AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function.

abstract：:A prominent feature of cell differentiation is the initiation and maintenance of an irreversible cell cycle arrest with the complex involvement of the retinoblastoma (RB) family (RB, p130, p107). We have isolated the HBP1 transcriptional repressor as a potential target of the RB family in differentiated cells. By homo...

journal_title：Genes & development

authors： Tevosian SG,Shih HH,Mendelson KG,Sheppard KA,Paulson KE,Yee AS

更新日期：1997-02-01 00:00:00

abstract：:A novel histone methyltransferase, termed Set9, was isolated from human cells. Set9 contains a SET domain, but lacks the pre- and post-SET domains. Set9 methylates specifically lysine 4 (K4) of histone H3 (H3-K4) and potentiates transcription activation. The histone H3 tail interacts specifically with the histone deac...

journal_title：Genes & development

authors： Nishioka K,Chuikov S,Sarma K,Erdjument-Bromage H,Allis CD,Tempst P,Reinberg D

更新日期：2002-02-15 00:00:00

abstract：:Nonhomologous end joining (NHEJ) and homologous recombination (HR) represent the two major pathways of DNA double-strand break (DSB) repair in eukaryotic cells. NHEJ repairs DSBs by ligation of cognate broken ends irrespective of homologous flanking sequences, whereas HR repairs DSBs using an undamaged homologous temp...

journal_title：Genes & development

authors： Mills KD,Ferguson DO,Essers J,Eckersdorff M,Kanaar R,Alt FW

更新日期：2004-06-01 00:00:00

abstract：:Rb mutants exhibit aneuploidy and aberrant chromosome structure during mitosis. In this issue of Genes & Development, a new paper from Longworth and colleagues (1011-1024) describes both physical and functional interactions between Drosophila Rbf1 and the dCAP-D3 subunit of condensin II. This work directly implicates ...

journal_title：Genes & development

authors： Lavoie BD

更新日期：2008-04-15 00:00:00

abstract：:All viruses require cellular ribosomes to translate their mRNAs. Viruses producing methyl-7 (m⁷) GTP-capped mRNAs, like Herpes Simplex Virus-1 (HSV-1), stimulate cap-dependent translation by activating mTORC1 to inhibit the translational repressor 4E-binding protein 1 (4E-BP1). Here, we establish that the HSV-1 kinase...

journal_title：Genes & development

authors： Chuluunbaatar U,Roller R,Feldman ME,Brown S,Shokat KM,Mohr I

更新日期：2010-12-01 00:00:00

abstract：:The HOP2 and MND1 genes are indispensable for meiotic recombination. The products of these genes associate to form a stable heterodimeric complex that binds DNA and stimulates the recombinase activity of Rad51 and Dmc1. Here we conduct molecular studies to delineate the action mechanism of the Hop2-Mnd1 complex. We pr...

journal_title：Genes & development

authors： Chi P,San Filippo J,Sehorn MG,Petukhova GV,Sung P

更新日期：2007-07-15 00:00:00

abstract：:Treatment with retinoic acid (RA) is known to produce complex teratogenic effects in vertebrates, and its presence in the developing embryo as an endogenous substance has led to the suggestion that RA might be a natural morphogenetic agent. Although our understanding of the molecular mechanism of RA action has improve...

journal_title：Genes & development

authors： Rossant J,Zirngibl R,Cado D,Shago M,Giguère V

更新日期：1991-08-01 00:00:00

abstract：:Cyclin D1 is part of a cell cycle control node consistently deregulated in most human cancers. However, studies with cyclin D1-null mice indicate that it is dispensable for normal mouse development as well as cell growth in culture. Here, we provide evidence that ras-mediated tumorigenesis depends on signaling pathway...

journal_title：Genes & development

authors： Robles AI,Rodriguez-Puebla ML,Glick AB,Trempus C,Hansen L,Sicinski P,Tennant RW,Weinberg RA,Yuspa SH,Conti CJ

更新日期：1998-08-15 00:00:00

abstract：:Chromosomal processes related to formation and function of meiotic chiasmata have been analyzed in Sordaria macrospora. Double-strand breaks (DSBs), programmed or gamma-rays-induced, are found to promote four major events beyond recombination and accompanying synaptonemal complex formation: (1) juxtaposition of homolo...

journal_title：Genes & development

authors： Storlazzi A,Tessé S,Gargano S,James F,Kleckner N,Zickler D

更新日期：2003-11-01 00:00:00

abstract：:The embryonic expression of COUP-TFII, an orphan nuclear receptor, suggests that it may participate in mesenchymal-epithelial interactions required for organogenesis. Targeted deletion of the COUP-TFII gene results in embryonic lethality with defects in angiogenesis and heart development. COUP-TFII mutants are defecti...

