Differentiation-induced gene expression in 3T3-L1 preadipocytes: CCAAT/enhancer binding protein interacts with and activates the promoters of two adipocyte-specific genes.

abstract：:Piwi-piRNA (Piwi-interacting RNA) ribonucleoproteins (piRNPs) enforce retrotransposon silencing, a function critical for preserving the genome integrity of germ cells. The molecular functions of most of the factors that have been genetically implicated in primary piRNA biogenesis are still elusive. Here we show that M...

journal_title：Genes & development

authors： Vourekas A,Zheng K,Fu Q,Maragkakis M,Alexiou P,Ma J,Pillai RS,Mourelatos Z,Wang PJ

更新日期：2015-03-15 00:00:00

abstract：:Subependymal nodules (SENs) and subependymal giant cell astrocytomas (SEGAs) are common brain lesions found in patients with tuberous sclerosis complex (TSC). These brain lesions present a mixed glioneuronal phenotype and have been hypothesized to originate from neural stem cells. However, this hypothesis has not been...

journal_title：Genes & development

authors： Zhou J,Shrikhande G,Xu J,McKay RM,Burns DK,Johnson JE,Parada LF

更新日期：2011-08-01 00:00:00

abstract：:Previous characterization of the Saccharomyces cerevisiae Spt4, Spt5, and Spt6 proteins suggested that these proteins act as transcription factors that modify chromatin structure. In this work, we report new genetic and biochemical studies of Spt4, Spt5, and Spt6 that reveal a role for these factors in transcription e...

journal_title：Genes & development

authors： Hartzog GA,Wada T,Handa H,Winston F

更新日期：1998-02-01 00:00:00

abstract：:AMP-activated protein kinase (AMPK) is a sensor of energy status that maintains cellular energy homeostasis. It arose very early during eukaryotic evolution, and its ancestral role may have been in the response to starvation. Recent work shows that the kinase is activated by increases not only in AMP, but also in ADP....

journal_title：Genes & development

authors： Hardie DG

更新日期：2011-09-15 00:00:00

abstract：:In this issue of Genes & Development, Abruzzi et al. (pp. 2374-2386) use chromatin immunoprecipitation (ChIP) tiling array assays (ChIP-chip) to show that physical interactions between circadian (≅24-h) clock machineries and genomes are more widespread than previously thought and provide novel insights into how clocks...

journal_title：Genes & development

authors： Edery I

更新日期：2011-11-15 00:00:00

abstract：:Hedgehog signaling has been linked to cell proliferation in a variety of systems; however, its effects on the cell cycle have not been closely studied. In the vertebrate retina, Hedgehog's effects are controversial, with some reports emphasizing increased proliferation and others pointing to a role in cell cycle exit....

journal_title：Genes & development

authors： Locker M,Agathocleous M,Amato MA,Parain K,Harris WA,Perron M

更新日期：2006-11-01 00:00:00

abstract：:Activated transcription by RNA polymerase II (Pol II) requires coactivators, one of which is the SRB/mediator. Whereas Srb4, an essential subunit of the SRB/mediator, is broadly required for Pol II transcription in yeast, we have shown that it is dispensable for the transcriptional activation of some genes. Here, we s...

journal_title：Genes & development

authors： Lee DK,Kim S,Lis JT

更新日期：1999-11-15 00:00:00

abstract：:Mice mutant for the bHLH gene Hes1, which is known to keep cells in a proliferative state, mostly lack thymus. Transfer of Hes1-null fetal liver cells into RAG2-null host mice normally reconstitutes B cells but fails to generate mature T cells in the thymus. In the reconstituted thymus, T cell differentiation is arres...

journal_title：Genes & development

authors： Tomita K,Hattori M,Nakamura E,Nakanishi S,Minato N,Kageyama R

更新日期：1999-05-01 00:00:00

abstract：:The bHLH-PAS transcription factor SIM1 is expressed during the development of the hypothalamic-pituitary axis in three hypothalamic nuclei: the paraventricular nucleus (PVN), the anterior periventricular nucleus (aPV), and the supraoptic nucleus (SON). To investigate Sim1 function in the hypothalamus, we produced mice...

journal_title：Genes & development

authors： Michaud JL,Rosenquist T,May NR,Fan CM

更新日期：1998-10-15 00:00:00

abstract：:Although Apc is well characterized as a tumor-suppressor gene in the intestine, the precise mechanism of this suppression remains to be defined. Using a novel inducible Ahcre transgenic line in conjunction with a loxP-flanked Apc allele we, show that loss of Apc acutely activates Wnt signaling through the nuclear accu...

journal_title：Genes & development

authors： Sansom OJ,Reed KR,Hayes AJ,Ireland H,Brinkmann H,Newton IP,Batlle E,Simon-Assmann P,Clevers H,Nathke IS,Clarke AR,Winton DJ

