Constitutive mTORC1 activation by a herpesvirus Akt surrogate stimulates mRNA translation and viral replication.

abstract：:Joints form within the developing skeleton through the segmentation and cavitation of initially continuous cartilage condensations. However, the molecular pathways controlling joint formation largely remain to be clarified. In particular, while several critical secreted signals have been identified, no transcription f...

journal_title：Genes & development

authors： Kan A,Tabin CJ

更新日期：2013-03-01 00:00:00

abstract：:The spectrum of tumors associated with oncogenic Ras in humans often differs from those in mice either treated with carcinogens or engineered to sporadically express oncogenic Ras, suggesting that the mechanism of Ras transformation may be different in humans. Ras stimulates primarily three main classes of effector pr...

journal_title：Genes & development

authors： Hamad NM,Elconin JH,Karnoub AE,Bai W,Rich JN,Abraham RT,Der CJ,Counter CM

更新日期：2002-08-15 00:00:00

abstract：:The Bloom's syndrome gene (BLM) plays a pivotal role in the maintenance of genomic stability in somatic cells. It encodes a DNA helicase (BLM) of the RecQ family, but the exact function of BLM remains elusive. To study this question, we have cloned the BLM homolog of the frog Xenopus laevis (xBLM) and have raised anti...

journal_title：Genes & development

authors： Liao S,Graham J,Yan H

更新日期：2000-10-15 00:00:00

abstract：:IkappaB kinases (IKKs) IKK1 and IKK2 are two putative IkappaBalpha kinases involved in NF-kappaB activation. To examine the in vivo functions of IKK1, we generated IKK1-deficient mice. The mutant mice are perinatally lethal and exhibit a wide range of developmental defects. Newborn mutant mice have shiny, taut, and st...

journal_title：Genes & development

authors： Li Q,Lu Q,Hwang JY,Büscher D,Lee KF,Izpisua-Belmonte JC,Verma IM

更新日期：1999-05-15 00:00:00

abstract：:Treatment of early Xenopus embryos with retinoic acid (RA) produces a concentration-dependent series of defects in anterior axial structures that range from small deletions to embryos lacking heads. The graded series of axial defects obtained after RA administration to early embryos appears to result, in part, from ac...

journal_title：Genes & development

authors： Ruiz i Altaba A,Jessell T

更新日期：1991-02-01 00:00:00

abstract：:Classical embryology has provided a clear view of the timing and hormonal cues that govern sexual differentiation. Molecular biology has added important details to this picture. The cloning of SRY, MIS, and INSL3 provide insight into the molecular signals that provide important cues at the cellular level. Continued un...

journal_title：Genes & development

authors： Nef S,Parada LF

更新日期：2000-12-15 00:00:00

abstract：:We hypothesized that basic helix-loop-helix (bHLH) MIST1 (BHLHA15) is a "scaling factor" that universally establishes secretory morphology in cells that perform regulated secretion. Here, we show that targeted deletion of MIST1 caused dismantling of the secretory apparatus of diverse exocrine cells. Parietal cells (PC...

journal_title：Genes & development

authors： Lo HG,Jin RU,Sibbel G,Liu D,Karki A,Joens MS,Madison BB,Zhang B,Blanc V,Fitzpatrick JA,Davidson NO,Konieczny SF,Mills JC

更新日期：2017-01-15 00:00:00

abstract：:As in many polarized cells, spindle alignment in yeast is essential and cell cycle regulated. A key step that governs spindle alignment is the selective binding of the Kar9 protein to only one of the two spindle pole bodies (SPBs). It has been suggested that cyclin-dependent kinase Cdc28, in complex with cyclin Clb4, ...

journal_title：Genes & development

authors： Maekawa H,Schiebel E

更新日期：2004-07-15 00:00:00

abstract：:Chromatin is organized into higher-order structures that form subcompartments in interphase nuclei. Different categories of specialized enzymes act on chromatin and regulate its compaction and biophysical characteristics in response to physiological conditions. We present an overview of the function of chromatin struc...

journal_title：Genes & development

authors： Hauer MH,Gasser SM

更新日期：2017-11-15 00:00:00

abstract：:Bloom's syndrome (BS) is an autosomal recessive disorder characterized by a strong cancer predisposition. The defining feature of BS is extreme genome instability. The gene mutated in Bloom's syndrome, BLM, encodes a DNA helicase (BLM) of the RecQ family. BLM plays a role in homologous recombination; however, its exac...

