Abstract:
:The cJun N-terminal kinase 1 (JNK1) is implicated in diet-induced obesity. Indeed, germline ablation of the murine Jnk1 gene prevents diet-induced obesity. Here we demonstrate that selective deficiency of JNK1 in the murine nervous system is sufficient to suppress diet-induced obesity. The failure to increase body mass is mediated, in part, by increased energy expenditure that is associated with activation of the hypothalamic-pituitary-thyroid axis. Disruption of thyroid hormone function prevents the effects of nervous system JNK1 deficiency on body mass. These data demonstrate that the hypothalamic-pituitary-thyroid axis represents an important target of metabolic signaling by JNK1.
journal_name
Genes Devjournal_title
Genes & developmentauthors
Sabio G,Cavanagh-Kyros J,Barrett T,Jung DY,Ko HJ,Ong H,Morel C,Mora A,Reilly J,Kim JK,Davis RJdoi
10.1101/gad.1878510subject
Has Abstractpub_date
2010-02-01 00:00:00pages
256-64issue
3eissn
0890-9369issn
1549-5477pii
gad.1878510journal_volume
24pub_type
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