更新日期：2004-06-15 00:00:00

abstract：:Export to the cytoplasm of U3 RNA transcribed from a rat U3 gene injected into the nucleus of Xenopus oocytes indicates that the biogenesis of U3 RNA, like that of the previously studied Sm-precipitable nucleoplasmic snRNAs (U1, U2, U4, and U5), includes a cytoplasmic phase. The regulation of import of the U3 snRNA in...

journal_title：Genes & development

authors： Baserga SJ,Gilmore-Hebert M,Yang XW

更新日期：1992-06-01 00:00:00

abstract：:Hundreds of microRNAs (miRNAs) have been discovered in metazoans and plants, and understanding of their biogenesis has advanced dramatically; however, relatively little is known about the cofactors necessary for miRNA regulation of target gene expression. In Caenorhabditis elegans, the conserved miRNA let-7 and its pa...

journal_title：Genes & development

authors： Hayes GD,Riedel CG,Ruvkun G

更新日期：2011-10-01 00:00:00

abstract：:It is now well appreciated that the apoptosome, which governs caspase-dependent cell death, also drives nonapoptotic caspase activation to remodel cells. However, the determinants that specify whether the apoptosome acts to kill or remodel have yet to be identified. Here we report that Tango7 collaborates with the Dro...

journal_title：Genes & development

authors： D'Brot A,Chen P,Vaishnav M,Yuan S,Akey CW,Abrams JM

更新日期：2013-08-01 00:00:00

abstract：:Activating JAK2 point mutations are implicated in the pathogenesis of myeloid and lymphoid malignancies, including high-risk B-cell acute lymphoblastic leukemia (B-ALL). In preclinical studies, treatment of JAK2 mutant leukemias with type I JAK2 inhibitors (e.g., Food and Drug Administration [FDA]-approved ruxolitinib...

journal_title：Genes & development

authors： Kim SK,Knight DA,Jones LR,Vervoort S,Ng AP,Seymour JF,Bradner JE,Waibel M,Kats L,Johnstone RW

更新日期：2018-06-01 00:00:00

abstract：:The Rad51 and Lim15 proteins of lily, which are homologs of the bacterial RecA protein, were found on chromosomes in various stages of meiotic prophase 1. The presence of both Rad51 and Lim15 proteins as discrete foci on leptotene and zygotene chromosomes and their colocalization suggest that meiotic recombination beg...

journal_title：Genes & development

authors： Terasawa M,Shinohara A,Hotta Y,Ogawa H,Ogawa T

更新日期：1995-04-15 00:00:00

abstract：:The recombination-activating gene 1 (RAG1) and RAG2 proteins initiate V(D)J recombination, the process that assembles the B- and T-lymphocyte antigen receptor genes of jawed vertebrates. RAG1 and RAG2 are thought to have arisen from a transposable element, but the origins of this element are not understood. We show th...

journal_title：Genes & development

authors： Carmona LM,Fugmann SD,Schatz DG

更新日期：2016-04-15 00:00:00

abstract：:The oncoprotein MDM2 binds to the activation domain of the tumor suppressor p53 and inhibits its ability to stimulate transcription. This same region of p53 is able to bind several basal transcription factors that appear to be important for the transactivation function of p53. It has therefore been suggested that MDM2...

journal_title：Genes & development

authors： Thut CJ,Goodrich JA,Tjian R

更新日期：1997-08-01 00:00:00

abstract：:In the Bar mutation of Drosophila, ommatidial differentiation is known to be suppressed in the anterior portion of the eye. Our structural analysis shows that the Bar region contains a pair of homeo box genes, BarH1 and BarH2. These genes encode polypeptides similar in size and sequence and share a common homeo domain...

journal_title：Genes & development

authors： Higashijima S,Kojima T,Michiue T,Ishimaru S,Emori Y,Saigo K

更新日期：1992-01-01 00:00:00

abstract：:Faithful duplication of the genome relies on the ability to cope with an imperfect template. We investigated replication of UV-damaged DNA in Escherichia coli and found that ongoing replication stops for at least 15-20 min before resuming. Undamaged origins of replication (oriC) continue to fire at the normal rate and...

journal_title：Genes & development

authors： Rudolph CJ,Upton AL,Lloyd RG

更新日期：2007-03-15 00:00:00

abstract：:The generation of neurons by progenitor cells involves the tight coordination of multiple cellular activities, including cell cycle exit, initiation of neuronal differentiation, and cell migration. The mechanisms that integrate these different events into a coherent developmental program are not well understood. Here ...

journal_title：Genes & development

authors： Nguyen L,Besson A,Heng JI,Schuurmans C,Teboul L,Parras C,Philpott A,Roberts JM,Guillemot F