journal_title：Genes & development

authors： Pereira FA,Qiu Y,Zhou G,Tsai MJ,Tsai SY

更新日期：1999-04-15 00:00:00

abstract：:The Komeda miniature rat Ishikawa (KMI) is a naturally occurring mutant caused by an autosomal recessive mutation mri, which exhibits longitudinal growth retardation. Here we identified the mri mutation as a deletion in the rat gene encoding cGMP-dependent protein kinase type II (cGKII). KMIs showed an expanded growth...

journal_title：Genes & development

authors： Chikuda H,Kugimiya F,Hoshi K,Ikeda T,Ogasawara T,Shimoaka T,Kawano H,Kamekura S,Tsuchida A,Yokoi N,Nakamura K,Komeda K,Chung UI,Kawaguchi H

更新日期：2004-10-01 00:00:00

abstract：:To determine the prevalence of cotranscriptional splicing in Drosophila, we sequenced nascent RNA transcripts from Drosophila S2 cells as well as from Drosophila heads. Eighty-seven percent of the introns assayed manifest >50% cotranscriptional splicing. The remaining 13% are cotranscriptionally spliced poorly or slow...

journal_title：Genes & development

authors： Khodor YL,Rodriguez J,Abruzzi KC,Tang CH,Marr MT 2nd,Rosbash M

更新日期：2011-12-01 00:00:00

abstract：:Genomic imprinting is an epigenetic process regulated by germline-derived DNA methylation, causing parental origin-specific monoallelic gene expression. Zinc finger protein 57 (ZFP57) is critical for maintenance of this epigenetic memory during post-fertilization reprogramming, yet incomplete penetrance of ZFP57 mutat...

journal_title：Genes & development

authors： Takahashi N,Coluccio A,Thorball CW,Planet E,Shi H,Offner S,Turelli P,Imbeault M,Ferguson-Smith AC,Trono D

更新日期：2019-01-01 00:00:00

abstract：:Plectin, a major linker and scaffolding protein of the cytoskeleton, has been shown to be essential for the mechanical integrity of skin, skeletal muscle, and heart. Studying fibroblast and astroglial cell cultures derived from plectin (-/-) mice, we found that their actin cytoskeleton, including focal adhesion contac...

journal_title：Genes & development

authors： Andrä K,Nikolic B,Stöcher M,Drenckhahn D,Wiche G

更新日期：1998-11-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer death in the United States with a median survival of <6 mo and a dismal 5-yr survival rate of 3%-5%. The cancer's lethal nature stems from its propensity to rapidly disseminate to the lymphatic system and distant organs. This aggressive biol...

journal_title：Genes & development

authors： Hezel AF,Kimmelman AC,Stanger BZ,Bardeesy N,Depinho RA

更新日期：2006-05-15 00:00:00

abstract：:The molecular mechanisms driving brain development at risk in autism spectrum disorders (ASDs) remain mostly unknown. Previous studies have implicated the transcription factor FOXP1 in both brain development and ASD pathophysiology. However, the specific molecular pathways both upstream of and downstream from FOXP1 ar...

journal_title：Genes & development

authors： Usui N,Araujo DJ,Kulkarni A,Co M,Ellegood J,Harper M,Toriumi K,Lerch JP,Konopka G

更新日期：2017-10-15 00:00:00

abstract：:Cancer stem cells (CSCs) are postulated to be a small subset of tumor cells with tumor-initiating ability that shares features with normal tissue-specific stem cells. The origin of CSCs and the mechanisms underlying their genesis are poorly understood, and it is uncertain whether it is possible to obliterate CSCs with...

journal_title：Genes & development

authors： Song Y,Lu B

更新日期：2011-12-15 00:00:00

abstract：:The retinoblastoma tumor suppressor (pRb) protein associates with chromatin and regulates gene expression. Numerous studies have identified Rb-dependent RNA signatures, but the proteomic effects of Rb loss are largely unexplored. We acutely ablated Rb in adult mice and conducted a quantitative analysis of RNA and prot...

journal_title：Genes & development

authors： Nicolay BN,Danielian PS,Kottakis F,Lapek JD Jr,Sanidas I,Miles WO,Dehnad M,Tschöp K,Gierut JJ,Manning AL,Morris R,Haigis K,Bardeesy N,Lees JA,Haas W,Dyson NJ

更新日期：2015-09-01 00:00:00

abstract：:Transcription of frog rDNA by mouse cell factors is the only documented exception to the observed species selectivity of rRNA gene expression. This heterologous transcription is authentic in that it uses the normal frog upstream and core promoter domains, as well as the normal mouse polymerase I transcription factors,...

journal_title：Genes & development

authors： Pape LK,Windle JJ,Sollner-Webb B

更新日期：1990-01-01 00:00:00

abstract：:We used Sarkosyl to analyze steps along the pathway of transcription initiation by RNA polymerase III. Sarkosyl (0.015%) inhibited transcription when present prior to incubation of RNA polymerase III, TFIIIB, and TFIIIC with the VAI gene, whereas it had no detectable effect on initiation or reinitiation of transcripti...