journal_title：Genes & development

authors： Bugreev DV,Yu X,Egelman EH,Mazin AV

更新日期：2007-12-01 00:00:00

abstract：:Ubiquitin-mediated proteolysis controls the abundance of many cell cycle regulatory proteins. Recent work in Saccharomyces cerevisiae suggests that a complex consisting of Cdc53, Skp1, and a third component known as an F-box protein (termed SCF) in combination with Cdc34 specifically targets regulatory proteins for de...

journal_title：Genes & development

authors： Kaiser P,Sia RA,Bardes EG,Lew DJ,Reed SI

更新日期：1998-08-15 00:00:00

abstract：:The neurofibromatosis type II (NF2) tumor suppressor encodes a putative cytoskeletal associated protein, the loss of which leads to the development of Schwann cell tumors associated with NF2 in humans. The NF2 protein merlin belongs to the band 4.1 family of proteins that link membrane proteins to the cytoskeleton and...

journal_title：Genes & development

authors： McClatchey AI,Saotome I,Ramesh V,Gusella JF,Jacks T

更新日期：1997-05-15 00:00:00

abstract：:The Agrobacterium Ti plasmid (T-DNA) 6b proteins interact with many different host proteins implicated in plant cell proliferation. Here, we show that Arabidopsis plants overexpressing 6b display microRNA (miRNA) deficiency by directly targeting SERRATE and AGO1 via a specific loop fragment (residues 40-55). In additi...

journal_title：Genes & development

authors： Wang M,Soyano T,Machida S,Yang JY,Jung C,Chua NH,Yuan YA

更新日期：2011-01-01 00:00:00

abstract：:We isolated a novel bHLH protein gene Mesp2 (for mesoderm posterior 2) that cross-hybridizes with Mesp1 expressed in the early mouse mesoderm. Mesp2 is expressed in the rostral presomitic mesoderm, but down-regulated immediately after the formation of the segmented somites. To determine the function of MesP2 protein (...

journal_title：Genes & development

authors： Saga Y,Hata N,Koseki H,Taketo MM

更新日期：1997-07-15 00:00:00

abstract：:To investigate the relationship between splicing and polyadenylation during the production of vertebrate mRNAs, we examined the effect of mutation of a poly(A) site on splicing of upstream introns. Mutation of the AAUAAA polyadenylation consensus sequence inhibited in vitro splicing of an upstream intron. The magnitud...

journal_title：Genes & development

authors： Niwa M,Berget SM

更新日期：1991-11-01 00:00:00

abstract：:The connection between RNA and protein export from the nucleus was examined in the budding yeast Saccharomyces cerevisiae. NPL3 encodes an RNA-binding protein that shuttles in and out of the nucleus. Export of poly(A)+ RNA has been shown previously to be blocked in np13-1 mutants. To understand the role of Np13p in RN...

journal_title：Genes & development

authors： Lee MS,Henry M,Silver PA

更新日期：1996-05-15 00:00:00

abstract：:In Escherichia coli, the major nucleoid protein H-NS limits transcription by acting as a repressor or transcriptional silencer, presumably by its ability to close the looped chromosome domains in the nucleoid through DNA-protein-DNA bridging. Here, we demonstrate the direct involvement of H-NS as a positive factor sti...

journal_title：Genes & development

authors： Park HS,Ostberg Y,Johansson J,Wagner EG,Uhlin BE

更新日期：2010-07-01 00:00:00

abstract：:Exposure of hematopoietic progenitors to gamma-irradiation (IR) induces p53-dependent apoptosis and a p53-independent G2/M cell cycle arrest. These responses to DNA-damage can be inhibited by treatment with cytokine growth factors. Here we report that gamma-IR-induced apoptosis and cell cycle arrest are suppressed by ...

journal_title：Genes & development

authors： Quelle FW,Wang J,Feng J,Wang D,Cleveland JL,Ihle JN,Zambetti GP

更新日期：1998-04-15 00:00:00

abstract：:Genome-wide association studies (GWASs) have identified a genetic variant of moderate effect size at 6p21.1 associated with erythrocyte traits in humans. We show that this variant affects an erythroid-specific enhancer of CCND3. A Ccnd3 knockout mouse phenocopies these erythroid phenotypes, with a dramatic increase in...

journal_title：Genes & development

authors： Sankaran VG,Ludwig LS,Sicinska E,Xu J,Bauer DE,Eng JC,Patterson HC,Metcalf RA,Natkunam Y,Orkin SH,Sicinski P,Lander ES,Lodish HF

更新日期：2012-09-15 00:00:00

abstract：:Organization into polarized three-dimensional structures defines whether epithelial cells are normal or malignant. In a model of morphogenesis, we show that inhibiting key signaling pathways in human breast cancer cells leads to "phenotypic reversion" of the malignant cells. Using architecture as an endpoint, we repor...

