论,杂志文章


    authors: Cornet F,Louarn J,Patte J,Louarn JM

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  • Novel pro- and anti-recombination activities of the Bloom's syndrome helicase.

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    journal_title:Genes & development

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    authors: Bugreev DV,Yu X,Egelman EH,Mazin AV

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    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Dutta A,Gogol M,Kim JH,Smolle M,Venkatesh S,Gilmore J,Florens L,Washburn MP,Workman JL

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  • Transcript levels and translational control of hsp70 synthesis in Xenopus oocytes.

    abstract::Until recently it was believed that Xenopus oocytes respond to heat shock by synthesizing the 70-kD heat shock protein hsp70 and that, uniquely amongst animal cell types, this response is mediated entirely at the translational level. This view has now been challenged and we present data that reevaluate the involvement...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Horrell A,Shuttleworth J,Colman A

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  • The function of Xenopus Bloom's syndrome protein homolog (xBLM) in DNA replication.

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    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Liao S,Graham J,Yan H

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  • Circular forms of developmentally excised DNA in Euplotes crassus have a heteroduplex junction.

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    journal_title:Genes & development

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    authors: Klobutcher LA,Turner LR,LaPlante J

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  • Control of translation and mRNA degradation by miRNAs and siRNAs.

    abstract::The control of translation and mRNA degradation is an important part of the regulation of gene expression. It is now clear that small RNA molecules are common and effective modulators of gene expression in many eukaryotic cells. These small RNAs that control gene expression can be either endogenous or exogenous micro ...

    journal_title:Genes & development

    pub_type: 杂志文章,评审


    authors: Valencia-Sanchez MA,Liu J,Hannon GJ,Parker R

    更新日期:2006-03-01 00:00:00

  • Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts.

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    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Wang H,Somers GW,Bashirullah A,Heberlein U,Yu F,Chia W

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  • Molecular analysis of reverse mutations from nonagouti (a) to black-and-tan (a(t)) and white-bellied agouti (Aw) reveals alternative forms of agouti transcripts.

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    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Bultman SJ,Klebig ML,Michaud EJ,Sweet HO,Davisson MT,Woychik RP

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    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Caudy AA,Myers M,Hannon GJ,Hammond SM

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    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Kamachi Y,Uchikawa M,Tanouchi A,Sekido R,Kondoh H

    更新日期:2001-05-15 00:00:00

  • Structural basis for corepressor assembly by the orphan nuclear receptor TLX.

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    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Zhi X,Zhou XE,He Y,Searose-Xu K,Zhang CL,Tsai CC,Melcher K,Xu HE

    更新日期:2015-02-15 00:00:00

  • Myc family oncoproteins function through a common pathway to transform normal cells in culture: cross-interference by Max and trans-acting dominant mutants.

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    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Mukherjee B,Morgenbesser SD,DePinho RA

    更新日期:1992-08-01 00:00:00

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    journal_title:Genes & development

    pub_type: 杂志文章


    authors: von Melchner H,DeGregori JV,Rayburn H,Reddy S,Friedel C,Ruley HE

    更新日期:1992-06-01 00:00:00

  • β-Actin mRNA compartmentalization enhances focal adhesion stability and directs cell migration.

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    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Katz ZB,Wells AL,Park HY,Wu B,Shenoy SM,Singer RH

    更新日期:2012-09-01 00:00:00