journal_title：Genes & development

authors： Kovelman R,Roeder RG

更新日期：1990-04-01 00:00:00

abstract：:The association of transcription corepressors SMRT and N-CoR with retinoid and thyroid receptors results in suppression of basal transcriptional activity. A key event in nuclear receptor signaling is the hormone-dependent release of corepressor and the recruitment of coactivator. Biochemical and structural studies hav...

journal_title：Genes & development

authors： Nagy L,Kao HY,Love JD,Li C,Banayo E,Gooch JT,Krishna V,Chatterjee K,Evans RM,Schwabe JW

更新日期：1999-12-15 00:00:00

abstract：:We have shown that Wnt signals are necessary and sufficient for neural crest cells to adopt pigment cell fates. nacre, a zebrafish homolog of MITF, is required for pigment cell differentiation. We isolated a promoter region of nacre that contains Tcf/Lef binding sites, which can mediate Wnt responsiveness. This promot...

journal_title：Genes & development

authors： Dorsky RI,Raible DW,Moon RT

更新日期：2000-01-15 00:00:00

abstract：:Genome integrity is constantly monitored by sophisticated cellular networks, collectively termed the DNA damage response (DDR). A common feature of DDR proteins is their mobilization in response to genotoxic stress. Here, we outline how the development of various complementary methodologies has provided valuable insig...

journal_title：Genes & development

authors： Polo SE,Jackson SP

更新日期：2011-03-01 00:00:00

abstract：:The ultraviolet (UV)-induced (6-4) pyrimidine-pyrimidone photoproduct [(6-4) PP] confers a large structural distortion in DNA. Here we examine in human cells the roles of translesion synthesis (TLS) DNA polymerases (Pols) in promoting replication through a (6-4) TT photoproduct carried on a duplex plasmid where bidire...

journal_title：Genes & development

authors： Yoon JH,Prakash L,Prakash S

更新日期：2010-01-15 00:00:00

abstract：:The human T cell-specific transcription factor TCF-1 alpha plays a key role in the tissue-specific activation of the T cell receptor (TCR) C alpha enhancer and binds to pyrimidine-rich elements (5'-PyCTTTG-3') present in a variety of other T cell-specific control regions. Using amino acid sequence information derived ...

journal_title：Genes & development

authors： Waterman ML,Fischer WH,Jones KA

更新日期：1991-04-01 00:00:00

abstract：:Adenomatous polyposis coli (APC) regulates the activity of β-catenin, an integral component of Wnt signaling. However, the selective role of the APC-β-catenin pathway in cerebral cortical development is unknown. Here we genetically dissected the relative contributions of APC-regulated β-catenin signaling in cortical p...

journal_title：Genes & development

authors： Nakagawa N,Li J,Yabuno-Nakagawa K,Eom TY,Cowles M,Mapp T,Taylor R,Anton ES

更新日期：2017-08-15 00:00:00

abstract：:The distal enhancer of the T-cell receptor (TCR) alpha chain gene has become a paradigm for studies of the assembly and activity of architectural enhancer complexes. Here we have reconstituted regulated TCR alpha enhancer activity in vitro on chromatin templates using purified T-cell transcription factors (LEF-1, AML1...

journal_title：Genes & development

authors： Mayall TP,Sheridan PL,Montminy MR,Jones KA

更新日期：1997-04-01 00:00:00

abstract：:To understand the organization of the transcriptional networks that govern cell differentiation, we have investigated the transcriptional circuitry controlling pseudohyphal development in Saccharomyces cerevisiae. The binding targets of Ste12, Tec1, Sok2, Phd1, Mga1, and Flo8 were globally mapped across the yeast geno...

journal_title：Genes & development

authors： Borneman AR,Leigh-Bell JA,Yu H,Bertone P,Gerstein M,Snyder M

更新日期：2006-02-15 00:00:00

abstract：:Expression of the Arabidopsis CGS1 gene that codes for cystathionine gamma-synthase is feedback regulated at the step of mRNA stability in response to S-adenosyl-L-methionine (AdoMet). A short stretch of amino acid sequence, called the MTO1 region, encoded by the first exon of CGS1 itself is involved in this regulatio...

journal_title：Genes & development

authors： Onouchi H,Nagami Y,Haraguchi Y,Nakamoto M,Nishimura Y,Sakurai R,Nagao N,Kawasaki D,Kadokura Y,Naito S

更新日期：2005-08-01 00:00:00

abstract：:The distal appendages (DAPs) of centrioles have been proposed to anchor cilia to the plasma membrane, but their molecular composition, assembly, and exact function in ciliogenesis remain poorly understood. Using quantitative centrosome proteomics and superresolution microscopy, we identified five DAP components, inclu...

journal_title：Genes & development

authors： Tanos BE,Yang HJ,Soni R,Wang WJ,Macaluso FP,Asara JM,Tsou MF

更新日期：2013-01-15 00:00:00