更新日期：2006-06-01 00:00:00

abstract：:Mitotic duration is determined by activation of the anaphase-promoting complex/cyclosome (APC/C) bound to its coactivator, Cdc20. Kinetochores, the microtubule-interacting machines on chromosomes, restrain mitotic exit when not attached to spindle microtubules by generating a Cdc20-containing complex that inhibits the...

journal_title：Genes & development

authors： Kim T,Lara-Gonzalez P,Prevo B,Meitinger F,Cheerambathur DK,Oegema K,Desai A

更新日期：2017-06-01 00:00:00

abstract：:Although progesterone has been recognized as essential for the establishment and maintenance of pregnancy, this steroid hormone has been recently implicated to have a functional role in a number of other reproductive events. The physiological effects of progesterone are mediated by the progesterone receptor (PR), a me...

journal_title：Genes & development

authors： Lydon JP,DeMayo FJ,Funk CR,Mani SK,Hughes AR,Montgomery CA Jr,Shyamala G,Conneely OM,O'Malley BW

更新日期：1995-09-15 00:00:00

abstract：:Wilms Tumor, the most common pediatric kidney cancer, evolves from the failure of terminal differentiation of the embryonic kidney. Here we show that overexpression of the heterochronic regulator Lin28 during kidney development in mice markedly expands nephrogenic progenitors by blocking their final wave of differenti...

journal_title：Genes & development

authors： Urbach A,Yermalovich A,Zhang J,Spina CS,Zhu H,Perez-Atayde AR,Shukrun R,Charlton J,Sebire N,Mifsud W,Dekel B,Pritchard-Jones K,Daley GQ

更新日期：2014-05-01 00:00:00

abstract：:Myxococcus xanthus fruiting body development is induced by amino acid limitation. The decision to grow or develop is established by the RelA-dependent stringent response and A-signaling. We identified two new members of this regulatory hierarchy, socE and the C-signaling gene csgA. SocE depletion arrests growth and in...

journal_title：Genes & development

authors： Crawford EW Jr,Shimkets LJ

更新日期：2000-02-15 00:00:00

abstract：:The mechanisms by which homeoproteins bind selectively to target genes in vivo have long remained unresolved. Here we report that PIAS1 confers DNA-binding specificity on the Msx1 homeoprotein by regulating its subnuclear localization and proximity to target genes. We demonstrate that the interaction of Msx1 with PIAS...

journal_title：Genes & development

authors： Lee H,Quinn JC,Prasanth KV,Swiss VA,Economides KD,Camacho MM,Spector DL,Abate-Shen C

更新日期：2006-04-01 00:00:00

abstract：:Adult mesenchymal stem cells (MSCs) derived from bone marrow contribute to the regeneration of multiple types of mesenchymal tissues. Here we describe the functional role of a novel form of cross-talk between the transforming growth factor beta1 (TGF-beta1) and Wnt signaling pathways in regulating the activities of hu...

journal_title：Genes & development

authors： Jian H,Shen X,Liu I,Semenov M,He X,Wang XF

更新日期：2006-03-15 00:00:00

abstract：:Experiments in Xenopus have illustrated the importance of extracellular morphogens for embryonic gene regulation in vertebrates. Much less is known about how induction leads to the correct positioning of boundaries; for example, between germ layers. Here we report that the neuroectoderm/mesoderm boundary is controlled...

journal_title：Genes & development

authors： Linder B,Mentele E,Mansperger K,Straub T,Kremmer E,Rupp RA

更新日期：2007-04-15 00:00:00

abstract：:Programmed cell death occurs in a highly reproducible manner during Caenorhabditis elegans development. We demonstrate that, during embryogenesis, miR-35 and miR-58 bantam family microRNAs (miRNAs) cooperate to prevent the precocious death of mothers of cells programmed to die by repressing the gene egl-1, which encod...

journal_title：Genes & development

authors： Sherrard R,Luehr S,Holzkamp H,McJunkin K,Memar N,Conradt B

更新日期：2017-01-15 00:00:00

abstract：:Mismatch repair (MMR) has important roles in meiotic and mitotic recombination, DNA damage signaling, and various aspects of DNA metabolism including class-switch recombination, somatic hypermutation, and triplet-repeat expansion. Defects in MMR are responsible for human cancers characterized by microsatellite instabi...

journal_title：Genes & development

authors： Siegl-Cachedenier I,Muñoz P,Flores JM,Klatt P,Blasco MA

更新日期：2007-09-01 00:00:00

abstract：:Cascades of zygotic gene expression pattern the anterior-posterior (AP) and dorsal-ventral (DV) axes of the early Drosophila embryo. Here, we used the global run-on sequencing assay (GRO-seq) to map the genome-wide RNA polymerase distribution during early Drosophila embryogenesis, thus providing insights into how gene...

journal_title：Genes & development

authors： Saunders A,Core LJ,Sutcliffe C,Lis JT,Ashe HL

更新日期：2013-05-15 00:00:00