journal_title：Genes & development

authors： Beliveau A,Mott JD,Lo A,Chen EI,Koller AA,Yaswen P,Muschler J,Bissell MJ

更新日期：2010-12-15 00:00:00

abstract：:The assembly of activated RNA polymerase II (pol II) transcription complexes has been investigated by assaying whether pre-assembly of intermediate complexes reduces the extended time required for start-site melting. The results show that a closed complex requiring factors IIA, IID, and the acidic activator GAL4-AH fo...

journal_title：Genes & development

authors： Wang W,Gralla JD,Carey M

更新日期：1992-09-01 00:00:00

abstract：:Gene silencing by double-stranded RNA is a widespread phenomenon called RNAi, involving homology-dependent degradation of mRNAs. Here we show that RNAi is established in the Drosophila female germ line. mRNA transcripts are translationally quiescent at the arrested oocyte stage and are insensitive to RNAi. Upon oocyte...

journal_title：Genes & development

authors： Kennerdell JR,Yamaguchi S,Carthew RW

更新日期：2002-08-01 00:00:00

abstract：:Kinase suppressor of Ras (KSR) is a recently identified component of Ras-dependent signaling pathways. In this report, we show that murine KSR1 (mKSR1) cooperates with activated Ras to promote Xenopus oocyte maturation and cellular transformation and provide evidence that this cooperation occurs by accelerating mitoge...

journal_title：Genes & development

authors： Therrien M,Michaud NR,Rubin GM,Morrison DK

更新日期：1996-11-01 00:00:00

abstract：:Gut homeostasis is controlled by both immune and developmental mechanisms, and its disruption can lead to inflammatory disorders or cancerous lesions of the intestine. While the impact of bacteria on the mucosal immune system is beginning to be precisely understood, little is known about the effects of bacteria on gut...

journal_title：Genes & development

authors： Buchon N,Broderick NA,Chakrabarti S,Lemaitre B

更新日期：2009-10-01 00:00:00

abstract：:The activity of the SCF(skp2) E3 ligase is required for the proteolytic turnover of several proteins involved in cell cycle control and transcriptional regulation. Loss of skp2 in the mouse leads to a complex phenotype including changes in cell size and DNA content as well as severe proliferation defects. Here we show...

journal_title：Genes & development

authors： Kossatz U,Dietrich N,Zender L,Buer J,Manns MP,Malek NP

更新日期：2004-11-01 00:00:00

abstract：:Specific recognition of splice sites within metazoan mRNA precursors (pre-mRNAs) is a potential stage for gene regulation by alternative splicing. Splicing factors of the SR protein family play a major role in this regulation, as they are required for early recognition of splice sites during spliceosome assembly. Here...

journal_title：Genes & development

authors： Labourier E,Bourbon HM,Gallouzi IE,Fostier M,Allemand E,Tazi J

更新日期：1999-03-15 00:00:00

abstract：:The circadian rhythm of pineal melatonin requires the nocturnal increment of serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase [AANAT]) protein. To date, only limited information is available in the critical issue of how AANAT protein expression is up-regulated exclusively at night regardless of its sp...

journal_title：Genes & development

authors： Kim TD,Woo KC,Cho S,Ha DC,Jang SK,Kim KT

更新日期：2007-04-01 00:00:00

abstract：:Eph receptors and ephrin ligands are key players in many developmental processes including embryo patterning, angiogenesis, and axon guidance. Eph/ephrin interactions lead to the generation of a bidirectional signal, in which both the Eph receptors and the ephrins activate downstream signaling cascades simultaneously....

journal_title：Genes & development

authors： Davy A,Aubin J,Soriano P

更新日期：2004-03-01 00:00:00

abstract：:FISH analysis of well-spread chromosomes reveals that homologs are paired in vegetatively growing budding yeast diploid cells, via multiple interstitial interactions, and independent of recA homologs and mating type heterozygosity. Pairing is present during G1 and G2, and in cells arrested at G1 by mating pheromone, b...

journal_title：Genes & development

authors： Burgess SM,Kleckner N,Weiner BM

更新日期：1999-06-15 00:00:00

abstract：:A transgenic mouse model for retinoblastoma was produced previously by directing SV40 T antigen expression to retinal photoreceptor cells using the promoter of the interstitial retinol-binding protein (IRBP) gene. This gene becomes active prior to the terminal differentiation of photoreceptors. Because T antigen-trans...

journal_title：Genes & development

authors： Howes KA,Ransom N,Papermaster DS,Lasudry JG,Albert DM,Windle JJ

更新日期：1994-06-01 00:00:00