Abstract:
:Gene silencing by double-stranded RNA is a widespread phenomenon called RNAi, involving homology-dependent degradation of mRNAs. Here we show that RNAi is established in the Drosophila female germ line. mRNA transcripts are translationally quiescent at the arrested oocyte stage and are insensitive to RNAi. Upon oocyte maturation, transcripts that are translated become sensitive to degradation while untranslated transcripts remain resistant. Mutations in aubergine and spindle-E, members of the PIWI/PAZ and DE-H helicase gene families, respectively, block RNAi activation during egg maturation and perturb translation control during oogenesis, supporting a connection between gene silencing and translation in the oocyte.
journal_name
Genes Devjournal_title
Genes & developmentauthors
Kennerdell JR,Yamaguchi S,Carthew RWdoi
10.1101/gad.990802subject
Has Abstractpub_date
2002-08-01 00:00:00pages
1884-9issue
15eissn
0890-9369issn
1549-5477journal_volume
16pub_type
杂志文章abstract::Chromosomal translocations are a hallmark of hematopoietic malignancies. The initial molecular events or pathways that lead to translocations in hematopoietic cells are largely unknown, particularly in the stem cell-enriched population postulated to be the initial target for these events. We used in vitro differentiat...
journal_title:Genes & development
pub_type: 杂志文章
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journal_title:Genes & development
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journal_title:Genes & development
pub_type: 杂志文章
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journal_title:Genes & development
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journal_title:Genes & development
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journal_title:Genes & development
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journal_title:Genes & development
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journal_title:Genes & development
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journal_title:Genes & development
pub_type: 杂志文章
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更新日期:2005-08-01 00:00:00
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journal_title:Genes & development
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更新日期:1997-09-15 00:00:00
abstract::Identifying modifiers of dosage-sensitive genes involved in neurodegenerative disorders is imperative to discover novel genetic risk factors and potential therapeutic entry points. In this study, we focus on Ataxin-1 (ATXN1), a dosage-sensitive gene involved in the neurodegenerative disease spinocerebellar ataxia type...
journal_title:Genes & development
pub_type: 杂志文章
doi:10.1101/gad.339317.120
更新日期:2020-09-01 00:00:00
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journal_title:Genes & development
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更新日期:2017-06-15 00:00:00
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journal_title:Genes & development
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更新日期:2004-09-15 00:00:00
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journal_title:Genes & development
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pub_type: 杂志文章,评审
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更新日期:2004-10-15 00:00:00
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journal_title:Genes & development
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journal_title:Genes & development
pub_type: 杂志文章,评审
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更新日期:2006-03-01 00:00:00
abstract::Treatment with retinoic acid (RA) is known to produce complex teratogenic effects in vertebrates, and its presence in the developing embryo as an endogenous substance has led to the suggestion that RA might be a natural morphogenetic agent. Although our understanding of the molecular mechanism of RA action has improve...
journal_title:Genes & development
pub_type: 杂志文章
doi:10.1101/gad.5.8.1333
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journal_title:Genes & development
pub_type: 杂志文章
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更新日期:2012-09-15 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
doi:10.1101/gad.332536.119
更新日期:2020-02-01 00:00:00
abstract::It is now well appreciated that the apoptosome, which governs caspase-dependent cell death, also drives nonapoptotic caspase activation to remodel cells. However, the determinants that specify whether the apoptosome acts to kill or remodel have yet to be identified. Here we report that Tango7 collaborates with the Dro...
journal_title:Genes & development
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journal_title:Genes & development
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journal_title:Genes & development
pub_type: 杂志文章
doi:
更新日期:2000-01-15 00:00:00